Search

Background. IGF-1 hormone decreases in patients with type 2 diabetes and NAFLD. The effect of exercise on this hormone requires further researches. The purpose of this study was to compare the effects of the interval, continuous, and combined aerobic exercise on IGF-1 hormone and body composition in type 2 diabetic patients with NAFLD. Methods. In this study, forty female type 2 diabetes patients with NAFLD (mean age 50.6 ± 4.5 years, height 1.58 ± 0.07 m, weight 74.4 ± 9.9 kg) were randomized into four groups. The exercise training groups performed exercises by cycle ergometer three days a week for eight weeks. The groups included: interval aerobic exercise group (75-80% maximum heart rate), continuous aerobic exercise group (60-75% maximum heart rate), combined exercise group (interval and continuous), and control group. Variance analysis was used for analysis and comparison between groups. The t-dependent test was used for intra-group compression (α≤0.05). Results. Decreased body weight, BMI, waist circumference, waist circumference, waist-to-height ratio, body fat percentage, body fat mass, and increased IGF-1 were significant in all three exercise groups (P≤0.05). In the control group, increased hip circumference and decreased IGF-1 were significant (P≤0.05). Among the three exercise groups, the interval aerobic exercise group had the most effect on improving type 2 diabetic patients with NAFLD. Comparing between the groups, IGF-1, body mass index, waist circumference, hip circumference, and waist-to-height ratio were significant in the interval, continuous, and combined aerobic exercise groups compared to the control group (P≥0.05). Conclusion. Interval, continuous, and combined aerobic exercise improves body composition and hormone IGF-1, and according to the findings, interval aerobic exercise had the greatest effect on diabetic patients with NAFLD. Therefore, it is recommended that these patients participate in aerobic exercise regularly, especially interval aerobic exercise. [ABSTRACT FROM AUTHOR]

Background: IGF-1 is an anabolic hormone that is effective in cell metabolism and growth. Flaxseeds contain unsaturated fatty acids and are useful. Previous studies have shown that physical activity and natural substances affect hormonal levels. Thus the present study aimed to investigate the effect of 10 weeks of high intensity interval training (HIIT) with and without flaxseed oil on plasma IGF-1 level in male rats. Methods: 20 adult male Wistar rats were present in study. Animals randomly divided into four groups (five in each group) including control- saline (CS), training- saline (TS), control- flaxseed oil (CO), and training- flaxseed oil (TO) groups. The training groups performed HIIT (10 weeks, five sessions per week, 90–95% VO2 max) on a rodent treadmill. The supplementation groups also received flaxseed oil supplement (300 mg/kg). The rats were sacrificed five days after the last training session. The plasma was collected, and plasma IGF-1 lever evaluated by ELISA method. Results: Training increased the level of the plasma IGF-1 than non-training groups (P=0.009). The level of plasma IGF-1 was higher in the flaxseed oil-supplemented groups than the saline-treated groups. (P=0.002). The interaction between training and supplementation also led to an increase in plasma IGF-1 level than training or supplement alone (P=0.001). Conclusion: HIIT and flaxseed oil consumption can increase the IGF-1 in body. [ABSTRACT FROM AUTHOR]

Background: Resistance training is the most effective way to increase muscle mass. The hormonal axis of GHIGF- 1 is considered important for the health of the musculoskeletal system in both childhood and adulthood .The purpose of this study was to compare two types to resistance training with and without blood flow restriction on GHIGF- 1 axis after the exercise. Methods: In this study, 36 adolescent gymnast boys aged 10 to 14 years participated in a quasi-experimental research design. The subjects (mean weight 37.11 ± 8.11 kg, height 145.16 ± 11.58 cm, body mass index 17.40 ± 1.77 kg m) were randomly divided into three groups; control (n=12), high intensity resistance training (n=12), and low intensity resistance training with blood flow restriction (n=12). Training protocol contained three motions included leg extension, elbow flexion and bench press. Blood samples were taken before and half an hour after training. Results: The results of inter-group showed that a GH variable after acute exercise in resistance exercise with blood flow restriction group (p=0.195), traditional resistance training groups (p=0.182), and control (p=0.317) was not significant; But IGF-1 variable increased significantly in blood flow restriction group (P=0/004). There was no significant difference between groups in levels of GH and IGF-1 (p>0.05). Conclusion: One session low intensity resistance training with blood flow restriction compared to high intensity resistance training, has a similar effect on increasing serum IGF-1 in children athletes. Such as high intensity resistance exercise seems appropriate to provide hypertrophy and increased in the muscle mass. [ABSTRACT FROM AUTHOR]

