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Unlabelled: The aim of the study was to investigate the stability of some oral liquid formulations containing 1 mg/ml captopril., Material and Method: The oral solutions were prepared using captopril substance, keeping the formulation as simple as possible to avoid potentially undesirable excipients. Samples were stored for 39 days below 8 degrees C and at 22 +/- 3 degrees C and analysed for physical, chemical and microbiological stability., Results: The formulations with ascorbic acid are stable for seven days either at 8 and 22 degrees C and could be prepared in hospital pharmacy as a more safely alternative to children terapy with tablets powders.

Unlabelled: The aim of flavonols complexation is to improve their specific activity., Material and Method: The flavonols sources were Morus alba L. and Morus nigra L., zinc being the biological active ion. Physico-chemical characterization was made by thin-layer chromatography, UV-VIS spectrophotometry, IR spectrometry and polarography., Results: The complexes results were within acceptability limits, but their obtaining is economically inefficient.

Indigene Stachys species have a high content in interesting compounds as iridoids, but also high quantities of flavonoids and phenol-carboxylic acids. These compounds present vasorelaxing effect on smooth vascular muscle interfering with metabolic degradation of nitric oxide pathways (inhibition of peroxynitrites formation) and by inhibition of phosphodiesterase. This work shows flavonoids spectrum of 3 Stachys species using HPLC methods. We identified quercetol, rutoside, miricetin and phenol-carboxylic acids (chlorogenic, caffeic and ferulic acids).