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Zileuton is an inhibitor of the 5-lipoxygenase enzyme that transforms essential fatty acid (EFA) substrates into leukotrienes (LTB4, LTC4, LTD4 and LTE4), but little is known about the use of this drug in teleost fish. Therefore, the objective of this study was to evaluate the clinical safety of treatments with 2,25 mg and 4,50 mg of zileuton/Kg-1 (bodyweight), administered orally in the diet, through biochemical and hematological analysis during the acute inflammatory reaction in Nile tilapia (Oreochromis niloticus), induced by Aeromonas hydrophila bacterins. The study used eighty tilapias, conditioned in 20 tanks (n=4), constituting the following treatments: T0 (control), T1 (2,25 mg zileuton) and T2 (4,50 mg zileuton), being sampled eight animals per treatment in three periods: 6, 24 and 48 hours post-inoculation, and a 10th group consisting of fish without any type of stimulus to obtain the reference values. In order to evaluate and determine the blood count and serum biochemical, it was necessary to collect blood samples. The hematology results of the tilapia treated with zileuton did not reveal alterations between tilapia subjected to different treatments and control fish (T0). The liver cytotoxicity analysis of tilapias treated with zileuton did not reveal significant (p=0,05) alterations in AST and ALT serum enzymatic activity. The study of tilapia blood total protein showed decrease in the T1 group at 48 HPI. As the treatment time progressed, the results indicated decrease in the serum albumin levels for T2 group at 24 HPI. The determination of serum biochemichal of creatinine, cholesterol, triglycerides, and glucose did not differ statistically between treatments. The results observed in the hematological and biochemical analyzes allows to conclude that zileuton administered orally, at doses of 2,25 and 4,50 mg/Kg-1 (body weight) demonstrated to be clinically safe. [ABSTRACT FROM AUTHOR]

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Copyright of Ceramica is the property of Associacao Brasileira de Ceramica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Femoral fractures are common in dogs and cats following significant trauma and typically cannot be treated non-invasively. They require internal surgical interventions. Various implant systems are employed to correct these fractures, including bone plates, intramedullary nails, combinations of plates and nails, interfragmentary screws, pins, wires, and external fixators. However, a deep understanding of anatomy, fracture physiology, diagnostic techniques, and surgical treatments is crucial for ensuring an effective recovery of the affected limb and a favorable prognosis for the patient. In this case report, an 8-month-old mixed breed female dog was brought to the Veterinary Hospital (UNICEP) after experiencing trauma to her right hind limb. Blood tests and radiographs were conducted to determine the type of fracture and the most suitable surgical approach. The radiograph revealed a complete and simple spiral fracture located in the proximal third of the diaphysis of the right femur. The surgical procedure chosen involved a combination of an intramedullary pin and a locking plate, an approach frequently used in femur fracture osteosynthesis due to its established effectiveness. The synchronization between the plate and the intramedullary pin allows for the neutralization of biomechanical forces, preventing complications. [ABSTRACT FROM AUTHOR]