Search

Context and Aim: Adherence to antiretroviral treatment (ART) among men who have sex with men (MSM) living with HIV poses a public health challenge. Although studies in developed countries emphasize the role of psychosocial factors in ART adherence, there is limited research on this association among Brazilian MSM living with HIV. This study examined the impact of depression, anxiety, internalized homonegativity, and HIV-related stigma on ART adherence in a sample of this population. Method: A cross-sectional study recruited 43 MSM living with HIV (Mage = 34.93, SD = 7.90) through social media. Instruments included sociodemographic and clinical questionnaires, the Questionnaire for Assessment of Adherence to Antiretroviral Treatment, the Beck Depression Scale, the Trait-State Anxiety Inventory, the Internalized Homophobia Scale, and the HIV Stigmatization Scale. Results: Twelve participants (27.9%) showed inadequate ART adherence, and 18 (41.8%) reported signs and symptoms of depression at clinical level. Depression was negatively and moderately correlated with ART adherence. HIV-related stigma was positively and moderately correlated with depression, trait anxiety, and homonegativity. Depression significantly impacted ART adherence, explaining 13.4% of the variance. Conclusions: Our results highlight the need for regular depression screening and affirmative interventions to support MSM living with HIV, addressing stigma, and promoting adherence to ART.

ABSTRACT Objective: To evaluate the frequency, reasons and factors associated with intentional nonadherence to drug therapy. Methods: A population-based cross-sectional study was conducted with data from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM). The questionnaire consisted of sociodemographic questions, presence of chronic diseases, medication use, self-rated health, and medication use behaviors. Data analysis included Poisson regression models adjusted for variance. Results: A total of 31,573 individuals were included, most of whom were women (53.8%), with low level of education (57.7%), and self-rated good health (56.5%). Of those interviewed, 8.8% reported increasing the medication dose and 21.2% reported reducing it. The most common reason for dose reduction was the adverse effects of the medication. There were no differences in the reasons for increasing doses. Increasing or reducing doses were most commonly reported by younger people, with lower per capita income and worse self-rated health. Conclusion: A considerable portion of the respondents did not intentionally adhere to drug therapy. Understanding nonadherence and identifying those who practice it is crucial for creating effective strategies that promote adherence to treatment and prioritize patients’ needs and perspectives.

Abstract Objectives: to analyze the choice and continuation rate of contraceptive methods in women with sickle cell disease (SCD). Methods: an exploratory prospective study was conducted at a hospital enrolling 44 women with SCD aged 15-40 years old. After contraceptive counseling, the women selected one of the available contraceptive methods and separated into two groups, and were followed up at one, three, six, and 12 months. To analyze the continuation rate of contraceptive use, the two groups were: group (G1) using progestin-only contraceptives, through any route of administration and group (G2) using other contraceptive methods (combined hormonal and non-hormonal contraceptives). The continuation rate was analyzed using Kaplan–Meier survival analysis, considering a p

Aims: Assessment of medication adherence in newly diagnostic and treated patients with Type 2 Diabetes Mellitus and Arterial Hypertension, in the Primary Health Care Units of Lisbon and Tagus Valley. Methods: This is an observational and retrospective cohort study. The population is composed of newly diagnosed patients with Type 2 Diabetes Mellitus and Arterial Hypertension, at the beginning of treatment. Data was extracted from the Lisbon and Tagus Valley Regional Health Administration Information System. Medication adherence was assessed in three periods: patients started therapy or not after the professional's prescription (initiation); medication possession rate during the follow-up period (MPR) (implementation) and medication discontinuation, marks the end of therapy (discontinuation). Results: An initiation rate of 84.2% was obtained in patients with both diseases (98% for oral antidiabetic therapy and 84.6% for antihypertensive therapy). The implementation rates (MPR) for both diseases was only 3.4% (4.2% were considered adherent to oral antidiabetic therapy and 8.5% to antihypertensive therapy). The discontinuation rate was 3.4% (5.5% for oral antidiabetic therapy and 13.2% for antihypertensive therapy). Most patients initiate taking drugs after prescription but very few patients have a MPR enough to consider them having good adherence. Moreover, few patients discontinue the medication. Conclusions: Patients had a higher implementation rate to antihypertensive therapy but, on the other hand, were more persistent to the oral antidiabetic therapy. Through this new assessment, the medication adherence pattern seems to be influenced by the patient and by the disease itself.

