80 results on '"Mill, José"'
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2. Body fat percentage is better than indicators of weight status to identify children and adolescents with unfavorable lipid profile
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Oliosa, Polyana Romano, Zaniqueli, Divanei, Alvim, Rafael de Oliveira, Barbosa, Miriam Carmo Rodrigues, and Mill, José Geraldo
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- 2019
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3. Hipertensão arterial e consumo de sal em população urbana
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Bisi Molina Maria del Carmen, Cunha Roberto de Sá, Herkenhoff Luis Fernando, and Mill José Geraldo
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Cloreto de sódio/análise ,Hipertensão arterial/epidemiologia ,Prevalência ,Sódio ,Potássio ,Fatores socioeconômicos ,Public aspects of medicine ,RA1-1270 - Abstract
OBJETIVO: Avaliar o consumo de sal e a relação sódio/potássio urinário em amostra randomizada de população urbana etnicamente miscigenada. MÉTODOS: Foi selecionada uma amostra randômica de 2.268 residentes de Vitória, ES, entre 25 e 64 anos de idade. Os indivíduos foram escolhidos por amostragem domiciliar realizada em 1999/2000, dos quais 1.663 (73,3%) compareceram ao hospital para a realização de exames padronizados. O consumo estimado de sal, Na+ e K+ foi determinado por meio da coleta de urina de 12h no período noturno (19h às 7h) e do gasto mensal de sal domiciliar referido durante a entrevista. A pressão arterial clínica foi medida duas vezes por diferentes pesquisadores treinados em condições padronizadas, usando esfignomamômetro de mercúrio. Para análise estatística foram utilizados o teste de Student e o teste de Tukey. RESULTADOS: A excreção urinária de Na+ foi mais alta em homens e em indivíduos de menores condições socioeconômicas (P
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- 2003
4. Prevalência de uso de medicamentos em população rural brasileira.
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Emerich Mendes, Samila Breder, Blaser Petarli, Glenda, Cattafesta, Monica, Zandonade, Eliana, de Paula Alves Bezerra, Olívia Maria, Geraldo Mill, José, and Bresciani Salaroli, Luciane
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DRUG utilization ,RURAL population ,HEALTH policy ,CHI-squared test ,POLYPHARMACY - Abstract
Copyright of Cadernos Saúde Coletiva is the property of Instituto de Estudos em Saude Colectiva (IESC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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5. Ativação da enzima conversora de angiotensina no coração após infarto do miocárdio e suas repercussões no remodelamento ventricular
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Mill José Geraldo, Milanez Maria da Conceição, Busatto Vera Cristina W., Moraes Andréa Cruz de, and Gomes Maria da Glória S.
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infarto do miocárdio ,remodelamento ventricular ,inibidores da enzima conversora de angiotensina ,angiotensina II ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
OBJETIVO: Determinar as alterações de atividade da enzima conversora de angiotensina (ECA) no coração com infarto do miocárdio (IM) e comparar os efeitos do captopril e losartan em parâmetros morfológicos e funcionais de ratos com IM. MÉTODOS: O IM foi produzido em ratos Wistar por ligadura de ramos da artéria coronária esquerda. Os controles (Con) foram submetidos a uma cirurgia fictícia. Animais com IM e Con foram tratados com captopril (30mg/kg/dia) ou losartan (15mg/kg/dia) e estudados 30 dias após, determinando-se a atividade da ECA nos ventrículos direito (VD) e esquerdo (VE), as alterações hemodinâmicas e as concentrações de hidroxiprolina (OH-Pro) e proteína total no VD e VE. RESULTADOS: A atividade da ECA aumentou no VD (+25%) e VE (+70%) após IM. A maior atividade foi observada na cicatriz fibrótica, onde atingiu cerca de 4,5 vezes a do músculo do VE que sobreviveu ao IM (420±68 vs 94±8nmoles/g/min; P
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- 1997
6. Fatores associados ao consumo de sal na população adulta brasileira: Pesquisa Nacional de Saúde.
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Geraldo Mill, José, Carvalho Malta, Deborah, Fernandes Nilson, Eduardo Augusto, Machado, Ísis Eloah, Constante Jaime, Patrícia, Ivata Bernal, Regina Tomie, de Magalhães Cardoso, Laís Santos, and Landman Szwarcwald, Célia
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CHRONIC kidney failure ,GENDER ,SOCIODEMOGRAPHIC factors ,CREATININE ,HEALTH surveys ,CROSS-sectional method ,URINE - Abstract
Copyright of Revista Ciência & Saúde Coletiva is the property of Associacao Brasileira de Pos-Graduacao em Saude Coletiva and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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7. PRECISÃO DA RAZÃO CINTURA/QUADRIL COMO PREDITOR DA HIPERTENSÃO ARTERIAL NUMA POPULAÇÃO DE ANGOLA
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Silva, Amílcar Bernardo Tomé Da, Mauer A. A. Gonçalves, Capingana, Daniel P., Magalhães, Pedro, S. Moulin, and Mill, José G.
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- 2016
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8. VO2MAX ESTIMATED BY PREDICTIVE EQUATIONS PRESENTS LOW CONCORDANCE WITH THAT OBTAINED BY CARDIOPULMONARY TEST - GOLD STANDARD
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Miranda,Augusto Luiz Nascimento, Lopes,Kristian Costa, Carletti,Luciana, Perez,Anselmo José, Mill,José Geraldo, and Lunz,Wellington
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Consumo Máximo de Oxigênio ,Maximal Oxygen Consumption ,Corrida ,Resistance Training ,Musculação ,Running - Abstract
RESUMOO objetivo foi avaliar a concordância entre mensurações do VO2maxobtidas em teste cardiopulmonar de exercício versus obtidas por equações preditivas. Homens (21-55 anos) foram agrupados em praticantes de musculação (PM; n=31) e corridas (PC; n=28) e não praticantes (SE; n=35). Testou-se 5 equações, uma delas elaborada a partir de amostra brasileira. A concordância foi avaliada por Bland-Altman e as correlações pelo coeficiente de correlação de Pearson (r). Os r entre medida padrão ouro vs. equações ficaram entre 0,27 a 0,75, com p40 mL.kg-1.min1. Conclui-se que as equações preditivas avaliadas nesse estudo geraram medidas de baixa concordância quando comparadas ao padrão ouro, principalmente para VO2max>40 mL.kg-1.min-1. ABSTRACTThe aim was to evaluate the concordance between measurements of VO2max obtained by exercise cardiopulmonary test (gold-standard) vs. that obtained by predictive equations. Men (21-55 years-old) were grouped into Resistance training (RT; n=31), long-distance runners (R; n=28) and non-exercise practitioners (C; n=35). Five equations were tested, one of them made from Brazilian sample. The concordance was evaluated by Bland-Altman, and correlation analysis by Pearson's coefficient (r). The r between gold-standard vs. equations ranged 0.27 to 0.75, with p40 mL.kg-1.min-1. In conclusion, the predictive equations tested generate low concordance when compared to VO2maxgold-standard test, mainly for VO2max>40 mL.kg-1.min-1.
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- 2015
9. Fatores associados à hipotensão ortostática em adultos: estudo ELSA-Brasil.
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Costa Velten, Ana Paula, Benseñor, Isabela, de Souza, Juliana Bottoni, and Geraldo Mill, José
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Copyright of Cadernos de Saude Publica is the property of Escola Nacional de Saude Publica Sergio Arouca and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2019
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10. Comparação da resposta autonômica cardiovascular de praticantes de musculação, corredores de longa distância e não praticantes de exercício
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Lunz, Wellington, Miranda, Rodrigo Nascimento, Dantas, Eduardo Miranda, Morra, Elis Aguiar dos Santos, Carletti, Luciana, Perez, Anselmo José, and Mill, José Geraldo
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The aim of the study was to compare the cardiovascular autonomic response (CAR) of recreational weight trainers, long distance runners and non-exercised subjects. Men, 21 to 55 years old, were grouped in: recreational weight trainers (W, n = 31), long distance runners (R, n = 28) and non-exercised (C, n = 35). Four strategies of evaluation of the CAR were selected: Resting heart rate (RHR), cold pressor test (CPT), heart rate variability (HRV) and heart rate recovery (HHR) following maximal exercise test. The RHR was lower (R = 54 ± 2; W = 62 ± 2; C= 65 ± 2 bpm; mean ± SE) and the HHR 60s post exercise was larger in the R group (R = 34 ± 3; W = 23 ± 1; C = 24 ± 2 bpm). The R group presented larger high-frequency (HF; 55.1 ± 4.0 n.u) and smaller low-frequency (LF; 43.1 ± 4.0 n.u) components of HRV than C group (HF = 40.7 ± 3.3; LF = 56.7 ± 3.5 n.u.). The W group did not show any differences compared to C group. The study's conclusion was that long-term weight-training program, unlike of long-term running training, it is not able to alter significantly the regulatory pattern of CAR. Objetivou-se comparar a resposta autonômica cardiovascular (RAC) de praticantes de musculação, corredores de longa distância e não praticantes de exercício. Homens, 21 a 55 anos, foram agrupados em: Praticantes Musculação (PM, n = 31); Praticantes Corrida (PC, n = 28); Controle (C, n = 35). Foram selecionadas quatro técnicas para avaliação da RAC: Frequência cardíaca de repouso (FCR), Teste pressórico do frio (TPF), Variabilidade da FC (VFC) e recuperação da FC pós-teste máximo em esteira. A FCR foi menor no grupo PC (PC = 54 ± 2; PM= 62 ± 2; C = 65 ± 2 bpm; média ± EPM). A recuperação da FC aos 60 s pós-teste de esforço foi maior no grupo PC (PC = 34 ± 3; PM = 23 ± 1; C = 24 ± 2; bpm). Quanto aos parâmetros espectrais de alta (HF) e baixa (LF) frequência da VFC, o grupo PC apresentou maior HF (55,1 ± 4,0 n.u) e menor LF (43,1 ± 4,0 n.u) comparado ao grupo C (HF = 40,7 ± 3,3; LF = 56,7 ± 3,5 n.u). O grupo PM não apresentou qualquer diferença de RAC em comparação ao grupo C. Conclui-se que prática contínua em musculação por longo prazo, diferentemente da prática de corrida de longa distância, não é capaz de alterar significativamente a RAC.
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- 2013
11. Relação entre volume do átrio esquerdo e disfunção diastólica em 500 casos de uma população brasileira
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Aouar, Lilia Maria Mameri El, Meyerfreud, Diana, Magalhães, Pedro, Rodrigues, Sérgio Lamêgo, Baldo, Marcelo Perim, Brasil, Yara, Aouar, Sumaya Mameri El, Aouar, Nabih Amin El, Mill, José Geraldo, and Campos Filho, Orlando
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lcsh:Diseases of the circulatory (Cardiovascular) system ,lcsh:RC666-701 ,Brasil ,Left ,Ventricular Dysfunction ,Função Atrial Esquerda ,Stroke Volume ,Atrial Function ,Brazil ,Volume Sistólico ,Disfunção Ventricular - Abstract
FUNDAMENTO: O aumento do Volume do Átrio Esquerdo Indexado (VAEi) tem sido associado à Disfunção Diastólica (DD) do Ventrículo Esquerdo (VE), considerado marcador de eventos cardiovasculares (fibrilação atrial, acidente vascular cerebral, insuficiência cardíaca, e óbito). OBJETIVO: Avaliar a relação entre VAEi e diferentes graus de DD em pacientes brasileiros submetidos ao ecocardiograma, estudando os determinantes do aumento do VAEi nesta amostra. MÉTODOS: Selecionamos 500 pacientes ambulatoriais submetidos a ecocardiografia, após exclusão de arritmia, cardiopatia valvar ou congênita, marca-passo permanente ou janela ecocardiográfica inadequada. O VAEi foi obtido pelo método de Simpson; classificou-se a DD segundo diretrizes atuais. Variáveis clínicas e ecocardiográficas foram submetidas a análise multivariada de regressão linear. RESULTADOS: A idade média foi de 52 ± 15 anos, 53% do sexo masculino, 55% hipertensos, 9% coronariopatas, 8% diabéticos, 24% obesos, 47% com hipertrofia VE, fração de ejeção média do VE: 69,6 ± 7,2%. A prevalência de DD na amostra foi de 33,8% (grau I: 66%, grau II: 29% e grau III: 5%). Houve aumento progressivo das dimensões do VAEi conforme o grau de DD: 21 ± 4 mL/m² (ausente), 26 ± 7 mL/m² (grau I), 33 ± 5 mL/m² (grau II), 50 ± 5 mL/m2 (grau III) (p < 0,001). Os preditores independentes de aumento do VAEi nesta amostra foram idade, massa ventricular esquerda, espessura relativa de parede, fração de ejeção do VE e relação E/e'. CONCLUSÃO: A DD contribui para o remodelamento atrial esquerdo. O aumento do VAEi expressa a gravidade da DD e está associado de forma independente com idade, hipertrofia ventricular esquerda, disfunção sistólica e aumento das pressões de enchimento do VE. BACKGROUND: Left atrial volume index (LAVI) increase has been associated to left ventricle (LV) diastolic dysfunction (DD), a marker of cardiovascular events (atrial fibrillation, stroke, heart failure, death). OBJECTIVE: To evaluate the relationship between LAVI and diferente grades od DD in Brazilian patients submitted to echocardiogram, studying LAVI increase determinants in this sample. METHODS: We have selected 500 outpatients submitted to echocardiography, after excluding arrhythmia, valvar or congenital cardiopathy, permanent pacemaker or inadequate ecocardiographic window. LAVI was obtained according to Simpson's method. DD was classified according to current guidelines. The clinical and echocardiographic variables were submitted to linear regression multivariate analysis. RESULTS: Mean age was 52 ± 15 years old, 53% were male, 55% had arterial hypertension, 9% had coronary artery disease, 8% were diabetic, 24% were obese, 47% had LV hypertrophy. The mean ejection fraction of the left ventricle was 69.6 ± 7,2%. The prevalence of DD in this sample was 33.8% (grade I: 66%, grade II: 29% e grade III: 5%). LAVI increased progressively according to DD grade: 21 ± 4 mL/m² (absent), 26 ± 7 mL/m² (grade I), 33 ± 5 mL/m² (grade II), 50 ± 5 mL/m2 (grade III) (p < 0,001). In this sample, LAVI increase independent predictors were age, left ventricular mass, relative wall thickness, LV ejection fraction and E/e' ratio. CONCLUSION: DD contributes to left atrial remodeling. LAVI increases as an expression of DD severity and is independently associated to age, left ventricle hypertrophy, systolic dysfunction and increased LV filling pressures.
