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Background and objectives: Technological advances in the food industry have led to the development of various processing methods to increase the shelf life of fruit and products divided from fruit to ensure access to them during the year, even for seasonal fruits. The conventional heating method causes undesirable changes in the final product such as color changes, unpleasant taste, and degradation of Ascorbic acid. The aim of this study was to investigate the effect of microwave processing as an alternative the conventional method on the physicochemical properties of orange juice. Materials and Methods: All chemicals used in this study were purchased with High-Purity from reputable companies. Jaffa orange was purchased from the local market in Gorgan (a city in the north of Iran). Effect of continuous flow microwave treatment (MW) at full power (900 W) and temperature (60, 70 & 80 °C) on physicochemical and qualitative properties of orange juice including vitamin C, browning index (BI), turbidity, cloud value, soluble solids (Brix), acidity, viscosity and pH of orange juice (com up time “CUT” phase) was evaluated. All indices were monitored until the end of the Holding phase (inactivation of PME to 90%). Results: Results of the experiments showed that various temperature treatments at full power microwave (900 W) caused a slight decrease in pH and a slight increase in acidity and Brix during the CUT phase (p <0.05). But no significant change was observed in these parameters at the holding phase (p> 0.05). All spectrophotometric parameters of juice including browning index, turbidity, and cloud value were raised after exiting from the microwave (CUT phase) with increasing in temperature (p <0.05). These parameters increased slowly until the end of the Holding phase. Increasing in temperature to the CUT phase; the viscosity was decreased significantly at high temperatures (70 and 80 °C) and no significant change was observed after the CUT phase. Vitamin C raised with increaseing in temperature in all thermal treatments. The degradation rate was high (at 80 °C) at the Holding phase. Different thermal treatments caused 70 to 80% decline in PME activity during the CUT phase. Conclusion: Continuous flow microwave heating is an emerging technology that can potentially be used to heating of liquid foods. Microwave aid processing of orange juice is an effective method to inactivate of PME enzyme, through a significant increase in degradation rate. The results showed that increases in temperature, enhanced the browning index, turbidity, and cloud value. Different treatments had no significant effect on the Brix, acidity and pH in the holding phase. On the other hand, increasing in temperature, enhanced the rate of vitamin C, and PME degradation. [ABSTRACT FROM AUTHOR]

The present study was carried out to determine the effects of UV irradiation on postharvest and quality of desert truffle. in order to increase the shelf life of desert truffles, truffles were irradiated with UV -C (2.2 mW cm - 1 ) at three different times, (control), 10 and 20 minutes and also storage in 7%, 10%, 13% 16% (w/w) NaCl and 5% vinegar solution (w/w). After applying the desired treatments, truffles were stored at 4 ° C for 160 days and sampling was performed at 40 - day intervals. Weight loss percentage, tissue firmness, phenolic compounds, vitamin C content and microbial load were evaluated.Tissue firmness was higher at the truffles that were exposed to radiation for 10 minutes than other treatments. Also, radiation had a significant effect on preventing weight loss of truffles. The lowest weight loss was related to 10 minutes of radiation treatment and also, the highest amount of weight loss was related to control treatment. Radiation at higher doses does not further improve tissue quality parameters and causes skin necrosis and damage to truffle tissue. Evaluation of truffles phenolic compounds such as caffeic acid, ferulic acid, vanillic acid, coumaric acid, cinnamic acid and catechin was measured by HPLC. Evaluation shows that radiation had a significant effect on the increase of phenolic compounds in truffles, however the amount of these compounds decreased significantly over time. Irradiation also had a significant effect on reducing the microbial load and irradiated truffle had the lowest amount of microbial growth. However, the most effective treatment to maintain tissue quality characteristics and prevent weight loss and inhibit bacterial spoilage, UV -C (10 minutes) and immersion in vinegar and Storage at 4 ° C compared to other treatments was expressed during 160 days of storage. [ABSTRACT FROM AUTHOR]

