1. Distúrbio mineral e ósseo: prevalência subestimada nos estágios iniciais da doença renal crônica.
- Author
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Nogueira Quadros, Karla Amaral, Augusto de Morais, Flávio, Coelho de Vasconcelos, Francisco Edson, Watanabe, Yoshimi José Ávila, de Morais Bessa, Allan, de Rezende e Silva, Fernanda Marcelino, Marques Guedes, João Victor, Silva Belo, Vinícius, Silva Cardoso, Clareci, and Otoni, Alba
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BONE diseases , *DISEASE progression , *GLOMERULAR filtration rate , *CHRONIC kidney failure , *STATISTICS , *BONES , *CONFIDENCE intervals , *CHRONIC diseases , *CARDIOVASCULAR diseases , *MANN Whitney U Test , *RENAL osteodystrophy , *TREATMENT effectiveness , *PARATHYROID hormone , *HYPERPARATHYROIDISM , *T-test (Statistics) , *PEARSON correlation (Statistics) , *DISEASE prevalence , *HYPOCALCEMIA , *HYPERPHOSPHATEMIA , *QUALITY of life , *DESCRIPTIVE statistics , *MINERALS , *DATA analysis , *EARLY diagnosis , *LONGITUDINAL method , *POISSON distribution , *DISEASE complications ,MORTALITY risk factors - Abstract
Introduction: mineral and bone disorder (BMD) is a serious complication of chronic kidney disease (CKD) that increases risks for death from cardiovascular causes and impairs quality of life of affected patients. Objective: to evaluate the prevalence of BMD in patients with CKD and the association between estimated Glomerular Filtration Rate (eGFR) and BMD indicators (calcium, phosphorus and PTH) in non-dialysis patients. Materials and Methods: sectional study of a two-year cohort of chronic renal adults and elderly patients on conservative treatment. BMD was identified by serum values of: PTH (> 150 pg/mL) and/or hypocalcemia (Ca < 8.8mg/dl) and/or hyperphosphatemia (P > 4.6 mg/dl). The statistical analysis used: Poisson regression; Student's T, Mann Whitney and Pearson and Spearman correlations with 5% significance level. Results: BMD prevalence was 54.6% (n=41) (95% CI: 43.45 - 65.43), more frequent in women, literate, elderly, non-drinkers, non-smokers, sedentary and white skin color. Correlations between P and PTH with GFRe were significant, inverse, moderate strength (p= <0.005 and p = 0.003; correlation coefficients = - 0.312 and - 0.379 respectively). the findings of this study highlighted gaps in the monitoring of BMD-DRC by primary care, requiring a review of clinical practices. Conclusion: robust prevalence of BMD in the early stages of CKD was identified, in addition to correlations between increased phosphorus and PTH levels and worsening kidney function. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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