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Opracowanie dotyczy oceny działania prokuratury po wniesieniu przez pokrzywdzonego zażalenia na postanowienie o odmowie wszczęcia lub umorzenia postępowania. Jak pokazuje obecna praktyka, spotykamy tutaj specyficzne zachowanie organu, które w konsekwencji może prowadzić do istotnego naruszenia uprawnień procesowych pokrzywdzonego. Przedmiotem publikacji jest krytyczna ocena takiego działania oparta na gruntownej analizie przepisów regulujących funkcjonowanie postępowania w tym właśnie zakresie. Wniesienie środka odwoławczego, czyli poddanie decyzji procesowej kontroli odwoławczej, powinno petryfikować postępowanie dowodowe i wyłączać jakąkolwiek aktywność procesową, bez uprzedniej decyzji o podjęciu postępowania na skutek uwzględnienia zażalenia. W przeciwnym wypadku zostaje podważony sens sądowej kontroli, a w konsekwencji prawo do sądu zostaje istotnie ograniczone. Poniższe rozważania mają na celu wskazanie problemu istniejącego w praktyce i zwrócenie uwagi na negatywne konsekwencje z niej wynikające. Jak bowiem wynika z prezentowanych analiz, nie ulega wątpliwości, że obecna sytuacja musi ulec zmianie.

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Introduction: There is strong evidence for the importance of genetic factors in the aetiology of anorexia nervosa (AN). Stress factors can be also associated with the clinical manifestation of AN. The hypothalamic-pituitary-adrenal axis plays an important role in stress control. The increased activity of the hypothalamic-pituitary-adrenal axis in AN is caused by corticotropin-releasing hormone hypersecretion. CRH concentration in cerebrospinal fluid is increased in patients with AN. Intracerebral administration of CRH suppresses appetite. CRH receptor type 2 (CRHR 2) is involved in the appetite suppression effects of CRH. Thus CRHR 2 gene can be a candidate gene for AN. Three CRHR 2 splicing isoforms are known: alpha, b and g. In the hypothalamus, the main appetite control centre, only the isoform CRHR 2alpha is expressed, whose mRNA is characterised by one unique exon 1alpha., Aim: The aim of the study was the screening for mutations in exon 1alpha of the CRHR 2 gene in patients with AN, which could play a role in the pathogenesis of the disease., Methods: The molecular analysis has been performed in 20 patients with AN and 10 healthy controls. DNA was isolated from peripheral blood leukocytes. DNA fragments were amplified by polymerase chain reaction (PCR) and sequencing was performed., Results: After screening, no genetic variants have been found in the analysed region, including exon 1alpha and the untranslated region, both in anorectic patients as in controls., Conclusion: The results do not confirm the hypothesis that the analysed region of the CRHR 2 gene is involved in the pathogenesis of AN.

Aim: There are clinical similarities between anorexia nervosa (AN) and hypothyroidism. Previous reports have shown decrease FT3, increase rT3, sporadically decrease FT4 and normal levels of serum TSH., Method: To assess thyroid function in 36 patients with AN (4 males, 32 females the subjects ages ranged from 12 to 18 yrs) serum levels of FT4, FT3, rT3, TSH were measured. Out of this group, 24 patients have been singled out to examine the lipid metabolism by measuring the level of cholesterol, HDL, LDL, triglycerides., Results: 67% (24) of the examined group resulted in low level of FT4 (0.75-0.97 ng/dcl), but decrease FT3 (= 0.67 pg/ml) was only found with 1 patient. The level of rT3 (measured in 94% (34) patients) were normal. The level of TSH were low (0.87-0.97 muIU/ml) in 25% (9) of patients, but 6 of them also manifested decrease FT4 (0.87-0.97 ng/dcl). At the same time, we found higher level of cholesterol in 63% of patients, decrease HDL in 71%. It is interesting to notice that in 80% of cases with a lipid metabolism disorder we found decrease FT4., Conclusions: Thyroid dysfunctions may be one of the essential reasons for lipid metabolism disorder in AN.