Search

Background: Diabetes mellitus is a chronic metabolic disorder with the main symptom of elevated blood sugar. Many drugs are now used to control diabetes. The aim of this study was to investigate the effect of Rosa damascena extract on blood glucose and insulin levels in diabetic rat models. Methods: In this study, 100 male rats were divided into 10 equal groups of control, untreated diabetic, gavage stress, insulin treatment, and three healthy groups receiving different doses of extract (300, 600, and 900 mg/kg). Blood samples were taken at the day 0, 17, 31, and 45, and blood glucose, insulin, and malondialdehyde (MDA) levels were measured. Statistical analysis was performed using analysis of variance (ANOVA), and P < 0.050 was considered statistically significant. Findings: There was no significant difference in mean fasting blood glucose and insulin level of different groups before beginning the interventions. Rose extract at the dose of 900 mg/kg significantly decreased blood glucose level (P = 0.007) and significantly increased blood insulin level (P = 0.009) in diabetic rats compared to diabetic control group. This dose of extract also reduced blood glucose and increased insulin levels in healthy non-diabetic rats. Conclusion: Using rose extract can decrease blood sugar, and increase insulin levels. It seems that this extract could be of interest to researchers as a suitable therapeutic potential.

Background: Diabetes is caused by a breakdown in insulin production or its malfunction in the body. So far, many studies have been done on its treatment. The aim of this study was to investigate the histological changes in endocrine part of the pancreas of diabetic rats treated with Rosa damascena extract. Methods: In this experimental study, 100 male rats were divided into 10 groups of control, untreated diabetic, gavage stress, insulin treatment, three healthy groups receiving different doses of extract, and three diabetic groups receiving different doses of extract (300, 600, and 900 mg/kg). Finally, pancreatic tissue was removed and immunohistochemically stained with hematoxylin-eosin to count pancreatic beta cells number, and to calculate islets of Langerhans. Statistical analysis was performed using ANOVA test, and P < 0.050 was considered as statistically significant. Findings: Rosa damascena extract at 900 mg/kg, significantly increased the area of the islets of Langerhans in diabetic rats compared to the diabetic control group (P = 0.021). This dose of extract also increased the percentage of beta cells in the islets of Langerhans compared to the diabetic control group (P = 0.017). Conclusion: According to the results, using rose extract can improve tissue changes in the pancreas. This extract can probably be considered as a suitable research potential in future studies.

Background and aims: This study was aimed to evaluate the effect of spinacetin 7-O-β-D-glucopyranoside, a flanovid compound separated from Centurea shmidi against MCF-7 breast cancer cell line and its effect on apoptosis induction. Methods: In this study, the inhibition rate of cell growth and induction of apoptosis in MCF-7 cell culture cells after treatment with different concentrations of spinostine glycoside was studied by MTT and flow cytometry. Results: According to the results of MTT test, after 48 hours treatment with spinostin-7-O- β-D-glucoside, a significant inhibition in cell proliferation was observed compared to the control group (P