Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:55:43Z No. of bitstreams: 1 S0102-09352006000100010.pdf: 815970 bytes, checksum: cf7c2264c7c8337b2a34bd2f371837d3 (MD5) Made available in DSpace on 2013-08-22T18:55:43Z (GMT). No. of bitstreams: 1 S0102-09352006000100010.pdf: 815970 bytes, checksum: cf7c2264c7c8337b2a34bd2f371837d3 (MD5) Previous issue date: 2006-02-01 Made available in DSpace on 2013-09-30T19:48:53Z (GMT). No. of bitstreams: 2 S0102-09352006000100010.pdf: 815970 bytes, checksum: cf7c2264c7c8337b2a34bd2f371837d3 (MD5) S0102-09352006000100010.pdf.txt: 31285 bytes, checksum: 5db087e28ca69a43619c4e45ddfe2fd4 (MD5) Previous issue date: 2006-02-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:39:02Z No. of bitstreams: 2 S0102-09352006000100010.pdf: 815970 bytes, checksum: cf7c2264c7c8337b2a34bd2f371837d3 (MD5) S0102-09352006000100010.pdf.txt: 31285 bytes, checksum: 5db087e28ca69a43619c4e45ddfe2fd4 (MD5) Made available in DSpace on 2014-05-20T13:39:02Z (GMT). No. of bitstreams: 2 S0102-09352006000100010.pdf: 815970 bytes, checksum: cf7c2264c7c8337b2a34bd2f371837d3 (MD5) S0102-09352006000100010.pdf.txt: 31285 bytes, checksum: 5db087e28ca69a43619c4e45ddfe2fd4 (MD5) Previous issue date: 2006-02-01 Avaliou-se o uso de biomaterial de origem bovina na regeneração de defeitos ósseos segmentares empregando-se 12 coelhos, fêmeas, da raça Norfolk, com idade de seis meses e pesos entre 3 e 4,5kg. Realizou-se falha segmentar bilateral de um centímetro de comprimento na diáfise do rádio, com inclusão do periósteo. No membro direito, o defeito foi delimitado por membrana de pericárdio liofilizada, contendo em seu interior mistura de proteínas morfogenéticas ósseas adsorvidas a hidroxiapatita, colágeno liofilizado e osso inorgânico. No membro esquerdo, o defeito não recebeu tratamento. Radiografias foram obtidas ao término do procedimento cirúrgico e aos sete, 30, 60, 90, 120 e 150 dias de pós-operatório. Após eutanásia de seis coelhos aos 60 dias e seis aos 150 dias de pós-cirúrgico, os resultados radiográficos e histológicos mostraram que a regeneração óssea foi inibida nos defeitos segmentares tratados com o biomaterial. Biomaterials of bovine origin in regenerating segmental bone defects were evaluated. Twelve six-month old Norfolk rabbits, weighting 3 to 4.5kg were used. A 1cm long segmental defect was created in the radial diaphysis, including the periosteum, of both forelimbs. In the right forelimb, the defect was filled using a mixture of bone morphogenic proteins adsorbed to hydroxyapatite, agglutinant of lyophilized collagen in granules and anorganic cortical bone in granules delimited by a pericardial membrane. In the left forelimb, the defect did not receive treatment and served as a control. Radiographies were taken immediately after surgery and at seven, 30, 60, 90, 120 and 150 days post-operatively. Six rabbits were euthanized at 60 days and the other six at 150 days post-surgery for histological evaluation. Radiographic and histological results revealed that bone regeneration was inhibited in the segmental defects receiving biomaterials. UNESP Faculdade de Medicina Veterinária e Zootecnia UNESP Faculdade de Medicina de Botucatu UNESP Faculdade de Odontologia de Bauru UNESP Faculdade de Medicina Veterinária e Zootecnia UNESP Faculdade de Medicina de Botucatu UNESP Faculdade de Odontologia de Bauru