1. Ocena ilościowa kompleksu remodelującego chromatynę typu SWI/SNF w przewlekłym zapaleniu zatok przynosowych-wyniki wstępne.
- Author
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STAŃSKA, KATARZYNA, ZAGOR, MARIOLA, SARNOWSKA, ELŻBIETA, RUSETSKA, NATALIA, TOMASZEWSKA, MAŁGORZATA, SIEDLECKI, JANUSZ A., and KRZESKI, ANTONI
- Abstract
Introduction. Over the last two decades, progress of science in the fields of immunology and molecular biology has brought understanding, at cellular level, of different pathophysiological processes involved in CRS. Nevertheless, the pathomechanisms of CRS remains unclear. SWI/SNF is a human ATP-dependent chromatin remodeling complex which plays an important role in several distinct cellular processes. SWI/SNF complex enables glucocorticoid receptor (GR) to function correctly and plays a role in regulation of inflammation. It has been hypothesized that SWI/SNF complex contributes to the pathogenesis of CRS. Aim. Assessment of the protein expression level of the SWI/ SNF complex subunits (BAF155, BRM and BRG1) in the group of patients with CRS. Materials. The study population consisted of 30 subjects, aged 19-81 (12 women and 18 men), including 10 patients with CRS without polyps, 10 patients with CRS and polyps and 10 subjects without CRS constituting the control group. Results. Results of the observation revealed lower expression of the SWI\SNF complex in both CRS groups in comparison to the control group. Conclusions. SWI/SNF complex may play an important role in pathogenesis of CRS, probably through the influence on steroid hormone signaling and GR function. Further analysis of this issue is needed. [ABSTRACT FROM AUTHOR]
- Published
- 2017