Objective: To identify the adherence to therapeutic regimens in patients with chronic kidney disease undergoing hemodialysis (HD). Method: This is a descriptive, cross-sectional study using a quantitative approach developed at an HD center in the south of Minas Gerais, Brazil. The study participants were 51 patients undergoing HD. Personal, socioeconomic, and objective data were collected, and the End-Stage Renal Disease Adherence Questionnaire (ESRD-AQ) was applied. The analysis was performed using simple descriptive statistics. Result: The average age was 56.7 years, and 58% of the patients were male. The percentages of non-adherence were diet (35.4%), hemodialysis (21.6%), fluid intake (15.7%), and medication (13.7%). Conclusion: Therapeutic adherence is a complex process that requires constant monitoring by a multidisciplinary team.

INTRODUCTION: Tuberculosis (TB), an infectious and contagious disease, requires prolonged treatment and usually affects socially vulnerable patients, which increases the risk of abandonment during its course. Children and adolescents are susceptible to this infection, requiring adequate treatment for a favorable clinical outcome. It is known that adherence to TB treatment is the main obstacle to cure the disease, and it is important to know the factors that could influence this adherence. The aim of this review is to analyze the factors that interfere with adherence to TB treatment in children and adolescents. METHODS: This systematic literature review was conducted by searching the descriptors Tuberculosis (OR Tuberculosis) AND Adherence (OR Adhesion) in the PubMed, Scielo and Lilacs databases. Articles about the adherence of children and adolescents to TB treatment were included. Duplicates were excluded. The selection of articles for review was conducted in the following steps: analysis of titles, reading of abstracts and full articles. At the end of the selection, 28 articles were reviewed. RESULTS: The main barriers to adherence to TB treatment were: prolonged treatment time, adverse effects, caregivers lack of knowledge about the disease and latent infection and socioeconomic status. The main facilitators were: shorter treatment, directly observed, financial support and advice from patients and caregivers. HIV-TB co-infection can increase adherence due to routine medication intake, or decrease due to the increase in adverse effects. CONCLUSION: The acknowledgement of the facilitators and barriers to adherence allows directing the necessary efforts to promote best response to TB treatment.

ABSTRACT Objectives: to develop a responsive website focused on treatment adherence for adult users living with HIV. Methods: technological study conducted between August and October 2020, in the light of Pierre Lévy’s theoretical-philosophical framework, using the Double Diamond Process methodology associated with the five stages of The Elements of User Experience framework. Results: it was developed the responsive website Positive Care (Positive o Cuidado), composed of an initial presentation screen and 13 other screens named: Family Health and You; Undetectable = Untransmissible; Antiretroviral Drugs; Routine Tests; Vaccination; Antiretroviral Delivery; Drug Interactions; Combined Prevention; Support Services; Healthy Life; Family and Reproductive Planning; Covid 19; and Questions, Curiosities, and Myths. Final Considerations: the responsive website was developed based on the software design and programming process and has requirements/functionalities with the potential to strengthen the collective intelligence about HIV and, consequently, to promote treatment adherence by its users.

Objective: to investigate the use of m-Health applications by patients with hypertension in adherence to medication treatment and reduction/stabilization of blood pressure. Method: non-randomized, controlled, and non-blind clinical trial. A total of 37 participants, adults and elderly, men and women, diagnosed with arterial hypertension and undergoing continuous medical treatment, were recruited. Over 3 months, the control group followed conventional treatment, while the intervention group used the m-Health application. Adherence to treatment was assessed using the Adherence to Refills and Medications Scale questionnaire. Results: there was no significant difference in treatment adherence between the groups, both preintervention (p=0.360) and post-intervention (p=0.065). Regarding blood pressure values, there was no significant difference between the groups. However, a decrease in pressure was observed in the intervention group of about 8 mmHg in systolic pressure (from 140.34±20.78 to 132.00±22.14). Conclusion: the app showed potential applicability in improving adherence of hypertensive patients to therapies. It is suggested that new studies in digital health be conducted with a stronger link between patients and professionals, recruiting non-adherent patients and over a more extended period. [ABSTRACT FROM AUTHOR]

