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Resumo Fundamento A Terapia Antiplaquetária Dupla (DAPT, do inglês dual antiplatelet therapy) é o tratamento de escolha para pacientes com síndromes coronarianas agudas e crônicas, uma vez que ela reduz mortalidade e previne complicações trombóticas recorrentes. A avaliação da carga isquêmica e do risco de sangramento é crucial na escolha da DAPT e de sua duração. Objetivos O objetivo de nosso estudo foi conduzir um acompanhamento clínico prospectivo de pacientes recebendo terapia combinada (AAS 75mg + clopidogrel 75 mg). Nosso estudo é um estudo multicêntrico, transversal, observacional, do tipo coorte. Métodos Foram incluídos 1500 pacientes que iniciaram DAPT combinada para o tratamento de síndrome coronariana aguda ou síndrome coronariana crônica. Os desfechos primários foram internação hospitalar por qualquer motivo, internação por causa cardiovascular, infarto agudo do miocárdio, trombose de stent, revascularização de vaso alvo e sangramento; os desfechos secundários foram morte por qualquer razão ou por causa cardiovascular e acidente vascular cerebral. O nível de significância adotado na análise estatística foi 5%. Resultados A idade mediana foi 63 anos; 78,5% dos pacientes estavam recebendo DAPT por síndrome coronariana aguda. As taxas de internação por causas cardiovasculares, de infarto agudo do miocárdio, de trombose de stent e de revascularização de vaso alvo foram 7,9%, 2,3%, 1,3% e 4,2%, respectivamente. Enquanto a taxa de sangramento segundo a escala BARC tipo 1 foi de 3,3%, a taxa de sangramento BARC tipo 5, 3, ou 2 foi 0,6%. As taxas dos desfechos secundários morte por qualquer razão, morte por causa cardiovascular e acidente vascular cerebral foram 0,5%, 0,3% e 0,3%, respectivamente. Conclusão Nosso estudo mostrou que a DAPT em regime combinado de doses fixas de AAS e clopidogrel é eficaz e seguro em pacientes com síndrome coronariana aguda ou crônica adequadamente selecionados.

A educação escolar quilombola e indígena no decorrer da história da educação no Brasil sempre esteve vinculada a uma realidade de precariedade, empobrecimento, negação do respeito ao direito de suas especificidades e particularidades. No século XX, a partir dos princípios trazidos na Constituição Federal de 1988, relacionados a educação escolar, vislumbra-se possibilidades para a instalação de maior investimento, respeito as especificidades, construção de propostas pedagógicas que dialoguem com a realidade dos povos indígenas e quilombolas. A partir daí se cria um elenco de políticas educacionais específicas nessa direção - diretrizes curriculares são aprovadas, surgem financiamentos para investimento nas escolas indígenas e quilombolas, formação de professores e professoras, há a consideração da educação intercultural, e em algumas cidades melhorias nas infraestruturas das escolas, dentre outras conquistas.

O artigo tem como proposta discutir como as políticas públicas de financiamento educacionais no Brasil, em especial o Programa Dinheiro Direto na Escola (PDDE), do Fundo Nacional de Educação (FNDE), tem exercitado a equidade em seus Programas, visando a melhoria da qualidade da Educação Escolar Quilombola. Objetivamos refletir sobre como o PDDE tem contribuído para a consolidação de uma educação mais plural e cidadã. É perceptível o esforço das políticas de financiamento educacional, em especial a do PDDE, em possibilitar a consolidação de uma gestão escolar democrática e equânime, porém, é necessário um aprimoramento da sua legislação para que atenda as especificidades das comunidades a serem atendidas pela Política. Ressalta-se que um exercício de mudança tem sido praticado, a fim de garantir a valorização dos pertencimentos e das identidades étnico e racial no contexto de uma política pública de financiamento da educação tão duradoura como é o PDDE.

With the proliferation of research in recent decades, pronunciation has ceased to be the “Cinderella” of language teaching. However, there are still gaps between research findings and classroom implementations (Olson, 2014). To this end, this classroom-based, experimental study explored pronunciation knowledge, perception, and production among first-year Turkish EFL teacher trainees in the context of a sixteen-week-long undergraduate course. Data were collected through three diagnostic tests. In this regard, eighty participants were pretested before and post-tested after the course. The collected data were examined descriptively and inferentially via the IBM SPPS Version 25. Findings indicated dissimilar levels of rise in knowledge (modest), perception (slight), and production (substantial) performances of teacher trainees. Nevertheless, specific gaps in knowledge and problems with segmental and suprasegmental pronunciation features remained. Results were discussed, pedagogical implications were thoroughly assessed, limitations to the study were recognized, and recommendations for future research were made.

Rapid advancements in artificial intelligence (AI) have the potential to be revolutionary, but they have also sparked questions about power relations and socioeconomic inequalities that are reminiscent of previous colonial practices. The risk of “techno-neocolonialism,” a phrase used to characterize the potential for dominance and exploitation analogous to historical colonial practices, is juxtaposed with the possibility of unprecedented technological advancements. This paper examines the idea of techno-neocolonialism as a modern form of dominance and exploitation, emphasizing how the AI revolution runs the risk of sustaining these practices in a globalized environment. Through an analysis of vital AI enablers like talent, data, infrastructure, and computing power, we contend that the advantages of AI are frequently centered in rich countries, marginalizing the Global South. The paper goes on to stress how important it is that cooperative frameworks give equity, respect for one another, and ethical issues top priority while developing AI. This study, which ends with a plea for fair collaborations, seeks to show the way toward a more inclusive AI ecosystem that actually empowers all parties involved while avoiding the exploitation traps that come with techno-neocolonial partnerships.

