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Introdu??o: a obesidade e a doen?a hep?tica gordurosa n?o alco?lica (DHGNA) causam preju?zos ? sa?de, interferem na qualidade de vida do indiv?duo e acarretam custos elevados para o sistema p?blico de sa?de. A gordura visceral est? intimamente relacionada ao desenvolvimento de uma mir?ade de anormalidades metab?licas e est? associado ? DHGNA. Objetivo: investigar a associa??o entre a ?rea de gordura visceral e a doen?a hep?tica gordurosa n?o alco?lica em pacientes com obesidade. M?todo: estudo transversal com coleta de dados retrospectiva. A amostra foi composta por pacientes com obesidade, de ambos os sexos, maiores de 18 anos, candidatos ? cirurgia bari?trica entre julho de 2015 a julho de 2017 no COM/HSL/PUCRS. Foram avaliados dados antropom?tricos e a ?rea de gordura visceral atrav?s da bioimped?ncia multi-frequencial. As vari?veis tabagismo e comorbidades tamb?m foram analisadas. A DHGNA foi avaliada por bi?psia hep?tica. O n?vel de signific?ncia adotado foi de 5% (p?0,05) e as an?lises estat?sticas foram realizadas pelo programa SPSS vers?o 21.0. O estudo foi aprovado pelo Comit? de ?tica em Pesquisa da PUCRS sob CAAE 51992321.0.0000.5336. Resultados: Foram inclu?dos 369 participantes, a maioria mulheres (79,4%), com m?dia de idade de 39,2 ? 10,6 anos e IMC m?dio de 45?7,1 kg/m?. N?o foi encontrada associa??o estatisticamente significativa com a DHGNA. Houve associa??o positiva (p

Partindo da premissa de que a obra de Pierre Bourdieu ? uma obra que pode contribuir para os desafios do ser humano no s?culo XXI, propomos como investiga??o filos?fica destacar de sua obra a concep??o de ser humano com a qual opera. Embora Bourdieu n?o apresente uma conceitua??o a respeito do ser humano, parte-se do princ?pio de que todo pensador trabalha com concep??es a respeito do ser humano e a respeito do mundo, no caso deste autor, do mundo social. A concep??o de ser humano bourdieusiana ? o objeto de pesquisa elaborado em quatro cap?tulos inter-relacionados. O primeiro cap?tulo parte da premissa que Bourdieu constr?i a concep??o de ser humano como um ser social a partir de sua perspectiva de vida, uma perspectiva voltada para a a??o como categoria relevante na problematiza??o da rela??o indiv?duo e sociedade. Com isso, propomos a reconstru??o da trajet?ria pessoal entrela?ada com a trajet?ria intelectual bourdieusiana a fim de elencar a concep??o de ser humano social. Enquanto ser humano social, propomos apresentar no segundo cap?tulo, o construtivismo bourdieusiano fundamentado na a??o coletiva. Tal proposta questiona a nomenclatura ofertada pelo autor, o estruturalismo construtivista ou construtivismo estruturalista a partir do encontro de Bourdieu com Jean Piaget e Lev S. Vigostki. A partir disso, no terceiro cap?tulo se imp?s como inicialmente necess?rio demonstrar as diferen?as que permitem colocar a n?o pertin?ncia de entender a teoria bourdieusiana como uma teoria estruturalista. A discuss?o ? com a antropologia estruturalista l?vistraussiana com e contra a qual Bourdieu constr?i sua teoria. Ap?s isso, o objetivo ? demonstrar a articula??o dos conceitos de habitus, campo e capital no escopo do construtivismo bourdieusiano a fim de finalizar com a concep??o de ser humano social como agente social assentado na a??o. A proposta doutoral almeja ofertar uma contribui??o ? pesquisa da obra bourdieusiana e ? filosofia contempor?nea. From the premise that Pierre Bourdieu's work can contribute to the challenges of the human being in the 21st century, we propose as a philosophical investigation to highlight the conception of the human being with which he operates from his work. Although Bourdieu does not present a concept about the human being, it is assumed that every thinker works with conceptions about the human being and about the world, in the case of this author, the social world. The Bourdieusian conception of the human being is the object of research elaborated in four interrelated chapters. The first chapter starts from the premise that Bourdieu builds the concept of human being as a social being from his perspective of life, a perspective