13 results on '"Wiener, Carolina"'
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2. Atividade física de lazer e uso de substâncias lícitas em uma amostra populacional de adultos jovens
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Nasser, Roberta Lacerda, Branco, Jerônimo Costa, Lara, Diogo Rizzato, Vecchio, Fabrício Boscolo Del, Wiener, Carolina, Mesquita, Paula, Souza, Luciano Dias de Mattos, Silva, Ricardo Azevedo da, and Jansen, Karen
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Atividades de lazer ,Tabaco ,Álcool ,Physical activity ,Atividade física ,Tobacco ,Adultos jovens ,Leisure-time activities ,Alcohol ,Young adults - Abstract
Resumo O objetivo do estudo foi mensurar a prevalência e os fatores associados à prática de atividade física de lazer, bem como verificar a associação desta com o uso de substâncias lícitas em uma amostra populacional de adultos jovens. Estudo transversal de base populacional com adultos jovens de 18 a 35 anos de idade, residentes da zona urbana da cidade de Pelotas-RS (Brasil). A seleção amostral foi realizada por conglomerados, sendo constituída por 1953 indivíduos, dentre 82 setores censitários sorteados. A prática de atividade física foi avaliada por meio do Questionário Internacional de Atividade Física (IPAQ). Para a análise estatística utilizou-se a regressão de Poisson. A prevalência de jovens ativos em atividade física de lazer foi de 25,3% e esteve associada a ser do sexo masculino, ter entre 18 e 23 anos de idade, pertencer ao maior tercil do indicador econômico nacional e não fazer uso diário de tabaco. Sabendo-se da importância da atividade física de lazer para a saúde, os incentivos para esta prática devem ser focados nos grupos de mulheres, de maior idade, de estratos econômicos inferiores e que fazem uso de tabaco. Abstract The scope of this study was to assess the prevalence and factors associated with leisure-time physical activity, as well as to verify its association with licit substance use in a population sample of young adults. It is a cross-sectional population-based study with young adults aged between 18 and 35 years old, living in the urban area of the city of Pelotas in the Brazilian State of Rio Grande do Sul. Sample selection was performed by clusters, being composed of 1953 individuals, among the 82 selected census tracts. The practice of physical activity was evaluated using the International Physical Activity Questionnaire (IPAQ). The chi-square and Poisson regression tests were used for statistical analysis. The prevalence of young adults active in leisure-time physical activity was 25.3%; most were single males between 18 and 23 years, belonging to the people in the highest economic bracket and not smoking on a daily basis. Specific strategies should be developed to promote an active and healthy lifestyle, focusing on incentives for older, lower income class women who smoke.
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- 2016
3. Níveis séricos de ácido úrico e as atividades a superóxido dismutase e da catalase nos transtornos de humor
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Wiener, Carolina David, Oses, Jean Pierre, Jansen, Karen, Lhullier, Alfredo Cardoso, Ghisleni, Gabriele Cordenonzi, Viola, Giordano Gubert, Moreira, Júlia Dubois, and Pinheiro, Karen Amaral Tavares
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#8765449414823306929# ,CIENCIAS DA SAUDE# ,NSE ,transtorno de humor ,marcadores bioquímicos ,estresse oxidativo ,ácido úrico ,catalase ,superóxido dismutase ,transtornos de humor ,#600 - Abstract
Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-09-13T16:35:46Z No. of bitstreams: 1 carolina - Copia.pdf: 1129007 bytes, checksum: deaef0e96e4837a47c36de1f6dc1e109 (MD5) Made available in DSpace on 2016-09-13T16:35:46Z (GMT). No. of bitstreams: 1 carolina - Copia.pdf: 1129007 bytes, checksum: deaef0e96e4837a47c36de1f6dc1e109 (MD5) Previous issue date: 2010-11-30 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES# #2075167498588264571# #600 Objectives: The aim of this study was evaluate uric acid level in a population–based sample of young adults (18 to 24 years old). People with bipolar and depression disorder were compared with healthy psychiatric subjects without a history of mood episodes. Methods: Case-control study nested in a population-based sample. The diagnosis was confirmed with the Structured Clinical