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Abstract PD-1 (programmed Death-1) immune checkpoint inhibitors have provided significant benefits to tumor patients. However, a considerable proportion of the patients develop immune-related adverse events (irAEs), of which cutaneous irAEs (cirAEs, e.g., psoriasis) occur relatively early. This review provides an overview of the current progress in psoriasis de novo or exacerbation by PD-1 checkpoint inhibitors. It not only describes the relevant influencing factors but also theoretically analyzes the immunological mechanisms that lead to the onset or exacerbation of psoriasis. Finally, the authors present guidelines for the treatment of psoriasis de novo or exacerbation by PD-1 checkpoint inhibitors. The review is intended to assist dermatologists in the early recognition and effective individualized management of such cirAE, which is helpful to continue or adjust the tumor-targeted immunotherapy on the basis of ensuring the quality of life of tumor patients.

Gendered ageism contributes to invisibility and homogenization of older women, harming their health, quality of life and limiting their social participation. Health issues related to aging have received increasing attention in the scientific literature. However, studies on aging that include a gender dimension or ethnic aspects remain scarce. This article presents the results of a systematic review on older women’s health and wellbeing, gender inequalities, age discrimination experienced by older women and their intersections with other forms of discrimination. Between January and February 2023, we conducted a literature review using PRISMA in the Web of Science Core Collection, MEDLINE and SciELO Citation Index. We selected 43 empirical studies from different countries focusing on women over 65 years. The findings show the incidence of discrimination and inequality in health care experienced by older women, ageist attitudes among health care providers and other professionals, experiences of abuse and gender-based violence among older women. Additionally, the study examines the impact of ageism and other forms of discrimination on the health of LGBTQ+ older people, ethnic minorities, older women with disabilities, and other non-traditional groups.

ABSTRACT: In this study,the causative pathogen was isolated from Eucommia ulmoides,verified using Koch’s postulates, identified by morphology and molecular biology, and assessed the biological characteristics. The effects of agar media, pH, temperature, light, carbon sources, and nitrogen sources on hyphal growth of Pestalotiopsistrachicarpicola were under investigation, and the influences of time, liquid matrix, light, temperature on conidial germination were studied. The results showed that P. trachicarpicola was a new pathogen causing black spot disease of E. ulmoides, and the mycelial growth of P.trachicarpicola was the best in the potato dextrose agar (PDA) medium, pH 7.0, the temperature was 20~25 °C, light, and glucose and beef extract were the best for carbon and nitrogen, respectively. The germination rate of the conidia increased from the time, darkness, and a proper supply of sugar. The lethal temperatures of the hyphae and conidia were 52 °C and 72 °C, respectively.We can conclude that appropriate environmental conditions are more conducive to the growth of the pathogen and the germination of spores, which leads to the occurrence of disease. This study constituted the first report on the new causative pathogen in E. ulmoides black spot and the biological characteristics. Theis study provided a theoretical basis to prevent the occurrence of this disease.

Chinese and Western sports are in two different social systems. Because of the difference in their origin, cognition and value trend, two kinds of sports cultures of different natures have been created. Each of which interprets the characteristics of human civilization in different forms. In Chinese culture, sports are often closely associated with Taoist and Confucian philosophies. Taoism emphasizes “letting nature take its course”, and physical exercise is regarded as a means of harmonizing body and mind, and achieving unity of body and mind. Confucianism believes that sports are to cultivate people’s morality and etiquette, not just to pursue physical limits. In contrast, Western sports philosophy usually emphasizes competition, challenge and self-transcendence. This idea can be traced back to ancient Greece’s Olympic spirit, which is to demonstrate individual honor, strength and courage through physical exercise. In general, although Chinese and Western sports philosophies both believe that sports are an exercise for the human body and spirit, they differ in values, goals and methods. This study takes the comparison between traditional Chinese sports culture and Western sports culture as the starting point and attempts to analyze the commonalities and differences between the two. This has important practical significance for enriching world sports culture and promoting the development of world sports culture.

ABSTRACT: The Linpan cultural landscape has been a masterpiece of harmonious coexistence between humans and nature since the Dujiangyan Hydraulic Engineering more than 2,300 years ago. With the rapid urbanization of the Chengdu Plain over the past thirty years, Linpan has gradually declined and faced a disappearance crisis. The protection and utilization of Linpan have become an urgent public demand. Our case study area was in Dujiangyan City. We used detailed field investigations, questionnaires, and unstructured interviews to understand the villagers’ perceptions of the Linpan and explore how their socioeconomic and resource backgrounds affected their landscape perceptions. The study revealed typical population loss and aging trends in Linpan settlements, and it found that the villagers recognized Linpan as a “joint masterpiece of man and nature” and that most villagers supported the utilization in Linpan rural areas. This study further revealed that villagers’ socioeconomic and resource background factors had complex and selective impacts on their landscape perceptions. It also found that economic factor, especially monthly income, was the key variables affecting villagers’ landscape perceptions. The study enriched the perception study of Linpan, a unique agro-cultural landscape in the Chengdu Plain. It provided an essential reference for the subsequent sustainable development of Linpan based on villagers’ participation.

ABSTRACT In this study, a mixture of estradiol benzoate, progesterone, and testosterone propionate was injected into Diannan small-ear sows to induce estrus. The 16S rRNA technology was used to comparatively analyze the differences in fecal microbial composition and diversity between induced and spontaneous estrus in Diannan small-ear sows. The most abundant phylum in the sows in estrus were Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria. There was a significant negative correlation between Firmicutes and Bacteroide and a significant positive correlation between Bacteroides and Bifidobacterium. The relative abundance of Stenotrophomonas, Neisseria, Anaerofustis, and Terrisporobacter in the sows during induced estrus was significantly higher than that during spontaneous estrus. Taken together, induced estrus affects the relative abundance of specific microbes in the feces of Diannan small-ear sows, but it does not affect the overall composition and diversity. These results provide fundamental knowledge about the gut microbiota of sows with induced estrus.