Introduction1 Medicinal plants have a long history of treating different diseases. Glaucium flavum (yellow horned poppy) is a summer-flowering plant in the family Papaveracae. It is native to Northern Africa, Macaronesia, temperate zones in Western Asia, and the Caucasus, as well as Europe. It has thick, leathery deeply segmented, wavy, bluishgrey leaves, which are coated in a layer of water-retaining wax. Yellow Horne Puppy (YHP) is an alkaloid medicinal plant with a high content of antioxidants and anti-inflammatory properties. This study aimed to evaluate the effect of hydro-alcoholic extract of Yellow Horne Puppy on some hematological indices in male rats compared with vitamin C. Vitamin C is an electron donor, and this property accounts for all its known functions. As an electron donor, vitamin C is a potent water-soluble antioxidant in humans. Materials and Methods In this experimental study, 36 adult male Wistar rats were randomly divided into six groups (six rats in each group): (1) The first group (control) did not receive any dose, and the experimental groups (2) treated with oral administration of 250 mg/kg of yellow horned poppy extract, (3) treated with Intra-peritoneal (IP) administration of 250 mg/kg of the extract and 100 mg/kg of vitamin C, (4) treated with IP administration of 100 mg/kg of vit C, (5) treated with oral administration of 500 mg/kg of extract, (6) treated with oral administration of 200 mg/kg of vit C. Thirty days after administration following induction of anesthesia and taking blood from the heart of rats, blood samples were collected and hematological parameters measurement including red and white blood cells, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, Red blood cell distribution width and platelets measured by a Hematology Auto Analyzer. The obtained data were subjected to the Shapiro-Wilk test for normality. Results were analyzed statistically by SPSS software version 22 and the One-way ANOVA test with Bonferroni post hoc test. Mean ± SD was considered significant if (P<0.05). Results and Discussion Medicinal plants have natural ingredients and many of these plants have fewer side effects. Because the most important known factor in yellow horned poppy is its alkaloids. The most important alkaloids of this plant include Glaucine, Berberine, Bolbucapanine, and Protopine. Glaucine is an alkaloid that has been shown to have antioxidant properties and can protect against double bond fatty acids against free radicalmediated peroxidation. Due to our result, the oral consumption of yellow horned poppy significantly increased the number of Neutrophils (76.84±14.02) and, decreased Lymphocytes (18.41±9.58). Elevated blood neutrophils due to the induction of stressful conditions and stimulation of the immune system. In this sense, these factors not only raise white blood cells but also affect other blood parameters but, in this study, Changes in white blood cell counts due to oral administration and injecting vitamin C have been shown to stimulate the immune system. Injection of vitamin C showed a significant increase in monocytes (4.16±0.75). The number of red blood cells among the groups under study showed no decreasing or increasing effect (P>0.05). Hb and MCH increased with both oral and IP administrated extracts. IP administration of YPH+vit C has led to a decrease in MCH and MCHC (17.56±0.66, 33.76±0.80). Platelets were also significantly increased by IP administration of Extract of Glaucium Flavum+ vitamin C (351000±126714). The rate of RDW was reduced by oral administration of YPH and injection (13.01±1.35, 12.73±0.53). Glaucium flavum contains Glaucine, an alkaloid similar in effect to codeine, in that it has cough suppressant activity but without being addictive. Glaucine is an alkaloid found in several different plant species such as Glaucium flavum, Glaucium oxylobum, Croton lechleri, and Corydalis yanhusuo. It has a bronchodilator and anti-inflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in some countries. Glaucine may produce side effects such as sedation, fatigue, and a hallucinogenic effect characterized by colorful visual images and has recently been detected as a novel recreational drug. Conclusion The findings of this study reveal that Oral administration of the yellow horned poppy extracts can have a good effect on blood parameters, as same as vit C, due to its antioxidant properties. Therefore, this plant extract can be used in the treatment of many diseases. [ABSTRACT FROM AUTHOR]

Due to scarcity of water resources, its negative effects on agricultural yield, and the need to ensure food security, it is necessary to provide effective strategies to improve management and water productivity in this sector. Accordingly, the present experiment has been carried out as a factorial based on completely randomized design during spring of 2019 in the research greenhouse of Shahid Bahonar University of Kerman. The research factors include 3 irrigation levels Fc100, Fc75, and Fc50 (100%, 75%, and 50% field capacity) as the first factor and two superabsorbent levels S0 and S5 (0 and 5 gr/kg soil) as the second factor, performed with five replications. The results show that the maximum yield (40. 23 ton/ ha) and water productivity (10.36 kg/m3) belong to FC100S5 treatment, increasing by 5.71% and 47.6%, respectively, compared to the values recorded in similar level of irrigation and non-superabsorbent polymer. The maximum value of total chlorophyll (25.12 mg/ml) are observed in FC100S5 treatment, which in turn increase by 19.44%, compared to the control. The maximum value of vitamin c occurs in FC100S0 treatment, being 18.27% higher than minimum recorded value. Finally, the results show that the difference between irrigation water production of cherry tomato in FC100S0 and FC75S5 has not been not significant, despite 25% reduction in field capacity moisture at FC75S5. According to the results of this research, the quadratic production function is recommended as the optimal function to estimate the mentioned traits in terms of application and non- application of super absorbent. [ABSTRACT FROM AUTHOR]

