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Griscelli syndrome is a rare autosomal recessive disorder characterized by hypopigmentation of skin and hair. Griscelli syndrome type 2, one of the three subtypes of Griscelli syndrome, is characterized by recurrent infections, in addition to pigmentary abnormalities. We present the case of a 15-year-old girl with late onset of Griscelli syndrome type 2 features: pigmentary changes of hair and skin, hepatosplenomegaly, pancreatitis and pancytopenia. We also highlight the diagnostic dilemma in patients with coexisting features of malnutrition. Both conditions show some overlapping clinical features and hence, establishing a diagnosis may be challenging.

Morphea en coup de sabre is a type of linear localized scleroderma, characterized by a sclerotic skin band in the forehaead and frontoparietal scalp area. It can cause cicatricial alopecia, when affecting the scalp. The disease is mostly unilateral and may be associated with neurological complications and eye defects. Herein, we present a case of bilateral morphea en coup de sabre in a young man, which developed following trauma to the head in childhood 10 years earlier. It produced linear bands of alopecia over the scalp and right eyebrow. The lesions progressed over 4 years, then remained quiescent for 6 years and then restarted progressing again. The patient also complained of repeated frontal headaches but the neurological and ocular examination was normal. Dermoscopy and histopathology were used to confirm the diagnosis. The case is unique because of the bilateral manifestation, preceding trauma and recurrence of disease activity.

Hutchinson-Gilford progeria syndrome is an extremely rare genetic disorder characterized by premature ageing involving the skin, bones, heart, and blood vessels. The incidence is 1 in several million births. It occurs sporadically and is probably an autosomal dominant syndrome. The diagnosis is essentially clinical and the manifestations become more evident from the first year of life. We report a case of a seven-month- old boy with clinical manifestations characteristic of this syndrome. He had a characteristic “plucked-bird” appearance, prominent eyes and scalp veins, senile look, loss of scalp hair, stunted growth and mottled pigmentation with sclerodermatous changes over the trunk and lower limbs. This interesting case is reported for its rarity.