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- 2013
12. Design and implementation of the ELSA-Brasil biobank : a prospective study in a Brazilian population
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Pereira, Alexandre da Costa, Benseñor, Isabela Judith Martins, Fedeli, Ligia Maria Giongo, Castilhos, Cristina Dickie de, Vidigal, Pedro Guatimosim, Maniero, Viviane Câmara, Leite, Claudia M., Pimentel, Robercia dos Anjos, Duncan, Bruce Bartholow, Mill, José Geraldo, and Lotufo, Paulo Andrade
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Hematologic tests ,Biomarcadores ,Biological markers ,Bancos de espécimes biológicos ,Estudos multicêntricos como assunto ,Biological specimen banks, organization & administration ,Medical examination, analysis ,Exames médicos ,Estudos de coortes ,Cohort studies ,Multicenter studies as topic, methods ,Testes hematológicos - Abstract
O Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil) é uma coorte prospectiva multicêntrica de funcionários públicos delineada para avaliar os determinantes das doenças crônicas, principalmente a doença cardiovascular e o diabetes tipo 2. Neste artigo são descritos os principais pontos do delineamento e implementação do projeto do biobanco do ELSA-Brasil. São detalhados aspectos econômicos, políticos, logísticos e tecnológicos do estudo. O artigo também discute o protocolo fi nal de estocagem de material biológico e as instalações implementadas para atingir esse objetivo. O processo de delineamento e implementação do biobanco do ELSABrasil durou três anos. Tanto os biobancos centrais quanto os locais foram constituídos de acordo com as melhores práticas de estocagem de material biológico, usando soluções tecnológicas diferentes para as diferentes necessidades previstas no estudo. The Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) is a multicenter prospective cohort of civil servants designed to assess the determinants of chronic diseases, especially cardiovascular diseases and type 2 diabetes. The present article describes the main design and implementation points of the ELSA-Brasil biobank project. Economic, political, logistical and technological aspects of this study are characterized. Additionally, it discusses the fi nal biorepository protocol and the facilities implemented to achieve this objective. The design and implementation process of the ELSA-Brasil biobank took three years to be performed. Both the central and local biobanks were built according to the best biorepository techniques, using different technological solutions for the distinct needs expected in this study.
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- 2013
13. Medical assessments and measurements in ELSA-Brasil
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Mill, José Geraldo, Pinto, Karina Araújo, Griep, Rosane Harter, Foppa, Murilo, Lotufo, Paulo Andrade, Maestri, Marcelo Krieger, Fuchs, Sandra Cristina Pereira Costa, Cunha, Roberto de Sá, and Benseñor, Isabela Judith Martins
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Doenças cardiovasculares ,Diagnostic techniques ,Adulto ,Diagnóstico ,Brasil ,Doença crônica ,Estudos longitudinais ,Cardiovascular ,Humanos ,Utilization ,Diabetes mellitus tipo 2 ,Estudos multicêntricos como assunto ,Diagnostic techniques and procedures ,Methods ,Cohort studies ,Multicenter studies as topic ,Técnicas e procedimentos diagnósticos ,Classificação ,Endocrine - Abstract
Este artigo descreve os exames clínicos realizados no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). Alguns deles (antropometria, pressão arterial e índice tornozelo-braquial) já têm uso clínico consolidado. Outros, como a velocidade de onda de pulso, variabilidade da frequência cardíaca e medida da espessura médio-intimal de carótidas, carecem de valor de referência na população brasileira não doente e podem constituir preditores importantes de desfechos cardiovasculares. A medida da pressão arterial após manobra postural foi incluída no ELSA-Brasil porque foi pouco testada em estudos epidemiológicos. O ELSA-Brasil inovou na realização do índice tornozelo-braquial, ao usar um aparelho automático em substituição à coluna de mercúrio na medida da pressão arterial, e também na medida do diâmetro ântero-posterior do lobo direito do fígado pela ultrassonografi a, proposta para avaliação quantitativa da doença hepática gordurosa não-alcoólica. Os participantes são indivíduos mais jovens (a partir dos 35 anos) do que em outras coortes focadas no estudo da aterosclerose subclínica. A inclusão de indivíduos mais jovens e a diversidade dos exames realizados tornam o ELSA-Brasil um estudo relevante no contexto da epidemiologia brasileira e internacional. The article describes assessments and measurements performed in the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil). Some assessments including anthropometric assessment, casual blood pressure measurement, and anklebrachial index have an established clinical application while others including pulse wave velocity, heart rate variability, and carotid intima-media thickness have no established application and do not have reference values for healthy Brazilian population but may be important predictors of cardiovascular outcomes. Blood pressure measurement following postural change maneuver was included in the ELSA-Brasil because it has not been much tested in epidemiological studies. Innovative approaches were developed for assessing the ankle-brachial index using an automatic device instead of the mercury column to measure blood pressure and for assessing the anterior-posterior diameter of the right lobe of the liver by ultrasound for quantitative assessment of nonalcoholic fatty liver disease. All ELSA-Brasil subjects were younger (35 years or more) than those included in other cohorts studying subclinical atherosclerosis. The inclusion of younger individuals and a variety of assessments make the ELSA-Brasil a relevant epidemiology study nationwide and worldwide.
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- 2013
14. Revista de Saúde Pública
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Mill, José Geraldo, Pinto, Karina, Griep, Rosane Härter, Goulart, Alessandra, Foppa, Murilo, Lotufo, Paulo Andrade, and Maestri, Marcelo K.
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Estudos de Coortes ,Técnicas de Diagnóstico Endócrino, utilização ,Técnicas de Diagnóstico Cardiovascular, utilização ,Técnicas e Procedimentos Diagnósticos ,Estudos Multicêntricos como Assunto, métodos - Abstract
p. 54-62 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-08T11:05:05Z No. of bitstreams: 1 0034-8910-rsp-47-00-2-0054.pdf: 149892 bytes, checksum: 8c7efd8418a5007da00ffc74e9b628d6 (MD5) Made available in DSpace on 2014-04-08T11:05:05Z (GMT). No. of bitstreams: 1 0034-8910-rsp-47-00-2-0054.pdf: 149892 bytes, checksum: 8c7efd8418a5007da00ffc74e9b628d6 (MD5) Previous issue date: 2013 Este artigo descreve os exames clínicos realizados no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). Alguns deles (antropometria, pressão arterial e índice tornozelo-braquial) já têm uso clínico consolidado. Outros, como a velocidade de onda de pulso, variabilidade da frequência cardíaca e medida da espessura médio-intimal de carótidas, carecem de valor de referência na população brasileira não doente e podem constituir preditores importantes de desfechos cardiovasculares. A medida da pressão arterial após manobra postural foi incluída no ELSA-Brasil porque foi pouco testada em estudos epidemiológicos. O ELSA-Brasil inovou na realização do índice tornozelo-braquial, ao usar um aparelho automático em substituição à coluna de mercúrio na medida da pressão arterial, e também na medida do diâmetro ântero-posterior do lobo direito do fígado pela ultrassonografia, proposta para avaliação quantitativa da doença hepática gordurosa não-alcoólica. Os participantes são indivíduos mais jovens (a partir dos 35 anos) do que em outras coortes focadas no estudo da aterosclerose subclínica. A inclusão de indivíduos mais jovens e a diversidade dos exames realizados tornam o ELSA-Brasil um estudo relevante no contexto da epidemiologia brasileira e internacional.
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- 2013
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15. Terapia antirretroviral altamente eficaz para infecção pelo vírus da imunodeficiência humana aumenta a rigidez aórtica
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Eira, Margareth, Bensenor, Isabela M., Dorea, Egidio Lima, Cunha, Roberto Sá, Mill, José Geraldo, and Lotufo, Paulo A.