Copyright of RIIS: Revista de Investigação & Inovação em Saúde is the property of RIIS: Revista de Investigacao & Inovacao em Saude and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A history of depression is associated with unfavorable maternal outcomes. The objective was to analyze adherence to medical prescriptions and to recommendations given by health professionals and reported by pregnant women with a previous history of depression in Brazil, 2019. Data were extracted from the 2019-National Health Survey, a household survey coordinated by the Brazilian Institute of Geography and Statistics. Almost 90% of the women reported having received medical prescriptions for depression treatment, but almost 70% did not use the prescribed medications. Referral to a specialized professional was indicated for 42% (N=24,733) of the pregnant women. Among the women who received a referral, almost 20% were unable to attend appointments with the specialist. Bearing in mind the non-negligible consequences of non-adherence to mental health care, it is crucial to include the topic in the health agenda, creating alternatives to face the reasons that force women to give up treatment for this important health problem. [ABSTRACT FROM AUTHOR]

A history of depression is associated with unfavorable maternal outcomes. The objective was to analyze adherence to medical prescriptions and to recommendations given by health professionals and reported by pregnant women with a previous history of depression in Brazil, 2019. Data were extracted from the 2019-National Health Survey, a household survey coordinated by the Brazilian Institute of Geography and Statistics. Almost 90% of the women reported having received medical prescriptions for depression treatment, but almost 70% did not use the prescribed medications. Referral to a specialized professional was indicated for 42% (N=24,733) of the pregnant women. Among the women who received a referral, almost 20% were unable to attend appointments with the specialist. Bearing in mind the non-negligible consequences of non-adherence to mental health care, it is crucial to include the topic in the health agenda, creating alternatives to face the reasons that force women to give up treatment for this important health problem. [ABSTRACT FROM AUTHOR]

This study aimed to gather scientific evidence on the role of sociodemographic factors in adherence to antihypertensive drugs in Primary Care in Brazil. This is an integrative review with studies published between 2015 and 2019 in national journals. Original studies developed with hypertensive Primary Care users in Brazil were included, and articles published outside the range between 2015 and 2019 were excluded, as well as literature reviews, and those that did not focus on the elements of interest in this review. Five studies that investigated sociodemographic variables in the context of adherence to antihypertensive drugs in Primary Care were selected. Although some studies have found a possible interference of some sociodemographic variables in adherence to antihypertensive drugs in Primary Care, there are, for each of these variables, divergent results, showing that the sociodemographic dimension may or may not interfere with medication adherence in a given population group. In this sense, there are also results suggestive that, with effective provision of assistance to users, such variables seem to lose their interference in adherence to antihypertensive drugs, in line with the hypothesis that organizational characteristics of health services have a much greater impact on adherence than sociodemographic differences.

Copyright of Revista de Atencao Primaria a Saude is the property of Revista de Atencao Primaria a Saude and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cadernos de Saude Publica is the property of Escola Nacional de Saude Publica Sergio Arouca and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract Objective: to evaluate the use of a renal health application by kidney transplant recipients. Method: a retrospective, observational study with a sample composed of individuals registered in the kidney transplant section of the application from July of 2018 to April of 2021. Demographic data, data entry, time of use, weight, blood pressure, blood glucose, creatinine, medication schedules, appointments, and tests were the variables collected. Descriptive analysis of the data was performed. Results: eight hundred and twenty-three downloads of the application were identified, and 12.3% of those were registered as kidney transplant recipients, the majority from southeastern Brazil (44.9%), 36±11 years old, and female (59.1%). Of the sample, 35.1% entered information such as creatinine (62%), weight (58.2%), and blood pressure (51.8%). Most used the application for one day (63.3%) and 13.9% for more than one hundred days. Those who used it for more than one day (36.7%) recorded weight (69%), medication intake (65.5%) and creatinine (62%), and scheduled appointments (69%). Conclusion: the kidney transplant recipient section of the Renal Health application generated interest in the young population, but showed low adherence throughout the assessed months. These results offer a relevant perspective on the implementation of mHealth technologies in kidney transplantation.

ABSTRACT The aim of this study was to evaluate health care quality and medication adherence in people living with human immunodeficiency virus in specialized care services. This is a cross-sectional, evaluative study, with a quantitative approach, carried out in ten services in Pernambuco. Two instruments were validated and analyzed by statistical tests were used and 306 adults and their service managers participated. The quality standard was equivalent for most indicators. Only in the countryside, the indicators referring to the availability of antiretroviral drugs and care in the absence of medication were associated with low adherence (p-value=0.033 and p-value=0.011), the latter being a predictor for low adherence. Services with insufficient quality standards showed a 19% higher occurrence of low medication adherence. 81% of users had low adherence to antiretroviral drugs. There is a deficiency in adherence to antiretroviral drugs, and those assisted in services in the countryside have more complicating factors related to the quality of health care for satisfactory adherence.

