12 results on '"Zerbini, Cristiano"'
Search Results
2. Diretrizes da Sociedade Brasileira de Reumatologia para diagnóstico e tratamento da osteoporose em homens
- Author
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Loures, Marco Antônio R., Zerbini, Cristiano Augusto F., Danowski, Jaime S., Pereira, Rosa Maria R., Moreira, Caio, Paula, Ana Patrícia de, Castro, Charlles Heldan M., Szejnfeld, Vera Lúcia, Mendonça, Laura Maria C., Radominiski, Sebastião C., Bezerra, Mailze C., Simões, Ricardo, and Bernardo, Wanderley M.
- Published
- 2017
- Full Text
- View/download PDF
3. Metodologia para a avaliação da atividade física habitual em homens com 50 anos ou mais
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Florindo Alex Antonio, Latorre Maria do Rosario Dias de Oliveira, Jaime Patrícia Constante, Tanaka Tomoe, and Zerbini Cristiano Augusto de Freitas
- Subjects
Exercício ,Avaliação ,Métodos ,Questionários ,Saúde do idoso ,Densidade óssea ,Atividade física habitual ,Public aspects of medicine ,RA1-1270 - Abstract
OBJETIVO: Descrever a metodologia de avaliação da atividade física habitual, utilizanda em uma pesquisa em população masculina, por meio de um questionário já validado. MÉTODOS: O questionário de atividade física habitual de Baecke, traduzido para a língua portuguesa e, a seguir, foi realizado o back translation. Em sua versão final o questionário foi aplicado em estudo epidemiológico transversal, realizado com 326 homens com idade igual ou superior a 50 anos. A consistência interna entre as questões foi analisada pelo a de Cronbach e foram calculados os coeficientes de correlação de Spearman entre os escores de atividade física habitual, bem como os coeficientes de correlação parcial, ajustados por idade, índice de massa corporal e escolaridade. RESULTADOS: A consistência interna mostrou-se satisfatória nas magnitudes de atividade física ocupacional e exercícios físicos no lazer. Foram obtidas correlações significativas entre todos os escores de atividades físicas com o escore total de atividade física habitual, independente da idade, escolaridade e índice de massa corporal. CONCLUSÕES: O questionário Baecke mostrou-se um instrumento prático para avaliar a atividade física habitual, aliando rapidez na aplicabilidade e facilidade no entendimento para as respostas, sendo indicado para estudos epidemiológicos no Brasil.
- Published
- 2004
4. Doença de Castleman multicêntrica não associada aos vírus HHV-8 e HIV
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Forteski, Denise de Fatima, Netto, Fernanda Calil Machado, Lomonte, Andrea Barranjard Vannucci, Anjos, Bruno César Cavalcanti dos, Zerbini, Maria Claudia Nogueira, and Zerbini, Cristiano Augusto de Freitas
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Inflammation ,Inflamação ,Interleukin-6 ,Autoimune ,Linfócitos B ,Doença de Castleman ,Castleman's disease ,Anaemia ,Anemia ,B lymphocytes ,Autoimmune ,Interleucina-6 - Abstract
A doença de Castleman (DC) é uma desordem linfoproliferativa policlonal, também conhecida como hiperplasia nodular gigante ou hiperplasia angiofolicular linfoide. Esta é uma doença rara que está frequentemente associada ao vírus da imunodeficiência humana (HIV) e ao herpes vírus 8 (HHV-8). Os achados histopatológicos encontrados na DC sugerem uma intensa resposta aos estímulos antigênicos observada em várias doenças associadas com ativação imune, como a artrite reumatoide. Um fator importante implicado na patogênese da DC é a produção autônoma da interleucina-6 (IL-6). Nessa doença, as manifestações clínicas estão relacionadas aos níveis de IL-6, e a remoção cirúrgica dos linfonodos acometidos ou a utilização de anticorpos anti-IL-6 fazem regredir os sintomas. Descrevemos um caso da DC multicêntrica em uma mulher jovem, não associada à infecção pelo vírus HHV-8 ou à imunossupressão. Uma breve revisão da literatura se segue à descrição do caso clínico. Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease suggest an exaggerated response to antigenic stimuli seen in other diseases associated with immune activation, such as rheumatoid arthritis. An important aspect of its pathogenesis is the autonomous production of interleukin-6 (IL-6). In this disease, the clinical manifestations are associated to IL-6 serum levels, and surgical removal of the compromised lymph nodes or use of anti-IL-6 antibodies can slow down the symptoms. We describe a multicentric Castleman's disease in a young woman not associated to HHV-8 virus infection or immunosuppression. A short review of the literature follows the description of this clinical case.