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Acquired Immunosyndrome ,Vascular Stiffness ,Rigidez Arterial ,Anti-Retrovirais ,Anti Retroviral Agents ,HIV Infections ,Síndrome de Imunodeficiência Adquirida ,Infecções por HIV - Abstract
FUNDAMENTO: Sabe-se que a terapia antirretroviral altamente potente para Aids reconhecida aumenta o risco cardiovascular, mas os efeitos dos agentes antirretrovirais de acordo com o gênero ainda são desconhecidos. OBJETIVO: O presente estudo avaliou o impacto do tratamento para o vírus da imunodeficiência humana (HIV) na rigidez aórtica de acordo com o gênero. MÉTODOS: Foram recrutados 28 pacientes com Aids submetidos à terapia antirretroviral altamente potente (HAART), 28 pacientes infectados pelo HIV virgens de tratamento, 44 pacientes com diabetes tipo 2, e 30 controles. A rigidez aórtica foi determinada pela medição da Velocidade da Onda de Pulso (VOP), utilizando um equipamento automático validado e não invasivo. RESULTADOS: Os resultados médios brutos da VOP (e intervalo de confiança de 95%) para participantes nos grupos terapia antirretroviral potente, HIV virgem de tratamento, diabéticos, e controles foram 9,77 m/s (9,17-10,36), 9,00 m/s (8,37-9,63), 9,90 m/s (9,32-10,49) e 9,28 m/s (8,61-9,95), respectivamente, para os homens (p de tendência = 0,14) e 9,61 m/s (8,56-10,66), 8,45 m/s (7,51-9,39), 9,83 (9,21-10,44) e 7,79 m/s (6,99-8,58), respectivamente, para as mulheres (p valor de tendência < 0,001). Análises post-hoc revelaram uma diferença significativa entre os valores médios de VOP no grupo com HAART e controles em mulheres (p < 0,01). Ajustes para as demais covariáveis potenciais, incluindo pressão arterial sistólica e diabetes, não alteraram esses resultados. Os achados indicam que o impacto do tratamento com HAART na rigidez aórtica foi amplificado nas mulheres com hipertensão, dislipidemia e síndrome metabólica. CONCLUSÃO: Agentes antirretrovirais potentes utilizados no tratamento da infecção pelo HIV aumentam a rigidez da aorta, especialmente em mulheres com maior risco cardiovascular. BACKGROUND: Highly active antiretroviral therapy for AIDS is known to increase cardiovascular risk, but the effects of potent antiretroviral agents according to gender are unknown. OBJECTIVE: The present study evaluated the impact of HIV infection treatment on aortic stiffness according to gender. METHODS: From university-affiliated hospitals, we recruited 28 AIDS patients undergoing highly active antiretroviral treatment (HAART), 28 treatment-naïve HIV-infected patients, 44 patients with type 2 diabetes, and 30 controls. Aortic stiffness was determined by measuring pulse wave velocity (PWV) using a validated and non-invasive automatic device. RESULTS: The crude mean PWV values and 95% confidence intervals (95% CI) for HAART, diabetics, and controls were 9.77 m/s (95% CI 9.17-10.36), , 9.00 m/s (95% CI 8.37-9.63), 9.90 m/s (95% CI 9.32-10.49), and 9.28 m/s (95% CI 8.61-9.95), respectively, for men (P-value for trend = 0.14), and 9.61 m/s (95% CI 8.56-10.66), 8.45 m/s (95% CI 7.51-9.39), 9.83 (95% CI 9.21-10.44), and 7.79 m/s (95% CI 6.99-8.58), respectively, for women (P-value for trend
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- 2012
16. Efecto de la fluoxetina sobre el tiempo de ejecución en una cinta en ratas no entrenadas
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Cuquetto, Douglas Colombi, Mill, José Geraldo, and Amaral, Fabian Tadeu do
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Nervous system ,Agotamiento ,La fluoxetina ,Exhaustion ,Fluoxetin ,Sistema nervoso ,Exaustão ,Fluoxetina ,El sistema nervioso - Abstract
Works of different authors have been shown that an increase in the concentration of serotonin (5-HT) in the brain during intense and long-term physical exercise, is directly associated with a harm in the function of the Central Nervous System (CNS), with corresponding development of the fatigue and consequence decrease of the performance. In the present work, 10 rats Wistar were submitted to run-sessions until the exhaustion in treadmill. The experimental protocols were splited in 4 phases: Phase 1: evaluation of the range run-time of the animals until the physical exhaustion. Phase 2: evaluation of the range run-time of the animals until the physical exhaustion on treatment with fluoxetine. Phase 3: washout seven days. Phase 4 washout 14 days. The present study suggest that chronic administration of fluoxetine increase substantially the run-time until the physical exhaustion in rats submitted to exercises in treadmill. Las obras de diferentes autores encontraron que un aumento en la concentración de la serotonina (5-HT) en el cerebro durante el ejercicio intenso y prolongado está directamente relacionado con deterioro de la función del Sistema Nervioso Central (SNC), con el correspondiente desarrollo de la fatiga y su consecuente reducción en el rendimiento. En este estudio, 10 ratas Wistar fueron sometidas a la ejecución de sesiones en una cinta hasta el agotamiento físico. Los protocolos experimentales fueron divididos en cuatro fases: Fase 1 - Evaluación de la carrera media de los animales al agotamiento físico, la Fase 2 - Evaluación de la carrera media de los animales al agotamiento físico, están en tratamiento con fluoxetina, la Fase 3 - "lavado "de siete días; Fase 4 -" lavado "de 14 días. Este estudio sugiere que la administración crónica de fluoxetina incrementa sustancialmente la tarifa media del agotamiento físico en ratas sometidas a ejercicio en una caminadora. Trabalhos de diferentes autores constataram que, um aumento na concentração de serotonina (5-HT) no cérebro, durante exercício físico intenso e prolongado, está diretamente relacionado a um prejuízo na função do Sistema Nervoso Central (SNC), com correspondente desenvolvimento da fadiga e consequente diminuição do desempenho. No presente trabalho, 10 ratos Wistar foram submetidos a sessões de corrida até o esgotamento físico em esteira rolante. Os protocolos experimentais foram divididos em quatro fases: Fase 1 - avaliação do tempo médio de corrida dos animais até o esgotamento físico; Fase 2 - avaliação do tempo médio de corrida dos animais até o esgotamento físico, sob tratamento com fluoxetina; Fase 3 - "washout" de sete dias; Fase 4 - "washout" de 14 dias. Este estudo sugere que a administração crônica de fluoxetina aumenta substancialmente o tempo médio de corrida até o esgotamento físico em ratos submetidos a exercício em esteira rolante.
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- 2012
17. Revista de Saúde Pública
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Aquino, Estela Maria Motta Lima Leão de, Duncan, Bruce Bartholow, Chor, Dóra, Bensenor, Isabela Judith Martins, Mill, José Geraldo, Schmidt, Maria Inês, Lotufo, Paulo Andrade, Vigo, Álvaro, and Barreto, Sandhi Maria
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Prevenção & controle ,Estudos de Coortes ,Obesidade ,Doenças Cardiovasculares ,Diabetes Mellitus ,Saúde do Adulto ,Epidemiologia ,Doença Crônica - Abstract
p. 126-134 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-24T13:34:36Z No. of bitstreams: 1 Estela M L Aquino.pdf: 130109 bytes, checksum: cf0c793e8fabf6b71d84054d36a2b05a (MD5) Made available in DSpace on 2014-04-24T13:34:36Z (GMT). No. of bitstreams: 1 Estela M L Aquino.pdf: 130109 bytes, checksum: cf0c793e8fabf6b71d84054d36a2b05a (MD5) Previous issue date: 2012 As Doenças Crônicas Não Transmissíveis representam a maior carga de morbimortalidade no Brasil. Em 2011, o Ministério da Saúde lançou seu Plano de Ações Estratégicas para o Enfrentamento das Doenças Crônicas Não Transmissíveis, enfatizando ações populacionais para controlar as doenças cardiovasculares, diabetes, câncer e doença respiratória crônica, predominantemente pelo controle do fumo, inatividade física, alimentação inadequada e uso prejudicial de álcool. Apesar da produção científica significativa sobre essas doenças e seus fatores de risco no Brasil, poucos são os estudos de coorte nessa temática. Nesse contexto, o Estudo Longitudinal da Saúde do Adulto (ELSA-Brasil) acompanha 15.105 servidores públicos do País. Seus dados espelham a realidade brasileira de altas prevalências de diabetes e hipertensão e dos fatores de risco. A diversidade das informações produzidas permitirá aprofundar o entendimento causal dessas doenças e subsidiar políticas públicas para seu enfrentamento.
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- 2012
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18. IMPACTO DA ATIVIDADE FÍSICA SOBRE O RISCO CARDIOVASCULAR NA POPULAÇÃO ADULTA DE VITÓRIA-ES
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Lunz, Wellington, Molina, Maria del Carmen Bisi, Rodrigues, Sérgio Lamêgo, Gonçalves, Christine Pereira, Baldo, Marcelo Perim, Viana, Elaine Cristina, Dantas, Eduardo Miranda, and Mill, José Geraldo
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gasto calórico ,atividade física de lazer ,Risco cardiovascular ,atividade física ocupacional - Abstract
A atividade física (AF) regular é considerada hábito de vida saudável por reduzir o risco de doenças cardiovasculares. Entretanto, há poucos estudos neste sentido realizados em amostras populacionais. Avaliar o impacto da AF de lazer (AFL), ocupacional (AFO) e mista (AFLO) sobre o risco cardiovascular medido pelo escore de Framingham (EF) na população adulta (25-64 anos) de Vitória. Métodos: Estudo transversal em amostra probabilística (N=1.663; ambos os sexos). Os dados foram coletados em questionário, avaliação clínica e laboratorial (coleta de sangue). A estimativa de gasto calórico semanal em AFL, AFO e AFLO foi feita por entrevista e 4 grupos foram constituídos: Sedentário, AFL, AFO e AFLO. Análises de variância e covariância, e testes qui-quadrado e Mantel-Haenszel foram usados para análise estatística. O grupo AFO apresentou valores inferiores para % gordura (%G), colesterol total (CT) e LDL comparado ao grupo Sedentário. A prevalência de tabagismo foi menor nos grupos AFL (11,5%) e AFLO (10,2%), e maior nos grupos Sedentário (26,4%) e AFO (30,2%). EF e o risco (%) de desenvolvimento de doença arterial coronariana em 10 anos (risco DAC) não ajustados foram menores no grupo AFO (EF= 3; 2,65±6,20; risco DAC= 4; 6,79±6,68%; mediana; média±DP) comparado ao Sedentário (EF= 5; 3,85±7,07; risco DAC= 6; 8,41±7,74%). Entretanto, após ajuste para idade e CT, o EF e o risco DAC foram menores no grupo AFL (EF: 2,54±4,18; risco DAC: 6,55±5,29%; média±DP) comparado aos grupos Sedentário (EF: 3,50±4,17; risco DAC: 8,05±5,33%) e AFO (EF: 4,09±4,19; risco DAC: 8,08±5,35%), evidenciando que as variáveis CT e idade foram as principais determinantes das diferenças iniciais em favor do grupo AFO. O estudo mostra impacto positivo da AF de lazer ou laboral na redução do risco cardiovascular populacional.
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- 2011
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19. Fatores de risco cardiovascular em crianças de 7 a 10 anos de área urbana, Vitória, Espírito Santo, Brasil
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Molina, Maria del Carmen Bisi, Faria, Carolina Perim de, Montero, Maria Pilar, Cade, Nágela Valadão, and Mill, José Geraldo
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Saúde da Criança ,Anthropometry ,Sobrepeso ,Hypertension ,Child Health ,Overweight ,Antropometria ,Hipertensão - Abstract
O objetivo do estudo foi identificar a ocorrência simultânea de fatores de risco cardiovascular em crianças de 7 a 10 anos de Vitória, Espírito Santo, Brasil, e investigar variáveis socioeconômicas associadas. Foram pesquisadas 1.282 crianças e obtidos dados antropométricos e medidas da pressão arterial com aparelho automático. Dados socioeconômicos, de alimentação e de atividade física foram obtidos com base em questionário. Para avaliação da ocorrência simultânea de fatores de risco cardiovascular foi desenvolvido um índice a partir da presença de excesso de peso, pressão arterial elevada, alimentação de baixa qualidade e lazer sedentário > 4h/dia. Presença simultânea de quatro fatores de risco cardiovascular foi identificada como risco alto. Classe socioeconômica e escolaridade materna foram incluídas no modelo de regressão logística. Cerca de 34% das crianças apresentaram dois fatores de risco cardiovascular, 20% três fatores e 6,4 quatro fatores de risco cardiovascular. A escolaridade materna se manteve associada ao risco cardiovascular alto (OR: 7,36, IC95%: 2,09-25,97) e médio (OR: 2,57, IC95%: 1,58-4,20). Baixa escolaridade materna foi o fator mais importante associado ao risco cardiovascular. The study aimed to identify the simultaneous occurrence of cardiovascular risk factors in children 7 to 10 years of age in Vitória, Espírito Santo State, Brazil, and investigate associated socioeconomic variables. In a sample of 1,282 children, anthropometric data were obtained and blood pressure was measured with an automatic device. Socioeconomic, nutritional, and physical activity data were obtained with a questionnaire. To evaluate the simultaneous occurrence of cardiovascular risk factors, an index was developed including overweight, high blood pressure, poor eating, and sedentary leisure > 4hours/day. The simultaneous presence of four cardiovascular risk factors was defined as high risk. Socioeconomic status and maternal schooling were included in the logistic regression model. Some 34% of the children presented two cardiovascular risk factors, 20% three factors, and 6.4% four cardiovascular risk factors. Maternal schooling remained associated with high cardiovascular risk (OR: 7.36, 95%CI: 2.09-25.97) and medium risk (OR: 2.57, 95%CI: 1.58-4.20). Low maternal schooling was the most important factor associated with cardiovascular risk.
