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This article adopts literature analysis and case study methods to explore the application and integration of Zen philosophy in modern minimalist art design, aiming to reveal the emotional resonance and aesthetic experience of Zen philosophy integrated into minimalist design for viewers. This article deeply analyzes the core concept of "emptiness" in Zen philosophy, explores its inherent connection with minimalist design principles, and compares and analyzes contemporary classic design works, revealing the unique role of Zen philosophy in enhancing the spiritual connotation and aesthetic value of design works. The research results indicate that integrating Zen philosophy into minimalist design endows works with deeper cultural and spiritual connotations and enhances viewers' emotional resonance and aesthetic experience. This integration provides new perspectives and methods for modern design practice, which helps promote the diversified development and innovation of the design field.

Background and Objectives: Local anesthetics are used broadly to prevent or reverse acute pain and treat symptoms of chronic pain. Local anesthetic-induced cardiotoxic reaction has been considered the accidental event without currently effective therapeutic drugs except for recently reported intralipid infusion whose possible mechanism of action is not well known., Contents: Cardiolipin, an anionic phospholipid, plays a key role in determining mitochondrial respiratory reaction, fatty acid metabolism and cellular apoptosis. Mitochondrial energy metabolism dysfunction is suggested as associated with local anesthetic cardiotoxicity, from an in vitro study report that the local anesthetic cardiotoxicity may be due to the strong electrostatic interaction of local anesthetics and cardiolipin in the mitochondria membrane, although there is a lack for experimental evidence. Herein we hypothesized that local anesthetic-cardiolipin interactions were the major determinant of local anesthetic-associated cardiotoxic reaction, established by means of theoretic and structural biological methods. This interacting model would give an insight on the underlying mechanism of local anesthetic cardiotoxicity and provide clues for further in depth research on designing preventive drugs for such inadvertent accidence in routine clinical practice., Conclusions: The interaction between local anesthetic and mitochondrial cardiolipin may be the underlying mechanism for cardiotoxicity affecting its energy metabolism and electrostatic status., (Copyright 2010 Elsevier Editora Ltda. All rights reserved.)