ABSTRACT: Based on national agricultural trade panel data of Regional Comprehensive Economic Partnership (RCEP) countries from 2002 to 2020, the structural characteristics of the RCEP national agricultural trade spatial network are reconstructed by the social network analysis method in this paper. Specifically, the characteristics consist of overall characteristics, individual characteristics, core-periphery structure analysis, and block models. Moreover, the influence factors on the agricultural trade network are also examined by the QAP regression model. The conclusions are summarized as follows. Firstly, the agricultural trade in RCEP countries has significant spatial correlation, showing favorable stability and accessibility. Secondly, Australia, China, Thailand, and Vietnam are the central actor’s leading position in the correlation network. While Cambodia, Laos, Myanmar, and other countries are in the marginal position. Thirdly, the network can be divided into four blocks, including the net benefit block, the two-way spillover block, the broker block, and the net spillover block. The spillover effect between the blocks is transitive. And finally, geographical distance, economic and social conditions, resource endowment, and language proximity index significantly impact the RCEP agricultural trade network structure.

Marxist philosophical thought is an important ideological weapon for people to understand and transform the world. This paper studies the application and influence of Marxist philosophy in the field of music education, as well as the current development status of music education, and provides theoretical support for music education by discussing how to combine Marxist philosophy with the field of music education. Music education is a means of cultivating and shaping a person’s musical heritage, thereby achieving quality education. In music education, Marxist philosophy is an important theoretical support for the development of music learning. The dialectical materialism epistemology in Marxist philosophy is closely related to music education. This article explored the influence and role of Marxist philosophical thought on the development of music education by combing Marxist philosophical thought and music education theory, combined with the current situation of contemporary music education development, and analyzed the problems that exist in the development of music education. Dialectical materialism in Marxist philosophy is closely related to the theory of music education. Applying Marxist philosophy to music education can promote the smooth development of music education and help the audience of music education achieve their training goals. This article indicates that in-depth research on the application of Marxist philosophical thoughts, in the development of music education, is of great practical significance.

ABSTRACT During high-speed seeding operations, collisions between seeds and seed guide tubes are very significant, resulting in poor seed spacing uniformity. To solve this problem, a high-speed seed guide device with conical spiral airflow was designed, which can use high-speed positive pressure airflow to move seeds smoothly. To improve the uniformity of the airflow field in the device, a single-factor test was carried out to determine the reasonable range of each factor. Then, the four-factor and five-level central composite test was carried out. The four main factors were screw pitch, cone angle, width of gap, and angle of air-tube, and the evaluation index was the mean variance of airflow velocity. The test results showed that the optimal parameters of the high-speed seed guide device with conical spiral airflow were a screw pitch of 24.98 mm, cone angle of 7.47/55, width of gap of 5.31 mm, and angle of air-tube of 25.09º. The verification test showed that the relative error between the verification test value and the predicted value was less than 5%, indicating that the model had high reliability. This research can provide references for the research of high-speed seed guide technology and the innovative design of seed guide devices.

Abstract Background stewart-treves syndrome (STS) is an angiosarcoma associated with chronic lymphedema. Objectives This article analyses the characteristics of twenty-two patients and proposes active intervention in lymphedema and the early diagnosis of STS. Methods Twenty-two patients with STS were diagnosed at the centre over an 11-year period. Clinical manifestations, a series of conventional analyses, and histopathology were used to study these cases retrospectively. Results The age range of 22 patients with STS was 15 to 78 years. The main clinical manifestations included multiple skin and subcutaneous nodules and scattered red or purplish-red rashes in the lymphoedematous limbs. These patients often showed clinical symptoms such as lymphedema, weakness, emaciation, pain, mass, lymphadenopathy and so on. The positive rates of ultrasonography, MRI and radionuclide imaging were 66.7% (6/9), 92.3% (12/13) and 18.2% (2/11), respectively. The main points regarding active intervention in lymphedema and early diagnosis of STS were summarized. Study limitations Since this was a retrospective study, the main points summarized by the author need to be further quantified in clinical work to guide the diagnosis of this kind of disease more conveniently. In addition, further clinical trials are needed to evaluate the role of lymphedema in the occurrence and development of malignant tumors. Conclusions STS can appear in lymphoedematous tissue many years after lymphedema onset. To avoid delays in the diagnosis and therapy of STS, physicians should actively look for signs or symptoms of malignant lymphedema during the follow-up period and promptly manage patients developing problems.

Referência do artigo comentado: XU, Yan. Chinese Cultural Landscapes: From the ideal of a balanced bond between humans and nature to ecological forms of life. Trans/Form/Ação: Unesp Journal of Philosophy, v. 47, n. 4, e0240067, 2024. Available at: https://revistas.marilia.unesp.br/index.php/transformacao/article/view/14623.

ABSTRACT: Acute liver injury (ALI) is an important medical problem that requires effective therapy. Astaxanthin (AST) is a carotenoid, and the beneficial effects of astaxanthin, including anti-oxidative, anti-inflammatory and anti-tumour activities, have been identified. The present study was designed to elucidate the protective effects of astaxanthin against ALI and their underlying mechanisms. RAW264.7 macrophages were treated with dimethyl sulfoxide combined with different doses of astaxanthin for 12 h. Mice were fed with or without astaxanthin for up to 7 days. LPS was administered to induce inflammation. We assessed histopathology, oxidative stress, inflammation and apoptosis .The results indicated that astaxanthin attenuated LPS-induced oxidative stress, inflammation and cell apoptosis both in vivo and in vitro. In vivo and in vitro experiments showed that astaxanthin down regulated the nuclear factor-kappa beta (NF-κB), nuclear factor erythroid 2-related factor 2 (Nrf2) and NLR family pyrin domain containing 3 (NLRP3) signalling pathways, inhibiting the LPS-induced inflammatory response, oxidative stress and cell apoptosis, and alleviating LPS-induced ALI in mice.