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- 2010
20. Efeitos agudos do alongamento estático no desempenho da força dinâmica em homens jovens
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Endlich, Patrick Wander, Farina, Giovanni Rampinelli, Dambroz, Cássio, Gonçalves, Washington Luiz Silva, Moysés, Margareth Ribeiro, Mill, José Geraldo, and Abreu, Gláucia Rodrigues de
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physical exercise ,exercício resistido ,tempo de alongamento ,força muscular ,muscular strength ,stretching time - Abstract
INTRODUÇÃO: O alongamento muscular é frequentemente utilizado nas práticas desportivas, com o objetivo de aumentar a flexibilidade muscular e amplitude articular, assim como diminuir o risco de lesões e melhorar o desempenho atlético. OBJETIVO: Analisar o efeito agudo do alongamento com diferentes tempos no desempenho da força dinâmica de membros superiores e inferiores em homens jovens. MÉTODOS: Participaram da amostra 14 voluntários do sexo masculino com idade de 23 ± 2 anos, peso corporal de 84 ± 10kg, estatura de178 ± 7cm, IMC de 26 ± 2kg/m² e percentual de gordura de 11 ± 3%. Eles foram avaliados com o teste de 10RM em três situações distintas: condição sem alongamento (SA), aquecimento especifico seguido do teste de 10-RM; condição com oito minutos de alongamento (AL-8), uma sessão de alongamento estático com oito minutos de duração, seguido do aquecimento e teste de 10RM; e a condição alongamento 16 minutos (AL-16), 16 minutos de alongamento seguidos dos procedimentos descritos anteriormente. Os testes foram feitos no supino reto e leg-press 45º; os alongamentos foram selecionados de forma a atingir as musculaturas solicitadas nos respectivos exercícios. RESULTADOS: Houve redução de 9,2% da força muscular dinâmica de membros superiores em comparação dos grupos SA e AL16, e entre os grupos AL8 e AL16 (p < 0,001). Em membros inferiores essa redução de força (p < 0,001) foi de 4,8% para AL-8 e de 14,3% para AL-16 em comparação com o grupo SA. CONCLUSÃO: Sessões de alongamentos estáticos efetuados antes de atividades que envolvam força dinâmica possuem a capacidade de alterar negativamente o desempenho dessa qualidade física, acarretando pior rendimento em longos períodos de alongamento. BACKGROUND: Muscular stretching is frequently used in sports practice with the aim to increase muscular flexibility and joint range of motion as well as to reduce injury risks and to improve athletic performance. AIM: To analyze the acute effect of stretching with different times in the dynamic strength performance of lower and upper extremities in young men. METHODS: The sample was composed by 14 healthy male volunteers aged 23 ± 2 years, weight of 84 ± 10 Kg , height of 178 ± 7 cm, BMI of 26 ± 2 Kg/m2 and body fat of 11 ± 3 %. They were evaluated in a 10-maximum repetition test (10-RM) in three situations: no stretching (NS); after an 8-minute session of static stretching followed by specific warm-up (SS-8); and after 16-minute and specific warm-up before 10 RM test (SS-16). Tests were performed in bench press and 45º leg press exercises, and stretching was selected as to reach the musculature required in these exercises. RESULTS: There was significant reduction (p
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- 2009
21. Revisão dos critérios de Sokolow-Lyon-Rappaport e cornell para hipertrofia do ventrículo esquerdo
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Mill, José Geraldo
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HIPERTENSÃO - Published
- 2008
22. Revision of the Sokolow-Lyon-Rappaport and cornell voltage criteria for left ventricular hypertrophy
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Rodrigues,Sérgio Lamêgo, DAngelo,Lílian, Pereira,Alexandre Costa, Krieger,José Eduardo, and Mill,José Geraldo
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ecocardiografia ,Electrocardiography ,hypertension ,hipertensão ,echocardiography ,Eletrocardiografia ,hipertrofia ventricular esquerda ,hypertrophy, left ventricular - Abstract
FUNDAMENTO: A hipertrofia do ventrículo esquerdo (HVE) detectada pela eletrocardiografia é um forte preditor de morbidade e mortalidade cardiovasculares. OBJETIVO: Analisar o desempenho dos critérios de Sokolow-Lyon-Rappaport (SLR) e de Cornell, em amostra populacional, em relação ao diagnóstico de HVE à ecocardiografia. MÉTODOS: Entre os 682 participantes da segunda fase do Projeto MONICA-OMS/Vitória, 641 foram avaliados por meio de eletrocardiografia e ecocardiografia. O subgrupo de indivíduos saudáveis (n = 269) foi usado para gerar valores de referência da massa do ventrículo esquerdo (MVE). As sensibilidades e especificidades dos critérios eletrocardiográficos foram determinadas pela curva ROC (receptor-operator characteristics) em relação ao diagnóstico de HVE definido pelo critério ecocardiográfico interno (MVE > 48 g/m2,7 e 46 g/m2,7 para homens e mulheres, respectivamente). RESULTADOS: A prevalência de HVE à ecocardiografia foi de 23,7% na amostra global, em que havia 49% de hipertensos. O critério de Cornell apresentou melhor associação com a MVE estimada pela ecocardiografia (r = 0,37; p < 0,01) que o critério de SLR (r = 0,19), além de melhor desempenho na análise da área sob a curva ROC. Os novos pontos de corte para o critério de Cornell definidos internamente (2,3 mV para homens e 1,9 mV para mulheres) apresentaram combinação aceitável de sensibilidade para homens e mulheres (22,5% e 28%, respectivamente), com alta especificidade (95%). CONCLUSÃO: Os critérios clássicos de SLR e Cornell apresentaram baixo desempenho em relação à HVE definida pela ecocardiografia. Entretanto, a acurácia pode ser melhorada, utilizando-se os critérios de Cornell definidos neste estudo. BACKGROUND: Electrocardiographically-detected left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular morbidity and mortality. OBJECTIVE: To assess the performance of the Sokolow-Lyon-Rappaport (SLR) and Cornell voltage criteria in a population sample regarding the diagnosis of LVH on echocardiogram (ECHO). METHODS: A total of 641 out of the 682 participants of the second phase of the MONICA-Vitória project were assessed using electrocardiogram and echocardiogram. A subgroup of healthy individuals (n=269) was used to generate reference values of LV mass (LVM). Sensitivities and specificities of the electrocardiographic criteria were determined by the ROC (receptor-operator characteristics) curve in relation to the diagnosis of LVH, as defined by the internal echocardiographic criterion (LVM > 48 and 46 g/m2.7 for males and females, respectively). RESULTS: The prevalence of LVH as detected by ECHO was 23.7% in the total sample, in which 49% of the individuals were hypertensive. The Cornell criterion showed a better association with the LVM as estimated by ECHO (r= 0.37, p < 0.01) than the SLR criterion (r= 0.19) as well as a better performance in the analysis of the area under the ROC curve. The new cut-off points for the internally-defined Cornell voltage criterion (2.3 mV for males and 1.9 mV for females) showed an acceptable combination of sensitivity (22.5 and 28% for males and females, respectively), with a high specificity (95%). CONLUSION: The classic SLR and Cornell voltage criteria showed a low performance in relation to LVH as detected by the ECHO. However, this accuracy may be improved by using the Cornell voltage criteria defined in the present study.
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- 2008
23. A administração precoce de hormônio de crescimento resulta em efeitos deletérios na remodelação ventricular após o infarto agudo do miocárdio
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Mill, José G., Zornoff, Leonardo A. M., Okoshi, Marina P., Okoshi, Katashi, Padovani, Carlos R., Sugisaki, Mário, Leite, Cláudia M., Cicogna, Antônio C., Universidade Federal do Espírito Santo (UFES), and Universidade Estadual Paulista (Unesp)
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Male ,muscle excitation ,animal experiment ,Myocardial Infarction ,Ventricular Function, Left ,animal tissue ,diastole ,heart left ventricle muscle ,Papillary muscle ,echocardiography ,Animals ,controlled study ,rat ,cardiovascular diseases ,rat strain ,Rats, Wistar ,systole ,Ventricular function ,heart muscle contractility ,isoprenaline ,calcium ,nonhuman ,heart muscle tension ,Ventricular Remodeling ,animal model ,drug effect ,Hypertrophy ,heart ventricle remodeling ,heart papillary muscle ,Rats ,acute heart infarction ,Disease Models, Animal ,Growth Hormone ,drug utilization ,heart left ventricle ejection fraction ,hormone action - Abstract
Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:21:16Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:39:53Z : No. of bitstreams: 1 2-s2.0-15244353911.pdf: 71891 bytes, checksum: 389cda8155d2e795832e250fb2a68756 (MD5) Made available in DSpace on 2014-05-27T11:21:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-02-01 Objective: To assess the effect of growth hormone (GH) on myocardial remodeling in infarcted rats. Methods: This study comprised 24 Wistar rats divided into 3 groups as follows: 1) AMI-GH group - comprising 8 rats that underwent infarction and were treated with GH; 2) AMI group - comprising 8 rats that underwent infarction and received only the diluent of the GH solution; and 3) control group (C group) - comprising 8 rats that underwent simulated infarction. After 30 days, the animals underwent functional study through echocardiography, and the changes in myocardial contractility of the isolated left ventricular (LV) papillary muscle were studied. Results: The echocardiography identified an increase in the diastolic (C=7.32±0.49; AMI=8.50±0.73; AMI-GH=9.34±0.73; P
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- 2005
24. VO2MAX ESTIMADO POR EQUAÇÕES PREDITIVAS APRESENTA BAIXA CONCORDÂNCIA COM O OBTIDO PELO TESTE CARDIOPULMONAR - PADRÃO OURO.
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Nascimento Miranda, Augusto Luiz, Costa Lopes, Kristian, Carletti, Luciana, José Perez, Anselmo, Geraldo Mill, José, and Lunz, Wellington
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Copyright of Revista da Educação Física/UEM is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2015
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25. Doenças Crônicas Não Transmissíveis no Brasil: prioridade para enfrentamento e investigação.
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Bartholow Duncan, Bruce, Chor, Dóra, Aquino, Estela M. L., Bensenor, Isabela M., Geraldo Mill, José, Schmidt, Maria Inês, Andrade Lotufo, Paulo, Vigo, Álvaro, and Barreto, Sandhi Maria
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Copyright of Revista de Saúde Pública is the property of Faculdade de Educacao da Universidade de Sao Paulo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2012
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26. Fatores de risco cardiovascular em crianças de 7 a 10 anos de área urbana, Vitória, Espírito Santo, Brasil.
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del Carmen Bisi Molina, Maria, de Faria, Carolina Perim, Montero, Maria Pilar, Cade, Nágela Valadão, and Mill, José Geraldo
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Copyright of Cadernos de Saude Publica is the property of Escola Nacional de Saude Publica Sergio Arouca and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2010
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27. Influência da poluição atmosférica por SO2, MP10, MP2,5 e sua composição elementar na incidência de doença respiratória aguda em crianças
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Nascimento, Antonio Paula, Mill, José Geraldo, Reis Junior, Neyval Costa, Andrade, Maria de Fátima, Leon, Antonio Carlos Monteiro Ponce de, Reisen, Valdério Anselmo, and Santos, Jane Meri
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Modelo aditivo generalizado ,Ar - Poluição ,Partículas ,Partículas inorgânicas ,Partículas finas ,Doenças respiratórias em crianças - Abstract
Submitted by Patricia Barros (patricia.barros@ufes.br) on 2016-07-08T12:35:06Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ANTÔNIO PAULA NASCIMENTO.pdf: 4898846 bytes, checksum: d48b99df16cd0e2d04fb8300af87c708 (MD5) Approved for entry into archive by Patricia Barros (patricia.barros@ufes.br) on 2016-07-08T12:35:22Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ANTÔNIO PAULA NASCIMENTO.pdf: 4898846 bytes, checksum: d48b99df16cd0e2d04fb8300af87c708 (MD5) Made available in DSpace on 2016-07-08T12:35:22Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ANTÔNIO PAULA NASCIMENTO.pdf: 4898846 bytes, checksum: d48b99df16cd0e2d04fb8300af87c708 (MD5) O objetivo deste estudo é investigar a influência dos poluentes atmosféricos SO2, MP10 e MP2,5 nos desfechos agudos de doenças respiratórias em crianças com idade até 12 anos, residentes em áreas urbanas e industrializadas e averiguar a influência dos elementos químicos inorgânicos e Black carbon presentes em partículas finas (MP2,5) nesses desfechos. Dados de concentração de SO2 e MP10 foram medidos e obtidos em seis estações da rede automática de monitoramento da qualidade do ar na Região Metropolitana da Grande Vitoria (RMGV). As amostras de MP2,5 foram coletadas nas mesmas localidades com amostrador MiniVol pelo período de 24 horas em dias alternados. Essas amostras de MP2,5 foram pesadas em balança de sensibilidade de 1 μm, e a análise de seus constituintes por meio da técnica de fluorescência de Raios-X por dispersão de energia e pela técnica de refletância. Eventos de atendimentos e internação hospitalar por doenças respiratórias agudas do grupo JJ00 - JJ99 do CID-10 foram obtidos em três hospitais (um público e dois privados). Todos os dados foram coletados nos períodos de inverno (21/06/2013 a 21/09/2013) e verão (21/12/2013 a 19/03/2014) no Hemisfério Sul. Para quantificar a associação dos eventos de doenças respiratórias agudas com a concentração dos poluentes foi aplicado o Modelo Aditivo Generalizado (MAG) com distribuição de Poisson. Os resultados evidenciaram maiores riscos de eventos respiratórios agudos devido à exposição ao SO2 com risco de 1,28 (IC 95%: 1,22 – 1,34) e ao MP10 com risco de 1,14 (IC 95%: 1,09 – 1,20) no dia da exposição. Com relação às partículas finas, os eventos respiratórios se manifestaram com mais intensidade para a defasagem de seis dias em relação à exposição, com risco de 1,05 (IC 95%: 1,01 – 1,10). Os constituintes químicos presentes nas partículas finas com maior risco às doenças respiratórias agudas foram: Si com risco de 1,22 (IC 95%: 1,15 – 1,29), S com risco de 1,09 (IC 95%: 1,06 – 1,12), Ti com risco de 1,09 (IC 95%: 1,01 – 1,17) e o Black Carbon (BC) com risco de 1,07 (IC 95%: 1,03 – 1,11); todos para o mesmo dia da exposição. Para defasagem de dois dias entre o desfecho e a exposição, o maior risco de doenças respiratórias está associado ao Se com risco de 1,14 (IC 95%: 1,06 – 1,23) e ao Ni com risco de 1,10 (IC 95%: 1,02 – 1,19). The aim of this study is to investigate the influence of atmospheric pollutants such as SO2, MP10 and MP2,5 in acute outcome of respiratory diseases in 12-year old children living in urban and industrial areas and to ascertain the influence of inorganic elements, as well as elemental carbon present in fine particulate (MP2,5) in those outcome within short periods, during Winter and Summer times in the South hemisphere. Data on SO2 e MP10 concentrations were obtained through measurements made in six stations of the air quality automatic monitoring net placed in the Great Vitoria Metropolitan Region (RMGV). Samples of MP2,5 were collected in the same region using the MiniVol sampler during a 24-hour period in alternate days. They were weighted in a scale with 1 μm sensitivity and the analysis of its components was carried out using the energy dispersion X-Ray fluorescence technique and by the reflectance technique. Cases of common health care as well as hospital patient admissions due to acute respiratory diseases in CID-10 JJ00 - JJ99 groups were obtained in three hospitals (one public and two private). All data were obtained during the Winter (from 21/06/2013 to 21/09/2013) and the Summer (from 21/12/2013 to 19/03/2014). To quantify the correlation between acute respiratory diseases to the pollutant concentrations the Generalized Additive Model (GAM) with Poisson distribution was applied. Results have pointed out greater relative risk (RR) of acute respiratory events due to the presence of SO2, a 1,28 RR (IC 95%: 1,22 – 1,34) and MP10, a 1,14 RR (IC 95%: 1,09 – 1,20), within the day of exposure (lag 0). With respect to fine particulate, exposure effects have shown more evident effects after a six-day period from the exposure, with a 1,05 RR (I.C. 95%: 1,01 – 1,10). Chemical components present in fine particulate showing a larger RR of causing acute respiratory diseases were: Si – 1, 22 RR (IC 95%: 1,15 – 1,29), S – 1,09 RR (IC 95%: 1,06 – 1,12), Ti – 1,09 RR (IC 95%: 1,01 – 1,17), the black carbon (BC) – 1,07 RR (IC 95%: 1,03 – 1,11) for a same day occurrence of exposure and outcome. For outcomes due to a two-day period after exposure, the greatest RR of respiratory diseases in the short term is associated with the presence of Se –1,14 RR (IC 95%: 1,06 – 1,23) and Ni – 1,10 RR (IC 95%: 1,02 – 1,19).