Introduction: There is growing evidence about the use of antioxidants to reduce the side effects of chemotherapy and cancer drug resistance. Therefore, this study aimed to use vitamin C as an antioxidant and determine its effect on drug resistance in HT29 cells. Materials & Methods: During this case-control study, HT29 cells were first cultured and evaluated by MTT assay for cell death in the presence of vitamin C and 5FU. DAPI staining was also performed to visualize cell apoptosis. After RNA extraction and cDNA preparation, to determine the molecular mechanism of apoptosis by the drug and the inhibition effect or aggravation of vitamin C on cellular signaling of apoptosis, expression of growth-related genes and apoptosis of Caspase-3 and Bax were measured by real-time PCR. Findings: The results of the MTT test showed that vitamin C had no significant effect on cell apoptosis induced by 5-FU. DAPI and DNA ladder assay results from HT29 cells showed qualitative changes in cell apoptosis. In addition, real-time PCR results revealed increased expression of Bax and Caspase-3 in HT29 colon cancer cells treated with chemotherapy. Discussions & Conclusions: Our findings showed that vitamin C did not prevent the effect of chemo drug although it had no positive effect on the growth of cancer cells. Therefore, vitamin C intake by patients undergoing chemotherapy will not affect the drug's effect on the tumor and may protect the patient from side effects.

Aiming at finding a suitable treatment for maintaining the fruit quality and increase the shelf life of strawberry, effects of ascorbic acid and essential oil of Thymbra spicata were evaluated. Fruits were dipped in 10 and 15 mM of ascorbic acid and essential oil of T. spicata (400 and 600 ppm) for two minutes, and after drying at room temperature, were packed by cellophane in the polyethylene container and transferred to 4 °C. Some of the qualitative, quantitative and biochemical parameters were measured at 7 and 14 days after storage. Results of analysis of variance showed that there were significant differences among the treatments in most of the evaluated parameters. Strawberry fruits treated with ascorbic acid and essential oil showed lower weight loss and lower fruit browning, while they had higher marketability than control plants. Ascorbic acid and essential oil treatments also led to decreases in polyphenol oxidase activity, total phenol content and electro leakage, while the vitamin C content and antioxidant capacity were significantly higher than control plants. Generally, ascorbic acid (15 mM) and essential oil (400 ppm) compounds reduced fruit’s degradation during cold storage and these treatments have the potential to be used as practical postharvest treatments to retain the quality of strawberry fruits.

Background and Aim: Topical supplements and vitamins have often been used to accelerate the healing of burn wounds. This study investigated the effects of topical application of vitamin C solution on burn wounds. Methods & Materials: This research was performed on 30 patients with extensive second-degree burns on one or two organs with similar burns. The study subjects were randomly divided into the intervention and control groups. The intervention group received topical application of vitamin C solution in addition to silver sulfadiazine ointment in the burn area; however, only silver sulfadiazine ointment was applied in the burn area in the control group. The wounds were examined and scored on days 1, 3, 7, and 14 using the Bates-Jensen Wound Assessment Tool. The collected data were analyzed in SPSS using repeated-measures Analysis of Variance (ANOVA). Ethical Considerations: This study was approved by the ethics committee of sabzevar university medical sciences. (Code: IR.MEDSAB.REC.1394.60). Results Eighteen of the 30 examined patients were male and 12 were female. Their Mean±SD age and body mass index were 43.03±11.90 years and 27.82±4.08 kg/m2, respectively. Conclusion: The repeated-measures ANOVA data indicated that the study groups were significantly different concerning the final mean scores given to the wounds (P=0.047). In other words, the research groups significantly differed in wound healing; thus, topical application of vitamin C significantly improved wound healing in the study participants.