- Published
- 2014
5. Doença de Castleman multicêntrica não associada aos vírus HHV-8 e HIV
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Zerbini, Cristiano Augusto de Freitas
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DOENÇAS RARAS - Published
- 2014
6. Os critérios da indústria farmacêutica no direcionamento dos ensaios clínicos: o que aumentaria a participação do Brasil?
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Faccioli, Marcos Aurélio, Escolas::EAESP, Alberto, Fernando Lopes, Zerbini, Cristiano A. F., and Vecina Neto, Gonzalo
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Patrocínio de ensaios clínicos ,Clinical trial countries ,Países participantes de ensaios clínicos ,Ensaios clínicos na indústria farmacêutica ,Patrocínio corporativo ,Pharmaceutical industry clinical trials ,Clinical trials locations ,Ensaio clínico ,Clinical trials ,Indicadores ,Ensaios clínicos ,Indústria farmacêutica ,Administração de empresas ,Participação em ensaios clínicos ,Localidades de ensaios clínicos ,Clinical trials participation ,Clinical trial sponsorship - Abstract
Os ensaios clínicos representam uma ferramenta essencial de geração de conhecimento e inovação para a indústria farmacêutica. Apesar de o Brasil ser o 7º maior mercado para a indústria e apresentar uma demografia diversa e favorável para a condução dos ensaios clínicos, o país parece não explorar seu potencial de participação no campo dos ensaios clínicos. A partir de uma análise dos registros dos ensaios clínicos de intervenção medicamentosa de fases II e III patrocinados pela indústria na base de dados internacional ClinicalTrial.gov esta pesquisa identificou os países que mais receberam ensaios clínicos nos últimos 15 anos, os países que ganharam destaque neste período e quais foram os patrocinadores que mais financiaram estes ensaios clínicos. Entrevistas semi-estruturadas com profissionais experientes deste campo de atuação exploraram o processo de escolha das localidades, os critérios utilizados pela indústria e as características que fazem com que o Brasil seja considerado para alguns ensaios, mas não para outros. Clinical trials represent an essential component for the pharmaceutical industry in the knowledge building and innovation process. Despite the fact that Brazil is the 7th largest pharmaceutical market in the world, and its diverse and favorable demographic for conducting clinical trials, the country does not seem to explore its potential in the field of clinical trials. Based on the phases II and III drug intervention clinical trials sponsored by the industry registered in the ClinicalTrial.gov database, this research identified the countries that received the most trials in the last 15 years and those that gained prominence in the same period. It was also identified the sponsors that financed such trials. Semi-structured interviews with experienced professional in this field explored the sponsors processes to choose the locations, the main criterias and the characteristics that make Brazil to be considered for some trials but not for others.
- Published
- 2022
7. Brazilian guidelines for the diagnosis and treatment of postmenopausal osteoporosis.
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Radominski SC, Bernardo W, Paula AP, Albergaria BH, Moreira C, Fernandes CE, Castro CHM, Zerbini CAF, Domiciano DS, Mendonça LMC, Pompei LM, Bezerra MC, Loures MAR, Wender MCO, Lazaretti-Castro M, Pereira RMR, Maeda SS, Szejnfeld VL, and Borba VZC
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- Absorptiometry, Photon, Accidental Falls prevention & control, Aged, Brazil, Exercise, Humans, Middle Aged, Osteoporosis, Postmenopausal prevention & control, Rheumatology, Societies, Medical, Bone Density Conservation Agents therapeutic use, Osteoporosis, Postmenopausal diagnosis, Osteoporosis, Postmenopausal therapy
- Abstract
Osteoporosis is the leading cause of fractures in the population older than 50 years. This silent disease affects primarily postmenopausal women and the elderly, and the morbidity and mortality rates are high. The main goal of treating osteoporosis is the prevention of fractures. The identification of populations at risk through early diagnosis and treatment is essential. The last Brazilian guideline for the treatment of postmenopausal osteoporosis was elaborated in 2002. Since then, new strategies for diagnosis and risk stratification have been developed, and drugs with novel action mechanisms have been added to the therapeutic arsenal. The Osteoporosis and Osteometabolic Diseases Committee of the Brazilian Society of Rheumatology, in conjunction with the Brazilian Medical Association and other Societies, has developed this update of the guidelines for the treatment of postmenopausal osteoporosis according to the best scientific evidence available. This update is intended for professionals in many medical and health specialties involved in the treatment of osteoporosis, for physicians in general and for health-related organizations., (Copyright © 2017. Published by Elsevier Editora Ltda.)