OBJECTIVE: To evaluate the epidemiological profile of symptomatic Meckels diverticulum in patients admitted to a specialized childrens hospital from January 2009 to December 2018. METHODS: This retrospective study analyzed the medical records of patients admitted to a childrens hospital in Curitiba (Paraná-Brazil) from 01/01/2009 to 31/12/2018. RESULTS: We found an incidence of 5.3 cases of symptomatic Meckels diverticulum per year. Of the 43 medical records, there was a predominance of male patients (69.7%) and 21 (48.8%) were less than 1-year-old. As for the clinical presentation,15 patients presented acute abdominal inflammation (34.8%), 9 acute abdominal hemorrhage (21%), and 6 acute abdominal obstruction (14%). 13 patients (30.2%) presented unspecific condition and were not classified. Regarding treatment, 41 patients (95.2%) underwent segmental enterectomy with enteroanastomosis. Ectopic mucosa was found in 19 anatomopathological examinations, 16 of which were gastric in origin, 1 pancreatic, and 2 had both mucosae. Post-operative complications included wound dehiscence (4.6%), paralytic ileus (4.6%), and peritonitis (2.3%). Of the 41 patients, 38 were discharged (88.4%), and 5 (11.6%) died. CONCLUSION: Meckels diverticulum had a propensity to manifest in children who were breastfeeding, most often with inflammation and hemorrhage. Of the 9 patients who manifested hemorrhage, 7 (78%) showed ectopic mucosa, which indicates a likely relationship between the presence of ectopic mucosa and hemorrhage. The percentage of patients who died is higher in our sample than in the literature; those who died were predominantly male and 4 (80%) were younger than 1

Resumo Fundamento A estratificação de risco precoce com biomarcadores simples é essencial em pacientes com infarto do miocárdio sem supradesnivelamento do segmento ST (IAMSSST). Objetivo Este estudo tem o objetivo de avaliar a associação entre nível de big endotelina-1 plasmática (ET-1) e o escore SYNTAX (SS) em pacientes com IAMSSST. Métodos Foram recrutados 766 pacientes com IAMSSST que passaram por angiografia coronária. Os pacientes foram divididos em três grupos: SS baixo (≤22), SS intermediário (23-32), e SS alto (>32). A correlação de Spearman, o ajuste de curva suave, a regressão logística, e a análise de curva característica de operação do receptor (ROC) foram realizados para avaliar a associação entre o nível de big ET-1 plasmática e o SS. Um p-valor

In this study, we propose a novel method to determine the vitamin C content in fruits and vegetables. The proposed method exploits the image and data processing abilities of computers by coupling a digital camera and a color reaction. An image acquisition device was developed to collect the image information of the solution to be measured after the color reaction. The corresponding RGB and Lab color components were obtained by an image analysis software. Further, the standard curves of the vitamin C concentration and color component were established by nonlinear, linear, and multivariate data fitting. The detection range was 0.81-20.00 µg mL-1 (R2 = 0.9994), LOD was 0.24 µg mL-1, LOQ was 0.81 µg mL-1, accuracy was 98.95%, and precision was determined with an RSD of 0.73%. A comparison of the results confirmed that the proposed method’s accuracy was higher than that of the spectrophotometric method. The proposed method has a simple design and facilitates easy operation, and the cost of the equipment is only US$ 31.43. Therefore, it can replace the traditional spectrophotometric method for the determination of vitamin C content in fruits and vegetables and is highly applicable in the food, chemical, and medical fields.

Resumo Fundamento: Estudos epidemiológicos recentes demonstraram que alterações na microbiota e seus metabólitos estão associadas à hipertensão arterial sistêmica. A Helicobacter pylori (H. pylori) é um dos patógenos bacterianos mais comuns, e a possível associação entre a infecção por H. pylori e a hipertensão é controversa. Objetivos: Este estudo teve o objetivo de esclarecer a associação entre eles e proporcionar uma nova base teórica para detectar a patogênese da hipertensão. Métodos: Foram selecionados estudos caso-controle e transversais sobre a associação entre H. pylori e hipertensão, publicados de 1996 a 2019 indexados nos bancos de dados PubMed, Google Scholar, Chinese Wan Fang Data, e Chinese National Knowledge Infrastructure (CNKI). As razões de chance (RC) combinadas e o intervalo de confiança (IC) 95% foram estimados. O I² foi realizado para avaliar a heterogeneidade estatística. O viés de publicação foi avaliado utilizando-se os testes de Beggs e de Egger. Os dados extraídos foram analisados no software Stata 12.0. A significância estatística foi definida com um p-valor < 0,05. Resultados: Foram cadastrados 17 estudos envolvendo 6376 casos de hipertensão e 10850 controles. A taxa de infecção por H. pylori em pacientes hipertensos e em controles foi de 64,9% e 56,3%, respectivamente. Foi demonstrada uma associação significativamente positiva entre a infecção por H. pylori e a hipertensão, com uma RC global de 2,07 (IC 95%: 1,46–2,94; p < 0,05). A análise de subgrupos revelou que a prevalência de infecção por H. pylori foi associada à hipertensão na região da Ásia e no grupo de caso-controle, as RC (IC 95%) foram 2,26 (1,51-3,38) e 2,53 (1,72-3,72), respectivamente. Depois de estratificar por métodos de detecção, ainda existiam diferenças entre os subgrupos (todos p < 0,05). Conclusão: Esta metanálise indicou que a infecção por H. pylori está associada positivamente à hipertensão.