Tomatoes are widely produced and consumed worldwide due to their high nutritional value as well as unique sensory properties. The high perishability and low shelf life of tomatoes necessitate the use of novel processing methods. In this research, the possibility of using vacuum frying technology in the processing of tomato slices, the effect of process variables (processing time, oil temperature and pressure inside the chamber) on some quality characteristics of the final product (moisture and fat content, shrinkage, ascorbic acid, color and texture brittleness) as well as determining the optimal processing conditions in a vacuum lab-scale frying systemwith precise control of process conditions were investigated. Initially, by performing pre-tests, the range of variables of the study included frying temperature (115-135°C), pressure inside the chamber (260-340 mbar) and process time (15-25 minutes) was determined. The results of study showed that the process temperature has significant effects (P≤0.05) on the moisture content, shrinkage, fat content, ascorbic acid content and texture brittleness, so that with increasing temperature, the moisture content and ascorbic acid content decrease and shrinkage, fat content and tissue brittleness increase. Processing time showed significant effects (P≤0.05) on the moisture content, shrinkage, fat content and texture brittleness, so that with increasing process time, the moisture content decreased and shrinkage, the fat content and texture brittleness, increased. Operating pressure had significant effects only on shrinkage and total color change characteristics (P≤0.05). Increasing the operating pressure led to a reduction in shrinkage and an increase in total color changes.Optimum vacuum frying conditions of tomato slices were a temperature of 135°C, time of 21.92 minutes and pressure of 260 mbar, under these conditionswere the moisture content, shrinkage, fat content, amount of ascorbic acid, total color changesand the breaking force were45.93%, 70.54%, 34.64%, 2.92 mg/100 mL, 64.86 and 2.58N, respectively. [ABSTRACT FROM AUTHOR]

In this study, cantalupe seed protein (Cucumis melo var cantalupensis) were used to obtain bioactive peptides with maximum antioxidant power (DPPH radical scavenging activity and reducing power for alkalase treatment,. For this purpose, in this study, the response surface methodology and central composite design with different levels of independent variables of enzyme to substrate ratio (E / S) 0.25%-3.25%, hydrolysis time 30-210 min, temperature 30C°-55 °C for alkalase enzyme. Optimal condition treatment obtained as enzyme to substrate ratio (E / S) 0.86, hydrolysis time 173.51 min and temperature 49.93 °C and adjasted- R2 for DPPH radical scavenging activity were 0.80 and 0.58, respectively, and for Fe2+ reducing power were 0.96 and 0.91 (alkalase treatment), respectively., indicating that the fitted model had a relatively good description of the data distribution. Antioxidant tests were performed using different concentrations of 50-200 ppm of the optimal treatment, and the results showed a positive effect of concentration on antioxidant properties. In all samples, hydrolyzed protein with alkalase showed higher antioxidant properties compared to unhydrolyzed protein, but was lower than the antioxidant activity of ascorbic acid as a positive control. The antioxidant properties of bioactive peptides make it possible to use them as a natural alternative to common antioxidant compounds in the food industry. [ABSTRACT FROM AUTHOR]

In this study, the effects of different levels of dietary supplementation with vitamin C, astaxanthin and lecithin on some biochemical indices of ovarian fluid (Total protein, ACP, ALP, LDH and AST enzymes) and reproductive performance (fecundity and fertilization rate) of Caspian brown trout (Salmo trutta caspius) were investigated. For this purpose, nine experimental diets were formulated and supplemented with different combinations of vitamin C at levels of 0, 300 and 700 mg kg-1 diet, astaxanthin at levels of 0, 50 and 100 mg kg-1 diet and soybean lecithin at levels of 0, 6 and 9% (C0A0L0, C300A50L0, C700A100L0, C0A50L6, C300A100L6, C700A0L6, C0A100L9, C300A0L9, C700A50L9) and broodstocks (2.51±0.05 kg) were fed for four months. After maturation and stripping, ovarian fluid was separated for biochemical indices and oocytes used for reproductive performance. Based on the results, a significantly increase was observed in the total protein content of ovarian fluid of fish fed with the treatments C300A100L6, C700A50L9, C700A0L6, C0A100L9 and C300A0L9 compared to the control (p<0.05). Also, the lowest LDH were obtained in treatments C300A100L6, C0A100L9 and C0A50L6, which were significantly different from the control (p<0.05). Treatments C700A0L6 and C0A100L9 had the lowest AST and the highest ALP values, both of which were significantly different from the control (p<0.05). The highest fecundity and fertilization rate were observed in C0A100L9 and C300A100L6 treatments which were significantly different from the control (p<0.05). In conclusion, dietary supplementation of 300 mg kg-1 vitamin C with 100 mg kg-1 astaxanthin and 6% lecithin led to a decrease in AST and LDH enzymes activity and improvement of fecundity and fertilization rates. [ABSTRACT FROM AUTHOR]