Interview for DSM-IV. The uric acid was assessed by commercial kits Results: The sample consisted of 216 subjects, 49 with diagnosis for bipolar disorder, 76 with depression and 91 population control. The uric acid levels were similar (control = 4.08 ± 1.27 mg/dL, depression = 3.78 ± 1.00 mg/dL e bipolar disorder =3.86 ± 1.33 mg/dL, p= 0,251). For maniac/hippomaniac and depressive episodes, were observed a tendency to increase in acid uric levels in maniac/hippomaniac episodes (4.43 ± 1.74 mg/dL) and a decrease in depressive episodes (3.70 ± 0.99 mg/dL) when compared to control subjects (4.08 ± 1.27 mg/dL)(p= 0.106). Conclusion: Uric acid levels is not correlated with diagnosis group, but the uric acid level have a tendency to presented increased in manic and/ or mixed episodes and decreased in depression episode, these result observed that levels of uric acid in mood disorders are altered according to the manifestation of symptoms. Objetivo: O objetivo deste estudo é avaliar o nível de acido úrico em pacientes com transtornos de humor oriundo de uma amostra de base populacional com jovens adultos (18 a 24 anos), para este fim jovens com transtorno de humor bipolar e depressão foram comparados com jovens sem histórico de transtorno de humor. Métodos: Trata-se de um estudo de caso-controle aninhado a um estudo de base populacional, o diagnostico foi realizado através da Entrevista Clínica Estruturada para o DSM-IV (SCID) e os níveis de acido úrico séricos foram dosados utilizando-se kits comerciais. Resultados: A amostra foi constituída de 216 jovens, 49 com diagnostico de transtorno bipolar, 76 com depressão e 91 controles sem historia psiquiátrica prévia, os níveis de acido úrico entre os três grupos foram similares (controle = 4.08 ± 1.27 mg/dL, depressão = 3.78 ± 1.00 mg/dL e transtorno bipolar =3.86 ± 1.33 mg/dL, p= 0,251). Quando avaliados os níveis de ácido úrico entre os episódios mania/hipomania e depressivo, observa-se uma tendência no aumento do ácido úrico no episódio maníaco/misto (4,43 ± 1,74 mg/dL) e uma diminuição no episódio depressivo (3,70 ± 0,99 mg/dL) quando comparados aos jovens do grupo controle (4,08 ± 1,27 mg/dL)(p= 0,106). Conclusão: Os níveis de ácido úrico não foram significativos entre os grupos diagnósticos, porém os níveis de acido úrico apresentaram uma tendência para o aumento nos episódios maníacos e/ou mistos e uma diminuição no episódio depressivo, com estes resultados podemos observar que os níveis de acido úrico nos transtornos de humor podem estar alterados de acordo com a manifestação dos sintomas
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- 2013
4. PREVALÊNCIA DE INATIVIDADE FÍSICA E FATORES ASSOCIADOS AO TRANSTORNO DE HUMOR EM ADULTOS JOVENS
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Branco, Jerônimo Costa, Jansen, Karen, Wiener, Carolina, Lopez, Mariane, Porto, Marcelo, and Silva, Ricardo
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Atividade Física ,Transtorno Bipolar ,Sedentarismo ,Depressão - Abstract
RESUMO: Os transtornos de humor caracterizam-se por manifestações afetivas consideradas inadequadas em termos de intensidade, freqüência e duração. O presente estudo tem como objetivo verificar a prevalência de inatividade física e sua associação com a prevalência de transtorno de humor em adultos jovens. O estudo transversal selecionou 279 jovens de um estudo de base populacional que entrevistou 1560 jovens de 18 a 24 anos. Os instrumentos utilizados foram um Questionário de Atividade Física Habitual e a Entrevista Clínica Semi-Estruturada de acordo com o Manual de Diagnóstico e Estatística das Perturbações Mentais 4ª Ed., realizada por psicólogas.. Os dados foram analisados por meio de estatística descritiva, teste do qui-quadrado e regressão de Poisson no programa STATA 9.0. O estudo foi aprovado pelo comitê de Ética em Pesquisa da Universidade Católica de Pelotas. Obtiveram-se os seguintes escores médios de atividade física: 12,74±8,43 no controle populacional; 8,75±8,07 na depressão e 11,95±7,31 no transtorno bipolar. Os fatores associados à inatividade física na amostra estudada foram ser do sexo feminino (p=0,010) e ter o diagnóstico clínico de depressão (p
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- 2012
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5. Atividade física de lazer e uso de substâncias lícitas em uma amostra populacional de adultos jovens.
