1. Assessment of Tp-e interval and Tp-e/QT ratio in patients with human immunodeficiency virus.
- Author
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Cetin S, Çetin AŞ, Gurdal A, Yıldız SS, Keskin K, Sığırcı S, and Bayraktar A
- Subjects
- Adult, Antiretroviral Therapy, Highly Active statistics & numerical data, CD4 Lymphocyte Count statistics & numerical data, Case-Control Studies, Echocardiography methods, Electrocardiography methods, Female, HIV genetics, HIV immunology, HIV Infections drug therapy, HIV Infections mortality, HIV Infections virology, Humans, Male, Middle Aged, Prospective Studies, Risk Assessment, Survival Analysis, Viral Load statistics & numerical data, Death, Sudden, Cardiac etiology, Electrocardiography statistics & numerical data, HIV Infections complications, Heart Conduction System physiopathology
- Abstract
Objective: Sudden cardiac death (SCD) plays an important part in all-cause mortality in patients infected with human immunodeficiency virus (HIV). The T-peak to T-end (Tp-e) interval, corrected Tp-e (Tp-ec) interval, and Tp-e/QT ratio on the ECG are parameters used to stratify risk for SCD. The objective of this study was to investigate the differences between HIV-infected patients and healthy individuals in terms of Tp-e interval, Tp-ec interval, and Tp-e/QT ratio, as well as other influencing factors., Methods: Ninety-eight HIV-infected patients and 62 healthy controls were included in this prospective case-control study. Tp-e interval, Tp-ec interval, and Tp-e/QT ratio were measured in all participants. Echocardiographic examination and routine laboratory analysis were performed. In addition, CD4 T-cell count and HIV RNA levels were assessed in HIV-infected patients., Results: All baseline characteristics were comparable in both groups. The median survival of those living with HIV was 20.63 months; 53% of them had controlled viral load, and 74% were receiving antiretroviral therapy. Mean baseline CD4 T-cell count was 409. In HIV-infected patients, the Tp-e interval and Tp-ec interval were prolonged, and the Tp-e/QT ratio was higher (p<0.001, p<0.001 and p=0.021, respectively). In bivariate and partial correlation analyses, there was a negative correlation between CD4 T-cell level and Tp-e interval, Tp-ec interval, and Tp-e/QT ratio., Conclusion: Tp-e interval, Tp-ec interval, and Tp-e/QT ratio were greater in HIV-infected patients compared with healthy individuals. HIV-infected patients, particularly those with low baseline CD4 T-cell counts, should be closely monitored due to risk of SCD., (Copyright © 2020 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2020
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