In this study, the effects of different levels of dietary supplementation with vitamin C, astaxanthin and lecithin on ionic (K+, Na+, Ca2+ and Mg2+) and biochemical (Total protein, cholesterol and glucose) indices of ovarian fluid, also its effect on sperm motility duration in Caspian brown trout (Salmo trutta caspius) were investigated. For this purpose, nine experimental diets: C0A0L0 (0 mg kg-1 vitamin C, 0 mg kg-1 astaxanthin and 0% soybean lecithin), C300A50L0, C700A100L0, C0A50L6, C300A100L6, C700A0L6, C0A100L9, C300A0L9 and C700A50L9 were formulated and broodstocks (2.51±0.05 kg) were fed for four months. After maturation and stripping, ovarian fluid was separated for ionic and biochemical indices. To evaluate sperm motility, 1 μl of milt was placed under a microscope with fresh water (as a control treatment) or ovarian fluid of experimental fishes. Sperm motility was measured with a chronometer. Results showed that the highest amounts of Na+, K+, Ca2+ and Mg2+ ions were obtained in ovarian fluid of C300A100L6, C300A100L6, C0A100L9 and C300A100L6, respectively, which were significantly different from C700A50L9 (p<0.05). Also, the highest levels of protein, cholesterol and glucose were observed in C700A50L9, C0A50L6 and C0A100L9 treatments, which were significantly different from C0A0L0 treatment (p<0.05). Lowest duration of sperm motility was obtained in fresh water (43.96±2.25 seconds) which was significantly different from other treatments (p<0.05); however, the highest sperm motility was observed in C300A100L6 and C0A100L9 treatments (80.76±2.03 and 80.7±1.76 seconds, respectively). This results show the effect of nutrition on ionic and biochemical parameters of ovarian fluid, so that the simultaneous addition of 300 mg kg-1 of vitamin C with 100 mg kg-1 of astaxanthin and 6% lecithin leads to an increase in ions, total protein, cholesterol and glucose of ovarian fluid, and eventually increased the motility of sperm. [ABSTRACT FROM AUTHOR]

Objective: Aging is associated with some changes in the liver function including increased collagen deposition and decreased mitochondrial function. This study aims to evaluate the effect of resistance exercise and vitamin C intake on the expression of Peroxisome Proliferator-Activated Receptor-Γ Coactivator-1α (PGC-1α) and Mitofusin 1 (MFn1) genes and collagen deposition in older rats. Methods: This is an experimental study conducted on 25 male Wistar rats aged 24 weeks and weighted 280-320 g. They were randomly divided into five groups of young control, older exercise, older vitamin C, older exercise + vitamin C, and older control. In the supplementation groups, rats were given liposomal vitamin C (100 mg/kg per body weight) by gavage daily. One-way ANOVA was used to examine the difference between the groups and Tukey’s post hoc test was used to determine the location of group differences. For all analyses, the significance level was set at 0.05. Results: Aging significantly reduced the expression of PGC-1α and MFn1 and increased collagen deposition in the liver tissue of rats (P=0.001). In the older exercise + vitamin C group, a significant increase in PGC-1α expression was observed compared to the older control group (P=0.001), but there was no significant changes in MFn1 expression. A significant decrease in collagen deposition was reported in the older exercise, older vitamin C, and older exercise + vitamin C groups compared to the older control group (P=0.001). Conclusion: Resistance exercise combined with vitamin C intake reduces collagen deposition in liver tissue and increases PGC-1α expression in older rats.

Background: Some studies have shown that vitamin C has a positive effect on reducing headaches after spinal anesthesia, but studies in this field are inadequate. The aim of this study was to determine the effect of vitamin C infusion on the decrease of headache after spinal anesthesia in cesarean section. Methods: This clinical trial study was performed on 160 patients undergoing cesarean section referred to Kowsar Hospital of Yazd in 2017. The patients were randomly divided into two groups including group 1, 2 gr of vitamin C in 500 cc normal saline, and group 2, 500 cc of normal saline was injected preoperatively. The two groups were compared for headache incidence. Results: At the time of recovery, 2 hours later, the frequency of headache in the intervention group was significantly lower than the control group (P 0.05). Conclusion: Considering the patient's condition, and according to the anesthesiologist and surgeon, vitamin C can be used to reduce pain in patients undergoing cesarean section with spinal anesthesia.