Resumo Fundamento Apesar das evidências crescentes de que o peptídeo natriurético N-terminal pró-cérebro (NT-proBNP) tem um valor prognóstico importante em adultos mais velhos, há dados limitados sobre seu valor preditivo prognóstico. Objetivos O objetivo deste estudo é avaliar o significado clínico do NT-proBNP em pacientes hospitalizados com mais de 80 anos de idade em Pequim, China. Métodos Este estudo prospectivo e observacional foi conduzido em 724 pacientes muito idosos em uma enfermaria geriátrica (idade ≥80 anos, variação, 80-100 anos, média, 86,6±3,0 anos). A análise de regressão linear multivariada foi utilizada para rastrear os fatores independentemente associados ao NT-proBNP, e o modelo de regressão de risco proporcional de Cox foi utilizado para rastrear as associações entre os níveis de NT-proBNP e os principais endpoints . Os principais endpoints avaliados foram mortes por todas as causas e ECAM. Valores de p

Resumo Fundamento O ácido úrico (AU), produto final do metabolismo dos nucleotídeos das purinas, participa dos processos de doenças metabólicas e cardiovasculares. Evidências experimentais sugerem que o ácido úrico é um mediador importante na resposta fisiológica ao aumento da pressão arterial. Objetivo Avaliar a associação entre os níveis séricos de AU e pré-hipertensão e hipertensão em uma população chinesa. Métodos Conduziu-se um estudo transversal entre março e setembro de 2017, e 1.138 participantes com idades entre 35 e 75 anos foram incluídos neste estudo, onde 223 normotensos, 316 pré-hipertensos e 599 hipertensos foram selecionados para avaliar a associação entre níveis séricos de AU e hipertensão. Considerou-se um valor de p

Few studies have examined the relationship between race and politics for Asian Brazilians. Using data from the Latin American Public Opinion Survey, we examine this relationship along two axes: cognitive orientation towards politics and institutional confidence. We use factor analysis to create representative indices of these axes and estimate regression models using race as a predictive variable. We find no evidence that Asian Brazilians differ from White Brazilians along either of these two axes. However, we find that a university education has an especially strong relationship with cognitive orientation towards politics for Asian Brazilians. On average, Asian Brazilians with a university education had a cognitive orientation towards politics score 17% higher than Asian Brazilians without a university education, though we do not find a similar effect for institutional confidence. Overall, we find that ethnic identity, particularly for Asians, does not have a strong effect on either of the axes but education has different effects on them between different ethnic groups. Key Words: Race and political behavior, minority political behavior, Asians in Latin America, factor analysis Resumo Poucos estudos têm examinado a relação entre raça e política para Brasileiros Asiáticos. Usando dados do Projeto de Opinião Pública de América Latina, examinamos essa relação através de dois eixos: orientação cognitiva à política e confiança institucional. Nós usamos analise fatorial para propor índices representativos e estimamos modelos de regressão usando raça como uma variável preditiva. Não encontramos evidencia que Brasileiros Asiáticos diferem com Brasileiros Brancos em ambos os eixos. Porém, achamos que educação superior tem uma relação particularmente forte com a orientação cognitiva à política para Brasileiros Asiáticos. Na média, Brasileiros Asiáticos com educação superior tem uma pontuação de orientação cognitiva à política 17% mais alta do que Brasileiros Asiáticos sem educação superior, apesar de não encontramos um efeito semelhante para a confiança institucional. No geral, descobrimos que a identidade étnica, particularmente para os asiáticos, não tem um forte efeito em nenhum dos eixos, mas a educação tem efeitos diferentes entre os diferentes grupos étnicos. Palavras Chave: Raça e comportamento política, comportamento política das minorias, Asiáticos em América Latina, analise fatorial

Abstract: As the “chaotic” edge of innovation system has strong innovation potential and is easy to form and develop the emerging technology innovation network, the formation process of emerging technologies and their relationship with the development trajectory of original technologies are analyzed, and the evolution mechanism of innovation network of advanced manufacturing industry is deeply studied combined with life cycle theory. Firstly, empirical analysis is carried out by collecting patents data in the industrial robotics field. Then, the IPC co-occurrence network and patentee citation network are plotted by combining patents citation analysis with social network analysis. Next, the technical characteristics and knowledge flow characteristics of an advanced manufacturing innovation network are verified by calculating various indicators of the network. Finally, the empirical results show that the technology structure in the field of industrial robotics has high heterogeneity, wide integration among technical fields, and knowledge flow network has a small-world effect, characterized by easy flow, wide flow direction, high efficiency, fuzzy network boundary, and numerous and diversified core the key players in innovation.

