1. [Studies of compounds with potential antiparasitic action. VIII. New oxime ethers in the 1-thiochromone system].
- Author
-
Kadłubowski R, Błaszkowska J, and Horwatt E
- Subjects
- Animals, Antifungal Agents administration & dosage, Antifungal Agents pharmacology, Antitrichomonal Agents administration & dosage, Candida albicans drug effects, Candida albicans growth & development, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Geotrichum drug effects, Geotrichum growth & development, In Vitro Techniques, Trichomonas vaginalis growth & development, Antitrichomonal Agents pharmacology, Chromones pharmacology, Oximes pharmacology, Sulfides pharmacology, Trichomonas vaginalis drug effects
- Abstract
The 50% antitrichomonal concentration of 7 examined ethers (T. vaginalis strain N. 1/86, Roiron medium, safranine staining, 30 min.) was estimated by means of dose-response curve. The minimal mycostatic concentration (Candida albicans L-45, Geotrichum candidum; 3% Sabouraud agar, 37 degrees C, 24 hr) was calculated with the aid of regression equation. All examined ethers show in vitro a marked antitrichomonal effect comparable with activity of ornidazole or phenol. Mycostatic activity of new compounds is many times higher than activity of phenol, but considerably lower than that of clotrimazole. The strongest complex antitrichomonal and mycostatic effect-comparable to ornidazole or clotrimazole - shows the new derivative N,N-diethylaminoethyl oxime of 1-tioflavone (compound II), which is fairly toxic for mammal.
- Published
- 1990