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O regime jurídico das farmácias de oficina, previsto no Decreto-Lei n.º 307/2007, de 31 de agosto, consagrou a possibilidade de as farmácias prestarem serviços farmacêuticos de promoção da saúde e do bem-estar dos utentes. As farmácias, pelas suas características em termos de acessibilidade e distribuição geográfica, são espaços de saúde que podem contribuir para o aumento da cobertura vacinal da população com benefícios em termos de saúde pública. No presente artigo faz-se o enquadramento internacional e nacional da implementação do serviço de vacinação das farmácias e seus resultados, bem como reflexões sobre o reforço do papel da farmácia e o seu contributo para promover o alinhamento entre a intervenção de proximidade e a qualidade das farmácias com os objetivos nacionais de cobertura vacinal e de saúde pública. Publicado em: Rev Port Farmacoter. 2015; 7: 160-6.

Acanthamoeba is a free-living protozoan widely distributed in the environment, occurring in vegetative trophozoite and resistance cyst stages during its life cycle. It constitutes an etiological agent of Acanthamoeba keratitis, a disease that may cause severe ocular inflammation and blindness. New drugs can be developed from molecules found in plants and thus help in its difficult treatment. Acanthospermum australe (Asteraceae), a plant used in folk medicine, had its effect tested on Acanthamoeba polyphaga. Aqueous and ethanolic extracts of A. austral were obtained from aerial parts for infusion and static maceration, respectively. Concentrations of 10, 5, 2.5, 1.25 and 0.625 mg/ml of the extract were tested against Acanthamoeba polyphaga trophozoites. The cytotoxic effect of the extracts was tested in mammalian cells using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. RESULTS: The 10 mg/ml concentration of ethanolic extract was lethal to 100% of the A. polyphaga trophozoites in 24 h and both extracts presented cytotoxic effect against mammalian cells. These findings suggest that the A. austral ethanolic extract may have compounds with relevance to the development of new amoebicidal drugs.

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