1. Long-term mortality of Dutch COVID-19 patients admitted to the intensive care medicine: a retrospective analysis from a national quality registry.
- Author
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Wortel SA, Bakhshi-Raiez F, Abu-Hanna A, Dongelmans DA, Keizer NF, Houwink A, Dijkhuizen A, Draisma A, Rijkeboer A, Cloïn A, Meijer A, Reidinga A, Festen-Spanjer B, van Bussel B, Eikemans B, Jacobs C, Moolenaar D, Ramnarain D, Koning D, Boer D, Verbiest D, van Slobbe-Bijlsma E, van Koppen E, Rengers E, van Driel E, Verweij E, van Iersel F, Brunnekreef G, Kieft H, Kreeftenberg H, Hené I, Janssen I, Drogt I, van der Horst I, Spijkstra JJ, Rozendaal J, Mehagnoul-Schipper J, Erasmus JE, Holtkamp J, Lutisan J, van Oers J, Lens J, van Gulik L, van den Berg L, Urlings-Strop L, Georgieva L, van Lieshout M, Hoogendoorn M, Mos MV, Graaff M, Bruin M, Hoeksema M, van Tellingen M, Barnas M, Erkamp M, Gritters N, Kusadasi N, Elbers P, Koetsier P, Spronk P, van der Voort P, Pruijsten R, Jong R, Bosman RJ, Wesselink R, Schnabel R, van den Berg R, Waal R, Arbous S, Knape S, Hendriks S, Frenzel T, Dormans T, Rijpstra T, Silderhuis V, and Ruijter W
- Subjects
- Humans, Male, Female, Netherlands epidemiology, Middle Aged, Aged, Retrospective Studies, Aged, 80 and over, Comorbidity, Adult, SARS-CoV-2, Age Factors, COVID-19 mortality, COVID-19 therapy, COVID-19 epidemiology, Hospital Mortality, Intensive Care Units statistics & numerical data, Registries, Respiration, Artificial statistics & numerical data
- Abstract
Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use., Methods: We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup. We used Cox regression models to analyze the effects of patient characteristics on 12-month mortality after hospital discharge., Results: We included 16,605 COVID-19 patients. The in-hospital mortality rate was 28.1%, and the 12-month mortality rate after intensive care unit admission was 29.8%. Among hospital survivors, 12-month mortality after hospital discharge was 2.5% (300/11,931). The hazard of death at 12 months after hospital discharge was greater in patients between 60 and 79 years (HR 4.74; 95%CI 2.23 - 10.06) and ≥ 80 years (HR 22.77; 95%CI 9.91 - 52.28) than in patients < 40 years of age; in male patients than in female patients (HR 1.38; 95%CI 1.07 - 1.78); and in patients with one (adjusted HR 1.95; 95%CI 1.5 - 2.53), two (adjusted HR 4.49; 95%CI 3.27 - 6.16) or more than two comorbidities (adjusted HR 4.99; 95%CI 2.62 - 9.5) than in patients with no comorbidities. Neither vasoactive medication use nor mechanical ventilation resulted in statistically significant results., Conclusion: For Dutch COVID-19 intensive care unit patients, most deaths occurred during their hospital stay. For hospital survivors, the crude 12-month mortality rate was low. Patient age (older than 60), sex and the number of comorbidities were associated with a greater hazard of death at 12 months after hospital discharge, whereas mechanical ventilation and vasoactive medication were not.
- Published
- 2024
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