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Lacerda Nasser, Roberta, Costa Branco, Jerônimo, Rizzato Lara, Diogo, Boscolo Del Vecchio, Fabrício, Wiener, Carolina, Mesquita, Paula, de Mattos Souza, Luciano Dias, Azevedo da Silva, Ricardo, and Jansen, Karen
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Copyright of Revista Ciência & Saúde Coletiva is the property of Associacao Brasileira de Pos-Graduacao em Saude Coletiva and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2016
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6. Classificação de transtorno bipolar, esquizofrenia e depressão utilizando redes neurais artificiais
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Fonseca, Mateus Beck, Oses, Jean Pierre, Wiener, Carolina David, Moreira , Fernanda Pedrotti, and Almeida, Sergio José Melo de
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biomarcadores ,redes neurais artificiais ,transtorno bipolar ,esquizofrenia ,depressão ,citocinas inflamatórias ,neurotrofinas ,biomarkers ,artificial neural networks ,bipolar disorder ,schizophrenia ,cytokines, neurotrophins ,mental disorders ,PSIQUIATRIA [MEDICINA] - Abstract
Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2019-05-24T13:44:22Z No. of bitstreams: 1 Mateus Beck Fonseca.pdf: 917017 bytes, checksum: 8d4582361a9da2b48dd9938561cfe410 (MD5) Made available in DSpace on 2019-05-24T13:44:22Z (GMT). No. of bitstreams: 1 Mateus Beck Fonseca.pdf: 917017 bytes, checksum: 8d4582361a9da2b48dd9938561cfe410 (MD5) Previous issue date: 2019-02-28 Bipolar disorder and schizophrenia are disorders of difficult diagnosis and differentiation, and studies point to the alteration of levels of inflammatory biomarkers with the diagnosis of diseases. Artificial neural networks (ANNs) are computational tools of artificial intelligence for modeling based on biological neural systems, which use mathematical formulas mimicking neural behavior. The objective of this work is to propose a model of ANN to aid in the diagnosis of bipolar disorder and schizophrenia using biomarkers and simple characteristics of the sampled population. The method of analysis is ANN training applied to a free distribution database of the Stanley Neuropathology Consortium, which consists of inflammatory biomarkers and characteristics of the population with diagnoses of schizophrenia, bipolar disorder and a control (without mental disorders) group. The RNA training program used is OpenNN, and is also freely distributed. As a result, it is expected to train a ANN with more than 80% accuracy in the classification of bipolar disorder diagnoses, schizophrenia and control group. Bipolar disorder, major depression and schizophrenia are disorders of difficult diagnosis and differentiation. Studies indicate that altered levels of inflammatory and neurotrophic biomarkers may be associated with the diagnosis of these diseases. Artificial neural networks (ANN) are computational tools of artificial intelligence for modeling based on biological neural systems, which use mathematical formulas mimicking neural behavior. The objective of this work is to propose an ANN model to aid in the diagnosis of bipolar disorder, major depression and schizophrenia, using biomarkers and simple characteristics of the population sampled. The method of analysis for the first article is ANN training applied to a free distribution database of the Stanley Neuropathology Consortium, which consists of inflammatory biomarkers and characteristics of the population with diagnoses of schizophrenia, bipolar disorder and one control group (without disorders); for the second article, another database was used, with biochemical variables, population characteristics and questionnaire responses with diagnoses of major depression, bipolar disorder and a control group (without disorders). The RNA training program used is OpenNN, and it is also freely distributed. As a result, trained RNAs with more than 80 % accuracy in diagnostic classifications O transtorno bipolar, a depressão maior e a esquizofrenia são transtornos de difícil diagnóstico e diferenciação. Estudos apontam que a alteração de níveis de biomarcadores inflamatórios e neurotróficos podem estar associados com o diagnóstico dessas doenças. Redes neurais artificiais (RNA) são