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Objective: To analyze the patent registrations registered in the nursing area from 2004 to 2019, relating to the beginning of the Professional Masters in Nursing., Method: Electronic documentary research carried out at the bases of the National Institute of Industrial Property and Lattes Platform. After data collection, requests, filing date, patent titles, international patent classification and areas of expertise of depositor / inventors were analyzed., Results: The study points out that there was no significant correlation between the number of registered patents with the prelude to the professional master's degree in nursing, corroborating with previous studies regarding incipience., Final Considerations: although two of the initial objectives of professional master's programs are creation and technological innovation, it is analyzed that the granted institutions need to simplify and equip researchers with regard to the patent registration process, so that we can take off in this technological universe.

Objective: To reflect on the key concepts of the book The Structure of Scientific Revolutions and its applicability in professional master's in nursing., Method: This is a theoretical-reflective study that uses the philosophical and epistemological conceptions of the philosopher Thomas Samuel Kuhn to consider its applicability on the paradigm shift of stricto sensu graduate courses in nursing. The main concepts of Kuhn were used as support: paradigm, anomaly, scientific community and scientific revolution., Results: The propositions of this philosopher are applied to and support the theoretical reflection on professional master's programs, contributing to clarify what would be a paradigmatic visionary perspective in stricto sensu master's models in nursing., Conclusion: From Kuhn's propositions it was possible to conclude that professional master's programs in nursing can break away from the dominant paradigm, strengthening a scientific revolution within the academia.

Objective: To summarize the production of the Professional Master's Program in Nursing Care Management of the Federal University of Santa Catarina, between 2013 and 2016., Method: electronic documental research. After data collection, we analyzed the numbers of defenses in relation to what was predicted by the respective public notices; as well as sex, training time and professional area of the authors; scenario, context and research line; general objective, analysis support model, methodological approach, instruments/techniques of data collection, and technique of analysis; and, finally, technological productions., Results: 57 dissertations were found and subjected to analysis. The highest number of defenses took place in 2016, in the public scenario, in a care context, with a qualitative approach and having assistance protocols as a final product., Conclusion: Although the country has weaknesses in its educational system, results of the post-graduate level stand out through the technological productions of professional master's studies in nursing.

Objective: To evaluate whether treatment with L-arginine influences the healing of skin flaps in rats exposed to nicotine., Methods: 40 male Wistar rats weighing 142.4 ± 10.1 g were separated into four groups: GC: treatment with 7.4 pH phosphate buffer, submitted to skin flap and observation for ten days; GN: exposure to nicotine for four weeks, submitted to skin flap and observation for ten days; GA: treatment with 7.4 pH phosphate buffer for four weeks, submitted to skin flap and arginine treatment for ten days; GAN: exposure to nicotine for four weeks, submitted to skin flap and treatment with arginine for ten days. We evaluated: areas of necrosis, re-epithelialization, inflammatory reaction and formation of granulation tissue by HE stain; the total area of deposition and differentiation of collagens I and III by histometry with picrosirius staining; and the scar vascular density by immunohistochemical staining with monoclonal anti-CD34 antibodies., Results: The percentages of necrotic areas in GN and GNA were higher (p <0.001) than in GC and GA. In histological scores, collagen deposition, and the percentage of type I collagen, GA and GC were similar to each other (p> 0.05), but higher (p <0.001) than GA and GNA; as for vascular densities, they were lower in GN and GAN (p <0.001) than in GC and GA., Conclusion: Exposure to nicotine inhibited the effects of arginine and in unexposed mice there was induction of angiogenesis and improvement in the total collagen deposition in the skin flaps.

Objective: To determine whether tacrolimus administered to rats, in the presence of pancreatitis induced by L-Arginine, interferes with the serum levels of amylase and glucose and the histological pattern of the pancreatic parenchyma., Methods: Forty Wistar rats were divided into four groups with 10 rats each: control group (C), tacrolimus group (T), pancreatitis group (P) and pancreatitis-tacrolimus group (PT). We evaluated serum levels of amylase, glucose, and tacrolimus and made histological assessments of the pancreas. Induction of pancreatitis was made by inoculation of L-Arginine at a dose of 500 mg/100g body weight intraperitoneally, and tacrolimus treatment at a dose of 1ìg/kg subcutaneously for four days., Results: Serum amylase was higher (p = 0.0000) in groups PT, P and T than in the control group. The PT group mean was higher (p = 0.0009) than in the T group, but did not differ (p = 0.6802) from the average of the P group. There was no difference between groups P and T (p = 0.2568). Neither in mean blood glucose between the groups (p = 0.4920); serum levels of tacrolimus were similar in PT and T groups (p = 0.7112). There were no histological changes in groups T and C and no hemorrhage in the pancreas of rats in groups P and PT. In group P, there was no edema in 30%, mild edema in 20% and in 50%, moderate; as for inflammatory infiltration, it was moderate in 80% and absent in 20%, and atrophy of the parenchyma was moderate in 60% and severe in 40%. In the PT group, there was edema, inflammatory infiltration or atrophy in the pancreas in all rats., Conclusion: Treatment with Tacrolimus induced an increase in serum amylase in normal mice, but did not affect blood glucose or the histological pattern of the pancreatic parenchyma. In the presence of pancreatitis induced by L-Arginine tacrolimus induced edema, inflammatory infiltration and more severe atrophy in the pancreatic parenchyma.

The main objective of this transverse study was to investigate the presence of serologic markers of infection with the hepatitis B virus (HBsAg or HBsAb) among dentistry students before and after they began to have contact with patients; among dentists; and, for purposes of comparison with the latter group, among professionals outside the biological sciences in the municipality of Belo Horizonte, Brazil. Secondarily, the association between the prevalence of infection, the frequency of performing potentially infective dental procedures, and the use of protective barriers was studied. Among 88 students at the beginning of their course of study (average age = 20.0 years), the proportion of positive individuals was 6.8%; among 84 students concluding their studies (average age = 23.4 years), the proportion was 7.1% (P = 0.829). In the group of 202 dentists (average age = 44.0 years), 23.3% were positive, while among the other professionals (202 individuals, average age = 44.3 years), the proportion was 14.9%, for an odds ratio of 1.75 (95% CI = 1.02 to 2.98; P = 0.042). While 91.7% of the students reported that they routinely used surgical masks, only 16.7% said they regularly wore gloves. Among the dentists, these proportions were 49.8% and 9.4%, respectively. No association was found between risk factors and the use of such protection and the prevalence of infection in the different groups studied.