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Background: The aim of this study was to investigate the effect of eight months of resistive training on growth hormone (GH), insulin-like growth factor1 (IGF1), and insulin-like growth factor binding protein3 (IGFBP3) plasma levels in patients with severe burns. Methods: The research method used in this study was of the individual-case type with multiple base lines for the participants. The examinees of this study included two women with severe burns (third degree) in the age range of 20 to 30 years confined in the Central Accidents and Burns Hospital, Isfahan, Iran. After determining the base-line position, the participants were entered into the project in a ladder step-by-step format. During the 8 months of individual intervention, they did the resistive training and one month after the finishing of the intervention period, they were put under follow-up examinations for 2 months. The measuring tool for this study was the blood tests taken for measuring GH, IGF1, and IGFBP3 plasma levels, which were taken at the fasting morning time and 24 hours after the exercises at the end of each month. Findings: Based on the visual analysis and descriptive statistical indexes, the resistive training in both examinees had caused a significant change in the GH, IGF1 and IGFBP3 plasma levels; as the percentage of non-overlapping data (PND) was 75% for the first and 87.5% for the second examinee in GH level, and 100% for both examinees in IGF1 and IGFBBP3 levels. Conclusion: It seems that long-term resistive training can cause elevation of the plasma level of some growth factors in patients with severe burns or it can prevent the reverse process and intense decline in these factors after the burn takes place. In addition, it would make these patients become free of the need for frequent surgeries and using different equipments.