The oral administration of drugs is the most common, the most comfortable, and the safest route of drug delivery. Absorption of drugs given orally takes place mainly in the small intestine; chronic diseases affecting this part of the gastrointestinal tract may thus lead to clinically important alterations in pharmacokinetics. As the extent and the rate of drug absorption as well as other pharmacokinetic processes are influenced simultaneously by many factors, it is not always possible to predict the pattern of drug malabsorption from knowledge of the physicochemical properties of the drug and the pathophysiology of the gut disorder. Pharmacotherapy, predominately the route of drug administration, may require modification in the presence of an altered intestinal function, but, due to the complexity of the problem, it is difficult to create universal guidelines for the oral administration of drugs in patients with malabsorption syndrome. Therefore, therapeutic drug monitoring by measuring clinical and laboratory parameters and, in some situations, also serum levels of administered drugs is recommended. [ABSTRACT FROM AUTHOR]