ferramentas computacionais de inteligência artificial para modelagem baseadas em sistemas neurais biológicos, as quais utilizam fórmulas matemáticas mimetizando o comportamento neural. O objetivo deste trabalho é propor um modelo de RNA para auxiliar no diagnóstico de transtorno bipolar, da depressão maior e da esquizofrenia, utilizando biomarcadores e características simples da população amostrada. O método de análise para o primeiro artigo é o treinamento de RNA aplicada à um banco de dados de distribuição livre da Stanley Neuropathology Consortium, o qual consiste de biomarcadores inflamatórios e características da população com diagnósticos de esquizofrenia, transtorno bipolar e um grupo controle (sem transtornos); para o segundo artigo utilizou-se outro banco de dados, com variáveis bioquímicas, características da população e respostas de questionários com diagnósticos de depressão maior, transtorno bipolar e um grupo controle (sem transtornos). O programa de treinamento da RNA utilizado é o OpenNN, e também é de distribuição livre. Como resultado tem-se RNAs treinadas com mais de 80% de acurácia nas classificações dos diagnósticos
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- 2019
7. Perfil de saúde em uma população quilombola: diferença entre os sexos
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Ferrugem, Sílvia Contreira Rodrigues, Silva, Ricardo Azevedo da, Moreira, Fernanda Pedrotti, Jansen, Karen, and Wiener, Carolina David
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Quilombola ,metabolic syndrome ,chronic diseases ,associated factors ,NUTRICAO [CIENCIAS DA SAUDE] ,síndrome metabólica ,doenças crônicas ,fatores associados - Abstract
Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2019-05-16T19:40:51Z No. of bitstreams: 1 Silvia Contreira Rodrigues Ferrugem.pdf: 795979 bytes, checksum: 3913233f62bd5082dc016fb8a4707bdd (MD5) Made available in DSpace on 2019-05-16T19:40:51Z (GMT). No. of bitstreams: 1 Silvia Contreira Rodrigues Ferrugem.pdf: 795979 bytes, checksum: 3913233f62bd5082dc016fb8a4707bdd (MD5) Previous issue date: 2018-11-27 The quilombola population is part of the so-called neglected populations, being a matter of concern for health professionals, researchers and managers. Low socioeconomic conditions, schooling, housing without infrastructure, as well as the habit of smoking and alcoholism contribute to the development of chronic diseases, including metabolic syndrome. Metabolic syndrome is the result of a set of interrelated metabolic risk factors, including abdominal obesity, dyslipidemia, hypertension and hyperglycemia, which are associated with an increased risk of cardiovascular disease morbidity and mortality. There are few studies on quilombola communities scattered throughout the country. Therefore, the objective was to evaluate the prevalence and factors associated with the metabolic syndrome in adolescent of a quilombola community, located in the city of Pelotas / Rio Grande do Sul. Data collection, interpretation and analysis are important for a more thorough evaluation in order to promote health, as well as the prevention and control of chronic diseases. A população quilombola faz parte das chamadas populações negligenciadas, sendo motivo de preocupação para profissionais da saúde, pesquisadores e gestores. As baixas condições socioeconômicas, escolaridade, moradias sem infraestrutura, bem como o hábito do tabagismo e do etilismo contribuem para o desenvolvimento de doenças crônicas, entre elas o surgimento da síndrome metabólica. A síndrome metabólica é o resultado de um conjunto de fatores de risco metabólicos inter-relacionados, incluindo obesidade abdominal, dislipidemia, hipertensão arterial e hiperglicemia, que estão associados ao aumento do risco de morbidade e mortalidade de doenças cardiovasculares. São escassos os estudos sobre as comunidades quilombolas existentes em todo o país. Por isso, o objetivo foi avaliar a prevalência e fatores associados a síndrome metabólica em adul tos de uma comunidade quilombola, localizada na cidade de Pelotas/ Rio Grande do Sul. O levantamento de dados, interpretação e análise são importantes para uma avaliação mais criteriosa tendo em vista a promoção da saúde, bem como a prevenção e controle de doenças crônicas.