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- 2017
- Full Text
- View/download PDF
8. Guidelines of the Brazilian Society of Rheumatology for the diagnosis and treatment of osteoporosis in men.
- Author
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Loures MAR, Zerbini CAF, Danowski JS, Pereira RMR, Moreira C, Paula AP, Castro CHM, Szejnfeld VL, Mendonça LMC, Radominiski SC, Bezerra MC, Simões R, and Bernardo WM
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- Absorptiometry, Photon, Adult, Aged, Aged, 80 and over, Brazil, Humans, Male, Middle Aged, Rheumatology, Societies, Medical, Osteoporosis diagnosis, Osteoporosis therapy
- Abstract
Osteoporosis, a metabolic disease characterized by low bone mass, deterioration of the bone tissue microarchitecture and increased susceptibility to fractures, is commonly regarded as a women's health problem. This point of view is based on the fact that compared with men, women have lower bone mineral density and longer lifespans and lose bone mass faster, especially after menopause, due to a marked decrease in serum estrogen levels. However, in the last 20 years, osteoporosis in men has become recognized as a public health problem due to the occurrence of an increasingly higher number of fragility fractures. Approximately 30% of all hip fractures occur in men. Recent studies show that the probability of fracture due to hip, vertebral or wrist fragility in Caucasian men older than fifty years, for the rest of their lives, is approximately 13% versus a 40% probability of fragility fractures in women. Men show bone mass loss and fractures later than women. Although older men have a higher risk of fracture, approximately half of all hip fractures occur before the age of 80. Life expectancy is increasing for both sexes in Brazil and worldwide, albeit at a higher rate for men than for women. This Guideline was based on a systematic review of the literature on the prevalence, etiology, diagnosis and treatment of osteoporosis in men., (Copyright © 2017. Published by Elsevier Editora Ltda.)
- Published
- 2017
- Full Text
- View/download PDF
9. [Multicentric Castleman disease not associated with HHV-8 and HIV viruses].
- Author
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Forteski Dde F, Netto FC, Lomonte AB, dos Anjos BC, Zerbini MC, and Zerbini CA
- Subjects
- Adult, Female, HIV-1, Herpesvirus 8, Human, Humans, Castleman Disease diagnosis
- Abstract
Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease suggest an exaggerated response to antigenic stimuli seen in other diseases associated with immune activation, such as rheumatoid arthritis. An important aspect of its pathogenesis is the autonomous production of interleukin-6 (IL-6). In this disease, the clinical manifestations are associated to IL-6 serum levels, and surgical removal of the compromised lymph nodes or use of anti-IL-6 antibodies can slow down the symptoms. We describe a multicentric Castleman's disease in a young woman not associated to HHV-8 virus infection or immunosuppression. A short review of the literature follows the description of this clinical case., (Copyright © 2014 Elsevier Editora Ltda. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
10. Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis.
- Author
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Pereira RM, Carvalho JF, Paula AP, Zerbini C, Domiciano DS, Gonçalves H, Danowski JS, Marques Neto JF, Mendonça LM, Bezerra MC, Terreri MT, Imamura M, Weingrill P, Plapler PG, Radominski S, Tourinho T, Szejnfeld VL, and Andrada NC
- Subjects
- Humans, Osteoporosis prevention & control, Glucocorticoids adverse effects, Osteoporosis chemically induced, Osteoporosis therapy
- Abstract
Glucocorticoids (GC) are used in almost all medical specialties, and approximately 0.5% of the general population of the United Kingdom receives those medications. With the increased survival of patients with rheumatological diseases, morbidity secondary to the use of those medications represents an important aspect of the management of our patients. The incidences of vertebral and non-vertebral fractures are elevated, ranging from 30% to 50% of the individuals on GC for over three months. Thus, osteoporosis and frailty fractures should be prevented and treated in all patients initiating or already on GC. There are several recommendations on this topic elaborated by several international societies, but consensus still lacks. Recently, the American College of Rheumatology has published new recommendations, but they are based on the WHO Fracture Risk Assessment Tool (FRAX®) to evaluate the risk for each individual, and, thus, cannot be completely used for the Brazilian population. Thus, the Committee for Osteoporosis and Bone Metabolic Disorders of the Brazilian Society of Rheumatology, along with the Brazilian Medical Association and the Brazilian Association of Physical Medicine and Rehabilitation, has elaborated the Brazilian Guidelines for Glucocorticoid-Induced Osteoporosis (GIO), based on the better available scientific evidence and/or expert experience., Method of