1. [TSG-6 protein and its role during maturation of ovarian follicles].
- Author
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Trzeciak P, Rąpała Ł, Starzyński R, Dąbrowski S, and Duszewska AM
- Subjects
- Biomarkers metabolism, Cell Adhesion Molecules analysis, Cumulus Cells metabolism, Extracellular Matrix metabolism, Female, Humans, Hyaluronic Acid analysis, Hyaluronic Acid metabolism, Oocytes metabolism, Ovarian Follicle chemistry, Cell Adhesion Molecules metabolism, Ovarian Follicle metabolism, Ovulation metabolism
- Abstract
TSG-6 is an ~35 kDa glycoprotein belonging to the hyaluronan binding family. Its expression is induced as a result of an inflammatory condition and during ovulation. TSG-6 is a crucial protein engaged in extracellular matrix synthesis and organization of cumulus-oophorus-complexes (COCs) in preovulatory ovarian follicles. TSG-6 catalyzes cross-linking via heavy chains of trypsin α inhibitor and hyaluronan. This reaction is essential for proper cumulus cell expansion. This process is correlated with purchasing competence by the oocyte. Disorders of the synthesis of TSG-6 cause irregularities in expansion of cumulus cells during ovarian follicle maturation. Therefore, TSG-6 is a potential molecular marker of oocyte maturation.
- Published
- 2012
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