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- 2015
28. Avaliação do risco cardiovascular e fatores associados na população de Anchieta-ES
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Araújo, Alana Alves, Molina, Maria del Carmen Bisi, Mill, José Geraldo, Araújo, Elizabete Regina, Herkhoff, Fernando, and Cade, Nágela Valadão
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Fatores de risco ,Coração - Doenças - Anchieta (ES) ,Grupos de risco - Abstract
Submitted by Maykon Nascimento (maykon.albani@hotmail.com) on 2016-03-01T18:33:21Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) dissertacao de mestrado Alana.pdf: 3550577 bytes, checksum: b4479e8b29f5f22f13762b8f92489ed4 (MD5) Approved for entry into archive by Patricia Barros (patricia.barros@ufes.br) on 2016-03-03T11:38:46Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) dissertacao de mestrado Alana.pdf: 3550577 bytes, checksum: b4479e8b29f5f22f13762b8f92489ed4 (MD5) Made available in DSpace on 2016-03-03T11:38:46Z (GMT). No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) dissertacao de mestrado Alana.pdf: 3550577 bytes, checksum: b4479e8b29f5f22f13762b8f92489ed4 (MD5) Previous issue date: 2015 As doenças cardiovasculares são as principais causas de morte no mundo e muitos constituem os fatores de risco para essas doenças. Objetiva-se investigar o risco cardiovascular para evento coronariano agudo de acordo com o escore de Framingham em população adulta do município de Anchieta-ES. Estudo transversal com dados da linha de base do estudo Carmen Anchieta, iniciado em 2010. A amostra foi sistemática e estratificada por micro área de abrangência das Unidades de Saúde da Família, sexo e idade e 539 pessoas foram selecionadas para este estudo por terem os dados completos. Os dados foram coletados mediante entrevista no domicílio, exames laboratoriais de sangue, verificação da pressão arterial e antropometria nas Unidades de Saúde. As variáveis de exposição constituem escolaridade, raça-cor, renda familiar, residência em espaço urbano ou rural, estado civil, consumo de álcool, atividade física, índice de massa corpórea e autoavaliação de saúde. Para a classificação do risco cardiovascular utilizou-se o escore de Framingham. Foi realizada análise bivariada e regressão logística multinomial para testar a hipótese de associação entre as variáveis e o risco cardiovascular mediante o cálculo da razão de chances (RC) e intervalo de confiança de 95%. O nível de significância foi p < 0,05. Os resultados mostraram predominância de pessoas nas faixas etárias entre 25 a 54 anos, casadas, pardas, ensino fundamental incompleto, baixa renda, insuficientemente ativas, com sobrepeso e obesidade em mais da metade da amostra, 38,6% ingeriam bebida alcoólica e 55,7% relaram saúde muito boa ou boa. O risco cardiovascular foi baixo em 74%, intermediário em 11,3% e elevado em 14,7%. Estiveram associados ao risco cardiovascular intermediário ser analfabeto 8,89 (3,193-24,756), ter ensino fundamental incompleto 3,17 (1,450-6,964) e ser viúvo/ separado 2,55 (1,165-5,583) e associados ao risco cardiovascular elevado ser analfabeto 11,34 (4,281-30,049), ensino fundamental incompleto 2,95 (1,362-6,407) e autoavaliação da saúde muito ruim/ruim 2,98 (1,072-8,307) e regular 2,25 (1,294-3,925). Ser solteiro constituiu fator de proteção 0,40 (0,183-0,902). Cardiovascular diseases are the leading causes of death in the world and are many risk factors for these diseases. The objective is to investigate the cardiovascular risk for acute coronary events according to the Framingham score in the adult population of the municipality of Anchieta-ES. Cross sectional analysis of data from the study Carmen, Anchieta baseline, started in 2010. The sample was systematic and stratified by micro area covered by the Family Health Units, sex and age and 539 people were selected for this study because their data were complete. Data were collected through interviews at home, laboratory blood tests, blood pressure and anthropometry in the health units. The exposure variables are education, race-color, family income, living in urban or rural areas, marital status, alcohol consumption, physical activity, body mass index and self-rated health. To determine cardiovascular risk it was used the Framingham score. Performed bivariate analysis and multinomial logistic regression to test the hypothesis of association between the variables and the risk of cardiovascular by Odds ratio with 95% confidence interval. The level of significance was p
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- 2015
29. Relationship between cardiac autonomic modulation and core temperature during hyperthermia induced by exercise and passive heating in rats
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Moura, Anselmo Gomes de, Cunha, Daise Nunes Queiroz da, Lima, Jorge Roberto Perrout, Gomes, Thales Nicolau Primola, Wanner, Samuel Penna, and Mill, José Geraldo
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Termorregulação ,Frequência cardíaca ,Pressão arterial ,Heart rate ,Blood pressure ,Physical exercise ,CIENCIAS DA SAUDE::EDUCACAO FISICA [CNPQ] ,Exercícios físicos ,Thermoregulation ,Ratos ,Rats - Abstract
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior The aim of this study was to compare the changes in cardiac autonomic modulation in two experimental situations: hyperthermia induced by exercise (HE) and by passive heating (PH). The study was approved by the Ethics Committee in Animal Use/UFV (CEUA # 08/2014). Eight male Wistar rats (328 ± 6 g, age: 13 ± 1 weeks) were selected and familiarized to a treadmill running (15m/min) and to an acrylic heating box (5 min) during 5 days. After, the animals underwent an incremental- speed exercise until fatigue (initial velocity: 10m/min followed by increments of 1m/min every 3 min) in a temperate environment (25°C) to measure the maximal running velocity (Vmax). After that, the animals were implanted a catheter into the ascending aorta to record pulsatile arterial pressure (PAP) and a telemetry sensor in the abdominal cavity to measure Tip. After recovering, the animals were randomly subjected to HE (80% Vmax, ambient temperature = 25°C) and PH (35oC) protocols. It consisted of a rest period of 60 min followed by T ip increases of 2°C. The Tip, tail skin temperature (Tskin) and PAP were measured. The mean arterial pressure (MAP), systolic (SBP) and diastolic (DBP) pressures, heart rate (HR), double product (DP), systolic blood pressure variability (SBPV), heart rate variability (HRV) and baroreflex sensitivity (BRS) were obtained from PAP. The SBPV and HRV were analyzed in the time (mean, standard deviation, variance and RMSSD) and frequency domains by spectral bands with very low (VLF), low (LF) and high (HF) frequencies. Low frequency/ high frequency ratio (LF/HF ratio) was calculated. Data for cardiovascular parameters, SBPV, HRV and BRS were analyzed as a function of the variation of Tip (ΔTip) to find a relationship of these variables with core temperature. Data with normal distribution are presented as mean ± SEM and those with non-normal distribution are presented as median. The significance level was α = 5%. The Tip (HE: 39.29 ± 0.11°C vs. PH: 38.97 ± 0.26°C, p> 0.05) and the time taken to increase Tip in 2oC (HE: 41.3 ± 9.8 min vs. PH: 35.0 ± 7.2 min, p> 0.05) did not differ between protocols. Tskin was higher (p 0.05), SBP (HE: 130.60 mmHg vs PH: 133.95 mmHg, p> 0,05) and DBP (HE: 119.85 mmHg vs PH: 121.07 mmHg, p> 0.05). However, HR showed higher values during HE as compared to HP (HE: 548.34 bpm vs. PH: 401.29 bpm, p 0.05). Nevertheless, the spectral density at all frequency bands examined exhibited higher (p 0.05) between protocols in the spectral density were found for HRV either at VLF or at HF. BRS values were not different between protocols (p 0,05) e o tempo para elevação da T ip em 2oC (HE:41,3 ± 9,8 vs. HP:35 ± 7,2 min, p>0,05) não diferiram entre as sessões. A T cauda foi maior na sessão HP comparada à HE (HP:38,49 ± 0,25 vs. HE:32,95 ± 0,46 oC, p0,05), a PAS (HE:130,60 vs. HP:133,95 mmHg, p>0,05) e a PAD (HE:119,85 vs. HP:121,07 mmHg, p>0,05) de forma equivalente. Já a FC (HE:548,34 vs. HP:401,29 bpm, p0,05), contudo a sessão HE apresentou maiores valores de densidade espectral em comparação à HP em todas as bandas de frequência para VPAS (MBF- HE:11,10 ± 2,13 mmHg2 vs. HP:7,8 ± 2,07 mmHg2; p0,05), AF da VFC (62,59 ± 9,3 ms2 vs. 40,02 ± 8,03 ms2; p>0,05). Os valores de SBR não diferiram entre os protocolos experimentais (HE: 2,87 ± 0,42 vs. HP 3,55 ± 0,62 ms.mmHg-1; p>0,05). Ao realizar as análises em função da ∆Tip, as diferenças entre os grupos permaneceram destacadas. Em conclusão, ambas as situações experimentais foram capazes de alterar a modulação autonômica cardíaca em ratos. Contudo, essa alteração foi mais pronunciada durante hipertermia induzida por exercício físico.
