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Objective (s): In a threatening situation such as Covid-19 Pandemic, E-health is more effective in providing public health, including prevention, monitoring, diagnosis, prioritization, treatment and follow-up patients. Regardless of E-health potential benefits, implementation and adaptation barriers is expected. In this regarding, it is essential to study the factors influencing EHCR adoption. Therefore, this study aimed to investigate the factors affecting the adoption of E-Health. Methods: In this research, the mixt method approach and exploratory design - typology creation model have been used. After conducting semi-structured interviews and a focus discussion group among physicians, specialists, health experts and CEOs, a research model was developed and tested one a sample of 417 physicians in an online survey. Structural Equation Modeling (SEM) has also been used to analyze the data and test the research hypotheses. Results: Trust and confidentiality, waiting time, authority, health provider-patient relationship are influencing factors that affect adoption of E-health factor. Five other factors were also found that were similar to the UTAUT2 model: performance expectancy, effort expectancy or ease of use, facilities, price value, habit. All hypotheses were significant because the absolute value of the significant number obtained from the t statistic in all hypotheses was higher than 1.96, with a 0.84 effect rate. Conclusion: The findings from this study help to understand the factors influencing behavioral tendency in using E-Health. Theoretical findings, development, and validation in this dissertation provide a framework that includes the factors influencing the adoption of health technology, theoretical foundations for designing and selecting health technology in future health care before they enter the market, or solving the problems of their acceptance implementation.