ABSTRACT Objective To verify the influence of patients’ level of functional health literacy on adherence to antidepressant treatment. Method Cross-sectional study, carried out in pharmacies of the Municipal Health Department of Marília-SP, in 2020/2021. The functional literacy questionnaire verified the numerical and interpretative skills of patients, in the face of texts related to the health area. The adherence to the treatment was verified using the Morisky therapeutic adherence scale, and the data were analyzed by Anova-one-way and Kruskal-Wallis tests. Results A total of 150 patients participated in the study, most of them showed failures in adherence and an inadequate level of functional health literacy. However, there was no correlation between functional health literacy and treatment adherence. Conclusion Although no correlation was found between the variables, there is a need for greater investments in terms of adherence to the treatment, with strategies that consider the level of functional health literacy in these patients.

This study aimed to gather scientific evidence on the role of sociodemographic factors in adherence to antihypertensive drugs in Primary Health Care (PHC)_in Brazil. This is an integrative review with studies published between 2015 and 2019 in national journals. Original studies developed with hypertensive PHC users in Brazil were included and articles published outside the time range were excluded, as well as literature reviews, and those that did not focus on the elements of interest of this review. A total of 5 studies that investigated sociodemographic variables in the context of adherence to this class of drugs in PHC were selected. Although some studies have found a possible interference of some sociodemographic variables in adherence to antihypertensive drugs in Primary Care, there are, for each of these variables, divergent results, showing that the sociodemographic dimension may or may not interfere with medication adherence in a given population group. In this sense, there are also results suggesting that, with effective provision of assistance to users, such variables seem to lose their interference capacity in user adherence, in line with the hypothesis that organizational characteristics of health services have a much greater impact on adherence than sociodemographic differences. [ABSTRACT FROM AUTHOR]

ABSTRACT Objective: To analyze the association between health literacy and the adherence to the pharmacological treatment of Brazilians with arterial hypertension. Methods: Cross-sectional study with 234 participants who responded an on-line sociodemographic and clinical characterization questionnaire, in addition to evaluation of health literacy and of the adherence to their pharmacological treatment. Data were analyzed using descriptive statistics and difference and correlation tests. Results: People with post-graduation, who were actively working and did not smoke, had better health literacy results. Elders and those who were retired or lived on government subsidies adhered better to the medication treatment. There was a correlation between the numerical dimension (rs=0.189; p=0.004) and the global health literacy result (r2=0.170; p=0.009) with the adherence. Conclusions: A better numerical and global understanding of health literacy was associated with better adherence to arterial hypertension medication treatment.

Objective: To assess adherence to antihypertensive treatment in patients at a Family Health Strategy (FHS) unit. Methods: quantitative, transversal, and observational study with 131 hypertensive patients registered in the HIPERDIA program of an FHS located in the city of Lagarto, Sergipe, Brazil, through the analysis of medical records and the application of structured questionnaires. The assessment of the degree of adherence was carried out through the Brief Medication Questionnaire. Results: Factors related to poor adherence were illiteracy (PR: 0.61; 95%CI: 0.42 - 0.89), per capita family income < 1 minimum wage (PR: 0.51; 95%CI : 0.33 - 0.78) and high pharmacological complexity (PR: 0.66; 95%CI: 0.45 - 0.97), while only regular physical activity (PR: 2.64; 95%CI: 1.28 - 5.46) and a good quality of life (PR: 1.44; 95%CI: 1.02 - 2.04) remained positively associated with adherence. Conclusion: As these are modifiable factors, the simplification of the therapeutic scheme and the regular practice of physical activity are key points for increasing adherence to the treatment of systemic arterial hypertension in Primary Care.

