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Start Over Author "Kitagawa, M." Language portuguese
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1. [Therapeutic effect of benzonidazole in mice infected by Trypanosoma cruzi and immunodepressed by the combination cyclosporin and prednisone].

Author

Okumura M, Amato Neto V, Kitagawa MM, Takamatsu NK, Ishikawa PS, Iizuza FH, and Iriya K

Subjects
Animals, Chagas Disease immunology, Cyclosporins administration & dosage, Male, Mice, Prednisone administration & dosage, Chagas Disease drug therapy, Immunocompromised Host, Nitroimidazoles therapeutic use, Trypanocidal Agents therapeutic use
Abstract

Because the organ transplantation is currently involving patients with Chagas' disease, we evaluated the therapeutic activity of benzonidazole in mice immunosuppressed by cyclosporine and prednisone. The purpose was to obtain further knowledge regarding the infection with Trypanosoma cruzi when the immune system is depressed. It was verified that benzonidazole, at least in the conditions of the present study, decreased the severity of the parasitic component of the infection and of the inflammatory process; it has not protected the animals, that died at the same proportion in the treated and non-treated series.

Published
1990

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