A satisfação profissional dos enfermeiros resulta da interação com vários fatores que podem influenciar o desempenho dos enfermeiros, o que acentuou a necessidade de aprofundar o seu conhecimento. Este estudo tem como objetivo: compreender a infuência da satisfação profissional na qualidade dos cuidados de enfermagem, para o efeito foi realizada uma revisão integrativa da literatura, tendo a pesquisa sido realizada através do motor de busca EBSCOhost em diversas bases de dados, nomeadamente, Academic Search Complete, APA PsycInfo, Complementary Index, CINAHL, Directory of Open Access Journals, MEDLINE e Science Direct, Supplemental Index. Após análise e respeitando os critérios de inclusão e exclusão previamente estabelecidos, apuraram-se 8 estudos, que destacam maior influência dos fatores organizacionais do que os fatores pessoais, na satisfação profissional, por outro lado, também referem a relação direta entre uma maior satisfação profissional dos enfermeiros e uma maior qualidade em saúde e dos cuidados prestados. A literatura disponível demonstra claramente que a satisfação profissional influencia a prestação dos cuidados de enfermagem e, consequentemente, a qualidade dos mesmos, bem como o desempenho dos serviços de saúde. É crucial que os gestores, independentemente dos contextos da prática, tenham em atenção a satisfação profissional como fator de melhoria da qualidade em saúde e definam políticas e estratégias para incrementar a satisfação profissional dos enfermeiros. O presente estudo é demonstrativo de que a satisfação profissional tem impacto inegável na qualidade dos cuidados de enfermagem, apesar das suas limitações, como a amostra e o limite temporal, não permitirem uma afirmação e/ou generalização inequívocas. Embora considerando necessária a realização de outros estudos similares e complementares a este, e a uma maior escala, é possível afirmar que se conseguiu dar um contributo para um melhor entendimento acerca da influência da satisfação profissional dos enfermeiros na qualidade dos cuidados de enfermagem.

En el centro de los debates sobre la desaparición y el resurgimiento del espacio público se encuentra el concepto de lo público, que a menudo se utiliza para definir las cualidades más deseables que desde el punto de vista normativo y prescriptivo debe poseer un espacio público. Este artículo, en lugar de proponer un ideal abstracto y normativo universalmente aplicable a lo público, aboga por su desnormalización, abordando este concepto como un estado del espacio que es público de una determinada manera y en un contexto determinado. Para ilustrar las múltiples capas posibles de lo público, el artículo utiliza como estudio de caso la regeneración del espacio público de la ribera del río Huangpu en Shanghai. Examinando la transformación de esta ribera en las dos últimas décadas y centrados en el reciente proyecto de conexión del espacio público, el artículo muestra las diferentes formas en las que el diseño y el desarrollo del espacio público se entrelazan con el ideal de metrópolis orientada a las personas, propuesto como la clave de la pretensión ambiciosa de que Shanghái se convierta en una «excellent global city» (ciudad global excelente). A partir del análisis de la retórica y de la realidad del desarrollo del espacio público en la ribera en Shanghái orientado a las personas, este artículo muestra tres capas diferentes de lo público: lo público localizado, lo público procedimental y lo público simbólico, que se refieren no solo a la calidad material sino también a los procesos de distribución y construcción discursiva del espacio público. Este debate sobre las múltiples caras posibles de lo público servirá de punto de partida para seguir investigando cómo abordar lo público más allá del confinamiento de los límites espaciales como parte de la amplia y compleja dinámica de poder de las ciudades contemporáneas.

Abstract The authors report a rare case of primary cutaneous mucormycosis caused by Mucor irregularis and cutaneous Klebsiella pneumoniae infections in a 67-year-old Chinese woman. After the administration of liposomal amphotericin B combined with cefoperazone/sulbactam sodium, the patient recovered. Invasive fungal infection combined with cutaneous bacterial infection should receive attention.

ABSTRACT Objective: To investigate the efficacy and safety of febuxostat on renal function in CKD stage 3 diabetic nephropathy patients. Methods: Patients in our hospital with chronic kidney disease (CKD) stage 3 diabetic nephropathy (DN) complicated by high serum uric acid (360 µmol/L) were recruited. Patients were then divided into treatment group and control group according to the random number table method. All the patients received low purine diet, renin-angiotensin-aldosterone system (RAAS) inhibitors, and adequate routine hypoglycemic treatment. Febuxostat was employed only in the treatment group. The levels of blood uric acid (sUA), serum creatinine (Scr), cystatin C (cys-c), eGFR, 24-hour urine protein quantification, albuminuria, and creatinine ratio (ACR) were evaluated in all patients before and after treatment at 4, 8, 12, and 24 week. Results: No difference was found before treatment between the two groups. After treatment at 4, 8, 12, and 24 week, the levels of sUA, SCr, cys-c, and eGFR between the two groups were significant different (P

ABSTRACT To improve the picking rate and reduce the wrong picking rate of the existing wolfberry harvesting machinery, in this study, the binding force and physical appearance of the immature fruit stalk, mature fruit stalk, flower, and leaf were studied to guide the designing of new-generation wolfberry harvesting machinery and lay theoretical foundation for further studies on biomechanical properties of wolfberry. By preprocessing the experimental data with the Pauta criterion, the distribution range of the binding force and physical appearance of stalk were obtained; the binding force was not influenced by the picking temperature, mass of the fruit, and location of the branch of the fruit. The length-diameter ratio of mature fruit was confirmed by image processing. The constitutive equations for immature fruit stalks and mature fruit stalks were established. The breaking strength of the mature fruit stalk was obviously higher than that of the immature fruit stalk; moreover, the breaking strength of the mature and immature fruit stalk of the four wolfberry varieties differed obviously. The experimental results obtained in this study can provide detailed data for the parameter design of a new-generation wolfberry harvesting machinery.

This essay foregrounds the processes and ramifications of sand’s extraction, displacement, and reassembly as critical material and political junctures to unfold the cross-strait geo-political impasse between the “two Chinas.” These processes, termed “geological afterlives of sand,” brought the gulf of waters between Xiamen and Kinmen to the fore. In this fluid space where border is ideologically fraught, sand has become a critical bordering entity that enables the encounter between geology and cross-strait politics. By focusing on sand’s mobile and malleable agency in rearranging geo-political order in this region, this essay draws on cartographic technology and documentary depiction of sand’s multifaceted metamorphoses to present and negotiate what it means for human and nonhuman actors to live through sand's afterlives of displacement.