Religiosity and spirituality (R/S) have stood out among factors associated with adherence to antiretroviral therapy (ART) in people living with HIV. This study aimed to identify evidence on the relationship between R/S and adherence to ART. An integrative literature review was conducted within the CINAHL, LILACS, PePSIC, PsycINFO, PubMed, SciELO, Scopus, and Web of Science databases. Empirical articles published between January 2008 and June 2019 were selected, and 49 studies were retrieved after applying the inclusion/exclusion criteria. Positive, negative, and neutral associations were found between R/S and adherence to ART, showing that R/S is a psychosocial dimension that can be a predictor of adherence to antiretrovirals. The meaning of this influence, however, is not yet a consensus in the scientific literature. It is recommended that these influences be understood from the contextual elements of this population and not just from personal markers. [ABSTRACT FROM AUTHOR]

Copyright of Saberes Plurais is the property of Saberes Plurais and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

ABSTRACT Objective: To characterize the self-reported adherence of patients with cardiovascular diseases to the use of new oral anticoagulants and to identify factors related to adherence to these drugs. Method: This is a descriptive, correlational, and cross-sectional study, carried out with outpatients. The collection of sociodemographic, clinical, and adherence data, through the Measurement of Adherence to Treatments, was made through telephone calls. Descriptive, correlation, and multiple linear regression analyses were used. Results: A total of 120 patients using new anticoagulants for 32.3 months, on average, participated in the study. More than half of the sample consisted of women, who were professionally inactive, with a mean age of 70.1 years and a mean family income of 6.7 minimum wages. The mean adherence score was 5.7, in a possible range between 1 and 6, indicating medication adherence. Inactive employment status, female sex, higher family income, and follow-up at a public outpatient clinic were related to greater adherence to these medications. Conclusion: The patients showed high adherence to new anticoagulants. Employment status, sex, family income, and type of outpatient follow-up were related to medication adherence, and should be considered in the design of interventions for this public.

This study analyzes the life stories of eight young people living with vertically transmitted HIV in order to understand their perceptions marked by secrecy and silence regarding their experiences with the virus. Conducted at a specialized outpatient clinic in Rio de Janeiro, the study adopted circle dance, a Complementary and Integrative Health Practice, as a care tool. Using a qualitative approach and Life History as a data collection method, the focus was to understand the youth's experiences related to the disease and the crucial aspects of their lives. Three girls and five boys participated in the study, all aware of their diagnosis. The principal emerging themes included family dynamics, school environment connection, challenges in treatment adherence, age at the time of diagnosis disclosure, and time elapsed since then. Analyzing these young people's narratives allowed us to explore individual and social aspects of their experiences, revealing their similarities and differences. The circle dance workshops provided a playful space for expressing emotions and feelings through body movements, expanding young people's perspectives on the future.

Objective: to detect factors related to negative adherence to self-care in individuals with diabetes mellitus. Methods: observational, cross-sectional, analytical, and exploratory study, conducted with individuals diagnosed with type 2 diabetes mellitus and followed-up by the Family Health Strategy. The sample consisted of 250 participants. The Summary of Diabetes Self-Care Activities Questionnaire was used for self-care assessment. Association tests, prevalence ratio and Poisson regression with robust variance were performed in the analysis. Results: negative attitudes related to self-care increased by 21% for single/divorced/widowed, 20% for retired, 54% for those who did not diet, 28% for those who did not practice physical activity, 24% for hypertensive, 30% for those with dyslipidemia, and 44% for those with retinopathy. Conclusion: socioeconomic factors, behavioral factors, presence of comorbidities and complications related to diabetes mellitus were related to negative adherence to self-care.

ABSTRACT Objective: To analyze actions promoting adherence to tuberculosis treatment that are being carried out by nurses in different countries. Method: Scoping review with selection of articles on the subject in LILACS, MEDLINE, IBECS, BDENF, SciELO, CINAHL, Embase, Web of Science, and Scopus databases. Results: Forty studies, published between 2009 and 2020, allowed the identification of nursing actions in two thematic categories. In the category “Nursing care: TB patients’ specific needs to promote adherence to treatment”, actions involving clinical aspects, professionals’ knowledge and skills, educational and relational processes were identified. In the category “The role of nursing in coping with the social determinants of health to promote adherence to treatment”, interventions related to the strengthening of family and community support, the inclusion of socioeconomic issues in care plans, and respect for cultural differences were highlighted. Conclusion: Nursing work directed to the adherence to disease treatment requires the development of technical, ethical and, above all, political skills, aiming to increase the success of the actions carried out by these professionals.

