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ABSTRACT: In the search for an early biomarker of renal injury, this study aimed to determine the urinary protein profile of dogs with leishmaniasis without treatment and treated as determined by Brazilian legislation. The identification of proteinuria, its classification and the circumstances in which it takes place instigated this study. For this, 30 dogs from an outpatient clinic at a Veterinary Hospital in Belo Horizonte were evaluated. All animals underwent clinical and laboratory tests, which included renal biomarkers. The proteins were characterized using the SDS-page electrophoresis technique, and thus, a urinary protein profile was developed comparing patients considered clinically healthy with dogs infected with leishmaniasis that were under treatment and with untreated infected dogs. The results showed that the hematological and biochemical parameters showed similar behavior between the groups of healthy dogs and dogs with leishmaniasis treated, however a very heterogeneous pattern of urinary proteins can be observed and differed between healthy animals and animals with leishmaniasis, as well as between treated and untreated animals. The results suggest that the classification of proteinuria can be a tool that helps in the staging of animals infected with L. infantum and can differentiate them as to the severity of existing kidney injuries.

Com o Objetivo de avaliar a Contribuição da Associação medicamentosa de ômega-3, vitamina E, selenito de sodio, gluconato de cobre, gluconato de zinco, sulfato de condroitina e glucosamina (Gerioox®), 12 CAES oriundos do atendimento clínico ambulatorial fazer Veterinário hospitalar Uma Instituição Federal de de ensino superior, Portadores de Doença Crônica renal (RDC), were estudados. Were Realizados Exames de hemograma, Medida de Concentração sérica de calcio, fósforo, uréia creatinina, urinálise, Razão proteína creatinina urinaria (RPC) e taxa de Filtração glomerular (TFG) e os antes de iniciado o experimento (T0), apos 30 (T1) , 90 (T2) e 120 dias (T3). Houve Correlação negativa significativa (P Houve melhora do estado clínico dos patients estudados observado Pela Sinalização dos Tutores Informando melhora da Vitalidade e apetite e Pelas OBSERVAÇÕES Clínicas de melhora do estado Geral, da pelagem e dos Parâmetros analisados. A Associação de ômega-3, vitamina E, selenito de sodio, gluconato de cobre, gluconato de zinco, sulfato de condroitina e glucosamina revelou Ser hum Importante coadjuvante no Tratamento conservador da DRC de Cães, causando aumento da TFG com diminuição da proteinúria, significando Que houve Uma melhora na Qualidade da excreção, e NÃO UM aumento da excreção, Por Um Efeito indesejado de aumento da pressao glomerular.