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The pancreas is a mixed organ that contains acinar cells that secrete digestive enzymes and pancreatic lipases and, in its endocrine portion, secretes glucagon and insulin to regulate blood sugar levels through the alpha (a) and beta (ß) cells. Exocrine pancreatic insufficiency (EPI) is a syndrome characterized by the insufficient secretion of pancreatic enzymes, causing a failure in nutrient absorption, leading to weight loss, diarrhea, coprophagia, and polyphagia. Dogs with a history of pancreatitis may develop diabetes, EPI, or both. Diabetes mellitus is a clinical syndrome caused by persistent hyperglycemia and glycosuria due to the total or partial insufficiency of insulin secretion by ß-cells.A dog was treated in Brasília-DF: a male, weighing 9.50 kg, Dachshund breed, neutered, 13 years old, with a history of vomiting and diarrhea, hyperglycemia and glycosuria, and dietary indiscretion. At that time, screening laboratory tests and an abdominal ultrasound were performed. The imaging identified the pancreas with increased echogenicity and heterogeneous echotexture, fibro-adipose infiltration with signs of chronicity, and a thickened duodenal wall. The patient was seen by an endocrinology specialist after 4 months, with weight loss (6.30 kg) despite receiving insulin, a low body condition score (BCS 4/9), coprophagia, and polyphagia. The canine trypsin-like immunoreactivity (cTLI) test was performed with a value of 2.10 (5.2-35 ng/ml). We observed that pancreatitis can lead to both diabetes and EPI in the same patient and that the cTLI was essential for the diagnosis. The patient showed significant clinical improvement with Pancreatin supplementation combined with insulin therapy. [ABSTRACT FROM AUTHOR]