Introdução O Ministério da Saúde, MS, vem adquirindo inovações promissoras e controvertidas e as testando mediante estudos controlados em polos de referência da Rede SUS. Apresenta-se o exemplo da aquisição de um robô cirúrgico visando avaliar segurança, efetividade e sua relação de custo-efetividade em um UNACON. Métodos Estudo controlado randomizado por blocos conforme os tipos de cirurgia de câncer contratualizados pelo MS nas especialidades de gastroenterologia, ginecologia, cirurgias de cabeça e pescoço, urologia e pneumologia. Casuística: portadores de neoplasias com indicação cirúrgica e elegíveis para as três técnicas cirúrgicas em estudo, i.e., cirurgia aberta, videolaparoscopia e videolaparoscopia robótica, informados e concordaram com o protocolo assinando o TCLE, foram randomizados. O protocolo delineado (NCT02292914/ ClinicalTrials.gov) foi executado segundo as Diretrizes Metodológicas/Avaliação Econômica do MS, com micro-custeio operacional. Os custos de treinamento, de aquisição de capital, de manutenção etc. e custos indiretos, foram excluídos. Instrumentos validados foram usados para comparar benefícios funcionais e qualidade de vida por 36 a 60 meses. Resultados Oito cirurgias de câncer foram avaliadas em 783 pacientes randomizados, (4 de gastroenterologia, 1 ginecologia, 1 de cabeça e pescoço, 1 urologia, e 1 pneumologia) nos 3 Grupos: Robô (n = 421), Videolaparoscopia (n = 173) e Convencional-Aberta (n = 189), Idade Média±DP de 62±9 anos e IMC 27,6±5,4 kg/m2, no ICESP/HCFMUSP entre 2014 e 2021, com impacto da pandemia COVID no seguimento. A distribuição absoluta dos custos dos controles (laparoscópicos, exceto prostatectomias vs. cirurgia aberta) e das diferenças médias incrementais pela robótica e desvios de dias de internação no período pós-operatório e de custos totais foi de Esofagectomias (R*n=21) -3,6 dias de internação e incremento de R$ 15.691,08± R$ 4.252,56 comparado aos 22/lap internados por 20,3±7,4 dias e custo de R$ 50.998,44± R$ 14.601,45; Gastrectomias (*n=20) -0,2 dias e incremento de R$ 14.644,03± R$ 1.758,44 vs. 24/ lap com 11,5±4,1 dias e custaram R$ 22.303,28± R$ 5.526,34; Reto (*n=24) -1,1 dias e mais R$ 7.642,08± R$ 1.959,34 vs. 24/lap com 10,0±2,5 e custo R$ 24.997,87± R$ 5.296,93; Pancreatectomias (*n=29) com 7,8±1,2 dias de internação e custaram R$ 23.901,79± R$ 3.785,65 sem controles; Histerectomias (R*n=43) com +0,1 dia adicionou R$ 9.141,37± R$ 744,27 vs. 42/lap com 3,3±1,3 dias e custo de R$ 22.025,58± R$ 10.054,45; Cabeça & Pescoço (*n=36) -2,5 e incrementou R$ 1.631,66± R$ 1.530,95 vs. 55/videolap com 7,3±5,4 dias e custo R$ 18.463,00± R$ 8.872,60; Prostatectomias (*n=169) -0,7 dias e mais R$ 9.660,99± R$ 3.305,69 que as 167/abertas com 3,7±0,9 dias e custo de R$ 8.989,73± R$ 1.909,38; e, Lobectomias pulmonares (R*n=43) -0,3 dia economizaram -R$ 420,60± R$ 2.602,66 vs. 40/lap que permaneceram 6,0±3,1 dias e custaram R$ 34.103,60± R$ 2.112,03, respectivamente. Não houve complicações maiores ou mortalidade relacionadas às cirurgias nos braços estudados. A qualidade de vida e escores funcionais tenderam a ser melhores até 12 meses e foram similares no seguimento extendido. Discussão e conclusões Embora com ganhos estruturais, trabalhistas, ensino e pesquisa, este estudo corroborou a controvérsia internacional sobre os modestos benefícios da robótica no local para os pacientes. Atualmente, o custo de materiais descartáveis e monopólio da empresa o tornam pouco sustentáveis no SUS.

The progressive increase in HIV infection among older adults requires constant research and monitoring, given that geriatric syndromes associated with HIV comorbidities have become an important public health problem. We reported this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and it has a central question: Is the incidence of cognitive impairment higher in older patients living with HIV than in their seronegative peers? The following databases were searched for this review: MEDLINE/PubMed, EMBASE, LILACS, Web of Science, and Scopus. The inclusion criteria were studies whose samples were ≥ 50% patients aged ≥ 50 years, with and without HIV, and a main outcome related to the incidence of cognitive impairment. Only cohort studies with follow-up lasting ≥ 24 months were considered. Three reviewers independently screened the documents for eligibility criteria, extracted the data, assessed the risk of bias (Newcastle-Ottawa Scale), and evaluated the quality of evidence. A narrative synthesis was prepared. In total, 10 798 trials were screened, 8884 were excluded, 14 were analyzed, and 5 were included in this review. Only 1 applied cognitive assessment tests; the rest used secondary data from the medical records. Most found that the incidence of cognitive disorders was higher among older people living with HIV, which highlights the need for public policies aimed at primary and secondary prevention strategies. Further research from other countries is still required. PROSPERO register (CRD42022321914).

Procura-se demonstrar neste estudo que há formas de silêncio e de vazio presentes em Uma Menina Está Perdida no seu Século à Procura do Pai, de Gonçalo M. Tavares, que podem ‘solucionar’ a crise da palavra e dizer o indizível. Para a consecução deste estudo, elege-se o encontro de Marius com Moebius e, a partir da leitura e análise dessa passagem, inicia-se um diálogo com as teorizações de Lauro José Siqueira Baldini (2017), Santiago Kovadloff (2003, 2014), David Le Breton (1999, 2013), Renato Lessa (2014), e George Steiner (1988), entre outros autores, para tentar compreender como o vazio nesse romance possibilita dizer o indizível.

