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The examination of 5-cholestasis indicating enzymes was carried out in patients with viral B hepatitis. The changes in activity of such enzymes: alkaline phosphatase, its liver isoenzyme, gamma glutamyltranspeptidase, 5'nucleotidase, leucine aminopeptidase and alanine aminopeptidase were estimated as for being useful in discovering the states of cholestasis. Already in the first week of observation all examined enzymes showed the highest level of activity, only in the case of FZ and FW, however the difference between the patients with and without cholestasis were markedly static. In the following weeks the differences in average activities between group with and without cholestasis were present in the case of 5'N and LAP. The activity of GGTP and AAP were high in both groups of patients. And so alkaline phosphatase is the enzyme which discovers the states of cholestasis in viral B hepatitis quickly and markedly.

Activity of alanine aminopeptidase (AAP), beta-glucuronidase, and N-acetyl-beta-D-glucosaminidase (NAG) in daily urine has been determined in 27 children with nephrotic syndrome, 14 children in remission, and 11 healthy children. It was found, that these enzymes activity is significantly increased in sick children in comparison with healthy ones. Similarly, the activity of AAP and NAG in daily urine is statistically significantly higher in children with remission, than that in healthy children. An assay of these enzymes in the urine may be used in the diagnosis of nephrotic syndrome and in the evaluation of its course.