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- 2018
8. Substâncias psicoativas e ritmo biológico em uma amostra comunitária de jovens
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REYDAMS, Louise Hallal, JANSEN, Karen, MONDIN, Thaíse Campos, and WIENER, Carolina David
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#-969369452308786627# ,biological rhythm ,substance use disorder ,alcohol use disorder ,ritmo Biológico ,transtorno por uso de substâncias ,transtorno por uso de álcool ,MEDICINA# [CIENCIAS DA SAUDE] ,#600 - Abstract
Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2018-08-08T12:13:43Z No. of bitstreams: 1 Louise Halla Reydams.pdf: 1479930 bytes, checksum: dbeb9959b561b6b01f81682d8d0dd3b9 (MD5) Made available in DSpace on 2018-08-08T12:13:43Z (GMT). No. of bitstreams: 1 Louise Halla Reydams.pdf: 1479930 bytes, checksum: dbeb9959b561b6b01f81682d8d0dd3b9 (MD5) Previous issue date: 2018-04-27 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES# #2075167498588264571# #600 Substance use disorder is related to numerous mental and physical health problems, associated with several functional impairments that affect several aspects of the life of the individual with the disorder. The objective of this study was to evaluate the relationship between psychoactive substances and biological rhythm in a community sample of young people. It is a cross-sectional population-based study with adults aged 24 to 30 years living in the urban area of the city of Pelotas, RS. The sample selection was performed by multi-stage conglomerates. Socio-demographic data were collected from the sample and substance abuse or dependence was assessed through the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), as well as the biological rhythm was evaluated through the Biological Rhythm Interview of Assessment Neuropsychiatry (BRIAN). A total of 1241 subjects were evaluated. The prevalence of substance use disorders in the sample was as follows: alcohol 14.1% (n=175), tobacco 30.8% (n=382), cannabis 10.5% (n=130), cocaine/crack 8.4% (n=104) and other psychoactive substance use disorder 9.2% (n=114). In the model of linear regression adjustment, alcohol use disorder was able to predict change in sleep/social pattern (p
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- 2018
9. Síndrome metabólica e episódio depressivo: estudo de base populacional
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MOREIRA, Fernanda Pedrotti, JANSEN, Karen, MONDIN, Thaíse Campos, WIENER, Carolina David, and OSES, Jean Pierre
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síndrome metabólica ,depressão ,transtorno bipolar ,anedonia ,ritmo biológico ,#-969369452308786627# ,MEDICINA# [CIENCIAS DA SAUDE] ,#600 - Abstract
Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2017-06-30T17:25:16Z No. of bitstreams: 1 Fernanda Pedrotti.pdf: 2330556 bytes, checksum: ddef2784e39ab69a1b9faa141cf2c1f4 (MD5) Made available in DSpace on 2017-06-30T17:25:16Z (GMT). No. of bitstreams: 1 Fernanda Pedrotti.pdf: 2330556 bytes, checksum: ddef2784e39ab69a1b9faa141cf2c1f4 (MD5) Previous issue date: 2017-01-24 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES# #2075167498588264571# #600 Metabolic syndrome (MetS) is a disorder with high prevalence in the general population and presents a high rate of comorbidity with depression. In addition, recent studies suggest that deregulation of the biological rhythm as well as specific symptoms of depression, such as anhedonia, might play a central role in this comorbidity. Thus, the aim of the current thesis was to assess the relationship between metabolic syndrome and depressive episode in a community sample of young adults from Pelotas-RS. This is a cross-sectional study corresponding to the second phase of a cohort study. The first paper sought to evaluate the relationship between metabolic syndrome and depressive episode. The results showed that individuals in a depressive episode and with metabolic syndrome had a worse metabolic profile. In addition, they also presented higher disruption in biological rhythm, with higher total BRIAN scores, as well as in sleep, social behavior and eating domains, when compared to individuals with depression, but without MetS. These findings suggest a strong association between MetS and biological rhythm disruption in depressed individuals. The second paper aimed to evaluate differences in the prevalence of MetS and metabolic parameters in young adults with bipolar disorder and major depressive disorder in current depressive episode. The results showed that individuals with bipolar disorder and depression, in the current depressive episode, present a high prevalence of MetS in relation to the population sample. In addition, there were no significant differences in metabolic parameters between individuals with depression and bipolar disorder, except for BMI, suggesting that MetS is associated with the depressive episode and not specifically with the diagnosis of mood disorder. In the third paper, it was verified that the prevalence of MetS is higher in depression subjects with anhedonia, when compared to depression subjects without anhedonia, and to population controls. This study