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More than 50% of pregnant women take over-the-counter painkillers, such as non-steroidal anti-inflammatory drugs (NSAIDs) or paracetamol. Due to the well-known fetotoxic risk, NSAIDs should not be used during the third trimester of pregnancy. In addition, there are several reports describing adverse effects in the fetus after NSAID therapy in the third trimester of pregnancy. However, the scale of this risk has not yet been sufficiently explored. The paper assesses the current knowledge on the use of NSAIDs during pregnancy. [ABSTRACT FROM AUTHOR]

In clinical practice, we encounter more and more errors and complications of pharmacotherapy, which are related to the ignorance of the pharmacokinetic profile occurring in the population of pregnant patients and in the pediatric population. Unfortunately, incorrect dosing of drugs in pregnant women is still common, and in practice they are treated in the same way as non-pregnant patients, and this can lead to errors in pharmacotherapy. This is important in pregnant patients hospitalized in the ICU. In this particular patient population, changes in pharma)cokinetics associated with pregnancy overlap with changes in pharmacokinetics that are associated with severe illness requiring ICU hospitalization. The paper collects the most important information on pharmacotherapy in pregnant patients. [ABSTRACT FROM AUTHOR]

The paper summarizes the recommendations of the Hereditary Angioedema Section of the Polish Society of Allergology regarding the management of this disease in a view on up-to-date data. Its classification, pathomechanism, clinical picture and diagnosis were discussed. The principles of treatment and prevention of edema attacks and disease monitoring were presented. Characteristic features related to the course and management during pregnancy and in the pediatric group of patients were mentioned. [ABSTRACT FROM AUTHOR]

Hypertension is one of the most common cardiovascular diseases during pregnancy. Primary hyperaldosteronism (PHA) is the most frequent endocrinological, secondary cause of hypertension, rarely diagnosed in pregnant women. In the available literature about 50 cases of PHA in pregnant women have been described. PHA is often a cause of resistant hypertension. PHA can cause life-threatening complications both for the pregnant woman and the fetus. Diagnosis of PHA in pregnancy is difficult due to the antagonistic effect of progesterone on aldosterone, physiological increase of aldosterone release during gestation and frequent normokalaemic clinical course. Typical pharmacological treatment of PHA is limited due to the anti-androgenic effect of spironolactone, lack of data concerning the safety of eplerenone and limited access to amiloride in Poland. Surgical treatment is a therapeutic option only in early pregnancy. This paper presents the current state of knowledge on diagnostic methods and treatment of PHA in pregnant women and a systematic review of cases described in the literature. [ABSTRACT FROM AUTHOR]

Preeklamsja, która dotyczy 2-5% ciężarnych, jest jedną z głównych przyczyn matczynej i perinatologicznej zacho-rowalności i śmiertelności. Współcześnie uznawaną teorią dotyczącą patogenezy stanu przedrzucawkowego jest hi-poteza zaburzeń w krążeniu matczyno-płodowym. W celu prognozowania wystąpienia stanu przedrzucawkowego po-szukuje się nieinwazyjnych metod diagnostycznych mogą-cych określić zwiększone ryzyko zachorowania. Badania dotyczące identyfikacji wczesnych markerów biochemicz-nych, opracowania algorytmu postępowania lub testu skri-ningowego trwają od wielu lat. Niniejsza praca przedsta-wia aktualny przegląd piśmiennictwa dotyczący osiągnięć w diagnostyce stanu przedrzucawkowego w ciąży. Preeclampsia, which affects 2-5% of pregnancies, is one of major causes of maternal and perinatal morbidity and mortality. Nowadays the leading hypothesis of pathogenesis of preeclampsia is the theory of dysfunction in maternal-fetal circulation. The aim of early identification of preeclampsia is to find non-invasive diagnostic methods that can determine the higher risk of morbidity rate. Research on early identification of biochemical markers, algorithm development or screening test is underway for many years. This paper presents a review of the literature on current developments in diagnostics ofpreeclampsia in pregnancy. [ABSTRACT FROM AUTHOR]

Psoriasis is one of the most common skin disease, affecting 1.5-3% population, with chronic course and complex clinical picture. It is characterized by abnormal epidermis proliferation, immunological disturbances with predominance of Th1 response activity and complex pathogenesis. Among many factors inducing the disease development hormonal disorders are mentioned. Half of all patients with psoriasis are females diagnosed mostly within childbearing period of their life. It is stated that pregnancy, puerperium, menstruation and menopause modulate a natural course of psoriasis. Based on current literature search, we evaluated in this paper the role of sex hormones in pathogenesis of this dermatosis. [ABSTRACT FROM AUTHOR]