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- 2014
30. Associação entre o consumo de antioxidantes e risco de doenças coronarianas em participantes do ELSA-Brasil
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Teixeira, Marina Galvão, Mill, José Geraldo, Pereira, Alexandre da Costa, Oliveira, Elizabete Regina Araújo, and Molina, Maria del Carmem Bisi
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Doença das coronárias ,Estresse oxidativo ,Antioxidantes - Abstract
Submitted by Elizabete Silva (elizabete.silva@ufes.br) on 2015-10-20T19:54:04Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) ASSOCIAÇÃO ENTRE CONSUMO DE ANTIOXIDANTES E RISCO DE DOENÇAS CORONARIANAS EM PARTICIPANTES DO ELSA-BRASIL.pdf: 2817288 bytes, checksum: 415a1e6068632ef2756eca22cc458f7e (MD5) Approved for entry into archive by Morgana Andrade (morgana.andrade@ufes.br) on 2015-11-25T20:36:33Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) ASSOCIAÇÃO ENTRE CONSUMO DE ANTIOXIDANTES E RISCO DE DOENÇAS CORONARIANAS EM PARTICIPANTES DO ELSA-BRASIL.pdf: 2817288 bytes, checksum: 415a1e6068632ef2756eca22cc458f7e (MD5) Made available in DSpace on 2015-11-25T20:36:33Z (GMT). No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) ASSOCIAÇÃO ENTRE CONSUMO DE ANTIOXIDANTES E RISCO DE DOENÇAS CORONARIANAS EM PARTICIPANTES DO ELSA-BRASIL.pdf: 2817288 bytes, checksum: 415a1e6068632ef2756eca22cc458f7e (MD5) Previous issue date: 2014 Baixas concentrações de antioxidantes plasmáticos estão associadas à disfunção endotelial, início do processo aterosclerótico. Alguns componentes dos alimentos com propriedades antioxidantes são capazes de minimizar esses distúrbios e estão associados à redução do risco cardiovascular. O objetivo foi identificar a associação entre o consumo de nutrientes antioxidantes e risco de doença coronariana aguda em 10 anos em participantes da linha de base do Estudo Longitudinal de Saúde do Adulto – ELSA-Brasil. Foram estudados 14.353 servidores públicos de seis instituições de ensino e pesquisa, na faixa etária de 35 a 74 anos. O consumo estimado de nutrientes antioxidantes (vitaminas A, E e C, zinco e selênio) foi obtido por meio do questionário de frequência alimentar (QFA), ajustado por energia total e categorizado em quintis. O risco coronariano (RC) foi calculado com base nas variáveis: sexo, idade, pressão arterial sistólica, tabagismo, terapia anti-hipertensiva, HDL-colesterol e colesterol total. Os participantes foram classificados em categorias de risco (baixo, intermediário e alto). Análises de regressão simples e multivariada foram realizadas para avaliar a relação entre o consumo de antioxidantes e RC e a influência de outras variáveis (escolaridade e IMC). Foi observado que 71% dos participantes encontravam-se no baixo risco, 7% em risco intermediário e 22% no alto risco coronariano. Participantes do sexo feminino, os de maior renda, escolaridade e idade apresentaram maior consumo estimado de antioxidantes. Foram observadas associações positivas e estatisticamente significativas entre a ingestão de antioxidantes e alto risco coronariano. Indivíduos com risco intermediário apresentaram a menor ingestão de antioxidantes. Nível de escolaridade foi positivamente associado com consumo de antioxidantes (p
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- 2014
31. Effects of low-intensity aerobic exercise training initiated 24 h after myocardial infarction on heart structure and function of rats
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Ramos, Regiane Maria Soares, Cunha, Daise Nunes Queiroz da, Gomes, Thales Nicolau Primola, Natali, Antônio José, and Mill, José Geraldo
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Myocardial infarction ,Treinamento físico ,Physical training ,Função cardíaca ,CIENCIAS DA SAUDE::EDUCACAO FISICA [CNPQ] ,Heart function ,Infarto de miocárdio - Abstract
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior This study aimed at investigating the effects of low-intensity aerobic training initiated 24 hours after myocardial infarction (MI) on the structure and function of the myocardium and cardiomyocytes. Four-weeks old Wistar rats were divided into 4 groups: Sham Sedentary (SHSD, n=15), Sham exercised (SHEX, n=15), infarcted Sedentary (IMSD, n=15) and infarcted exercised (IMSD, n=15). Twenty-four hours after MI and sham operation animals from the training groups were placed on a treadmill with a 5º angle of inclination, during 20 minutes per day, at a speed of 12m/min for 5 consecutive days. On the 6th and 35th days animals were evaluated for tolerance to physical exertion. Exercise tolerance was estimated by the maximum physical exertion in a progressive treadmill running test and quantified by the total time until fatigue (TTF, min) achieved in the mentioned test. The maximum running speed (MRS) achieved in the 6th day test was used to calculate the intensity adopted in the training program (VMC%, m/min). This program consisted of treadmill running (5 days/week, 60min/day, and inclination of 5º) at a speed of 65-75% of MRS. Thirty-five days after the induction of MI, half of animals of each group were used for cardiomyocytes isolation. After euthanasia, cardiomyocytes were isolated from the non-infarcted area of the left ventricle (LV) by enzymatic dispersion. The cardiomyocytes were stimulated at 1Hz, under controlled temperature (~37°C) for measurements of contractile function. The remaining animals in each group were used to obtain in the hemodynamic recordings. After that, these animals were euthanized and the hearts were removed, fixed and stained with hematoxylin-eosin and picrosirius red for histological analysis. The exercise program did not affect the survival of infarcted animals. Animals in the training program had greater running capacity compared to sedentary (p
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- 2013
32. Condições de nascimento e amamentação e saúde cardiovascular de crianças de 9 e 10 anos
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Batista, Milena Santos, Mill, José Geraldo, Cade, Nagela Valadão, and Molina, Maria del Carmen Bisi
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Prematuros ,Baixo peso ao nascer ,Crianças ,Breastfeeding ,Amamentação ,Rigidez arterial ,Obesidade ,Low birth weight ,Hypertension ,Arterial Stiffness ,Obesity ,Prematurity ,Artérias - Doenças ,Hipertensão - Abstract
Submitted by Morgana Andrade (morgana.andrade@ufes.br) on 2016-04-12T21:31:42Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) tese_6422_2011_Milena Batista Santos.pdf: 4504155 bytes, checksum: 2e5a0bc2576eeeb83dab522c8a5772df (MD5) Approved for entry into archive by Patricia Barros (patricia.barros@ufes.br) on 2016-04-13T15:40:56Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) tese_6422_2011_Milena Batista Santos.pdf: 4504155 bytes, checksum: 2e5a0bc2576eeeb83dab522c8a5772df (MD5) Made available in DSpace on 2016-04-13T15:40:56Z (GMT). No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) tese_6422_2011_Milena Batista Santos.pdf: 4504155 bytes, checksum: 2e5a0bc2576eeeb83dab522c8a5772df (MD5) Há evidências de que fatores de risco para ocorrência de Doenças Crônicas não Transmissíveis têm início silencioso em etapas precoces do desenvolvimento. Essa questão foi suscitada a partir de estudos que relacionaram o peso ao nascer com o desenvolvimento de doenças na vida adulta, cuja hipótese se baseia na ideia de que o feto seria programado intra-útero, principalmente por fatores nutricionais que influenciariam no metabolismo e na fisiologia do indivíduo por toda a vida. O objetivo deste estudo foi investigar a saúde cardiovascular de crianças de 9 a 10 anos e sua relação com as condições de nascimento (baixo peso ao nascer e prematuridade) e de amamentação. Foram avaliadas 231 crianças, de ambos os sexos, matriculadas em escolas públicas e privadas do município de Vitória/ES. As crianças compareceram em jejum, acompanhadas de seus responsáveis, no Centro de Investigação Cardiovascular da UFES para realização de exames antropométricos, laboratoriais e hemodinâmicos (pressão arterial e velocidade de onda de pulso carótida-femoral - VOP). No dia da visita, as crianças e seus responsáveis responderam a um questionário sobre questões de saúde atuais e pregressas. O teste Kolmogorov-Smirnov foi utilizado para testar a normalidade das variáveis contínuas e depois realizados os testes t de Student para amostras independentes ou Mann Whitney. O teste do qui-quadrado (X2) foi utilizado para avaliar a distribuição das variáveis categóricas. Variáveis hemodinâmicas, categorizadas em tercis, foram analisadas utilizando ANOVA a uma via, seguida do teste de Tukey para avaliação entre grupos. Variáveis contínuas foram correlacionadas utilizando teste de Pearson ou de Spearman. Aplicou-se a análise de regressão linear múltipla para identificar a contribuição parcial e total dos fatores na determinação dos valores de VOP e de pressão arterial. O nível de significância estabelecido para todos os testes foi de =0,05. Observou-se maior frequência de meninos nas classes socioeconômicas A+B (61%) e na condição de sobrepeso (meninas= 38%, meninos= 51%, p=0,05). O baixo peso ao nascer foi mais frequente entre meninas (meninas=18%, meninos=7%, p=0,01). Crianças do sexo masculino apresentaram maiores médias de PAS (p=0,05), VOP (p=0,03) e peso ao nascer (p
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- 2013
33. Risco cardiovascular entre vegetarianos e onívoros: um estudo comparativo
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Teixeira, Rita de Cássia Moreira de Almeida, Molina, Maria Del Carmen Bisi, Chor, Dora, and Mill, José Geraldo
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cardiovascular risk ,risco cardiovascular ,alimentação vegetariana e onívora ,CIENCIAS DA SAUDE::SAUDE COLETIVA [CNPQ] ,non transmittible chronic diseases ,Doenças crônicas não transmissíveis ,vegetarian and omnivorous eating habits - Abstract
Made available in DSpace on 2016-12-23T13:47:01Z (GMT). No. of bitstreams: 1 pre-textual.pdf: 85079 bytes, checksum: c0b538425c70af6046e3d2f2163a9f4f (MD5) Previous issue date: 2005-09-01 O aumento das doenças crônicas não transmissíveis (DCNTs) vem sendo associado às mudanças do estilo de vida, principalmente aquelas relacionadas com a alimentação e o sedentarismo. Sobre esse tema, há considerável evidência epidemiológica sugerindo que a alimentação vegetariana está associada ao baixo risco para essas doenças, em particular para as doenças cardiovasculares (DCVs). Para a avaliação do risco cardiovascular (RCV) em vegetarianos (VEGs) e onívoros (ONIs), foi realizado estudo de coorte histórico com 201 indivíduos (35 a 64 anos). Foram incluídos na pesquisa 67 VEGs há no mínimo cinco anos, provenientes da Grande Vitória e 134 ONIs do Projeto MONICA/WHO/Vitória, pareados por classe socioeconômica, sexo, idade e raça/etnia. Dados dietéticos de três recordatórios de 24 horas, medidas antropométricas, bioquímicas e hemodinâmicas foram obtidos na Clínica de Investigação Cardiovascular da UFES. O consumo estimado de Na+e k+ foi determinado pela coleta de urina de doze horas no período noturno. Para comparação de proporções, foi usado o teste X2 e, para médias, o teste t de Student. Foi calculado o risco relativo e quantificado o risco cardiovascular por meio do algoritmo de Framingham. A idade média do grupo foi 47+8 anos e o tempo médio de vegetarianismo 19+10 anos, sendo a dieta ovolactovegetariana seguida por 73% dos VEGs. A maioria dos participantes pertencia às classes B e C e a religião predominante foi a de Adventistas do Sétimo Dia. VEGs relataram menor ingestão de proteínas e gorduras de origem animal e maior de carboidratos e fibras. Pressão arterial, glicemia de jejum, colesterol total, LDL-c e triglicerídeos foram mais baixos entre os VEGs (P 30kg/m2 (obesidade) não foi identificado em nenhum VEG. Entre os ONIs, 20% apresentaram obesidade e 38% sobrepeso. Na+ e Na/K também foram menores entre os VEGs, assim como a razão cintura/quadril. De acordo com o algoritmo de Framingham, os VEGs apresentaram menor RCV (P 30kg/m2 (obesity) was not identified in any VEG. Among ONIs, 20% presented obesity and 38% overweight. Na+ and Na/K were also smaller among VEGs, as well as the waist/hip reasoning. In agreement with the Framingham algorithm, VEGs presented smaller RCV (P < 0,001). The unbalanced omnivores eating habits, with protein excess and animal fats can largely be blamed for NTDCs unlocking, especially in hypertension, diabetes and obesity.
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- 2005
34. Higher Arterial Stiffness Predicts Chronic Kidney Disease in Adults: The ELSA-Brasil Cohort Study.
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Cândido J, Camelo LDV, Brant L, Cunha RS, Mill JG, and Barreto SM
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- Adult, Female, Male, Humans, Cohort Studies, Longitudinal Studies, Pulse Wave Analysis, Vascular Stiffness, Renal Insufficiency, Chronic, Hypertension complications, Diabetes Mellitus
- Abstract
Background: Central Illustration : Higher Arterial Stiffness Predicts Chronic Kidney Disease in Adults: The ELSA-Brasil Cohort Study., Background: Arterial stiffening can directly affect the kidneys, which are passively perfused by a high flow. However, whether the relation between arterial stiffness and renal function depends on diabetes and hypertension conditions, is a matter of debate., Objective: To investigate the relationship between arterial stiffening by carotid-to-femoral pulse wave velocity (cfPWV) and chronic kidney disease (CKD) incidence in individuals and verify whether this association is present in individuals without hypertension and diabetes., Methods: A longitudinal study of 11,647 participants of the ELSA-Brasil followed up for four years (2008/10-2012/14). Baseline cfPWV was grouped per quartile, according to sex-specific cut-offs. Presence of CKD was ascertained by glomerular filtration rate (eGFR-CKD-EPI) < 60 ml/min/1.73 m2 and/or albumin-to-creatinine ratio ≥ 30 mg/g. Logistic regression models were run for the whole cohort and a subsample free from hypertension and diabetes at baseline, after adjustment for age, sex, race, schooling, smoking, cholesterol/HDL ratio, body mass index, diabetes, use of antihypertensive, systolic blood pressure, heart rate, and cardiovascular disease. Statistical significance was set at 5%., Results: The chance of CKD was 42% (CI 95%: 1.05;1.92) greater among individuals in the upper quartile of cfPWV. Among normotensive, non-diabetic participants, individuals in the 2nd, 3rd, and 4th quartiles of cfPWV presented greater chances of developing CKD, as compared to those in the lower quartile, and the magnitude of this association was the greatest for those in the upper quartile (OR: 1.81 CI 95%: 1.14;2.86)., Conclusion: Higher cfPWV increased the chances of CKD and suggests that this effect is even greater in individuals without diabetes and hypertension.