Introduction[1] It has been documented many times in various articles that the plasma vitamin C concentrations have been severely reduced during stress and disease in calves. Another report shows that the production of endogenous vitamin C was not apparently observed in dairy calves up to 4 months of age, and therefore the suckling calf depended on relatively low concentrations of vitamin C in consumed milk. Therefore, suckling calves are exposed to various pathogens that cause various diseases and consequently economic loss. One of the most important causes of mortality in suckling calves is their susceptibility to infections, since calves are more susceptible to intestinal and respiratory infections resulting in high mortality during this period. Therefore, use of dietary supplements and vitamins can improve the immune system and growth performance. Vitamin C is a water-soluble vitamin that has antioxidant properties and can kill free radicals produced in cells. The amount of vitamin C in the animal is reduced during stress and exposure to the disease. Therefore, providing it through starter rations can improve animal performance. There is limited research about the effects of vitamin C on the immune system and its beneficial effects in suckling calves. Hence, this study was aimed to evaluate the supplementation of vitamin C on growth performance and immune system of Holstein suckling calves. Materials and Methods For this experiment, 40 newborn Holstein calves with an average age of 1-10 days, and about 36±1 kg weight, were used in a completely randomized design with 2 treatments and 20 replications. The treatments included: 1) Control (starter and whole milk) 2) Control + daily 600 mg vitamin C. Average daily gain and feed intake were measured and feed efficiency was determined. Blood samples from each calf were taken 4 times, including 48 h immediately after birth, 7, 21, and 45 days after birth. Total protein, albumin, triglyceride, cholesterol levels were measured by commercial kits (made by Pars Test Co.). Serum concentrations of vitamin C, super oxide dismutase and glutathione peroxidase were measured by commercial kits. Results and Discussion Results showed that using 600 mg vitamin C in the diets of suckling calves had significant effect on final weight. Supplementation of vitamin C in calf starter diet increased dry mater intake in second months and total period (P < 0.05). Vitamin C supplementation had no significant effect on feed efficiency in the first, second months and the total period. Feed intake decreased with increasing vitamin C content in feeds but improved feed conversion ratio. These researchers also reported that that vitamin C use had no effect on final weight. Vitamin C supplementation in suckling calves diet had no effect on serum concentrations of glucose, cholesterol, triglyceride, albumin, and total protein at 48 hours postpartum, days 7, 21 and 45 after birth compared with the control group (P>0.05). The effects of ascorbic acid at levels of 0, 10 and 15 g in Buffalo decreased glucose concentrations, these researchers stated that as the amount of ascorbic acid increased, glucose concentration decreased. Vitamin C supplementation had no significant effect on blood concentration of superoxide dismutase except 21 days after birth and glutathione peroxidase concentration except for 45 days after birth compared to the control group. Calves received ascorbic acid had the highest amount of superoxide dismutase in the first week after birth and the lowest in the fifth week. Glutathione peroxidase also reached its lowest level 45 days after birth. Furthermore, serum vitamin C concentration in suckling calves received vitamin C containing diet increased significantly at 45 days after birth compared with the control group. This may be due to the intake of vitamin C as an agent for the control of oxidative stress. Conclusion By studying the effects of vitamin C on growth performance, blood parameters and bioavailability in suckling calves, it can be concluded that using this vitamin increased dry mater intake and average daily gain, glutathione peroxidase concentration and serum vitamin C bioavailability throughout the period. In general, supplementation of the diet of suckling calves with vitamin C had beneficial effects on the performance. It is concluded that vitamin C as supplementation of the diet (milk replacer or starter diet) may enhance immunity and resistance in Holstein suckling calves.