Abstract This research aimed to estimate the shelf-life of smoked shark catfish coated with chitosan and red galangal extract and packed with aluminum foil using the acceleration method. The prediction of the smoked catfish shelf-life was carried out by storing the smoked catfish at temperatures of 35, 45, and 55 °C for 30 days. The parameters observed during storage were color, sensory score of rancidity, and thiobarbituric acid (TBA) value. Data were analyzed using linear regression, and the equations obtained were used to calculate the shelf-life of smoked catfish at 30 °C. The color values of L*, a*, and b* of the smoked catfish coated with chitosan decreased faster, and the shelf-life was shorter than that of the smoked catfish coated with chitosan and red galangal extract. The shelf-life and activation energy of smoked catfish coated with chitosan at 30 °C were 29.63 days and 2873.146 cal/mol, while the smoked catfish coated with chitosan and red galangal extract were 38.52 days and 3380.371 cal/mol, respectively.

Resumo Fundamento: A análise de indicadores como taxa de readmissão hospitalar é crucial para aprimorar a qualidade dos serviços e gestão em processos hospitalares. Objetivo: Identificar as variáveis correlacionadas a readmissão hospitalar até 30 dias após cirurgia de revascularização miocárdica (CRM). Métodos: Estudo de coorte transversal no banco de dados Registro Paulista de Cirurgia Cardiovascular II (REPLICCAR II)(N=3.392), de junho de 2017 a junho de 2019. Avaliaram-se retrospectivamente 150 pacientes para identificar os fatores correlacionados a readmissão hospitalar até 30 dias após-CRM via regressão logística univariada e multivariada. As análises foram realizadas no software R, com significância de 0,05 e intervalos de confiança de 95%. Resultados: Cento e cinquenta pacientes foram readmitidos até 30 dias após a alta hospitalar de CRM (150/3.392, 4,42%) principalmente por infecções (mediastinite, ferida operatória e sepse) totalizando 52 casos (52/150, 34,66%), outras causas foram: complicações cirúrgicas (14/150, 9,33%) e pneumonia (13/150, 8,66%). Os preditores de readmissão identificados foram: O modelo de regressão multivariada apontou intercepto (OR: 1,098, p

ABSTRACT Fish, like all other species, can be impacted by a variety of environmental conditions, including parasitic infections. Although there are several parasitological researche on ectoparasitic monogeneans, few are published on those that infect sparid fish. Forty samples of Acanthopagrus bifasciatus were collected during this study from coastal regions along the Arabian Gulf (Saudi Arabia). Gills from all fish were isolated and examined to identify monogeneans. The parasites were studied morphologically using light microscopy. Overall prevalence and mean intensity were 20% and 9, respectively. Eight out of 40 (20%) fish samples were found to be naturally infected with a monogenetic species, namely, Bivagina pagrosomi (Murray, 1931) Dillon and Hargis, 1965 belonging to Microcotylidae (order Mazocraeidea). This parasite is characterized by the presence of haptor provided 43-47 clamps of microcotylid-type that deeply penetrated the gill lamellae and caused severe pathological impacts including hyperplasia, telangiectasis, and deformity of the respiratory epithelial cells Our finding indicates that this is the first report of A. bifasciatus being infected with B. pagrosomi from Saudi marine waters as well as the research of its deleterious effects on its host gills. More research is needed to confirm the parasite species’ taxonomic status at the molecular level.

ABSTRACT Among marine creatures including squids, cephalopods and Octopus, one of the most unique features is production of ink which is an extremely valuable source of pharmaceuticals. The current study investigates the ink produced from Octopus vulgaris chemically as well as its potential antioxidant, anticancer, antimicrobial, and anti-schistosomal activities in vitro. Twenty-one different compounds were identified by GC-MS analysis of Octopus vulgaris ink. Results revealed that O. vulgaris ink had antioxidant capability to cover DPPH free radical when compared to ascorbic acid. Moreover, Octopus vulgaris ink exhibited antibacterial activity against Bacillus subtilis followed by Escherichia coli and Pseudomonas aeuroginosa and exhibited a molluscicidal activity against adult Biomphalaria alexandrina snails and had a distinguished mortal effect on free larval phases of Schistosoma mansoni. Furthermore, its anticancer activity was confirmed, where IC50 value of breast cancer cell line MCF-7, human hepatocellular carcinoma (HCT) and human liver cancer cell line (HepG2) were 29.8, 38.29 and 30.38μg/mL, respectively. In conclusion, ink extracted from O. vulgaris may be considered as source of valuable compounds that can be used as molluscicidal, antioxidant, antimicrobial, anticancer and anti-schistosomal agents.

In this research paper, we introduce some concepts of λf-density in connection with modulus functions under certain conditions. Furthermore, we establish some relations between the sets of λf-statistically convergent and λf-statistically bounded sequences.

ABSTRACTS This study was carried out to investigate the effects of adding artichoke vinegar to the drinking water of broilers on their fattening performance and carcass characteristics. In the experiment, 204-day old broiler chickens were used, and the study was continued for 42 days. In the study, 4 different groups were formed, one of which was the control group, and the other 3 were different doses of vinegar (0.5%, 1.0 and 1.5). The experiment was carried out in 3 replications and 17 birds were included in each replication. During the fattening period, the live weight, feed consumption, vinegar water consumption and slaughter weight of the chickens were measured. After slaughter, characteristics such as hot carcass weight, hot carcass yield, internal organ weights and abdominal fat weights were determined. According to the results obtained, in the 0-6 weeks period, the daily average live weight gain, daily average feed intake, total feed intake, feed conversion ratio, average daily water intake and total water intake of the broilers were significantly higher than the values obtained in the treatments with vinegar (P