focused on action as a relevant category in problematizing the relationship between individual and society. With that, we propose the reconstruction of the personal trajectory intertwined with the Bourdieusian intellectual trajectory in order to list the concept of social human being. As a social human being, we propose to present in the second chapter, the Bourdieusian constructivism based on collective action. Such proposal questions the nomenclature offered by the author, the constructivist structuralism or structuralist constructivism from Bourdieu's encounter with Jean Piaget and Lev S. Vigostki. From this, in the third chapter it was imposed as initially necessary to demonstrate the differences that allow to place the irrelevance of understanding Bourdieusian theory as a structuralist theory. The discussion is with the L?vi-straussian structuralist anthropology with and against which Bourdieu constructs his theory. After that, the objective is to demonstrate the articulation of the concepts of habitus, field and capital within the scope of Bourdieusian constructivism. Finally, the fourth chapter is devoted to the conception of a social human being as a social agent based on action. The doctoral proposal aims to offer a contribution to the research of Bourdieusian work and contemporary philosophy.

O v?rus sincicial respirat?rio (VSR) ? um agente viral altamente contagioso e o mais comum nas doen?as respirat?rias do trato inferior sendo uma das maiores causas de morbidade e mortalidade em crian?as, idosos e imunodeprimidos. O tratamento inclui terapia de suporte e ribavirina. Contudo, as terapias antivirais s?o caras, dif?ceis de administrar e n?o s?o comprovadamente eficazes. O objetivo deste estudo foi investigar in vitro a atividade antiviral de tr?s azocompostos sintetizados a partir da altera??o estrutural do estilbeno modificado do resveratrol em c?lulas MRC-5 e A549 frente ? infec??o pelo VSR. Foram avaliados o efeito sobre a viabilidade celular, a concentra??o inibit?ria, a redu??o do efeito citop?tico e o efeito virucida dos compostos REDRESV 01, REDRESV 02 e REDRESV 03 utilizando-se a t?cnica de MTT. Os dados mostraram que REDRESV 01 ? mais citot?xico para as duas linhagens apresentando IC50 58,6?M (MRC-5) e 17,43?M (A549). Por apresentarem valores de IC50 maiores seguiu-se o estudo apenas com os compostos REDRESV 02 (MRC-5 = 87,58?M e A549 = 40,73?M) e REDRESV 03 (MRC-5 = 150,1?M e A549 = 43,44?M). Os resultados indicaram que as baixas porcentagens de inibi??o da replica??o viral pelos compostos testados n?o foram promissoras na pesquisa de novos f?rmacos antivirais uma vez que estes n?o foram capazes de manter um n?mero significativamente vi?vel de c?lulas durante a infec??o. No entanto, no tratamento p?s-infec??o os compostos REDRESV 02 e REDRESV 03 mostraram seletividade na concentra??o de 20?M para a c?lula tumoral (A549) quando infectada. Os dois compostos diminu?ram cerca de duas vezes mais a viabilidade da c?lula A549 infectada quando comparados com o controle viral. Os compostos tamb?m mostraram um poss?vel efeito virucida o que pode ser um indicativo que al?m destes terem um efeito citot?xico para as c?lulas tumorais eles ainda podem inativar as part?culas circulantes quando estas c?lulas estiverem infectadas. Apesar dos compostos terem apresentado resultados promissores para o tratamento de pacientes oncol?gicos infectados com VSR novos estudos devem ser realizados para investigar outros tipos de v?rus e outros tipos de c?ncer, bem como, os mecanismos envolvidos nesse processo. Respiratory syncytial virus (RSV) is a highly contagious viral agent and the most common respiratory diseases of lower tract being one of the major causes of morbidity and mortality in children, elderly and immunocompromised. Treatment includes supportive therapy and ribavirin. However, antiviral therapies are expensive, difficult to administer and are not proven to be effective. The aim of this study was to investigate in vitro the antiviral activity of three azo compounds synthesized from the structural alteration of the modified resveratrol stilbene in MRC-5 and A549 cells against RSV