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- 2024
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- View/download PDF
35. Validation of glomerular filtration estimation equations adjustable by race/colour in adults from Vitória, Espírito Santo, Brazil.
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Almeida WLDC and Mill JG
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- Adult, Humans, Brazil, Color, Creatinine, Analysis of Variance, Renal Insufficiency, Chronic diagnosis
- Abstract
The assessment of renal function is performed using the glomerular filtration rate (GFR) whose measurement by creatinine clearance (ClCr) and is dependent on a 24-hour urine sample, hindering it use in primary healthcare. The equations that estimate GFR from serum creatinine make the test more accessible, however, their adjustments by race/color have been questioned in mixed populations. To test the agreement between CrCl and GFR estimated by formulas (Modification of Diet in Renal Disease [MDRD-4] and Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]), with or without adjusting for race/color, data were used from a sub-study of the National Health Survey (NHS) including 272 adults from Vitória/Espírito Santo who underwent a 24-hour urinary sampling. Analysis of variance (ANOVA) and the Bland-Altman method were adopted. There was adequate agreement between ClCr and equations, but the adjustment by race/color decreases the accuracy of both equations. In the race/color factor, there was similarity between groups for CrCl (p=0.21), suggesting that there is no difference in creatinine metabolism induced by skin color. It is concluded that MDRD and CKD-EPI equations perform satisfactorily in the evaluation of renal function, and the use of corrections for race/color is not recommended.
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- 2024
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- View/download PDF
36. Validation of equations to estimate kidney function with and without adjustment by race/color in Brazilian adults (ELSA-Brazil).
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Almeida WLDC, Barreto SM, Vidigal PG, and Mill JG
- Subjects
- Adult, Humans, Male, Female, Brazil, Creatinine, Longitudinal Studies, Reproducibility of Results, Glomerular Filtration Rate, Kidney, Renal Insufficiency, Chronic diagnosis
- Abstract
Objective: To evaluate accuracy and agreement between creatinine clearance (CrCl) measured in 12-h urine and glomerular filtration rate (GFR) calculated by the Modification of Diet in Renal Disease (MDRD-4) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas, with and without adjustment for race/color., Methods: Baseline data from the Longitudinal Study of Adult Health (ELSA-Brazil) in adults (35-74 years of age) of both genders were used. Serum creatinine was measured in fasting blood and urinary creatinine was measured in an overnight 12-h urine collect. The agreement between CrCl and the calculated GFR was analyzed by the Bland-Altman method. One-way analysis of variance (ANOVA) with race/color factor was used to verify differences between means of CrCl and GFR with and without correction for race/color. Statistical significance was accepted for p<0.05., Results: From 15,105 participants in the ELSA-Brazil, 12,813 had a validated urine collect. The Bland-Altman diagrams showed that formulas and CrCl agree with each other with a better accuracy for GFR <90 mL/.min x 1.73m2. The adjustment by race/color increased data dispersion. In this range, one-way ANOVA of CrCl with race/color factor showed similarity between groups (p=0.27)., Conclusion: MDRD-4 and CKD-EPI are useful formulas for screening cases of chronic kidney disease, and correction by race/color, only in blacks or in black and brown subjects, proved to be unnecessary and reduced the reliability of the equations.
- Published
- 2023
- Full Text
- View/download PDF
37. Post-COVID Syndrome or Long COVID: A New Challenge for the Healthcare System.
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Mill JG and Polese J
- Subjects
- Humans, Delivery of Health Care, Post-Acute COVID-19 Syndrome, COVID-19
- Published
- 2023
- Full Text
- View/download PDF
38. Sedentary Behavior, Dietary Habits, and Cardiometabolic Risk in Physically Active Children and Adolescents.
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Fontes PADS, Siqueira JH, Martins HX, Oliosa PR, Zaniqueli D, Mill JG, and Alvim RO
- Subjects
- Male, Female, Humans, Child, Adolescent, Cross-Sectional Studies, Sedentary Behavior, Feeding Behavior, Risk Factors, Obesity, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology
- Abstract
Background: Sedentary behavior has been associated with several cardiometabolic risk factors during childhood. However, little is known about the impact of sedentary behavior on the health and eating habits of physically active children and adolescents., Objective: To evaluate the association between sedentary behavior and cardiometabolic risk factors and eating habits in physically active children and adolescents., Methods: This cross-sectional study was conducted, including 516 physically active children and adolescents (10 to 18 years old; both sexes) enrolled in the social project "Estação Conhecimento-Vale" were evaluated. Biochemical and lifestyle variables (questionnaire) were collected. Sedentary behavior was determined indirectly (questionnaire), by using sitting time ≥ 3 hours per day as a cutoff point. A p-value < 0.05 was considered statistically significant for all tests., Results: Sedentary behavior was not associated with overweight/obesity (odds ratio = 0.72 [95% confidence interval (CI): 0.325-1.389]), hypertriglyceridemia (odds ratio = 0.63 [95% CI: 0.306-1.297]), low HDL cholesterol (odds ratio = 0.57 [95% CI: 0.323-1.019]), or high non-HDL cholesterol (odds ratio = 0.63 [95% CI: 0.283-1.389]). However, children and adolescents with sedentary behavior were more likely to regularly consume food in front of the television (odds ratio = 1.96 [95% CI: 1.114-3.456]) and to consume at least one ultra-processed food per day (odds ratio = 2.42 [95% CI: 1.381-4.241]). In addition, they were less likely to consume fruit regularly (odds ratio = 0.52 [95% CI: 0.278-0.967])., Conclusion: There was no association between sedentary behavior and cardiometabolic risk factors in physically active children and adolescents. However, sedentary behavior was associated with inadequate eating habits. Thus, we may suggest that the regular engagement in physical activity may attenuate the deleterious effects of sedentary behavior on the cardiometabolic parameters of children and adolescents.
- Published
- 2023
- Full Text
- View/download PDF
39. Obesity and Risk of Hypertension: A Growing Problem in Children and Adolescents.
- Author
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Mill JG
- Subjects
- Humans, Child, Adolescent, Obesity complications, Risk Factors, Prevalence, Hypertension complications, Hypertension epidemiology
- Published
- 2023
- Full Text
- View/download PDF
40. Within-Visit Blood Pressure Variability and Cardiovascular Risk in ELSA-Brasil Study Participants.
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Zarife AS, Fraga-Maia H, Mill JG, Lotufo P, Griep RH, Fonseca MJMD, Brito LL, Almeida MDC, Aras R, and Matos SMA
- Subjects
- Adult, Male, Humans, Female, Blood Pressure physiology, Brazil epidemiology, Longitudinal Studies, Cross-Sectional Studies, Risk Factors, Heart Disease Risk Factors, Cardiovascular Diseases epidemiology
- Abstract
Background: Blood pressure variability (BPV) is of prognostic value for fatal and non-fatal cardiovascular outcomes., Objective: This study aimed to evaluate the association between within-visit BPV and cardiovascular risk among participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)., Methods: The present cross-sectional study was carried out using baseline data (2008-2010) of 14,357 ELSA-Brasil participants with no prior history of cardiovascular disease. Within-visit BPV was quantified by the coefficient of variation of three standardized systolic blood pressure (SBP) measurements using an oscillometer. Anthropometric measurements and laboratory tests were also performed. Cardiovascular risk was assessed using the atherosclerotic cardiovascular disease risk estimator (ASCVD) and multivariate logistic regression analysis was employed with a significance level of 5%., Results: Significantly higher cardiovascular risk was determined by increased BPV for both sexes. A significantly higher prevalence of high risk was found in men than women across all quartiles, with the highest difference observed in the fourth quartile of variability (48.3% vs. 17.1%). Comparisons among quartiles in each sex revealed a significantly higher cardiovascular risk for men in the third (OR=1.20; 95%CI: 1.02 - 1.40) and fourth quartiles (OR=1.46; 95%CI: 1.25 -1.71), and for women in the fourth quartile (OR=1.27; 95%CI: 1.03 - 1.57)., Conclusion: Analysis of baseline data of the ELSA-Brasil participants revealed that blood pressure variability was associated with increased cardiovascular risk, especially in men.
- Published
- 2022
- Full Text
- View/download PDF
41. Differences among Angiotensin Receptor Blockers (BRA) in the Treatment of Arterial Hypertension.
- Author
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Mill JG
- Subjects
- Antihypertensive Agents pharmacology, Antihypertensive Agents therapeutic use, Calcium Channel Blockers therapeutic use, Humans, Renin-Angiotensin System, Angiotensin Receptor Antagonists therapeutic use, Hypertension drug therapy
- Published
- 2022
- Full Text
- View/download PDF
42. Multimorbidity and health care of community health workers in Vitória, Espírito Santo, Brazil, 2019: a cross-sectional study.
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Martins HX, Siqueira JH, Oliveira AMA, Jesus HC, Pereira TSS, Sichieri R, Mill JG, and Molina MDCB
- Subjects
- Adult, Brazil epidemiology, Cross-Sectional Studies, Delivery of Health Care, Humans, Middle Aged, Community Health Workers, Multimorbidity
- Abstract
Objective: To assess health conditions, health care and lifestyle habits of community health workers (CHW) in Vitória, Espírito Santo, Brazil., Methods: This was a cross-sectional study using baseline data from an intervention study. Biochemical, anthropometric and hemodynamic examinations and interviews were carried out between October 2018 and March 2019 in Vitória. Appropriate statistical tests, in accordance with the sample design, were performed using SPSS software version 21.0, adopting p<0.05., Results: We assessed 262 CHWs with a mean age of 46.1±9.3 years. High prevalence of prediabetes (22.9%), diabetes mellitus (17.2%), hypertension (37.0%), obesity (39.8%), hypercholesterolemia (57.3%), hypertriglyceridemia (27.1%), multimorbidity (40.8%), physical inactivity (60.9%) and use of anxiolytics/antidepressants (22.5%) was found. Some 40% of the CHWs had three or more morbidities., Conclusion: High percentages of chronic diseases, multimorbidity, sedentary lifestyle and use of anxiolytics/antidepressants were found in CHWs in Vitória.
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- 2022
- Full Text
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43. Brazilian Guidelines of Hypertension - 2020.
