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Background and Aim: Traditional Post-operative rehabilitation programs focus on quadriceps strengthening and knee range of motion. Hip muscles weakness is although evident in patients with knee osteoarthritis. The aim of this trial is to investigate the effect of adding early hip muscles strengthening exercises to traditional rehabilitation program on pain, range of motion, quality of life and physical function in patients wih unilateral Total knee Arthroplasty (TKA). Materials and Methods: The intervention started from second day after surgery and continued for ten sessions, three times a week on twenty four participants in Control and Intervention groups. Both groups recieved Transcutaneous Electrical Neural Stimulation (TENS) and Infra Red (IR) and then started doing exersice. The control group did knee extensor and flexor strengthening and range of motion exersices. The intervention group did hip strengthening exercises in addition. Outcome measures include pain, knee flexion & extension range of motion, quality of life using Short Form 36, Timed up and go test, step test, six minute walk test and strength of hip and knee muscles. Ethical Considerations: Research Ethics Code: 1396.9511340012 and Iranian Registry of Clinical Trials Code: IRCT 20150314021459N6. Findings: All of outcome measures improved in both groups. Pain (P=0/03), knee extension range of motion (P=0/007), Timed up and go test (P=0/033) improvement was significantly higher in intervention group than control group. The Strength of knee flexors (P=0/023), hip flexors (P=0/040), hip extensors (P=0/028), hip adductors (P=0/040), hip external rotators (P=0/047) was significantly better improved in intervention group. Conclusion: According to the results, both treatments could be effective on patients with unilateral total knee arthroplasty. Considering better result of some of outcome measures in intervention group, addition of hip strengthening exercises to knee exercises can be useful. [ABSTRACT FROM AUTHOR]