Search

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior The prevalence of obesity and type 2 diabetes mellitus is growing worldwide. It is known that prevention and treatment of these diseases occur by adopting an interdisciplinary approach, with dietary advice. Results of clinical and epidemiological studies indicated a possible beneficial effect of peanut consumption on glycemic control, appetite and food intake. This study aims to investigate the effect of peanut (raw and butter) consumption on glucose homeostasis (glucose, insulin, free fatty acids and GLP-1), hormonal control of appetite (CCK and PYY), subjective appetite sensations and food intake in obese women with high risk for type 2 diabetes mellitus. This is a randomized crossover clinical trial in which 15 women participated in three experimental steps: Breakfast control (DC), breakfast with the addition of raw peanut (DAG) and addition of nut butter (DAP). Lunch was served 240 minutes after breakfast intake. In the times 10, 15, 45, 60, 90, 120, 180, 240, 265, 295, 310, 340, 370, 430 and 490 minutes after breakfast intake blood samples were taken for evaluation of glucose homeostasis (glucose, insulin, GLP-1 and FFA) and the subjective appetite sensations. At the time -10 to 240 additional samples were collected to determine the levels of incretins hormones (CCK and PYY). The palatability scores were assessed immediately after breakfast and lunch intake. We used analysis of variance with repeated measures plus Tukey's post-hoc test to examine the effect of treatments on glucose homeostasis, appetite and incretins hormones. To compare the palatability scores and the areas under (AUC) and above (AAC) the curve of the results of variables were applied to analysis of variance with Tukey's posthoc test. Analyses were performed using SigmaPlot, version 11.0 (Systat Software Inc, USA®), adopting as a criterion for statistical significance p