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Diabetes mellitus in all its forms is the pathological state, which includes the atherogenic mechanisms of intensive action. This results in a very significant increase of the incidence, morbidity and mortality due to atherosclerotic complications. Such negative relationship is observed since decades and everywhere. Atherosclerosis is the main case of death in the subpopulation of diabetics in the degree much higher than in the general population. Therefore the studies of the mechanisms of the atherogenic influence of diabetes mellitus also of the possibility of preventive and therapeutic interventions are of utmost importance. Many of such studies are documenting, that such interventions are effective in practice. Active prevention and early individual diagnosis of atherosclerotic risk appears as the affective approach. The bare fact of such possibility was reminded in the paper.