ABSTRACT: The responses of two maize (Zea mays L.) cultivars, ‘LY336’ (shade tolerant) and ‘LC803’ (shade sensitive), to shade stress in a pot experiment conducted in the 2015 and 2016 growing seasons were investigated. The impact of 50% shade stress treatment on shoot biomass, photosynthetic parameters, chlorophyll fluorescence, and malondialdehyde (MDA) content was evaluated. The shoot biomass of the two maize hybrids was decreased significantly by shade stress treatment, for shade stress 7 d, the LC803 and LY336 were reduced by 56.7% and 44.4% compared with natural light. Chlorophyll fluorescence parameters of LY336 were not significantly affected by shade stress, whereas those of LC803 were significantly affected, the Fo increased under shade stress; however Fm, FV/FM and ΦPSII were decreased under shade stress. Among photosynthetic parameters measured, net photosynthetic rate (Pn), stomatal conductance (Gs), and transpiration rate were significantly decreased compared with natural light, LY336 and LC803 reduction by 28.0%, 22.2%, 57.7% and 35.5%, 18.9%, 62.4%; however, intercellular CO2 concentration (Ci) was significantly increased, for the two cultivars. Under shade stress for different durations (1, 3, 5, 7 d), Pn, Gs, Ci, and MDA content differed significantly between the two cultivars. Results indicated that different maize genotypes showed different responses to shading. Shade-tolerant genotypes are only weakly affected by shade stress.

ABSTRACT The enhancement of rice production numbers can be achieved by using quality rice cultivars and fertilizers. The double rice cropping model has given rise to an important rice production system in southern China. Exploring the possibility of whether hybrid vigor could make a substantial contribution to early and late season rice production, and how the heterosis expression of hybrid rice functions under different levels of fertilizer application is of great significance. The objective of this study was to evaluate the grain yield and associated plant traits of popular hybrid and inbred rice varieties with large–scale promotion under conditions of customary (high) and combined (low) fertilization in the early and late seasons of 2017–18 in Changsha County, Hunan Province, China. We found that hybrid rice varieties displayed their respective advantages in the early and late rice seasons, but the advantages in their relative yield traits varied. The leading advantages of early season rice were effective panicle number per hill (EPN), 1000–grain weight (KGW), harvest index (HI), yield, and nitrogen use efficiency (NUE), whereas in late season rice, the foremost advantages were grain number per panicle (GNP), HI, yield, and NUE. The EPN was the prime advantage of early season hybrid rice with a short growth period, and the GNP was the main advantage of late season hybrid rice with a long growth period. Notably, the main yield advantage of hybrid rice was stronger under combined (low) fertilization than under customary (high) fertilization. Hence, high yield can be achieved by selecting the best hybrid rice varieties supported by combined fertilization (lower fertilizer use with higher efficiency).

This study aimed to investigate the association of vegetable and fruit consumption with carotid plaque (CP) and carotid intima-media thickness (CIMT), two predictors of carotid atherosclerosis, within urban and rural adults at high risk of developing cardiovascular diseases (CVDs) in regional China. A total of 11,392 adults at high CVD risk were identified from general population of 71,511 in this cross-sectional study, conducted between November of 2015 and May of 2016 in the Jiangsu Province. Among these 11,392 high risk participants, CP prevalence was 36.7%. The independent variables, vegetable and fruit intake frequency, were assessed by a food frequency questionnaire. The outcome variables, CIMT and CP, were measured by ultrasound examination. The ANCOVA analysis showed no association between CIMT values and vegetable and fruit intake frequencies. Multivariate logistic regression models were introduced to examine the association between vegetable and fruit intake and CP. After adjustment for potential confounders, the odds ratios (ORs) for participants who occasionally and daily consumed vegetable to experience any CP were 0.67 (95%CI: 0.58-0.78) and 0.70 (95%CI: 0.62-0.79), respectively, compared with those rarely consumed vegetable. While the adjusted ORs were 0.77 (95%CI: 0.64-0.92) and 0.80 (95%CI: 0.68-0.94), separately, for occasional and daily vegetable consumers to develop single CP relative to their counterparts who rarely consumed any vegetables. However, no significant association between fruit consumption and CP was observed. Among the Chinese population at high CVD risk, consumption of fresh vegetables was negatively associated with the risk of developing carotid plaque.

Abstract Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology. Cutaneous involvement occurs in up to 30% of patients and skin findings are often the initial presenting symptom. The facial atrophic form of sarcoidosis without associated ulceration in adolescents has rarely been described in the literature. We report a case of 13-year-old male patient with a facial atrophic sarcoidosis who was successfully treated with the combination of prednisone and hydroxychloroquine.

Abstract This report describes a case of unusual deep skin ulcers with tortuous sinus tract formation in an immunocompetent woman. She was initially diagnosed with a Staphylococcus aureus skin infection and histopathologically diagnosed with pyoderma gangrenosum. However, culture from the deep end of ribbon gauze inserted into the subcutaneous sinus tract revealed shiny, light-yellow mucoid colonies, which were identified as Cryptococcus neoformans var. grubii. She was treated with fluconazole for nine months and completely healed. Cryptococcosis is an opportunistic infection caused by variants of C. neoformans species. Cutaneous manifestations of cryptococcosis are quite divergent, rarely occurring as deep skin ulcers with sinus formation.