Study Design: Study Design: This mixed-methods study. Objective: To describe action plans related to the behavior of adherence to oral antidiabetic medications produced by people with type 2 diabetes mellitus and identify the challenges and coping strategies for the establishment of this behavior. Methods: The study followed-up 44 people with type 2 diabetes mellitus who used oral antidiabetic medications from southeast Brazil. Adults were invited to build action and coping plans based on the Implementation Intention Theory. The plans were quantitative and qualitatively analyzed. Results: Action plans included three major themes: (1) binding oral antidiabetic medication to time markers or the sleep/wake cycle; (2) in specific environments; (3) associated with daily life activities. The motivation for coping with the perceived barriers focused on placing the pills in visible places, asking for help from family members, establishing a routine and feeding properly. Conclusions: The most effective way to manage satisfactory oral antidiabetic medication adherence seems to be recognizing the perceived barriers by patients. The implementation of specific and individualized action and coping plans to overcome perceived barriers was the stark difference.

N/a.

Copyright of Saúde Coletiva is the property of MPM Comunicacao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Arterial hypertension (hypertension) is highly prevalent worldwide, constituting a serious health problem worldwide. Medidcation adherence is a major factor in the adequate control of blood pressure, in the prevention of associated complications and in the improvement of the quality of life of people with hypertension. The health professionals play a differentiating role in the context of this issue. This study aims to understand the factors that facilitate and hinder medicacion adherence, in people with hypertension. An integrative literature review was carried out, carried out on the databases: Complementary Index; Academic Search Complete and ScienceDirect, with articles indexed from January 1, 2018 to May 15, 2019, with MeSH descriptors. A free secondary search was also carried out, including documents of high scientific suitability. The results obtained include: 614 articles in the initial search of the databases and 21 articles in the complementary search, considering the inclusion criteria previously defined. Medication adherence is essential in the treatment of hypertension. There are several factors that can influence adherence. The nurse's intervention ispreponderant in the identification of conditioning factors or facilitate of adherence, in education, training of clients and or family members. [ABSTRACT FROM AUTHOR]

Abstract: Background: Actinic keratosis (AK) represents a risk of progression to squamous cell carcinoma. Ingenol mebutate gel is a novel therapeutic option for field-directed treatment. Objectives: To evaluate the safety, tolerability and patients' perspectives, related to the therapeutic success of managing AKs on the face and scalp with ingenol mebutate gel in Brazilian individuals. Methods: This was an observational, retrospective and descriptive study of 68 areas of actinic keratosis on the face and scalp treated with Ingenol mebutate gel involving a total of 37 patients. The drug was applied for three consecutive days on an area of of 25 cm2 and documentation was performed on baseline and days 4, 8, 15, 60 and 180. On day 4, the composite local skin reaction score was calculated. At the end, a questionnaire was applied to evaluate patients' perspectives about the treatment. Results: Adherence was 100%, no serious adverse events were recorded and the mean composite local skin reaction score (standard deviation) was 8.61±4.22. The treatment was considered optimum by 75.68% of the patients. Study limitations: Calculation of composite local skin reaction score performed only on the fourth day. Conclusions: Treatment with ingenol mebutate gel was considered safe and tolerable in Brazilian subjects. Patients had a maximum adherence rate and a great improvement in self-esteem. The results of this research reproduce the findings of the literature.

ABSTRACT Objective: To determine the factors associated with the high complexity of medication regimen in patients with coronary artery disease. Methods: A cross-sectional study was carried out in a multiprofessional cardiology outpatient clinic, in the Secondary Care of the Unified Health System, where sociodemographic (age, sex, and education), clinical (number of health conditions, cardiovascular diagnoses, and comorbidities) and pharmacotherapeutic (adherence, polypharmacy, and cardiovascular polypharmacy) characteristics were collected. These were related to complexity of medication regimen, measured through the medication regimen complexity index. The classification of high complexity of medication regimen was carried out using standardization for the older adults and stratification for adult patients, as suggested in the literature. Results: The total complexity medication regimen of 148 patients had a median of 17.0 (interquartile range of 10.5). In the univariate analysis, the factors associated with high complexity were heart failure, diabetes mellitus, hypertension, five or more diseases, and non-adherence to treatment. In the final model, after logistic regression, there was a statistically significant association (p

