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Background and aims: Acute lymphocytic leukemia (ALL) is an aggressive neoplasm and appearing of that with severe eosinophilia is a rare coincidence. In this study a case of severe leukemia with aggressive appearance of eosinophilia is reported. Case report: In this report an 1-years old boy with severe eosinophilia is presented. An 18- years old boy with fatigue, low fever, tachy cardia, periodic weakness and diffuse erythroderma is presented. On physical examination, splenomegaly was seen in his visit sessions. Total leucocytes were 50000 cu/mm with 60% eosinophil in his complete blood. The level of Hemoglobin and hemotoblast was normal. His bone marrow examination showed a hyperplasic marrow incretion with increase in eosinophilia and lymphoblast. The bone marrow examination and blood samples experiment of flow cytometry showed pre B cell ALL with eosinophilia. Patient was treated with hyper CVAD, but it didn't work. Then he was treated with FLANG diet which results in complete remission achievement. Finally, patient was gone under allogenic bone marrow transplantation. Conclusion: Therefore, it is suggested to concern about ALL in patients with increasing Eosinophilia, and prerequisites treatment should be done [ABSTRACT FROM AUTHOR]