Search

Among 231 alcohol-dependent men aged 24-67 years and treated for this dependence in a special institution specific antigens and antibodies being immunoserological markers of hepatitis virus B and hepatitis virus C were found in 13.4% of subjects and in 0.77% respectively. Anti-delta antibodies were not found among patients with HBs antigenemia. Asymptomatic HBV infection is concerned with relatively high percentage of alcoholics. However, asymptomatic HCV infection concerus relatively low percentage of the examined population.

Chromosomal analysis has been carried out in 4 patients with the symptoms of hepatic coma. An analysis included lymphocytes cultured from peripheral blood. Chromosomal disorders have been assessed with two techniques: structural chromosomal aberrations test, and sister chromatid exchange (SCE) test. It has been shown that the extend of chromosomal damage in the form of the gaps, breaks, acentric chromosomes as well as the presence of ring and dicentric chromosomes, and micronuclear cells have been higher in the examined patients. Such changes may evidence DNA repair disorders, and the presence of micronuclear forms may seem an unfavourable prognosis.