infection. The effect of compounds REDRESV 01, REDRESV 02 and REDRESV 03 on cell viability, inhibitory concentration, cytopathic reduction activity and virucidal activity were evaluated by MTT assay. Data showed that REDRESV 01 is cytotoxic for both cell lines showing IC50 58.6?M (MRC-5) and 17.43?M (A549). The study was followed only with the compounds REDRESV 02 (MRC-5 = 87.58?M and A549 = 40.73?M) and REDRESV 03 (MRC-5 = 150.1?M and A549 = 43.44?M) because of the higher IC50 values. Data indicated that the low percentages of inhibition on viral replication were not promising in the search for new antiviral drugs since compounds tested were not able to maintain a significantly viable number of cells during infection. However, in post-infection treatment REDRESV 02 and REDRESV 03 showed selectivity at concentration of 20 ?M for the tumor cell (A549) when infected. Both compounds decreased viability twice of the infected A549 cell as compared to the viral control. Compounds also showed a possible virucidal activity which may indicate besides having a cytotoxic effect on tumor cells they may still inactivate the circulating particles when cells are infected. Although the compounds have shown promising results for the treatment of cancer patients infected with RSV new studies should be conducted to investigate other types of virus and other types of cancer, as well as the mechanisms involved in this process. Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES

O ponto de partida do constructo te?rico do fil?sofo e soci?logo franc?s Pierre Bourdieu s?o as desigualdades existentes na realidade social. Na busca pela compreens?o da realidade social e a posi??o do indiv?duo perante a mesma, o autor elabora uma teoria a qual visa ? supera??o da dicotomia das teorias subjetivistas e objetivistas presentes em sua ?poca. Assimilando o pensamento relacional como fio condutor da teoria identificada como construtivismo estruturalista ou estruturalismo construtivista, o autor prop?e relevar das pesquisas emp?ricas o senso pr?tico das a??es dos agentes sociais. Tal proposta apresenta uma teoria da pr?tica ou praxiologia, na qual a pr?tica ? considerada o motor propulsor das posi??es, disposi??es e tomadas de posi??o do agente social. Com isso as no??es de habitus, campo e capital s?o elaboradas oportunizando uma vis?o global do meio social a partir da no??o de espa?o social. A partir disso, a proposta desta pesquisa dissertativa possui como objetivo demonstrar a inter-rela??o da tr?ade de no??es: habitus, campo e capital. No intuito de alcan?ar esse objetivo, inicialmente se prop?e a contextualiza??o do espa?o-tempo do pensamento bourdieusiano, seguido da apresenta??o isolada de cada no??o para finalizar com o levantamento dos pontos que auxiliam a demonstra??o da inter-rela??o da tr?ade das no??es bourdieusianas. The starting point of French philosopher and sociologist Pierre Bourdieu?s theoretical construct are inequalities in social reality. In seeking to understand social reality and the individual's position in it, the author develops a theory aimed at overcoming the dichotomy between the subjectivist and objectivist theories of his time. Taking relational thinking as a guide to the theory identified as structuralist constructivism or constructivist structuralism, the author proposes to highlight from empirical research the practical sense in the actions of social agents. This proposal results in a practice theory or praxeology, in which practice is the driver of positions, dispositions and position-taking by social agents. Thus, the concepts of habitus, field and capital are developed to provide an overview of the social environment from the notion of social space. On these grounds, the aim of this dissertation is to demonstrate the interrelationship between the triad of concepts: habitus, field and capital. In order to achieve this goal, it proposes an initial contextualization of the Bourdieusian thought in space-time, followed by an independent presentation of each concept, and finally a survey of the points which help demonstrate the interrelations between the triad of Bourdieusian concepts.