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Barroso WKS, Rodrigues CIS, Bortolotto LA, Mota-Gomes MA, Brandão AA, Feitosa ADM, Machado CA, Poli-de-Figueiredo CE, Amodeo C, Mion Júnior D, Barbosa ECD, Nobre F, Guimarães ICB, Vilela-Martin JF, Yugar-Toledo JC, Magalhães MEC, Neves MFT, Jardim PCBV, Miranda RD, Póvoa RMDS, Fuchs SC, Alessi A, Lucena AJG, Avezum A, Sousa ALL, Pio-Abreu A, Sposito AC, Pierin AMG, Paiva AMG, Spinelli ACS, Nogueira ADR, Dinamarco N, Eibel B, Forjaz CLM, Zanini CRO, Souza CB, Souza DDSM, Nilson EAF, Costa EFA, Freitas EV, Duarte EDR, Muxfeldt ES, Lima Júnior E, Campana EMG, Cesarino EJ, Marques F, Argenta F, Consolim-Colombo FM, Baptista FS, Almeida FA, Borelli FAO, Fuchs FD, Plavnik FL, Salles GF, Feitosa GS, Silva GVD, Guerra GM, Moreno Júnior H, Finimundi HC, Back IC, Oliveira Filho JB, Gemelli JR, Mill JG, Ribeiro JM, Lotaif LAD, Costa LSD, Magalhães LBNC, Drager LF, Martin LC, Scala LCN, Almeida MQ, Gowdak MMG, Klein MRST, Malachias MVB, Kuschnir MCC, Pinheiro ME, Borba MHE, Moreira Filho O, Passarelli Júnior O, Coelho OR, Vitorino PVO, Ribeiro Junior RM, Esporcatte R, Franco R, Pedrosa R, Mulinari RA, Paula RB, Okawa RTP, Rosa RF, Amaral SLD, Ferreira-Filho SR, Kaiser SE, Jardim TSV, Guimarães V, Koch VH, Oigman W, and Nadruz W
- Subjects
- Brazil, Humans, Hypertension diagnosis, Hypertension prevention & control
- Published
- 2021
- Full Text
- View/download PDF
44. Factors associated with salt intake in the Brazilian adult population: National Health Survey.
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Mill JG, Malta DC, Nilson EAF, Machado ÍE, Jaime PC, Bernal RTI, Cardoso LSM, and Szwarcwald CL
- Subjects
- Adult, Brazil epidemiology, Cross-Sectional Studies, Female, Health Surveys, Humans, Feeding Behavior, Sodium Chloride, Dietary
- Abstract
This paper aims to identify the factors associated with high salt intake in the Brazilian adult population. This is a cross-sectional study with 8,083 adults participating in the National Health Survey (PNS, 2014/15). Salt intake was based on the estimation of 24-hour urinary sodium calculated from the sodium/creatinine ratio in spot urine samples. The highest quartile of the distribution was considered high salt intake. The relationship between high salt consumption and sociodemographic factors, lifestyles, morbidity, and self-rated health status was analyzed by calculating the crude prevalence ratios and the prevalence ratios adjusted for age and gender. Approximately 28.1% had an estimated salt intake higher than 10.56 g/day. Overweight (Adjusted Prevalence Ratio; 95%CI - PRadj 1.23; 1.09-1.39), obesity (PRadj 1.61; 1.43-1.83), and diabetes (PRadj 1.36; 1.17-1.58) were positively associated with high salt intake. Female gender (PRadj 0.73; 0.66-0.80), high schooling level (PRadj 0.88; 0.79-0.99), living in the North and chronic kidney disease (PRadj 0.71; 0.56-0.90) were protective factors. Salt consumption is elevated nationwide and in all population subgroups, requiring coordinated actions.
- Published
- 2021
- Full Text
- View/download PDF
45. Prevalence of Orthostatic Hypotension and the Distribution of Pressure Variation in the Longitudinal Study of Adult Health.
- Author
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Velten APC, Bensenor I, Lotufo P, and Mill JG
- Subjects
- Adult, Aged, Blood Pressure Determination, Brazil epidemiology, Humans, Longitudinal Studies, Middle Aged, Prevalence, Blood Pressure physiology, Hypotension, Orthostatic epidemiology
- Abstract
Background Orthostatic hypotension (OH) has been neglected in clinical practice, and there are no studies on its prevalence in the Brazilian population. Objective To determine the prevalence of OH and blood pressure (BP) changes after the postural change maneuver in participants of the Longitudinal Study of Adult Health. Methods In this descriptive study of baseline data (N = 14,833 adults, ages 35 - 74 years), participants remained lying down for 20 minutes and subsequently stood up actively. BP measurements were taken while the participants were supine and at 2, 3, and 5 minutes after standing. OH was defined as a reduction of ≥ 20 mmHg in systolic BP and/or a reduction of ≥ 10 mmHg in diastolic BP at 3 minutes, and its prevalence was determined with a 95% confidence interval (CI). The distribution of BP variation after the postural change maneuver was determined in a subsample (N = 8,011) obtained by removing patients with cardiovascular morbidity and/or diabetes. Results The prevalence of OH was 2.0% (95% CI: 1.8 - 2.3), increasing with age. If the criterion applied were a BP reduction during any measurement, the prevalence would increase to 4.3% (95% CI: 4.0 - 4.7). Symptoms (dizziness, scotoma, nausea, etc.) were reported by 19.7% of participants (95% CI: 15.6 - 24.6) with OH and 1.4% (95% CI: 1.2 - 1.6) of participants without OH. The -2 Z-scores of BP variation before and after the postural change maneuver in the subsample were -14.1 mmHg for systolic BP and -5.4 mmHg for diastolic BP. Conclusion Prevalence of OH varies depending on when BP is measured. Current cutoff points may underestimate the actual occurrence of OH in the population. (Arq Bras Cardiol. 2020; 114(6):1040-1048).
- Published
- 2020
- Full Text
- View/download PDF
46. TRI-PONDERAL MASS INDEX IS USEFUL FOR SCREENING CHILDREN AND ADOLESCENTS WITH INSULIN RESISTANCE.
- Author
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Neves FS, Alvim RO, Zaniqueli D, Pani VO, Martins CR, Peçanha MAS, Barbosa MCR, Faria ER, and Mill JG
- Subjects
- Adolescent, Anthropometry methods, Blood Glucose analysis, Brazil, Child, Cholesterol, HDL blood, Cholesterol, LDL blood, Cross-Sectional Studies, Female, Humans, Male, Sex Distribution, Body Height, Body Mass Index, Body Weight, Insulin Resistance
- Abstract
Objective: To investigate whether tri-ponderal mass index and body mass index Z scores are equivalent for screening children and adolescents with insulin resistance., Methods: Cross-sectional study with 296 children and adolescents enrolled at public schools of Vitória, Espírito Santo, Brazil, aged eight to 14 years. The tri-ponderal mass index was calculated as the ratio between weight and height cubed. The body mass index was calculated as the ratio between weight and height squared. Insulin resistance was defined with the homeostatic model assessment (HOMA-IR)., Results: The HOMA-IR was higher in the 4th quartile of body mass index Z scores and tri-ponderal mass index compared to 1st and 2nd quartiles for both girls and boys. The areas under the age-adjusted receiver operating characteristic curves were similar between the indices for girls (body mass index Z scores=0.756; tri-ponderal mass index=0.763) and boys (body mass index Z scores=0.831; tri-ponderal mass index=0.843). In addition, according to the simple linear regression analyses estimations, both body mass index Z scores and tri-ponderal mass index explained a significant fraction of the homeostatic model assessment variability for girls (body mass index Z scores: R2=0.269; tri-ponderal mass index: R2=0.289; p<0.001) and boys (body mass index Z scores: R2=0.175; tri-ponderal mass index: R2=0.210; p<0.001)., Conclusions: The tri-ponderal mass index and body mass index Z scores were similar to discriminate children and adolescents with insulin resistance. It is noteworthy that the use of tri-ponderal mass index is clearly advantageous, because it can be calculated with no concerns on adjustments for the age, a fact that makes it very applicable in the clinical practice.
- Published
- 2020
- Full Text
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47. [Associations between consumption of dairy products, C-reactive protein, and lipid profile in adults: results of the ELSA-Brasil study].
- Author
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Ribeiro AG, Mill JG, Matos SMA, Velasquez-Melendez G, Cade NV, and Molina MDCB
- Subjects
- Adult, Biomarkers blood, Brazil, Cholesterol, HDL blood, Cholesterol, LDL blood, Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Socioeconomic Factors, Triglycerides blood, C-Reactive Protein analysis, Cardiovascular Diseases blood, Dairy Products statistics & numerical data, Diet Surveys, Feeding Behavior, Lipids blood
- Abstract
Lipid abnormalities and subclinical systemic inflammation are associated with atherosclerosis and are used as markers of cardiovascular risk. Studies have suggested a possible beneficial effect of dairy products on cardiovascular health, but the results in lipid and inflammatory markers are still controversial. This study aimed to assess the association between consumption of dairy products and their different subgroups and C-reactive protein (CRP), LDL-cholesterol (LDL-C), and triglyceride/HDL-cholesterol ratio (TG/HDL-C) in participants in the Longitudinal Study of Adult Health (ELSA-Brasil) (n = 9,372). Consumption of dairy products was assessed via a validated food frequency questionnaire and expressed as servings/day. Total consumption of dairy products was described in four categories (≤ 1 serving/day to > 4 servings/day). The associations were estimated via odds ratios (OR), using the group with the lowest consumption (≤ 1 serving/day) as the reference. The lowest ORs for TG/HDL-C in the multivariate model (0.70; 95%CI: 0.55-0.90 in men; and 0.55; 95%CI: 0.43-0.70 in women) were found in the group that consumed > 4 servings day of dairy products. These results were supported by the inverse associations between different subgroups of dairy products and the TG/HDL-C ratio. No association was found between consumption of dairy products and their subgroups and LDL-C and CRP. The results suggest a possible beneficial effect of dairy products on lipid profile, but longitudinal and intervention studies are needed to elucidate the effect mechanisms of different types of dairy products.
- Published
- 2019
- Full Text
- View/download PDF
48. Social Determinants of Hypertension.
- Author
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Mill JG
- Subjects
- Adult, Brazil, Humans, Prevalence, Risk Factors, Hypertension, Social Determinants of Health
- Published
- 2019
- Full Text
- View/download PDF
49. Estimation of salt intake in the Brazilian population: results from the 2013 National Health Survey.
- Author
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Mill JG, Malta DC, Machado ÍE, Pate A, Pereira CA, Jaime PC, Szwarcwald CL, and Rosenfeld LG
- Subjects
- Adolescent, Adult, Age Distribution, Brazil epidemiology, Female, Health Surveys statistics & numerical data, Humans, Male, Middle Aged, Nutrition Surveys, Reference Values, Sex Distribution, Socioeconomic Factors, Time Factors, Young Adult, Diet statistics & numerical data, Health Surveys methods, Sodium Chloride, Dietary urine
- Abstract
Objective: To estimate the salt intake in the Brazilian population according to their urinary sodium excretion., Methods: The National Health Survey (2013) aimed to gather data on the health of adults (≥ 18 years) through a random selection of households. In each household, one adult was selected to have their biological data collected (anthropometry, blood pressure, and blood and urine tests). The urine sample was sent to a central laboratory to determine sodium (ion-selective electrode) and creatinine (Jaffé method) concentrations. Sodium excretion was estimated with the Tanaka equation., Results: Urinary sodium and creatinine concentrations were measured in 8,083individuals (58% women). The mean salt intake was estimated at 9.34 g/day (95% confidence interval - 95%CI 9.27 - 9.41) and was higher in males (9.63 g/day; 95%CI 9.52 - 9.74) than in females (9.08 g/day; 95%CI 8.99 - 9.17). Wefound no significant differences regarding age group, ethnicity, or schooling. Salt intake was higher in the Southeast and South regions and lower in the Northeast and North. Only 2.4% (95%CI 2.0 - 2.8) of the sample consumed less than 5 g/day, and 58.2% (95%CI 56.7 - 59.6) of participants had an estimated intake of 8 to 12 g/day., Conclusion: The mean salt intake in the Brazilian population is approximately twice the recommended by the World Health Organization (5g/day).Given the association of high salt intake with hypertension and decreased renal function, these data indicate the need to adopt comprehensive public policies to reduce the consumption in the Brazilian population.
- Published
- 2019
- Full Text
- View/download PDF
50. Relationship between body composition and dyslipidemia in children and adolescentes.
- Author
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Oliosa PR, Zaniqueli DDA, Barbosa MCR, and Mill JG
- Subjects
- Adipose Tissue physiology, Adolescent, Anthropometry, Body Composition physiology, Body Mass Index, Child, Electric Impedance, Female, Humans, Male, Sex Factors, Waist Circumference physiology, Young Adult, Cholesterol blood, Dyslipidemias epidemiology, Lipids blood, Pediatric Obesity epidemiology
- Abstract
We studied the relationship between different anthropometric indexes and plasma lipids. Data were collected from 2014 to 2016 in 854 schoolchildren (6-18 years). Waist circumference (WC), body fat percentage (BFP) by bioimpedance, body mass index (BMI), and waist-to-height ratio (WHtR) were measured. Total cholesterol (TC), HDLc, and triglycerides were measured in fasting blood samples and Non-HDL cholesterol (Non-HDLc) was calculated. Data are presented as mean ± standard deviation, with percentages. Means were compared using the t test or ANOVA followed by Tukey's test. The association between variables was tested by linear regression. The study was approved by the Research Ethics Committee of the Universidade Federal do Espírito Santo. Obese boys had higher TC, non-HDLc, and LDLc than eutrophic boys (p < 0.05). In girls this difference was found only for non-HDLc (p < 0.05). Children with inappropriate BFP and WHtR presented higher LDLc and non-HDLc concentrations (p < 0.001), which showed positive association (p<0.001) with lipid fractions (TC and non-HDLc). Excess body fat increased the probability of cholesterol above the reference value (170 mg/dL) by 21%. Excess body fat was associated with an atherogenic lipid profile (higher non-HDLc), especially in boys.
- Published
- 2019
- Full Text
- View/download PDF
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