The study aimed to describe sociodemographic and clinical characteristics of eldery with mellitus diabetes and/or arterial hypertension in the District Health Strategy follow-up and its relation to therapy adherence. Cross-sectional study developed with 99 elderly with mellitus diabetes and/or arterial hypertension in drug treatment. Data collection occurred in District Health Strategies in a city in the Extreme West of Santa Catarina. A characterization questionnaire and Morisky's Therapeutic Adherence Scale were used. As for the characterization, most of the elderly were female, completed elementary school, received up to 2 minimun wage, considered their healthy eating and did not smoke. As for therapeutic adherence, 71 were adherent and 28 non adherent. Greater levels of therapeutic adherence to arterial hypertension and/or diabetes are related to having a formal study level, healthy eating and non-smokers and those who did not live with someone who smoked. [ABSTRACT FROM AUTHOR]

Copyright of Saúde Coletiva is the property of MPM Comunicacao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: to describe the perception of people with arterial hypertension of the aspects that facilitate and hinder treatment adherence. Method: descriptive qualitative study developed with 16 people met in Nursing consultations. Interviews were conducted with a semi-structured guide and the content analysis technique was used. Data were collected between January and August 2017. Results: having willpower, family and multidisciplinary support, knowledge about the pathology and forms of prevention and fear of death facilitated adherence; on the other hand, little knowledge, laziness, lack of urban infrastructure and climatic conditions, habit of consuming unhealthy foods, alcoholic beverages and tobacco, cost of treatment and forgetfulness of taking the medication hindered adherence. Conclusion: the treatment of hypertension causes changes in the dynamics of life, being essential to have willpower, family and professional support, in addition to overcoming unhealthy habits. [ABSTRACT FROM AUTHOR]

Copyright of Cogitare Enfermagem is the property of Cogitare Enfermagem and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Eletrônica de Enfermagem is the property of Revista Eletronica de Enfermagem and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract Objective: To analyze the association between adherence to antihypertensive treatment and frailty syndrome in hypertensive older adults. Method: A descriptive, cross-sectional study with a quantitative approach with older adults. The data collection took place between November 2017 and March 2018, evaluating sociodemographic information, adherence to antihypertensive treatment, lifestyle and frailty through the Edmonton Frail Scale. The Kruskal-Wallis test and the Chi-squared test were used for data analysis, considering a 95% confidence interval and a significance level of p

ABSTRACT Objective: To investigate the association between social support, adherence to HIV anti-retroviral therapy, and clinical and sociodemographic factors. Method: A cross-sectional study conducted from July 2016 to August 2018 in a specialized outpatient clinic in southern Brazil. Individual interviews were conducted for the application of the following instruments: Questionnaire for the Evaluation of Adherence to Anti-retroviral Treatment (CEAT-HIV) and Social Support Scale for People Living with HIV/AIDS. The Spearman bivariate correlation test was used for analysis purposes. Results: Among the 168 participants, the mean social support score was 3.53 points (SD = 0.66), and 64.9% (n = 109) of the respondents had insufficient adherence. There was a significant association (p < 0.05) between emotional social support and the following adherence domains: antecedents of non-adherence behaviors and doctor-patient communication. Conclusions: Social support is associated with antecedents of non-adherence behaviors and doctor-patient communication.

ABSTRACT Objectives: Describe the importance of guidelines provided during pharmaceutical consultation about compliance with medication therapy based on interviews with polymedicated elderly patients. Methods: A qualitative methodological study carried out during consultations with 40 elderly patients of both genders at the Health Care Center for Elderly Patients and Caregivers. The study used the technique of content analysis, applying a questionnaire with two open questions. Results: Two categories and eight subcategories emerged after the transcription of interviews and exhaustive reading of the data. The category “Pharmaceutical consultation as an education instrument for the self-care of polymedicated elderly patients” presented the highest frequency. The subcategory with the highest frequency was “Concern of elderly patients about self-care”. Final Considerations: In the case of polymedicated elderly patients, pharmaceutical consultation is an important education instrument which, through the provision of pharmaceutical guidelines, allows the minimization of concerns about pharmacotherapy, contributing to compliance and self-care.

