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Background & Aims: Diabetes is the most common metabolic disorder in the world, which can disrupt ovarian function. The present study was designed to examine the effect of Okra powder on ovary histology in high-fat diet fed-streptozotocin (HFD/STZ) induced diabetic female rats. Materials & Methods: 25 adult Female Wistar rats were divided into 5 equal groups. Group I: (control group): served as helthy rats received normal diets. Group II diabetic(HFD+ STZ): rats were fed HFD (60% fat + 25% carbohydrate + 15% protein ) for 4 weeks and then injected with STZ (35 mg/kg body weight). GroupIII(HFD+STZ+A.E): HFD + STZ rats were treated with 200 mg/kg powder A. esculentus. Group IV (HFD+STZ+metformin): HFD + STZ rats were treated with 200 mg/kg metformin. Group V: Normal Diet + A. esculentus (200 mg/kg). After 4 weeks of treatment, animals were euthanized and body weight, ovary weight and insulin resistance markers (insulin and glucose levels and HOMA-IR) were determined. The right ovary was isolated and floated in appropriate fixative. 5-6 μm sections was prepared as paraffine embedding method and stained by H&E and PAS and studied by light microscopy. Results: Hyperglycemia, insulin resistance and reduced body weight of diabetic rats were improved after administration of Okra for 4 weeks. This effect was relatively similar to metformin. Okra powder was caused a significant increase in primordial, primary and graffian follicles (P

Background & Aim: Diabetes mellitus is the most common endocrine disorder in the world which causes ovarian dysfunction. The aim of this study was to evaluate the effect of omelette powder on ovarian tissue changes in diabetic rats using a high-fat diet based on streptozotocin HFD / STZ. Methods: In this experimental study, 25 female rats (Wistar rats) were divided into 5 groups of 5. The first group, as the control group, the second group was received high-fat diet (HFD) (fat 60% + 25% carbohydrate + protein 15%), followed by STZ (35 mg / kg) intravenous 4 weeks. the third group received diazepam (200 mg / kg), the fourth group received metformin (200 mg / kg), the fifth group as sham or the control group of healthy rats (200 mg / kg) received only Abelmoschus esculentus powder. After 4 weeks of treatment the animals were euthanized body weight, ovary weight and insulin resistance markers (levels of insulin, glucose and HOMA-IR) were measured. From the right ovary sections of 5 to 6 micrometers in diameter were prepared, stained and then studied.Data were analyzed using ANOVA and LSD tests. Results: Hyperglycemia, insulin resistance and reduced body weight of diabetic rats were improved after administration of Abelmoscus esculentus powder in duration of 4 weeks. This effect was relatively similar to metformin. Abelmoscus esculentus powder was caused a significant increase in primordial, primary and graffian follicles (P