ABSTRACT Objective: To determine the role of the IL8 rs4073 polymorphism in predicting the risk of central nervous system (CNS) toxicity in patients receiving standard pharmacological treatment for multidrug-resistant tuberculosis (MDR-TB). Methods: A cohort of 85 consenting MDR-TB patients receiving treatment with second-line antituberculosis drugs had their blood samples amplified for the IL8 (rs4073) gene and genotyped. All patients were clinically screened for evidence of treatment toxicity and categorized accordingly. Crude and adjusted associations were assessed. Results: The chief complaints fell into the following categories: CNS toxicity; gastrointestinal toxicity; skin toxicity; and eye and ear toxicities. Symptoms of gastrointestinal toxicity were reported by 59% of the patients, and symptoms of CNS toxicity were reported by 42.7%. With regard to the genotypes of IL8 (rs4073), the following were identified: AA, in 64 of the study participants; AT, in 7; and TT, in 11. A significant association was found between the dominant model of inheritance and CNS toxicity for the crude model (p = 0.024; OR = 3.57; 95% CI, 1.18-10.76) and the adjusted model (p = 0.031; OR = 3.92; 95% CI, 1.13-13.58). The AT+TT genotype of IL8 (rs4073) showed a 3.92 times increased risk of CNS toxicity when compared with the AA genotype. Conclusions: The AT+TT genotype has a tendency to be associated with an increased risk of adverse clinical features during MDR-TB treatment.

This paper aims to study the role of institutional quality on agri-food trade (import and export) between China and 48 African countries during the 2001-2021 period. The gravity model of trade was employed by estimating the Generalised Least Square (GLS) and the Poisson Pseudo-Maximum Likelihood (PPML) estimators, which include zero trade flows for panel data. The main results show that voice and accountability, control of corruption, and the rule of law all enhance agri-food trade flows. While political instability encourages agri-food exports to China. In addition, the economic size of China, the trade cost (distance), and the population of African countries also encourage agri-food trade between China and African economies. Moreover, access to the sea, exchange rate policy, and the economic size of African nations deplete China’s agri-food imports from Africa. We showed the mechanism through which each institutional variable affects China’s agri-food trade flows to African nations.

Introdução: Os antimicrobianos são frequentemente prescritos em ambientes hospitalares como terapia essencial. No entanto, o seu uso inadequado pode desencadear a resistência antimicrobiana (RAM), aumentando o risco de doenças potencialmente fatais. Objetivo: Analisar o padrão de uso de antimicrobianos nos serviços de internamento do Hospital Provincial de Tete. Métodos: Trata-se de uma pesquisa retrospetiva e de coorte transversal com abordagem quantitativa conduzida em cinco serviços de internamento de Cirurgia I, Medicina I e II, Ortopedia e Pediatria, durante o mês de maio de 2023. A seleção da amostra foi realizada por meio de técnica probabilística aleatória. Os dados foram coletados e inseridos no software estatístico Microsoft Excel. Em seguida, foram analisados utilizando o SPSS versão 27 para Windows, com aplicação de análises descritivas. Resultados: Foram analisados 300 processos clínicos que continham pelo menos um antimicrobiano, totalizando 591 antimicrobianos prescritos. Predominantemente, os antimicrobianos foram administrados por via endovenosa (89,0%), sendo as penicilinas (41,5%), a classe mais prescrita, seguido de aminoglicosídeos (12,4%) e cefalosporinas (10,3%). Cerca de 2,3% prescrições continham um erro na dosagem. Conclusão: Os resultados destacam a necessidade de implementar programas abrangentes de sensibilização sobre a utilização de antibióticos e a resistência antimicrobiana entre os profissionais de saúde do hospital.

Recursos didáticos são ferramentas auxiliares na prática docente, estimulando a aprendizagem e promovendo a superação de fenômenos como a impercepção botânica. O objetivo deste trabalho foi relatar a implementação de quatro tipos de coleções em um campus do IFS: herbário, jardim didático, lâminas de histologia vegetal e modelos didáticos. Para isso, foram realizadas pesquisas em literatura especializada; seleção de plantas para o jardim didático e para as lâminas de histologia; e seleção de estruturas vegetais para os modelos didáticos. Para a confecção do herbário, foram realizadas coletas de plantas e montagem de exsicatas em parceria com outra instituição federal. O herbário possui 56 exsicatas; o jardim didático, 26 espécimes da flora regional; a coleção de lâminas conta com 50 peças; e a coleção de modelos, seis estruturas vegetais. Espera-se que a utilização destas coleções contribua para uma aprendizagem condizente com a formação de cidadãos conscientes do seu papel junto à natureza.

ABSTRACT Cadmium (Cd) is an environmental pollutant affecting various tissues and organs, including the testis. Many studies demonstrated that Cd toxicity causes testicular impairment through oxidative stress and inflammatory action. Therefore, this study aimed to demonstrate Cd's testicular toxicity and the protective action of zeolite against cadmium's deleterious effects. Adult male rats were given Cd at a dose of 30mg/kg/day for 28 consecutive days with or without zeolite, which was given at a dose of 100mg/kg/day for 28 days. Testis weight, sperm (count, motility, and abnormalities), serum testosterone and luteinizing hormone (LH), testicular enzymes Acid phosphatase (ACP) and Alkaline phosphatase(ALP), inflammatory cytokines Tumor Necrosis Factor Alpha (TNF-α) , interleukin-1beta (IL-1β) , and Nuclear Factor Kappa B (NF-κB) and oxidative stress were evaluated. Herein, we found that cadmium caused alterations in sperm characteristics, sex hormone disturbance, decline in testicular enzymes, elevated malondialdehyde (MDA) contents, decreased glutathione (GSH), increased Nuclear Factor Kappa B (NF-κB) and pro-inflammatory cytokines Tumor Necrosis Factor Alpha (TNF-α) and interleukin-1beta (IL-1β) levels in testis homogenate. In contrast, zeolite significantly amended these deleterious effects, and the potential mechanism involved the downregulation of Nuclear Factor Kappa B (NF-κB), Tumor Necrosis Factor Alpha (TNF-α) and interleukin-1beta (IL-1β), restoring glutathione (GSH) and reducing malondialdehyde (MDA). Also, zeolite was associated with an increased rate of pregnancy. Our data suggested that oxidative stress and inflammation are responsible for Cd-induced testicular injury and co-administration of zeolite exerts a protective effect via NF-κB /TNF-α/IL-1β pathway.