ABSTRACT: Soybean cyst nematode (SCN, Heterodera glycines) is a chief plant–parasitic nematode of soybean. Application of synthetic chemical nematicides poses negative side effects to human health and the environment. Therefore, the search for a safe and effective approach is more relevant. This study evaluated the effects of Genistein and Daidzein on the physiological index of soybean cyst nematodes, individual morphology, reversal frequency, respiration, and body fluid leaking of second–stage juveniles (J2s) of soybean cyst nematode. The results showed that body length of J2s decreased, while stylet and tail transparent area elongated. Additionally, after the treatment, the body became hollow and shrunken, the J2s stiffened, whereas the reversal frequency decreased dramatically after 24 h of treatment. Moreover, the body fluid leakage was intensified and respiration was inhibited. Oxygen consumption decreased by 86.7 % and 70.1 %, while, in contrast, electrical conductivity increased by 40.1 % and 36 % at 100 μg mL−1 of Genistein and Daidzein, respectively, after 48 h of exposure. The smaller number of J2s in soybean roots, the slower development rate, and the abnormal sexual differentiation were found in greenhouse assay. Thus, Genistein and Daidzein, especially Genistein, have strong effects on the physiological index of soybean cyst nematodes. Moreover, the effects were time and dosage–dependent.

ABSTRACT: The current article looks at the effects of climate change on agriculture, especially crop production, and influence factors of agricultural development in terms of their rational use in Pakistan. Due to the dependence of economic development, and agriculture in the South Asian region on access to renewable national resources and the associated vulnerability to climate change, the limited financial and professional resources of the Islamic Republic of Pakistan require a clear definition of national priorities in this area. In the preparation of this article, general scientific cognition methods, in particular, empirical-theoretical methods were used. Grouping and classification methods have been used to process and systematize the data. The ability to change productivity, depending on the variation of the average annual air temperature and the average annual precipitation rate, was considered using a two-factor regression model. The main finding of the study is that temperature and precipitation have a negative impact on agricultural production. This study can provide a scientific justification for the specialization of agricultural production in the regions of Pakistan as well as the execution of the necessary agricultural activities.

ABSTRACT The present study investigated the effects of various concentrations of trehalose in Tris-fructose egg yolk diluent on ram semen preservation at 0 ℃. Semen was collected by artificial vagina ejaculation from six rams of proven fertility. High-quality ejaculates were diluted with 0 (control), 5, 10, 15, and 20 mM trehalose of Tris-fructose egg yolk extender and control (tris-fructose egg yolk extender without trehalose), respectively. Then, the ejaculates were diluted to a concentration of 5×108 sperm/mL, cooled to 0 ℃ for 90 min, and maintained at that temperature for twelve days. The diluted semen samples were examined, and their sperm progressive motility, membrane functionality, and acrosome integrity recorded at 0, 24, 72, 144, 216, and 288 h. Two hundred ninety-six ewes were transcervically inseminated with the 216-h control (without trehalose) or the optimal trehalose concentration group semen, and the pregnancy and lambing rates were measured. No significant differences were established in the sperm progressive motility and membrane functionality among the control and 5, 10, 15, and 20 mM groups. The sperm samples of trehalose addition groups had no significant difference in the acrosome integrity of sperm, but they were, nonetheless, significantly higher than those in the control. No significant difference was detected in the lambing and pregnancy rates between the 5 mM and control groups. These results suggest that ram sperm is capable of fertilization after cooling and preservation at 0 ℃ by the use of 5 mM trehalose for Tris-fructose egg yolk diluent. Under these conditions, ram sperm can be more effectively preserved than under other four concentrations of diluents.

ABSTRACT: Monochasma savatieri Franch. ex Maxim is a perennial, parasitic herb used in traditional Chinese medicine and its wild resources have decreased sharply in recent years due to destructively harvesting and habitat destruction. Haustorium formation is a key event of parasites, but the concentrations of haustorium-inducing factors vary with species and cultivation conditions. In this study, we investigated the effects of the 2,6-dimethoxy-p-benzoquinone (DMBQ) concentration and cultivation density on the growth traits, haustorium formation and biomass of M. savatieri in the absence of a host plant. The results showed that both the DMBQ concentration and cultivation density regulated growth traits, haustorium formation and biomass in M. savatieri. The number of haustoria was significantly positively correlated with seedling height, maximum root length, the number of root tips and total dry weight. Membership function analysis revealed an overall greater increase in growth traits, haustorium formation and biomass when M. savatieri was treated with 10 μmol·L-1DMBQ and grew solitarily. These results offer an understanding of growth in M. savatieri influenced by the DMBQ concentration and cultivation density, which may aid in the establishment of a comprehensive cultivation system for M. savatieri or similar plants.

Abstract BACKGROUND: Recent mutation analysis identified several missense mutations in CARD14 in psoriasis. OBJECTIVES: We performed the genomic sequence analysis on CARD14 in southern Chinese Han Cantonese with Psoriasis Vulgaris (PsV) to reveal more causative missense mutations. METHODS: A total of 131 patients with PsV and 207 matched controls were included. We conducted sequence analysis of all the exon and exon-intron boundaries of CARD14 in the group of PsV patients and subsequent case control analysis of potential sequence variants of significance. RESULTS: We found five rare mutations and four of them are annotated or reported. Only the variant (c.1291C>G) has not been reported and annotated, but the variant was also found in controls. No significant difference was detected among all rare variant allele frequencies of patients and controls. CONCLUSION: None of the new definite variants were pathogenic. The other pathogenic mutations for PsV are still elusive in our cohort.

