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Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:21:16Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:39:53Z : No. of bitstreams: 1 2-s2.0-15244353911.pdf: 71891 bytes, checksum: 389cda8155d2e795832e250fb2a68756 (MD5) Made available in DSpace on 2014-05-27T11:21:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-02-01 Objective: To assess the effect of growth hormone (GH) on myocardial remodeling in infarcted rats. Methods: This study comprised 24 Wistar rats divided into 3 groups as follows: 1) AMI-GH group - comprising 8 rats that underwent infarction and were treated with GH; 2) AMI group - comprising 8 rats that underwent infarction and received only the diluent of the GH solution; and 3) control group (C group) - comprising 8 rats that underwent simulated infarction. After 30 days, the animals underwent functional study through echocardiography, and the changes in myocardial contractility of the isolated left ventricular (LV) papillary muscle were studied. Results: The echocardiography identified an increase in the diastolic (C=7.32±0.49; AMI=8.50±0.73; AMI-GH=9.34±0.73; P

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:17:59Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:44:09Z : No. of bitstreams: 1 2-s2.0-0029079165.pdf: 40189 bytes, checksum: 3d3771936a1100a9d225e6f71aa73fec (MD5) Made available in DSpace on 2014-05-27T11:17:59Z (GMT). No. of bitstreams: 0 Previous issue date: 1995-01-01 Purpose - To analyse the influence of mannitol added to Krebs-Henseleit (KH) solution on the myocardium edema and myocardial function. Methods - Isolated rat heart under isovolumetric contractions studied according to Langendorff's technique were perfused with KH solution at constant flow during 90 min. The coronary perfusion pressure, diastolic and systolic pressures were recorded at every 15 min. At the end of the experiment, myocardium water content was measured in hearts perfused with KH solution (group I, n = 9) and in hearts perfused with KH solution plus 8 mM mannitol (group II, n = 8). These results were compared to non-perfused control heart (n = 9). Results - Myocardial water content was statistically higher in group I (80.8 ± 1.3%) compared to group II (78.1 ± 0.7%) and control group (75.5 ± 0.5%). Systolic arterial pressure was statistically higher in group I (86.2 ± 11.5 mmHg) compared to group II (72.7 ± 21.1 mmHg). There was no difference in the diastolic pressure between the two groups. Coronary perfusion pressure (Pp) increased progressively during the experiment in both groups. However, Pp was lower in group II than in group I. Conclusion - Mannitol added to KH solution significantly attenuates the myocardium edema in the isolated perfused rat heart. Faculdade de Medicina UNESP Depto de Clinica Medica, CEP 18618-000 - Botucatu, SP Faculdade de Medicina UNESP Depto de Clinica Medica, CEP 18618-000 - Botucatu, SP

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:17:31Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:28:12Z : No. of bitstreams: 1 2-s2.0-0027572997.pdf: 49390 bytes, checksum: d4ef74947d7759c47359d756b77a9d3f (MD5) Made available in DSpace on 2014-05-27T11:17:31Z (GMT). No. of bitstreams: 0 Previous issue date: 1993-04-01 PURPOSE--To evaluate the effects of age on mechanical performance of rat myocardium. METHODS--Left ventricular papillary muscles were isolated from male Wistar rats at 1, 3, 6 and 12 months of age. Muscles were studied isometrically and isotonically, stimulated at 0.2 Hz, perfused with Krebs-Henseleit solution having an external calcium concentration of 2.52 mM, and maintained at 28 degrees C. RESULTS--Peak isometric developed tension was significantly higher in 1 month than 3, 6 and 12 months. Peak rate of isometric tension rise decreased substantially between 1, 3 and 12 months. Time to peak isometric developed tension showed a significant increase of both 3 and 12 months of age. Time to half relaxation increased significantly from 3 to 6 and from 3 to 12 months. Maximum rate of tension decline decreased from 3 to 6 and from 3 to 12 months. No difference in resting tension was noted among any group. Isotonically, peak shortening and time to peak shortening increased from 1 to 3 months of age. Time to half re-lengthening increased from 3 to 6 and from 3 to 12 months of age. No difference in peak shortening velocity, peak relaxation velocity and relative change in muscle length was noted among any groups. CONCLUSION--The maturation affects the mechanical performance of cardiac muscle.

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:17:24Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:33:16Z : No. of bitstreams: 1 2-s2.0-0025538651.pdf: 597222 bytes, checksum: e0a3c89461b8f8a0a449d1c194b6534e (MD5) Made available in DSpace on 2014-05-27T11:17:24Z (GMT). No. of bitstreams: 0 Previous issue date: 1990-12-01 The effects of ultrasound on the wound healing process after teeth extractions were studied histologically. The right upper incisor was extracted in 56 rats. They were divided into 2 groups, one control (I) and one experimental (II). Group II received ultrasound stimulation that was applied with the frequency of repetition of 1,000 Hz and pulse length of 2,000 us continuously, during five minutes daily since the extraction day until 24 hours before the death. The rats were sacrificed at 3, 6, 9, 12, 15, 18, and 21 postoperative days. The results showed a precocious granulation tissue formation, faster remodeling of osseous ridges, and consequently acceleration of the alveolar wound healing process.

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-26T22:05:32Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:33:07Z : No. of bitstreams: 1 2-s2.0-0021250398.pdf: 183731 bytes, checksum: 2e6495afd1a973d8f25fc99504861ef5 (MD5) Made available in DSpace on 2014-05-26T22:05:32Z (GMT). No. of bitstreams: 0 Previous issue date: 1984-01-01