Abstract The article discusses Mearsheimer’s interpretation of Russia’s use of force against Ukraine based on concepts and categories of Offensive Realism. It is argued that external balancing lost its place during unipolarity. However, Russian internal balancing is one of the factors that enabled the current conflict, and Russia’s rapprochement with China diminishes the prospects for conflict in Asia, allowing Russian military efforts to be concentrated in the European theater. Additionally, the decision to use force will be analyzed in its strategic dimension. It is concluded that Russia’s activities against Ukraine are entirely consistent with Offensive Realism, despite of Mearsheimer’s allegations contrarywise.

In the present paper, we study $p(x)-$biharmonic problem involving $q(x)-$Hardy type potential with no-flux boundary condition. By using the mountain pass type theorem and Ekeland variatoinal principle, we obtain at least two nontrivial weak solutions.

In this paper, we investigate the existence and uniqueness of solutions for fuzzy boundary value problems involving fuzzy Caputo fractional derivatives of order q 2 (2, 3). As a preliminary step, we construct a generic structure of the solution associated with our proposed model by utilizing the Green’s function. We establish the existence of a unique solution of the proposed model paired with the given initial conditions by using Banach fixed point theorem. At last, as application, an illustrative example is given to show the applicability of our theoritical results.

Recorrendo a uma escrita seca e fragmentária, Gonçalo M. Tavares, em Uma menina está perdida no seu século à procura do pai, combina palavras com outros códigos simbólicos (números, pontos, traços) e, no vão entre essas ligações raras, faz com que o silêncio e o vazio, e de modo especial, formas de “silêncio do vazio” expressem o indizível e o inefável. Essa presença confirma o esforço de recriação da escrita literária nesse contexto de crise e de desumanização da linguagem. A partir do encontro das personagens protagonistas desse romance com Agam Josh, o artista, discu­te-se a possibilidade do “silêncio do vazio” poder oferecer resistência ao eco das palavras e à superficialidade do quotidiano ao dizer o indizível. Para tanto, as referências amparam-se em Paz (2012), Tofalini (2020) e nos escritos de Gonçalo M. Tavares.

La rhizosphère est très importante pour la croissance et les rendements des cultures et peut être affectée par des facteurs comme les pratiques agricoles ou les fertilisants. L’effet du type de fumure organique sur la densité des spores mycorhizogènes dans la rhizosphère de la tomate et sur les paramètres agronomiques a été évalué dans la zone de Saguiya (Niger). Le dispositif expérimental mis en œuvre comporte 48 parcelles traitées avec trois types de fumure organique (bouse de vache, bouse de chèvre et fumure de volaille) à trois niveaux de fertilisation (100%, 125% et 150%) en quatre replicats, pendant une campagne de trois mois. La variété de tomate exotique Tropimech a été cultivée avec suivi des paramètres agronomiques, et des échantillons du sol ont été prélevés pour l’extraction et le dénombrement des spores de champignons mycorhiziens arbusculaires (CMA). Le traitement T3 de l’essai 3 (soit 150% de la fiente de volaille plus matière organique) est le plus efficace parmi les traitements, avec 38 t ha-1 pour le rendement en fruits, 13 t ha-1 de rendement pour la partie foliaire et 6 t ha-1 pour la partie racinaire. Les principaux genres de spores CMA trouvés sont des Glomus sp, Gigaspora sp et Scutellospora sp. La densité de Scutelospora sp est aussi plus élevée pour le traitement avec fiente de volaille, avec une forte corrélation positive entre la densité des spores et les paramètres agronomiques. Les résultats ont montré que les fumures, en particulier la fiente de volaille, améliorent la fertilité du sol de cette région ainsi que la densité des spores CMA.

ABSTRACT Cystic echinococcosis (CE) is a parasite-borne disease caused by the larval stage of Echinococcus granulosus belonging to family Taeniidae, is an endemic disease, distributed worldwide as a neglected parasite with socioeconomic repercussions. It causes severe alterations in liver of infected host, and it could be fatal if untreated. The main objective of the present study is to measure and evaluate the condition of hydatidosis in slaughtered sheep in Al Baha region, Saudi Arabia. A total of 601 slaughtered sheep in Al Baha abattoirs were examined for hydatidosis during the year 2020. Various organs were examined for the presence of parasite cysts, and the cyst contents were examined by light microscopy. Also, liver sections infected with cysts were examined for pathological alterations and host-parasite interactions. Forty-two animals were infected (6.09%) with the highest prevalence during summer. During gross examination, it was observed that the sheep liver is the most affected organ by the disease. The liver contained multiple cysts with varying sizes, filled with clear to slightly turbid fluid containing protoscoleces. Detailed sections of the infected liver revealed significant fibrosis around the central vein, portal vein congestion, infiltration of inflammatory cells, and necrosis. Sections through hydatid cysts showed the presence of three surrounding layers with a laminar membrane bordering the cyst lined by a germinal epithelium surrounding several brood capsules with many protoscolesces inside supported by a set of rostellar hooklets. Considerable efforts should be spent to control the transmission of parasitic cysts and inhibit the incorrect disposal of infected meat from slaughterhouses. Also, more focus should be done on epidemiological and control programs of these parasites.

ABSTRACT The present work aims to evaluate anticancer performance of Cassia alata methanolic leaf extracts (CMLE) in ethyl carbamate-stimulated lung adenocarcinoma (LAD) in differentiation to the function of Cisplatin (CIPL). Rats were divided into four groups: (1) control (CONT), (2) lung-adenocarcinoma (LAD) injected intra-peritoneally with 1g/kg ethyl carbamate once weekly for a month, (3) LAD+CMLE administered 500 mg/kg CMLE orally for the last two months of the experiment, and (4) LAD+CIPL treated group, injected 2.5 mg/kg Cisplatin intraperitoneally once weekly for the last two months of the experiment. Light and electron microscopic examinations revealed adenocarcinoma development in terminal bronchiole besides some histopathological changes in the LAD group such as atypical, exaggerated collagen fibers, increment of mucinous content, and increasing of PCNA positive immunoreactivity whereas electron microscopy investigation exposed that papillary adenocarcinoma originated from Clara cells in the LAD group. The LAD+CMLE treated group showed no tumor masses and nearly all with normal lung histology. It also recovered the normal ultrastructure of bronchiolar Clara cells. CMLE treatment offers a new alternative cure with less toxicity than Cisplatin for lung cancer therapy. Hence, CMLE would be employed as a novel supply of anti-cancer compounds combating lung cancer.