also showed that individuals in depression with anhedonia have a worse metabolic profile in relation to glucose, triglycerides, total cholesterol and LDL cholesterol than the depression group without anhedonia. Thus, the present study shows an important relationship between MetS and depression, and stresses the importance of designing intervention strategies focused on reducing the high rates of comorbidity among these diseases. A síndrome metabólica (SM) é um transtorno de alta prevalência na população geral e apresenta alta taxa de comorbidade com a depressão. Além disso, estudos recentes propõem que a desregulação do ritmo biológico, bem como de sintomas específicos da depressão, como a anedonia, podem desempenhar um papel central nesta comorbidade. Assim, o objetivo desta tese foi avaliar a relação entre síndrome metabólica e episódio depressivo através de um estudo populacional com adultos jovens da cidade de PelotasRS. Trata-se de um estudo transversal correspondente à segunda fase de um estudo de coorte. O primeiro trabalho buscou avaliar a relação entre síndrome metabólica e episódio depressivo. Os resultados demonstraram que indivíduos em episodio depressivo e com síndrome metabólica, apresentaram pior perfil metabólico. Além disso, também apresentaram maior desregulação no ritmo biológico, com maiores escores na escala BRIAN total, bem como dos domínios sono, padrão social e alimentação, quando comparados aos indivíduos com depressão, mas sem SM. Estes achados sugerem uma forte associação entre SM e desregulação do ritmo biológico em indivíduos em episodio depressivo. O segundo artigo teve como objetivo avaliar diferenças na prevalência da SM e parâmetros metabólicos entre adultos jovens com transtorno bipolar e transtorno depressivo maior, ambos em episódio depressivo atual. Os resultados revelam que indivíduos com transtorno bipolar e depressão, em episódio depressivo atual, apresentam alta prevalência de SM em relação à amostra populacional. Além disso, não houve diferenças significativas em relação aos parâmetros metabólicos entre os indivíduos com transtorno depressivo maior e transtorno bipolar, exceto para o Índice de massa corporal (IMC), sugerindo que a SM está associada ao episódio depressivo e não especificamente ao diagnóstico de transtorno de humor. No terceiro artigo, verificou-se que a prevalência da SM é maior em indivíduos com depressão e anedonia, quando comparados a indivíduos com depressão sem anedonia e a controles populacionais. Este estudo também mostrou que indivíduos com depressão e anedonia apresentam pior perfil metabólico, em relação aos níveis de glicose, triglicerídeos, colesterol-total e colesterol-LDL, do que o grupo depressão sem anedonia. Dessa forma, o presente trabalho mostra a importante relação entre SM e depressão, e salienta a necessidade de se traçar estratégias de intervenção focadas na redução das altas taxas de comorbidade entre estas doenças
- Published
- 2017
10. Níveis séricos de BDNF (Brain derived neurotrophic factors) na tentativa de suicídio em amostra de base populacional
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BORGES, Cristiane Jackson, OSES, Jean Pierre, MONDIN, Thaise, and WIENER, Carolina David
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BDNF ,attempted suicide ,major depression ,bipolar disorder ,mental disorders ,biomarker ,tentativa de suicídio ,depressão maior ,transtorno bipolar ,transtornos mentais ,biomarcador ,PSIQUIATRIA [MEDICINA] - Abstract
Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2021-10-04T11:54:15Z No. of bitstreams: 1 Dissertação - Cristiane Jackon Borges.pdf: 1719287 bytes, checksum: 08a4776df14bdbcec0614c68d24c04d1 (MD5) Made available in DSpace on 2021-10-04T11:54:15Z (GMT). No. of bitstreams: 1 Dissertação - Cristiane Jackon Borges.pdf: 1719287 bytes, checksum: 08a4776df14bdbcec0614c68d24c04d1 (MD5) Previous issue date: 2016-12-21 A suicide attempt causes sequels to those who practice self-harm, as well as to their family members and a society in general. It is estimated that for each suicide there are at least ten attempts with seriousness to request medical attention, although for each documented attempt there are four that have not been registered. A great ability to deal with suicide attempts can lead to a reduction in the number of suicides and consequently the social and family impact. Suicide is a multifactorial phenomenon and an important global public health problem that affects about one million people a year in the world. It is estimated that 90% of suicides are associated with mental disorders as a risk factor. The suicidal behavior in its pathogenesis involves altered neural plasticity makes the nervous system central to stressors and environmental results. Neurotrophins in turn play an important role in synaptic regulation, morphological plasticity and modulation of strength and number of synaptic and neurotransmission, among them BDNF can be used. A possible biomarker of great importance is not diagnostic and risk of suicide. The aim of this study is to evaluate the serum levels of BDNF between individuals with attempted suicide and a control group without mental disorders from a population-based