Evidence Collection: The bibliographic review of scientific articles of this guideline was performed in the MEDLINE database. The search for evidence was based on real clinical scenarios, and used the following keywords (MeSH terms): Osteoporosis, Osteoporosis/ chemically induced*= (Glucocorticoids= Adrenal Cortex Hormones, Steroids), Glucocorticoids, Glucocorticoids/administration and dosage, Glucocorticoids/therapeutic use, Glucocorticoids/adverse effects, Prednisone/adverse effects, Dose-Response Relationship, Drug, Bone Density/drug effects, Bone Density Conservation Agents/pharmacological action, Osteoporosis/prevention & control, Calcium, Vitamin D, Vitamin D deficiency, Calcitriol, Receptors, Calcitriol; 1-hydroxycholecalciferol, Hydroxycholecalciferols, 25-Hydroxyvitamin D3 1-alpha-hydroxylase OR Steroid Hydroxylases, Prevention and Control, Spinal fractures/prevention & control, Fractures, Spontaneous, Lumbar Vertebrae/injuries, Lifestyle, Alcohol Drinking, Smoking OR tobacco use disorder, Movement, Resistance Training, Exercise Therapy, Bone density OR Bone and Bones, Dual-Energy X-Ray Absorptiometry OR Absorptiometry Photon OR DXA, Densitometry, Radiography, (Diphosphonates Alendronate OR Risedronate Pamidronate OR propanolamines OR Ibandronate OR Zoledronic acid, Teriparatide OR PTH 1-34, Men AND premenopause, pregnancy, pregnancy outcome maternal, fetus, lactation, breast-feeding, teratogens, Children (6-12 years), adolescence (13-18 years)., Grade of Recommendation and Level of Evidence: A) Data derived from more consistent experimental and observational studies; B) Data derived from less consistent experimental and observational studies; C) Case reports (uncontrolled studies); D) Expert opinion without explicit critical appraisal, or based on consensus, physiological studies or animal models., Objective: To establish guidelines for the prevention and treatment of GIO.
- Published
- 2012
11. [2008 official positions of the Brazilian Society for Clinical Densitometry--SBDens].
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Brandão CM, Camargos BM, Zerbini CA, Plapler PG, Mendonça LM, Albergaria BH, Pinheiro MM, Prado Md, and Eis SR
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- Adolescent, Adult, Brazil, Child, Female, Humans, Male, Middle Aged, Societies, Medical, Young Adult, Bone Density, Densitometry methods
- Abstract
With the evolution of bone densitometry, differences in technologies, acquisition techniques, reference databases, reporting methods, diagnostic criteria and terminology have developed and the International Society for Clinical Densitometry (ISCD) periodically holds Position Development Conferences, the latest in 2007. The Brazilian Society for Clinical Densitometry (SBDens), with support from many Brazilian societies interested in bone health, gathered numerous specialists to discuss the ISCD proposals and to evaluate the validity of the extension of those norms to Brazilian population. The SBDens reunion of consensus made a very useful document to help the understanding and interpretation of bone densitometry and other methods of bone assessment.
- Published
- 2009
- Full Text
- View/download PDF
12. [Methodology to evaluation the habitual physical activity in men aged 50 years or more].
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Florindo AA, Latorre Mdo R, Jaime PC, Tanaka T, and Zerbini CA
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- Aged, Body Mass Index, Bone Density, Cross-Sectional Studies, Educational Status, Humans, Male, Middle Aged, Reproducibility of Results, Exercise, Leisure Activities, Surveys and Questionnaires standards, Translations
- Abstract
Objective: To describe the methodology for evaluating habitual physical activity that was adopted for a survey among the male population utilizing a questionnaire validated earlier., Methods: The Baecke questionnaire on habitual physical activity was translated into Portuguese and then back-translated into English by two anglophone teachers. The final version of the questionnaire was applied in a cross-sectional epidemiological study done on 326 men aged 50 years or over. The internal consistency among the questions was evaluated using the Cronbach a statistic. The Spearman correlation coefficients between the habitual physical activity scores were calculated. Partial correlation coefficients with adjustments for age, body mass index and schooling were also calculated., Results: There was satisfactory internal consistency in relation to the magnitudes of occupational physical activity and leisure-time physical exercises. Significant correlation was obtained between all the physical activity scores and the total habitual physical activity score, independent of age, body mass index and schooling., Conclusions: The Baecke questionnaire was found to be a practical instrument for assessing habitual physical activity that is quickly applied and easily understood, and it is recommended for epidemiological studies in Brazil.
- Published
- 2004
- Full Text
- View/download PDF
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