Resumo Fundamento: A isquemia com artéria coronária não obstrutiva (INOCA) é uma doença cardíaca isquêmica que inclui principalmente disfunção microvascular coronariana e/ou vasoespasmo coronariano epicárdico devido à disfunção vascular coronariana subjacente e pode ser observada mais comumente em pacientes do sexo feminino. O índice de inflamação imunológica sistêmica (SII, relação plaquetas × neutrófilos/linfócitos) é um novo marcador que prediz resultados clínicos adversos na doença arterial coronariana (DAC). Objetivo: Este estudo tem como objetivo investigar a relação entre INOCA e SII, um novo marcador associado à inflamação. Métodos: Um total de 424 pacientes (212 pacientes com INOCA e 212 controles normais) foram incluídos no estudo. Amostras de sangue venoso periférico foram recebidas de toda a população do estudo antes da angiografia coronária para medir o SII e outros parâmetros hematológicos. Em nosso estudo o valor de p

Resumo Fundamento: O no-reflow (NR) é caracterizado por uma redução aguda no fluxo coronário que não é acompanhada por espasmo coronário, trombose ou dissecção. O índice prognóstico inflamatório (IPI) é um novo marcador que foi relatado como tendo um papel prognóstico em pacientes com câncer e é calculado pela razão neutrófilos/linfócitos (NLR) multiplicada pela razão proteína C reativa/albumina. Objetivo: Nosso objetivo foi investigar a relação entre IPI e NR em pacientes com infarto do miocárdio com supradesnivelamento do segmento ST (IAMCSST) submetidos a intervenção coronária percutânea primária (ICPp). Métodos: Um total de 1.541 pacientes foram incluídos neste estudo (178 com NR e 1.363 com refluxo). A regressão penalizada LASSO (Least Absolute Shrinkage and Select Operator) foi usada para seleção de variáveis. Foi criado um nomograma baseado no IPI para detecção do risco de desenvolvimento de NR. A validação interna com reamostragem Bootstrap foi utilizada para reprodutibilidade do modelo. Um valor de p bilateral

The ergogenecity of caffeine (CAF) and pre-exercise music have been studied extensively in male and mixed-gender groups, but there is limited information on their synergistic effects in females. This study assessed the effects of combining a low dose of CAF with warm-up music on taekwondo specific performance, perceived exertion (RPE), and psychological aspects in female athletes. In a double-blinded, randomized, placebo-controlled crossover study, 16 female taekwondo athletes (M ± SD; age: 17.69 ± 0.60 years) performed the taekwondo-specific agility test (TSAT), 10 s frequency speed of kick test (FSKT-10s) and its multiple version (FSKT-mult) under the following conditions: 1) no supplement with music (NS+M); 2) no supplement without music (control); 3) CAF without music (CAF+NM), 4) placebo without music (PL+NM), 5) CAF with music (CAF+M), 6) PL with music (PL+M). After each test, athletes rated their RPE, feeling scale (FS), felt arousal scale (FAS) and physical enjoyment (PACES). CAF+M induced better physical performance than other conditions on the FSKT-10s, FSKT-mult, and more desirable psychophysiological responses including RPE post_TSAT, RPE post_FSKT-10s, PACES post_FSKT-10s, FS, FAS post_warm-up, FAS post_FSKT-10s and FAS post_FSKT-mult (all p < 0.05). Except for PL+M, CAF+M also elicited more desirable responses than other conditions for FAS post_TSAT (p < 0.05). Furthermore, CAF+M and CAF+NM conditions enhanced TSAT, PACES post_TSAT, RPE post_FSKT-mult greater than the other conditions (p < 0.05). Preceding warm-up music stimulus with a low dose of CAF may be a more efficient strategy to enhance physical performance and affective valence in female taekwondo athletes compared with using either strategy in isolation.

Workplace bullying has consistently been observed to have negative impacts on employee well-being by researchers. In the field of bullying research, there hasn't been a study that integrates mediators and explains the nexus between the many different factors that have been studied. Therefore, this study aimed to determine the impact of bullying on workers' performance at hotels in North Cyprus and the mediating role played by emotional intelligence and psychological resilience. Data were randomly collected from 442 hotel employees, including those from five- and four-star hotels on the island. The data were analysed using descriptive analysis. Furthermore, the heuristic model was tested using partial least squares structural equation modelling (PLS-SEM). According to the results, workplace bullying significantly and negatively influences an employee's performance. Secondly, emotional intelligence and psychological resilience positively mediated the relationship between bullying and performance among TRNC hotel employees. More cross-cultural and longitudinal research is needed to determine if these mediators have an enduring effect over time and across different cultures.