sample. This is a cross-sectional, matched, crosssectional study with a population-based cross-sectional study involving 2,348 young adults aged 18-35 living in the urban area. For the evaluation of mental disorders and suicide attempt the subjects are interviews through a diagnostic interview - Mini International Neuropsychiatric Interview (M.I.N.I.). After a diagnostic interview, the assays were performed at a temperature of 10 ml of blood, and the serum was stored at -80 ° C for further dosing. For the measurement of serum levels of BDNF, commercial kits (DuoSet ELISA Development, R & D Systems, Inc., USA) were used by the ELISA technique (Enzime Linked Immuno Sorbent Assay). The hypothesis of the study is that individuals who have undergone one or more suicide attempts show a reduction in serum BDNF levels when compared to the control group. A tentativa de suicídio causa sequelas para quem pratica o ato de autoagressão, bem como também para seus familiares e a sociedade em geral. Estima-se que para cada suicídio existam pelo menos dez tentativas com gravidade para requerer atendimento médico, considerando ainda que para cada tentativa documentada existam quatro que não foram registradas. Uma maior habilidade em lidar com as tentativas de suicídio poderá fazer com que haja uma redução no número de suicídios e consequentemente o impacto social e familiar. O suicídio é fenômeno multifatorial e importante problema de saúde pública mundial que afeta cerca de um milhão de pessoas por ano no mundo. Estima-se que 90% dos suicídios estejam associados com transtornos mentais como fator de risco. O comportamento suicida em sua patogênese envolve plasticidade neural alterada resultante do sistema nervoso central frente a agentes estressores e fatores ambientais. As neurotrofinas por sua vez desemprenham papel importante na regulação sináptica, plasticidade morfológica e na modulação da força e número de ligações sinápticas e neurotransmissão, dentre elas se destaca o BDNF que se apresenta diminuído em pacientes com comportamento suicida, sendo assim, o BDNF pode ser um possível biomarcador de grande importância no diagnóstico e risco de suicídio. O objetivo desse estudo é avaliar os níveis séricos de BDNF entre indivíduos com tentativa de suicídio e um grupo controle sem transtornos mentais oriundos de uma amostra de base populacional. Trata-se de um estudo transversal pareado, aninhado a um estudo transversal de base populacional envolvendo 2348 adultos jovens de 18 a 35 anos, residentes na área urbana. Para avaliação dos transtornos mentais e tentativa de suicídio os sujeitos serão avaliados através de uma entrevista diagnóstica – Mini International Neuropsychiatric Interview (M.I.N.I.). Após a entrevista diagnóstica, os indivíduos serão convidados a realizar uma coleta de 10 mL de sangue, e o soro resultante será armazenado à -80ºC para posterior dosagem. Para mensurar os níveis séricos de BDNF, serão utilizados kits comerciais (DuoSet ELISA Development, R&D Systems, Inc., USA) pela técnica de ELISA (Enzime Linked Immuno Sorbent Assay). A hipótese do estudo é que os indivíduos que tenham realizado uma ou mais tentativas de suicídio apresentem uma redução nos níveis séricos de BDNF quando comparados com o grupo controle.
- Published
- 2016
11. Atividade física e transtornos de humor
- Author
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Branco, Jerônimo Costa, Silva, Ricardo Azevedo da, Jansen, karen, Orcy, Rafael, Motta, Janaína Vieira dos Santos, and Wiener, Carolina David
- Subjects
#5178284805913411594# ,EDUCACAO FISICA# [CIENCIAS DA SAUDE] ,#600 ,transtorno de humor ,depressão ,atividade física ,citosinas ,idosos ,adultos jovens - Abstract
Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2017-02-14T12:15:48Z No. of bitstreams: 1 Tese Jeronimo Branco _ PPG SAÚDE E COMPORTAMENTO.pdf: 2163180 bytes, checksum: 4837498bdd5db48931f27ac96fa081c3 (MD5) Made available in DSpace on 2017-02-14T12:15:48Z (GMT). No. of bitstreams: 1 Tese Jeronimo Branco _ PPG SAÚDE E COMPORTAMENTO.pdf: 2163180 bytes, checksum: 4837498bdd5db48931f27ac96fa081c3 (MD5) Previous issue date: 2014-11-11 Mood disorders are characterized by affective manifestations which are inappropriate in terms of intensity, frequency and duration of such occurrences. The practice of physical activities has been identified as a positive intervention on the treatment of mental disorders. Also, research works have found a relationship between physical exercise and the regulation of neurobiological markers associated with mood disorders. The present thesis has three objectives: 1) To analyze the association between mood disorders and the practice of physical activities; 2) To verify the relationship between inflammatory markers and the practice of physical activity in depressed young adults; and 3) To evaluate the effect of a walking and running program on the remission of depressive symptoms in the elderly. The first two objectives were achieved by a population-based cross-sectional study that evaluated 1953 young adults aged 18 to 35 years from a southern city of Brazil. The third objective was attained by an intervention study with 26 Portuguese elderly individuals who participated in