Objective: to verify the association between the health-related quality of life of chronic renal patients on hemodialysis with sociodemographic, clinical, depression and medication adherence characteristics. Method: a cross-sectional study with 183 chronic renal patients undergoing hemodialysis in the state of Rio Grande do Sul, Brazil. A sociodemographic and clinical questionnaire, Kidney Disease and Quality of Life Short-Form, Beck Depression Inventory and Morisky Medication Adherence Scale - eight items were used. Among the variables, comorbidities, complications of kidney disease and intercurrences during and after hemodialysis were evaluated. The analysis was performed with descriptive and analytical statistics. Results: 55.2% of the patients were 60 years old or older, 35.0% were hypertensive, with regular quality of life, average of 62.61. Scores below average in the dimensions of quality of life were mainly associated with repetitive infections and edema as complications of the disease, pain during hemodialysis and weakness afterwards. Low drug adherence resulted in a worse quality of life, impacting ten of the 20 dimensions evaluated and depression in all, except for patient satisfaction. Conclusion: reduced quality of life in this population is associated with depressive symptoms, complications such as repetitive infections, pain and anemia, weakness after the dialysis session and low medication adherence. Actions aimed at changing these factors can promote well-being.

Objective: To assess adherence, adverse drug reaction and Sustained Virological Response (SVR) in the therapy for hepatitis C. This follow-up retrospective observational study was conducted in a specialized center for hepatitis treatment in Southern Brazil. Methods: This research included 257 patients under hepatitis C treatment with all‐oral direct‐acting antivirals in a clinical setting from March to August 2016. The data was obtained from medical records. Adherence was measured by medicines refill and Medication Possession Ratio. Results: Of the 253 patients evaluated, 8,7% had some problem with adherence to the treatment. No cases of treatment discontinuation due to adverse drug reaction was observed. However, 1433 adverse drug reactions were identified and classified as mild, with an average of 5,6 per patient. The most frequent reactions were headache (55,7%), asthenia (47,3%), altered appetite (41,9%), dry skin (37,2%), and nausea/vomiting (35,9%). The overall SVR rate was 90,9%. Other outcomes were no response to treatment (2,0%), relapsed (2,0%), dead (0,4%), dropout (0,4%) and lost to follow-up (4,3%). In the multivariate analysis, hepatitis C virus and human immunodeficiency virus co-infection and longer treatment time were associated with higher SVR (p = 0,028 and p = 0,020, respectively). Conclusion: The treatments evaluated have high response rate and were well tolerated by the patients. Adherence to treatment proved to be adequate and contributed to the results. The care offered in a specialized center provides the appropriate management of the patients’ needs, contributing thus to a successful therapy.

Abstract Objective: To evaluate the effectiveness of home visits in a group of children and adolescents with severe asthma by using the inhalation technique score and adherence rates to drug treatment. Method: A 12-month randomized controlled trial involving patients aged between three and 17 years under regular follow-up treatment at a pediatric pulmonology outpatient clinic of a university hospital in southeastern Brazil. A group of patients received only outpatient consultations and the other group received home visits from nurses in addition to outpatient consultations. The differences between groups were analyzed through the outcomes of inhalation technique scores and treatment adherence rate. Results: Participation of 29 patients. In the intervention group, there was a statistically significant increase in inhalation technique scores (p

Copyright of Revista de Atencao Primaria a Saude is the property of Revista de Atencao Primaria a Saude and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Currently, polypharmacy used in patients with chronic diseases and low adherence to therapy has been one of the serious problems faced in Brazil. The inadequacy of treatment interferes with disease control and, consequently, the quality of life, especially of seniors. This paper aims to verify the methods used to determine the medication adherenc. We chose the articles used in this study after the date of the insertion of federal law 13021/14. It was concluded that the most used questionnaires are: Haynes test; TMG; ARMS, BMQ(1), BMQ(2) and QAM-Q. Each method has negative and positive points, and in Brazil, BMQ(2) and TMG are constantly used by researchers. In contrast, there is no gold standard method; we believed that the concomitant use of assessment instruments provides greater precision in the results in assessments of adherence to drug treatment. [ABSTRACT FROM AUTHOR]

Copyright of Enfermagem Brasil is the property of Atlantica Editora and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ciencia, Cuidado e Saude is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Chronic obstructive pulmonary disease is a chronic condition that requires the engagement of our patients in lifestyle changes and pharmacological treatment. Although there are guidelines on many aspects of chronic obstructive pulmonary disease management, the challenge of engaging our patients persists. We propose a simple mnemonic that we hope will make it easier for patients and clinicians to achieve this goal together.