Abstract Objective It was aimed to compare visceral adiposity index (VAI) levels in patients with normal bone mineral density (BMD), osteopenia, and osteoporosis. Methods One hundred twenty postmenopausal women (40 with normal BMD, 40 with osteopenia, and 40 with osteoporosis) between the ages of 50 to 70 years were included in the study. For females, the VAI was calculated using the formula (waist circumference [WC]/[36.58 + (1.89 x body mass index (BMI))]) x (1.52/High-density lipoprotein [HDL]-cholesterol [mmol/L]) x (triglyceride [TG]/0.81 [mmol/L]). Results The time of menopause from the beginning was similar in all groups. Waist circumference was found to be higher in those with normal BMD than in the osteopenic and osteoporotic groups (p = 0.018 and p < 0.001, respectively), and it was also higher in the osteopenic group than in the osteoporotic group (p = 0.003). Height and body weight, BMI, blood pressure, insulin, glucose, HDL-cholesterol, and homeostasis model assessment-insulin resistance (HOMA-IR) levels were similar in all groups. Triglyceride levels were found to be higher in the normal BMD group, compared with the osteoporotic group (p = 0.005). The level of VAI was detected as higher in those with normal BMD, compared with the women with osteoporosis (p = 0.002). Additionally, the correlation analysis showed a positive correlation between dual-energy X-ray absorptiometry (DXA) spine T-scores, WC, VAI, and a negative correlation between DXA spine T-scores and age. Conclusion In our study, we found higher VAI levels in those with normal BMD, compared with women with osteoporosis. We consider that further studies with a larger sample size will be beneficial in elucidating the entity.

Abstract Objective: To evaluate and compare peripheral, pelvic floor, respiratory muscle strength, and functionality in the immediate puerperium of normal delivery and cesarean section. Methods: This is a cross-sectional study that verified respiratory, pelvic floor, peripheral, and functional muscle strength through manovacuometry, pelvic floor functional assessment (PFF), dynamometry, and the Time Up and Go (TUG) test, respectively. The groups were divided according to the type of delivery, into a cesarean section group and a normal parturition group. Results: The sample was composed of 72 postpartum puerperae, 36 of normal parturition, and 36 of cesarean section, evaluated before hospital discharge, mean age ranged from 25.56 ± 6.28 and 28.57 ± 6.47 years in puerperae of normal parturition and cesarean section respectively. Cesarean showed higher pelvic floor strength (PFF) compared to normal parturition (p < 0.002), but puerperae from normal delivery showed better functionality (p < 0.001). As for peripheral muscle strength and respiratory muscle strength, there was no significance when comparing the types of parturirion. Conclusion: There is a reduction in pelvic muscle strength in puerperae of normal delivery and a decrease in functionality in puerperae of cesarean section.

El objetivo de este estudio es examinar las cuentas de TikTok de bibliotecas en Indonesia. La investigación se llevó a cabo en 12 cuentas de TikTok con un total de 688 publicaciones para obtener una mejor comprensión del contenido de TikTok, el tipo de información publicada y la interacción de los seguidores en las publicaciones. Los datos se recopilaron observando todas las cuentas y publicaciones de TikTok. Los resultados mostraron que la mayoría de las bibliotecas comenzaron a utilizar TikTok en 2020, en respuesta al creciente número de usuarios de TikTok y el cambio durante la pandemia. Los tipos más comunes de información publicada son información de la colección de la biblioteca y otra información. Los anuncios, servicios y espacio de la biblioteca son los tres tipos de información que reciben más interacción. Este estudio tiene implicaciones prácticas para las bibliotecas que utilizan TikTok como una alternativa de redes sociales. TikTok podrá llegar a una audiencia más joven, impulsar la creatividad, difundir la alegría y ahorrar dinero a las bibliotecas. Basándose en los hallazgos de este estudio, los bibliotecarios pueden considerar el formato de la información publicada. Este estudio ofrece perspectivas de la plataforma de redes sociales TikTok como una nueva oportunidad para promocionar las bibliotecas. Se enfatiza el enorme potencial de utilizar plataformas de redes sociales como TikTok para llamar más la atención y acercar las bibliotecas a los usuarios

Purpose – This research aimed to study the impact of compensation on employee retention and turnover intentions among healthcare employees. The study also tested the mediation role of job satisfaction in the relationship. Design/methodology/approach – In the present study, self-administrated questionnaires were distributed among 600 doctors working in public hospitals of Pakistan, following stratified sampling. The data analysis was conducted through SPSS and smart-PLS. Findings – Results of the present study supported all the hypotheses (H1–H7), such as the significant relationship of compensation with employee retention and turnover intentions. Results further confirmed the mediation effect of job satisfaction between compensation and employee retention as well as compensation and turnover intentions. Practical implications – This study is useful for policymakers and organizational managers since the study provides guidelines on employee retention and high turnover intentions and how these factors are influenced by improved compensation. Originality/value – This study sheds light on the relationship of compensation together with employee retention and turnover intentions through the mediating role of job satisfaction in healthcare context, which was overlooked in the existing literature.

meticulously curated exhibits with themes such as sustainability and cultural exchange displayed in pavilions dedicated to individual countries. This research study uses biophilic or biomimetic design strategies to assess the sustainability practices employed in a group of pavilions at the Dubai Expo 2020 that employ biophilic and/or biomimetic design strategies. Biophilic philosophy emphasizes nature-based concepts to foster positive relationships between humans and living organisms, whereas biomimicry imitates natural processes/systems for building practices. Incorporating biophilic and/or biomimetic techniques into pavilion design provides visitors with a one-of-a-kind experience while displaying explicit sustainability principles that go beyond the event's existing architectural framework guidelines. The research evaluation process includes architectural structure designs, materials used during production/creation periods, energy efficiency measurements implemented, and sustainable water management plans based on natural ecological systems. It will also evaluate the adherence of each pavilion chosen to genuine sustainability values by analyzing the incorporation of nature-based concepts into its overall design for potential future reference applications. These techniques have significant potential to improve human health, reduce environmental impact, and encourage global resiliency when implemented beyond Dubai Expo 2020. In conclusion, the research aims to inspire sustainable designs well beyond the Dubai Expo 2020 by demonstrating how biophilic or biomimetic practices are crucial facilitators in constructing spaces that maximize human welfare without endangering the environment. It is also a foundational resource for architects and urban planners committed to advancing sustainable architectural practices through future development projects prioritizing human welfare and environmental protection.