ABSTRACT: Toxic metals contamination of soil has become a serious problem in recent years. In this study, Chinese cabbage (a relatively high-accumulator of cadmium (Cd)) and cabbage (a relatively low-accumulator of Cd) were cultured in monoculture and in intercropping in the Cd-contaminated soil, to evaluate the effect of intercropping on the alteration of Cd extraction. Both the pot experiments and field experiments indicated that intercropping increased the Cd extraction by Chinese cabbage and decreased the Cd extraction by cabbage. Thus, Cd extraction was advanced while safe production was obtained. Further pot experiment was conducted to investigate the alterations of soil Cd fractions, soil pH, and soil enzyme activities to reveal their possible relationship with Cd extraction between different planting patterns. Results revealed that three individual Chinese cabbages in one intercropping pot played the same effect on alteration of these factors as six individual Chinese cabbages in one monoculture pot. The intercropping increased Cd extraction by Chinese cabbage and decreased Cd extraction by cabbage, probably by influencing mechanisms such as soil enzyme activities (especially the urease activity) in the cultivation system. Effect of intercropping on Cd accumulation is an important issue in cultivation of vegetables in potentially contaminated land.

Abstract Background: Platelets are important in the initiation of thrombosis, and their morphological and functional changes are closely related with the occurrence and development of coronary artery thrombosis. Platelet parameters might be valuable in distinguishing between acute myocardial infarction (AMI) and stable coronary artery disease (SCAD). Objective: This study was designed to detect and compare changes in platelet parameters, such as mean platelet volume (MPV) in patients with acute myocardial infarction (AMI) and stable coronary artery disease (SCAD) and to investigate their roles in these diseases. Methods: Specimen collection: Between January 2011 and December 2013, 2 mL of elbow vein blood was drawn from each of 31 patients primarily diagnosed with AMI, 34 SCAD patients and 50 healthy subjects; and placed in EDTA-K2 anticoagulant tubes. Platelet count (PLT), MPV, plateletcrit (PCT), platelet distribution width (PDW), white blood cell (WBC) and neutrophil (NEU) counts were determined using an STKS automated hematology analyzer (Beckman Courter). Results: Compared with the control group, MPV levels were significantly higher in the AMI and SCAD groups (p < 0.05), while PLT was significantly lower (p < 0.05). Conclusion: These results suggest that MPV and other related parameters have a certain value in the diagnosis of SCAD and AMI.

Abstract BACKGROUND: Chronic urticaria (CU) can be provoked by a wide variety of causes. Some studies suggest contact sensitization may play a role in the disease. OBJECTIVE: To investigate the incidence and distribution characteristics of allergic contact sensitization in central Chinese subjects with CU, and assess contact allergen avoidance measures in managing CU. METHODS: Patch tests were performed, following the recommended standard procedure, with 20 selected allergens, in line with the European baseline series. All subjects with positive results were prescribed appropriate avoidance measures for the sensitizing substances, while subjects with negative results served as the control group. CU severity was assessed daily from week1 to week4 and for each subject, applying the Urticaria Activity Score. RESULTS: 42.9% (233/543) of subjects with CU showed positive reactions to one or more contact allergen(s). Potassium dichromate, benzene mix and carba mix were more common in male patients, while nickel sulfate was more frequent in females. The positive rates for different allergens varied with age and occupation. The median (interquartile range) severity scores at week 1 were 20 (14-21) and 15 (14-27) for the allergen avoidance group and control group, respectively (P>0.05); and 12 (7-15) and 14 (12-17) at week 4 (P

Objective : To describe the surgical technique and preliminary clinical outcomes in a series of open reduction internal fixation of basal acromion process fractures applying a double-plating technique. Methods : Nine consecutive patients, mean age 33.4 years old (range, 23-61 years old) with unilateral acromion fracture (Type 3 AO/OTA) with more than 1cm displacement who underwent fixation utilizing a locked double-plating technique, were evaluated on average at 7.8 months (range, 3-15 months) for outcomes related to pain, shoulder function, and surgical complications. Results : Eight patients recovered with complete radiographic union and favorable shoulder function. One case failed to be fully evaluated for more than 3 months follow-up. The overall scores of Constant, Shoulder Pain and Disability Index (SPADI) and DASH for the eight patients reviewed were 91.9± 6.31, 3.11± 3.79 and 5.2± 6.35, respectively. No post-operative infection or surgical hardware irritation was identified at final follow-up of these eight patients. Conclusion : While more evidence is needed to justify its advantages over traditional implants, perpendicular double-plate with a locking system may be indicated for acromion pedicle fracture treatment, since it performed well for fracture healing and joint function rehabilitation. Level of Evidence IV, Therapeutic Study.

Este artigo utiliza os dados da pesquisa com graduados em Universidades chinesas que faziam parte do ‘Projeto 985’ em 2010. Pela primeira vez, analisa-se sistematicamente a questão da casa própria entre jovens de classe média que nasceram nos anos 1980, e seus fatores de influência. A pesquisa mostra que a taxa de jovens com casa própria entre os entrevistados no ‘Projeto 985’ é inferior à taxa dos pares em países desenvolvidos, mas superior à taxa média entre a juventude urbana na China. Os graduados que possuem uma casa tendem a vir de famílias com nível socioeconômico mais elevado, e a ter uma melhor qualidade de vida, o que revela certa divisão social; a ajuda financeira dos pais, seu estado civil e idade são os fatores mais importantes que influenciam a possibilidade de contar com casa própria. Os resultados enfatizam a cada vez mais importante função de estratificação social da habitação. O governo precisa aumentar o controle macroeconômico sobre imóveis e reforçar as políticas de bem-estar habitacional, de modo a evitar mais segregação social

Abstract: Primary localized cutaneous amyloidosis is a skin-limited amyloidosis that does not involve internal organs. It is clinically subclassified into 3 general categories and some rare variants. However, there is considerable overlap within the classification. Though there are a variety of therapeutic measures, the treatment is often unsatisfactory, particularly when the disease is severe and extensive. We describe a rare case of primary localized cutaneous amyloidosis with lichen and poikiloderma-like lesions that showed an excellent response to systemic acitretin.