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BACKGROUND AND OBJECTIVE: Non-alcoholic fatty liver is one of the most common causes of chronic liver disease and is considered as one of the hepatic manifestations of metabolic syndrome, and since one of the effective treatments for this disease is exercise, the aim of this study was to evaluate the changes in Fetuin-B and retinol binding protein 4 (RBP4) during eight weeks of high-intensity interval training (HIIT) in women with fatty liver. METHODS: This experimental study was performed on 25 women with fatty liver disease in the age range of 30-50 years in two groups of training (n=13) and control (n=12). The training group was included in the intermittent high-intensity exercise protocols (8 weeks and four sessions per week and each session for 48 to 60 minutes) and the control group participated in the study without any intervention. Fetuin-B and RBP4 were evaluated and compared by ELISA using a kit made by Elabscience Inc. FINDINGS: The results of the present study showed that the levels of Fetuin-B in the training group (752.50±191.23) had a significant decrease compared to the control group (1141.90±227.23) (p=0.001). Moreover, RBP4 had a significant decrease in the training group (25.42±1.11) compared to the control group (30.33±3.09) (p=0.001). CONCLUSION: The results of the study showed that a course of high-intensity interval training can be a suitable and preventive strategy to improve Fetuin-B and RBP4 levels in women with fatty liver.