Introduction: Inadequate physical activity is a contributing factor to various non-communicable diseases. The benefits of regular exercise have been well demonstrated, and evidence shows that adults are becoming more sedentary and obese due to a lack of opportunities and obstacles to exercise participation. Objective: The study aimed to identify physical exercise's perceived benefits and barriers among school teachers. Methods: The exercise benefits and barriers were assessed by conducting a cross-sectional design with 500 school teachers in Duhok City in Kurdistan Region, Iraq. Teachers enrolled using stratified simple random sampling from 15th September 2021 to 1st April 2022. Data on socio-demographic characteristics, perceived benefits and barriers of exercise, and physical activity levels were obtained. Results: The majority of school teachers (65.8%) had a low physical activity level. Exercise improves the appearance of the body as well as a disposition; mental health, cardiovascular functioning system, flexibility, and ability to sleep better at night were the most important exercise perceived benefits. Furthermore, "too few exercise places" was the most significant barrier to exercise, followed by other significant barriers including "inconvenient exercise facility schedules," "fatigue," "too far away from exercise places," "tiredness," "time limitations," "family responsibilities," and "being embarrassed to exercise." There was a significant difference between PA levels and exercise benefit, and the barrier score was p

Objectives: This review will determine whether the incidence of cognitive impairment in HIV patients aged ≥ 50 years is greater than that of their HIV-negative peers. Methods: The MEDLINE, EMBASE, LILACS, Web of Science, and Scopus databases will be searched for studies with a sample of individuals aged ≥ 50 years or a mixed population with ≥ 50% aged ≥ 50 years). It will include studies that evaluate seropositive patients compared to and an unexposed control group. Study design: Cohort studies with follow-up ≥ 24 months will be included. Three reviewers will independently screen for eligibility criteria, extract data, and assess the risk of bias in the included studies, as well as evaluate the overall quality of evidence. A narrative synthesis will be prepared according to synthesis without meta-analysis guidelines. Expected results: We expect to find correlations between older age, HIV, and cognitive impairment. Relevance: The association of geriatric syndromes and HIV is becoming an important field of study. Increased life expectancy accompanied by an active sex life is contributing to this public health problem. This protocol is reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols and is registered in PROSPERO (CRD42022321914). This study was financed in part by the CAPES foundation (financial code: 001).

ABSTRACT Members of the order Trypanorhyncha are cestode parasites that are frequently found infecting the muscles of several marine fish species, affecting fish health, and resulting in consumers’ rejection of fish. Fifty-two specimens of marine fish were freshly caught throughout the year 2020 from boat landing sites at the Alexandria coast along the Mediterranean Sea in Egypt, including the grey trigger fish Balistes carolinensis (F: Balistidae); the mottled grouper Mycteroperca rubra (F: Serranidae) and the common sole Solea vulgaris (F: Soleidae). Blastocysts were isolated and ruptured; the generated pleurocerci were described morphologically and morphometrically by light and scanning electron microscopy. Also, multiple-sequence alignment was performed, and a phylogenetic tree was constructed following maximum likelihood analysis of the 18s and 28s ribosomal RNA sequences of the recovered worms. Thirty fish were infected; the infection was recorded as blastocysts embedded in fish flesh. Three different parasitic species were recovered and classified morphologically as Gymnorhynchus isuri, Pseudotobothrium dipsacum and Heteronybelinia estigmena. The taxonomic position of these parasites was justified by molecular analysis of their 18s and 28s rRNAs, which revealed high percentages of homology with species recovered from the GenBank. The accession numbers ON157059, ON139663 and ON139662 were respectively assigned to the recovered parasites after their deposition in GenBank. The results obtained from the molecular analyses confirmed the morphological records of the recovered parasites. Since metacestodes are found in the musculature of infected fish specimens, it is necessary to remove these areas in the commercialization of fish.

Objective. The destructive activities of man have become obvious in the Northern parts of Nigeria where a terrorist group known as Boko Haram and Fulani herdsmen have engaged in destructive activities like burning down of churches, schools as well as destruction of lives and property in some of the higher institutions in Northern Nigeria. Libraries and their resources have also been affected at some points. Method. Based on the expository nature of this study the use of qualitative and quantitative research methodology was employed. The population of the study consists of all the librarians and library officer categories of personnel of the public libraries in North-west Nigeria. However, only 74 of these personnel that were accessible at the headquarters of the six public libraries were selected for the study by means of purposive sampling techniques. This sampling method is largely limited to exploratory research. Results. The reliability is as follows: Disaster Incident Experience= .551; Disaster Risk Management=.603; Disaster Management Facilities/equip=.775; Staff opinion= .533. Based on the above mentioned, it is noteworthy to say that it is only Disaster management facility that has higher score of reliability while others are satisfactorily reliable. Conclusions. It will therefore be proper for these libraries to be conscious of the adverse effects of disaster The overall findings have demonstrated that public libraries in the North have experienced disasters at one point in time or the other. However, they are not quite prepared to manage disaster as seen in the responses.

Resumo Fundamento: As matrizes metaloproteinases (MMPs) podem afetar o volume extracelular (VEC) e seus compartimentos, e isso pode oferecer informações mais detalhadas sobre o mecanismo de remodelação adversa (RA) do ventrículo esquerdo (VE) após o infarto agudo do miocárdio (IM). Objetivos: Investigar o papel que as alterações (Δ) nos compartimentos de VEC (volume matriz (MVi) e volume celular (CVi)) desempenham no desenvolvimento de RA após o IM, e sua relação com as expressões de MMP-2. Métodos: Um total de noventa e dois pacientes com primeiro IM passaram por exames de imagens por ressonância magnética cardiovascular 3 Tesla realizados 2 semanas (linha de base) e 6 meses após o IM. Medimos o mapeamento T1 com sequências MOLLI. O VEC foi obtido após o realce pelo gadolínio. O VEC e a massa do VE foram usados para calcular o MVi e o CVi. A RA foi definida como um aumento de ≥ 12% no volume diastólico final do VE em 6 meses. As MMPs foram medidas usando-se um sistema de imunoensaio multiplex em grânulos no primeiro dia (linha de base) e 2 semanas após o IM. Um P valor