1. Effects of a high-intensity pulmonary rehabilitation program on the minute ventilation/carbon dioxide output slope during exercise in a cohort of patients with COPD undergoing lung resection for non-small cell lung cancer.
- Author
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Perrotta F, Cennamo A, Cerqua FS, Stefanelli F, Bianco A, Musella S, Rispoli M, Salvi R, and Meoli I
- Subjects
- Aged, Carbon Dioxide metabolism, Carcinoma, Non-Small-Cell Lung physiopathology, Carcinoma, Non-Small-Cell Lung surgery, Exercise Test, Female, Forced Expiratory Volume physiology, Humans, Lung Neoplasms physiopathology, Lung Neoplasms surgery, Male, Middle Aged, Oxygen Consumption physiology, Pulmonary Disease, Chronic Obstructive physiopathology, Reference Values, Retrospective Studies, Spirometry, Time Factors, Treatment Outcome, Vital Capacity physiology, Carcinoma, Non-Small-Cell Lung rehabilitation, Exercise Therapy methods, Lung Neoplasms rehabilitation, Pulmonary Disease, Chronic Obstructive rehabilitation
- Abstract
Objective: Preoperative functional evaluation is central to optimizing the identification of patients with non-small cell lung cancer (NSCLC) who are candidates for surgery. The minute ventilation/carbon dioxide output (VE/VCO2) slope has proven to be a predictor of surgical complications and mortality. Pulmonary rehabilitation programs (PRPs) could influence short-term outcomes in patients with COPD undergoing lung resection. Our objective was to evaluate the effects of a PRP on the VE/VCO2 slope in a cohort of patients with COPD undergoing lung resection for NSCLC., Methods: We retrospectively evaluated 25 consecutive patients with COPD participating in a three-week high-intensity PRP prior to undergoing lung surgery for NSCLC, between December of 2015 and January of 2017. Patients underwent complete functional assessment, including spirometry, DLCO measurement, and cardiopulmonary exercise testing., Results: There were no significant differences between the mean pre- and post-PRP values (% of predicted) for FEV1 (61.5 ± 22.0% vs. 62.0 ± 21.1%) and DLCO (67.2 ± 18.1% vs. 67.5 ± 13.2%). Conversely, there were significant improvements in the mean peak oxygen uptake (from 14.7 ± 2.5 to 18.2 ± 2.7 mL/kg per min; p < 0.001) and VE/VCO2 slope (from 32.0 ± 2.8 to 30.1 ± 4.0; p < 0.01)., Conclusions: Our results indicate that a high-intensity PRP can improve ventilatory efficiency in patients with COPD undergoing lung resection for NSCLC. Further comprehensive prospective studies are required to corroborate these preliminary results.
- Published
- 2019
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