Objective: Cell aging is one of the most important and fundamental step in cellular behavior and reduces muscle mass and myofibrils. This study aims to investigate the effect of resistance exercise along with vitamin C consumption on the expression of Telomerase Reverse Transcriptase (TERT) and Telomere Repeat Binding Factor-2 (TRF2) genes and the diameter and number of skeletal muscle myofibrils in old male Wistar rats. Methods: This is an experimental study using control groups. Twenty-five male Wistar rats (280-320 g and aged 24 weeks) were randomly divided into five groups of young control, old+resistance exercise, old+vitamin intake, old+resistance exercise+vitamin intake, and old control. In the supplementation groups, rats received liposomal vitamin C daily by gavage per body weight. Weight attached to the tail gradually increased during 8 weeks of exercise (weeks 1 and 2 by 50%; weeks 3 and 4 by 50%; weeks 5 and 6 by 75%; weeks 7 and 8 by 100% of total body weight). Exercises were performed at 3-5 sets of 8-12 repetitions, 3 or 4 days a week. The Quantitative polymerase chain reaction method was used to evaluate the expression of TERT and TRF2 genes in muscle tissue. One-way ANOVA was used to examine the difference between the groups and Tukey’s post hoc test was used to determine between which groups the difference was significant. Results: Aging significantly reduced the expression of TERT, TRF2 genes and the diameter and number of myofibrils in skeletal muscle of rats (P=0.001). Resistance exercise along with vitamin C intake had no significant effect on TERT and TRF2 expression (P≥0.05), but caused a significant increase in the diameter and number of myofibrils (P= 0.001). Conclusion: Eight weeks of resistance exercise along with vitamin C supplementation can significantly increase the number and diameter of skeletal muscle myofibrils in old rats.

One of the reasons of the bakery products poor quality and quality defection in the country is the low quality and the impropriety of wheat. Regarding the uncontrollability of so many effective factors in wheat quality. Using of improving agents in wheat flour has been highly considered. In this study, the effect of tow improving agents, ascorbic acid in three levels (20, 40, 60 ppm) and α-amylase enzyme in three levels (25, 50 and 75 ppm) over dough was investigated. Rheological tests results showed that increasing level of ascorbic acid from 20 ppm to 60 ppm is effective in dough stability time and dough developing time increment, reduction in dough softening degree, increasing elasticity, improving gluten structure and increasing the usage level of α-amylase enzyme from 25 ppm to 75 ppm is effective in the collapse of polymeric structure of starch, dough softening, stability, developing time and reduction elasticity characteristics. In simultaneous use of additives in constant amount of α-amylase enzyme, increase of ascorbic acid from 20ppm to 60ppm causes rheological individually betterness. Dough stability time, developing time and dough elasticity as well. This effect in constant amount of ascorbic acid shows a diverse relationship specially with high amount of added α-amylase (50 and 75 ppm). Generally, in addition to ascorbic acid containing treatment on its own using of α-amylase enzyme in 50 ppm level with 60 ppm ascorbic acid in improving the rheological and quality specialty of dough is suggested. [ABSTRACT FROM AUTHOR]

Background: Coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass pump may cause systemic inflammatory reactions by releasing cytokines which leads to multiple organ failure. Vitamin C has anti-inflammatory and antioxidant properties. The study aimed to determine the effect of vitamin C on inflammatory markers and atrial fibrillation in patients undergoing CABG. Materials and Methods: In the present single-blind randomized controlled clinical trial, 80 patients were divided to experimental and control groups. The experimental group received vitamin C 2 g IV, and the control group received the same amount (equivalent to 4×5 cc shots) of normal saline IV 10 minutes after induction of anesthesia. Arterial blood samples were taken at specified intervals to assess IL-6 and hsCRP levels. The data were analyzed in SPSS-24. Results: The changes in IL-6 values at the specific intervals were not statistically significant (P> 0.05). Significant differences were observed in hsCRP levels only 24 hours after CABG. The incidence of atrial fibrillation was not significantly different between the two groups after the intervention. Conclusion: This study showed that ascorbic acid has no effect on reducing IL6 and hsCRP levels in patients undergoing CABG, and similarly, does not cause a reduction in post-CABG atrial fibrillation.

Background and Aim: Deferasirox (Exjade) is an iron-chelating drug used in patients with beta-thalassemia major. Oxidative stress is among f the major causes of nephrotoxicity and its progression. Deferasirox, due to oxidative stress and increased cell apoptosis causes the dysfunction of renal tubules and renal toxicity. According to its antioxidant and anti-inflammatory properties, the present study explored the effect of vitamin C on deferasirox-induced kidney damage. Methods & Materials: This study was performed on 30 Wistar rats in 3 groups of control, deferasirox, and deferasirox plus vitamin C. To induce the nephrotoxicity, the intra-peritoneum injection of deferasirox (75 mg/kg/day) was used. After taking plasma from the blood samples of the explored rats, we determined the values of Cr, Na+, K+, Mg+, osmolality, and BUN in the obtained plasma and urine samples. The creatinine clearance, as well as the relative and absolute excretion of sodium and potassium, were also calculated. After separating the two kidneys, they were used for the histologic study with Hematoxylin and Eosin (H&E) staining, as well as Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP) biochemical studies. Ethical Considerations This study was approved by the Research Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1396.309). Results: Cotreatment with deferasirox and vitamin C reduced renal tissue MDA and relative and absolute Na and K excretion and urine osmolarity; this method also increased creatinine clearance and renal tissue FRAP. Conclusion: The co-administration of vitamin C presented a significant protective effect on the renal toxicity induced by deferasirox. The protective property of deferasirox is because of the antioxidant impacts of vitamin C in reducing oxidative stress and lipid peroxidation.