a walking and running program in the city of Porto, Portugal. The Brazilian study contained the Mini International Neuropsychiatric Interview 5.0 (M.I.N.I.) and the International Physical Activity Questionnaire 8.0 (IPAQ); inflammatory markers levels were measured through ELISA technique using commercial kits. The intervention from the Portuguese study was based on three weekly sessions of a 30-minute walk with 50-75% maximal cardiac frequency, for six months. Baseline and post-intervention evaluations were carried out through the Geriatric Depression Scale (GDS) by Yesavage and the Rikli&Jones Test for evaluation of physical fitness. In addition, a bioimpedance balance Tanita MC.180 and a stadiometer were used for collection of anthropometric data. The accelerometer MTI Actigraph was used to measure the levels of physical activity for seven days. Statystical analyses were carried out using the SPSS 21 software where associations 9 were considered statistically significant when p
- Published
- 2014
12. Níveis seritônicos de NGF ( fator de crescimento neural) em pacientes com depressão e risco de suicídio
- Author
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Ferreira, Sharon de Mello, Oses, Jean Pierre, Wiener, Carolina David, and Lhullier, Alfredo Cardoso
- Subjects
NGF ,neurotrofinas ,suicide risk ,major depressive disorder ,transtorno depressivo maior ,CIENCIAS DA SAUDE::MEDICINA::PSIQUIATRIA [CNPQ] ,risco de suicidio ,neurotrophins - Abstract
Made available in DSpace on 2016-03-22T17:27:35Z (GMT). No. of bitstreams: 1 SharonMFerreir.pdf: 2163870 bytes, checksum: d5e466194ea4c397ec8640eb900fa160 (MD5) Previous issue date: 2014-10-27 % Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders that affect approximately 17% of the population in a lifetime. Neurotrophins (NGF) are a group of structurally related proteins, which control the development and differentiation of nerve cells that play a role in cellular migration proliferation, differentiation and phenotypic maintenance central nervous system development. Thus, the role of NGF in neuronal plasticity and support, may suggests that these NGF plays an important action in the etiology and pathophysiology of suicide individuals. Therefore, the aim of this study was to evaluate serum levels of NGF in healthy and depressed person with and without suicide risk in a population-based sample of individuals. This study was performed 47 individuals with current depressive episode and suicide risk without a history of mania, and allocated to major depression and suicide risk groups. Two groups of 47 individuals each, were matched by sex and age: the active control group was composed of those with current depressive episode without risk of suicide; while the population control group included individuals with no history of affective disorder.This study was conducted by a questionnaire with demographic questions (gender, ethnicity, age and education level). After the diagnostic interview, a collection of blood from each individual was performed. Measurement of serum levels of NGF by ELISA. The comparison between the levels of NGF with the group of depressed individuals at risk for suicide without a depressed suicide risk and healthy control was performed by ANOVA with Bonferroni through post-hoc test.. NGF levels were significantly lower (p
- Published
- 2014
13. Job satisfaction and work overload among mental health nurses in the south of Brazil.
- Author
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Oliveira JF, Santos AMD, Primo LS, Silva MRSD, Domingues ES, Moreira FP, Wiener C, and Oses JP
- Subjects
- Adult, Aged, Brazil, Cross-Sectional Studies, Fatigue epidemiology, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Workload psychology, Young Adult, Health Personnel psychology, Job Satisfaction, Mental Health Services organization & administration, Nurses psychology
- Abstract
This study assessed job satisfaction and work overload among doctors, nurses, psychologists, and nursing technicians working in community mental health services and conducted a comparison between nurses and other healthcare professionals. Using convenience sampling, a cross-sectional study was conducted with 61 healthcare professionals working in psychosocial care centers in a municipality located in the South Region of Brazil. Data was collected using a sociodemographic questionnaire, work impact assessment scale (Impacto - Br), and mental health professional satisfaction scale (Satis - Br). Data analysis was performed using the statistical software package SPSS 21.0. The average overall work overload score of nurses was 2.92 ± 0.42 and the average overall job satisfaction score was 3.38 ± 0.51. The level of satisfaction of nurses with the quality of services provided was lower than that of other professionals (3.36 ± 0.77 compared to 3.78 ± 0.56, respectively; p = 0.04). The factor that had the greatest negative influence on work overload among nurses was feeling physically tired (2.99 ± 0.92), while the factor that had the greatest positive influence on job satisfaction was good working relationships (4.06 ± 0.65).
- Published
- 2019
- Full Text
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