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2. [New concepts in hyperactive malarial splenomegaly].

Author

Moraes MF, Soares M, Arroz MJ, Do Rosário VE, Da Graça JP, and Abecasis P

Subjects
DNA, Protozoan blood, DNA, Protozoan isolation & purification, Female, Humans, Lymphoproliferative Disorders diagnosis, Lymphoproliferative Disorders drug therapy, Malaria pathology, Middle Aged, Recurrence, Splenomegaly drug therapy, Malaria complications, Splenomegaly diagnosis
Abstract

Hyperreactive malarial splenomegaly is thought to represent an immunological dysfunction due to recurrent episodes of malaria. The authors present a case of hyperreactive malarial splenomegaly in a patient from São Tomé e Príncipe and discuss aspects of its differential diagnosis and treatment. A revision is made of recent concepts related to its pathogenesis and relationship with lymphoproliferative disorders. Malarial DNA was found in the absence of parasite forms in the peripheral blood. This may indicate that latent infection plays a role in its pathogenesis.

Published
2003

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