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Objective: Introduction: Cognitive limitations are a serious health and social problem, which concerns elderly people. Effective prevention and treatment of cognitive dysfunction is one of the challenges of modern medicine. There is not enough consistent data in the literature to indicate to indicate the relationship between various clinical and demographic factors with cognitive functioning in different age ranges. The aim: To analyze clinical and demographic predictors of mild cognitive impairment by age group., Patients and Methods: Material and methods: The analysis included 817 participants (669 with normal cognitive function and 148 people with MCI). The evaluation of the level of depressive symptoms was measured by the Short Form Geriatric Depression Scale. All participants were screened for cognitive functioning using the Mini-Mental State Examination and Addenbrooke's Cognitive Examination-III. Different cognitive domains were evaluated with different neuropsychological tools: the Rey Auditory Verbal Learning test, Clock Drawing test, Verbal Fluency test, Digit Span Test and Trail Making test., Results: Results: It has been shown that independently associated with MCI ware age (OR = 1.09, 95% CI: 1.05-1.13) and level of education (OR = 0.75, 95% CI: 0.69-0.81). Depending on the age, it turned out that in the younger MCI group, age, education and depression were significant, and the age and level of education were significant in the older MCI group., Conclusion: Conclusions: The identification of cognitive dysfunctions is an important element of the diagnostic and therapeutic process.

Introduction: Current research from around the world indicates a trend toward younger ages at the first menstruation. At the same time more and more studies point out the negative consequences of early puberty. Early age at menarche is significantly correlated with the risk of metabolic syndrome, breast cancer and female reproductive system cancer, as well as illnesses such asthma and bulimia. The aim of the study was to examine the relationship between age at menarche and socioeconomic status and selected factors connected with biological conditions., Material and Methods: The data were obtained from 671 female university students. Height, weight, waist and hip circumference were measured, and BMI, WHR, WHtR were calculated. A questionnaire form was used to assess the age at menarche, biological conditions and socioeconomic status of the surveyed students., Results: There were no significant differences in the number of the early, average and late maturing students between the socioeconomic groups. The early maturing girls were characterized by higher values of waist circumference, BMI, WHR and WHtR. The prevalence of obesity and abdominal obesity was highest among the early maturing girls. The analysis did not show statistically significant relationships between age at menarche and selected factors connected with biological conditions., Conclusion: Early maturation increases the risk of obesity and central adiposity distribution.

The effect of cytostatic drugs used in the treatment of haemopoietic system diseases: cerubidin, hydroxyurea. cytosine arabinoside and their combinations on the platelet count, platelet ultrastructure, metabolic activity and participation in the processes of haemostasis was investigated. The experiments were done using two concentrations of the drugs: clinical corresponding to the maximal single dose and a fivefold as high concentration, It was found that the investigated cytostatic agents and their cominations in the first concentration had no effect of the platelet count, level of free nucleotides, activity of glucose-6-phosphate dehydrogenase and lactic dehydrogenase, and on the reaction of adenine nucleotides release from the platelets induced with thrombin. Using the higher concentration of the drugs it was observed that cerubidin and the combination of cytostatic agents tested changed the shape and ultrastructure of the platelets.

The relationship between the conditions of platelet preservation and their ultrastructure, metabolic activity, and the ability to carry out physiological functions was studied. It was found that storage of platelet concentrates at +4 degrees C for 72 hours reduced the number of platelets, changed their shape decreased the ATP level and the ability of release of adenine nucleotides in response to thrombin. The platelet at +22 degrees C for 72 hours preserved the initial number, normal ultrastructure, intact metabolic activity and the ability of participation in heamostasis processes.