Background: Insulin-like growth factor -1 (IGF-I) has a variety of roles, But the abundance of scientific evidence indicates that it is a metabolic biomarker associated with indicators of physical fitness and health. The present study examined the relationship between serum levels of IGF-I and aerobic fitness, anaerobic capacity and body fat percent, systolic, and diastolic blood pressure before and after the eight weeks of high intensity intermittent training (HIIT) in adolescent boys. Methods: In this experimental study, 22 adolescent boys in a randomly and double-blinded design were allocated in two equal groups: HIIT group (N=11) and control group (N=11). Training programs were conducted 3- 4 times per week for 8 weeks. The HIIT program consisted of 6-8 running sprints (30-60 seconds) with a 3.5-4 min recovery. Mentioned indicators assessments were performed 18-24 hours pre and post intervention. Results: IGF-1, Maximum Oxygen uptake (VO2max(, Peak Power Output (PPO) and mean power output (MPO) were significantly higher after 8 week HIIT than the pre-exercise training evaluations (P<0.001). Fatigue index and body fat percent decreased in HIIT trial after 8 week HIIT (P<0.001). Also, there was a significant positive correlation between IGF-I changes and aerobic fitness, anaerobic and body fat percentage. However, Systolic and diastolic blood pressure did not change significantly after the training period (P > 0.05). Conclusion: The IGF-I can be used as an indicator to assess the fitness of adolescent boys. [ABSTRACT FROM AUTHOR]

Background and Aim: Type 2 diabetes is more prevalent in middle-aged women due to menopause, decreased body metabolism, and increased fat tissue. The purpose of this study was to investigate the effect of eight weeks aerobic periodic training with increasing intensity on insulin-like growth factor (IGF-1) and insulin resistance in middle-aged women with type 2 diabetes. Materials and Methods: In this experimental study, 30 middle-aged women with type 2 diabetes were selected through targeted sampling and randomly divided into two groups of 15 Interval training and control groups. The training group performed for 8 weeks an intensive training session on the Davis test on the monocular bicycle, So that in the first week, the subjects performed their exercises with 65% of their maximum strength and in the eighth week with 80% of their maximum strength. During this period, the control group did not participate in any kind of sports activities. For all subjects, body mass index, IGF-1 hormones and insulin resistance were measured using the HOMA-IR formula. To compare pre-test and posttest data in each group and between groups, t-test and independent t-test were used. Results: Eight weeks of training had a significant increase in insulin-like factors and a significant decrease in insulin resistance in the experimental group (P≤0.001). These changes also showed a significant difference in comparison with the control group. Conclusion: High-intensity aerobic interval training through the effect on hormonal levels can be effective in improving the status of people with type 2 diabetes. [ABSTRACT FROM AUTHOR]

Background: Insulin like growth factor I (IGF-I) is a member of large single-chain polypeptides, similar to proinsulin protein. This gene increases cell growth. The purpose of this study was to investigate polymorphism of Adenosine-Cytosine (CA) in IGF-I gene promoter among breast cancer patients and healthy individuals and its relation to risk of breast cancer. Methods: This study was a case-control study on 100 patients and 100 controls women. DNA was extracted from the blood of study subjects, the sequence were amplified by the technique of Polymerase Chain Reaction (PCR). Thereafter the number and sequence of CA was measured by gel electrophoresis on Polyacrilamid. Finding: The results of this study shown that IGF-I gene allele distribution in Isfahan population varies between 11 and 23 repeats and (CA)19 was the most common allele between patients and controls. Women with sequences larger than 19 were in a greater risk of breast cancer. Conclusion: These findings indicate a direct relationship between the numbers of repetitive sequences of IGF-I gene promoter and increased risk of breast cancer. In other words, increasing the number of CA repeat (greater than 19) located in the promoter gene, increases the risk of breast cancer in women. [ABSTRACT FROM AUTHOR]

Objective: Immunohistochemical localization and immunoreactivity of insulin-like growth factor-I (IGF-I) were investigated during the ovarian developmental stages in Persian sturgeon. In addition, the effects of growth hormone and thyroxine were investigated on IGF-I immunoreactivity in vitro. Materials and Methods: Ovarian samples were taken from two brood stocks (caught from the sea and from a river) during their reproductive migration and at three different developmental stages based on their polarization index (PI). The effects of two hormones on IGF-I immunoreactivity were studied at two ovarian developmental stages (PI > 0.1 and PI < 0.07). In both experiments the immunoperoxidase method was performed in order to detect immunohistochemical localization and immunoreactivity of IGF-I. Results: Immunohistochemical localizations of IGFI were detected in the follicular layers. There was no significant immunoreactivity difference between the two brood stocks, however in the river brood stock IGF-I immunoreactivity was more intense in the ovaries with PI < 0.07 than of PI > 0.1 (p < 0.05). Growth hormone (10 ng/ml) increased IGF-I immunoreactivity in ovarian samples from the river brood stock when their PI was less than 0.07, however thyroxine had not such effect (p < 0.05). Conclusion: Our results showed that IGF-I is present in the ovaries of Persian sturgeon and its reactivity is different among their gonadal development stages. This may support a role for IGF-I during reproductive physiology in female brood stocks of the Persian sturgeon. Moreover, growth hormone is a potential hormone to increase IGF-I immunoreactivity in the ovaries of this species. [ABSTRACT FROM AUTHOR]