Made available in DSpace on 2015-04-22T22:06:27Z (GMT). No. of bitstreams: 1 gabriel cortes.pdf: 6425050 bytes, checksum: 04e6ed2fef6be8960b0f8f25cf58eacb (MD5) Previous issue date: 2013-02-25 CAPES - Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior Aim: The aim of this study was to assess the prevalence of caries and investigate its association with socioeconomic, feeding and oral hygiene factors in Kotiria Indians from the Upper Uaup??s River, Amazonas, Brazil. Methods: A cross sectional study was conducted with 93,5% of the indigenous population aged from 1-5 (n=54), 12 (n=11), and 15-19 (n-22) years old resident at the traditional Kotiria land. Caries and treatment needs were assessed using the World Health Organization criteria. The Simplified Debris Index (DI-S) and gingival bleeding (SG) were taken as oral hygiene status. Interview was used to record socioeconomic, feeding and oral hygiene data. Cariogenic food intakes frequency was assessed using 24 hours recall alimentary inquiry. Data analyses included exploratory statistics, Pearsons Chi-Square Test, Likehood Ratio, Fisher??s Exact Test, Pearson??s Correlation, T Test and Anova. Results: The dmft was 4,72 at 1-5 years and 8,11 at 5 years. The DMFT was 5,36 at 12 and 6,45 at 15 - 19 years. Only 21,8 % of the indigenous evaluated were caries free. The most frequent treatment need was filling followed by extraction for all ages. DI-S and SG status was considered good to 9,93% and 13,2% of all participants. Exclusive breastfeeding until the sixth months was reported to 72% of the children aged 1-5 years and 35,9% reported to use baby bottle. The average consumption of sucrose was 1,4 times a day, and 0,7 times in between meals. The average house income was 366,00 US dollars, and 6 houses (16%) had no income. Parents education was 8,7 and 5,1 years of study for fathers and mothers respectively. Higher sucrose intake between meals and interrupted toothpaste access were associated to higher caries frequency (p

Submitted by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2021-02-17T20:23:15Z No. of bitstreams: 6 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ata de Defesa Eleucimar.pdf: 1216250 bytes, checksum: 1a52acba35e217c2864ea1079507f8aa (MD5) CartaEncaminhamento DISSERTA????O_Eleucimar.pdf: 118000 bytes, checksum: e403551a05cfc4958778c5b0efb40fe3 (MD5) DISSERTA????O VFINAL Eleucimar.pdf: 609355 bytes, checksum: 132d2606bab8606ec6d841d5100b9014 (MD5) PRODUTO-_Eleucimar.pdf: 6205038 bytes, checksum: 9ca4e0e2700e325f4c7f765b0fba8116 (MD5) TAutoriza??ao Publicacao_Eleucimar.pdf: 335518 bytes, checksum: d91b28424a0127e372e845d5f4884217 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2021-02-17T20:27:58Z (GMT) No. of bitstreams: 6 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ata de Defesa Eleucimar.pdf: 1216250 bytes, checksum: 1a52acba35e217c2864ea1079507f8aa (MD5) CartaEncaminhamento DISSERTA????O_Eleucimar.pdf: 118000 bytes, checksum: e403551a05cfc4958778c5b0efb40fe3 (MD5) DISSERTA????O VFINAL Eleucimar.pdf: 609355 bytes, checksum: 132d2606bab8606ec6d841d5100b9014 (MD5) PRODUTO-_Eleucimar.pdf: 6205038 bytes, checksum: 9ca4e0e2700e325f4c7f765b0fba8116 (MD5) TAutoriza??ao Publicacao_Eleucimar.pdf: 335518 bytes, checksum: d91b28424a0127e372e845d5f4884217 (MD5) Made available in DSpace on 2021-02-17T20:27:58Z (GMT). No. of bitstreams: 6 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ata de Defesa Eleucimar.pdf: 1216250 bytes, checksum: 1a52acba35e217c2864ea1079507f8aa (MD5) CartaEncaminhamento DISSERTA????O_Eleucimar.pdf: 118000 bytes, checksum: e403551a05cfc4958778c5b0efb40fe3 (MD5) DISSERTA????O VFINAL Eleucimar.pdf: 609355 bytes, checksum: 132d2606bab8606ec6d841d5100b9014 (MD5) PRODUTO-_Eleucimar.pdf: 6205038 bytes, checksum: 9ca4e0e2700e325f4c7f765b0fba8116 (MD5) TAutoriza??ao Publicacao_Eleucimar.pdf: 335518 bytes, checksum: d91b28424a0127e372e845d5f4884217 (MD5) Previous issue date: 2020-12-17 The relationship between health and the environment must be understood in an interdependent, changeable and systemic way in primary health care. In this regard, when considering the interface between health and environment, it is essential that nursing takes a position in the discussion. Thus, the general objective of this work was to investigate the presence of the environmental theme in professional technical courses in nursing at two Federal Institutions in Amazonas. The study was based on the theoretical approach of Systemic complexity, aiming at a transformation in educational practices towards new knowledge, capable of guiding a sustainable world. It was developed at the Federal Institute of Education Science and Technology of Amazonas Campus S??o Gabriel da Cachoeira -AM, and Federal Institute of Roraima. The research subjects correspond to the students and professors of the Nursing Technician course in the subsequent form. The research is classified, as for the purposes, exploratory and descriptive, the approach of the object involved qualitative techniques. The research result showed the superficiality of the themes in the course's PPC as well as in the teaching plans of the teachers. However, it also demonstrated that students and teachers are aware of the intrinsic relationship that exists between health and the environment and the importance in their education. The data resulted in the elaboration of a protocol that inserts the Environmental Themes in the Professional Technical Training in Nursing. A rela????o entre sa??de e meio ambiente deve ser compreendida de forma interdependente, mut??vel e sist??mica na aten????o prim??ria ?? sa??de. Nessa vertente, quando pensada a interface sa??de e meio ambiente, torna-se imprescind??vel que a enfermagem tome posi????o na discuss??o. Assim, o objetivo geral deste trabalho foi investigar a presen??a da tem??tica ambiental em cursos t??cnicos profissionalizantes em enfermagem em duas Institui????es Federais de ensino do Amazonas. O estudo sustentou-se na abordagem te??rica da complexidade Sist??mica, visando uma transforma????o nas pr??ticas educativas em dire????o ao novo saber, capaz de nortear um mundo sustent??vel. Sendo desenvolvido no Instituto Federal de Educa????o Ci??ncias e Tecnologia do Amazonas Campus S??o Gabriel da Cachoeira-AM, e Instituto Federal de Roraima. Os sujeitos da pesquisa correspondem aos discentes e docentes do curso T??cnico em Enfermagem na forma subsequente. A pesquisa classifica-se, quanto aos fins, explorat??ria e descritiva, a abordagem do objeto envolveu t??cnicas qualitativas. O resultado da pesquisa mostrou a superficialidade das tem??ticas no PPC do curso assim como nos Planos de ensino dos docentes. Porem demonstrou tamb??m que, discentes e docentes s??o conscientes da rela????o intr??nseca que existe entre sa??de e ambiente e a import??ncia em sua forma????o. Os dados resultaram na elabora????o de um protocolo de orienta????o para inser????o das Tem??ticas Ambientais na forma????o T??cnica Profissionalizante em Enfermagem.