Background: There has not been yet reports regarding the protective effect of vitamin C on spermatocytes in epileptic rats. The present study aimed to evaluate the protective role of vitamin C on numbers and structure spermatocytes in rats with pentylentetrazol-induced epilepsy. Methods: Forty male rats were randomly divided into five groups of 8, and were kindled with pentylentetrazol (40 mg/kg). The first group (sham) received normal saline. The second, third, and forth experimental groups treated with 125, 250, and 500 mg/kg of vitamin C, respectively. The negative control group was given only normal saline via intraperitoneal injection. All rats were then deep anesthetized and sacrificed, and their right testis were dissected. Histological sections were prepared, and stained with hematoxylin-eosin (H/E). The number of spermatocytes in sections were counted, and morphological changes were studied using histology and immunohistochemical methods. Data were analyzes using ANOVA test to determine significant differences between cases and controls. Findings: There was a significant decrease in spermatocytes numbers in epileptic rats compared with intact control group (P < 0.001). The spermatocytes significantly increased in rats, which received 250 mg/kg vitamin C compared to those received 125 mg/kg vitamin C or normal saline (P < 0.010). The morphological changes such as dense nuclei and more acidophilic cytoplasm were observed in epileptic rats compared to control groups. Conclusion: The present study showed that vitamin C supplementation would protect spermatocytes by decreasing the neurotoxin effects of pentylentetrazol in epileptic rats.

Ultraviolet radiation is one of the environmentally friendly methods that was used in the present study to process lemon juice. The designed UV system had five UVC lamps and irradiation was performed based on the distance of the lamps (10, 20, and 30 cm) from the fluid layer and the circulation time (10, 20, and 30 minutes) of lemon juice in the system. Non-irradiated sample was also considered as a control treatment. The control and irradiated samples were filled in dark polyethylene bottles and stored at ambient temperature for 90 days. Immediately after irradiation and during the storage period, parameters such as pH, titratable acidity, total soluble solids, ascorbic acid content, color indices (L*, a*, and b*) and browning index, as well as sensory attributes (color, taste, aroma, and overall acceptance) were evaluated. The pH, acidity, and total soluble solids did not show a definite trend. The results showed that among the color indices, L* decreased significantly, but a* and b* increased significantly during the storage period. The rate of color changes in irradiated samples from a distance of 10 cm was higher than other treatments. Irradiation also significantly reduced the ascorbic acid content of irradiated samples from a distance of 10 cm compared to other samples and control. However, the browning of irradiated samples from 10 cm distance was significantly less than that of irradiated samples from 20 and 30 cm distance. The score of the panelists indicated that irradiation and storage time altered the quality characteristics of lemon juice. The panelists' scores showed more acceptance of irradiated samples from 20 and 30 cm distance compared to irradiated samples from 10 cm distance. In general, the designed system in this study is not recommended for lemon juice processing due to the destructive effect of UV-C radiation on the content of ascorbic acid. [ABSTRACT FROM AUTHOR]

Cornelean cherry is a very perishable fruit that requires proper postharvest management to reduce losses. This study was aimed to increase the postharvest life and marketability of the product using postharvest calcium chloride treatments. The present study was conducted in a factorial experiment based on a completely randomized design with three replications. Factors included 3 immersion calcium chloride treatments (0, 60 and 80 mM), 4 storage times (0, 10, 20 and 30 days) and two cornelean cherry genotypes. Fruit samples were harvested at maturity (more than 90% of red skin) and immersion treatments were applied on them. During and after the experiment, different physicochemical traits of fruits were studied. The results showed that KKP2 genotype had lower mean firmness and sugar content and higher weight loss percentage than Hir genotype. The results showed that the two genotypes did not show significant differences in terms of pH and titratable acidity. Firmness, titratable acid, ascorbic acid, anthocyanin and phenol decreased over time. Among immersion treatments, the highest and lowest firmness, titratable acid and ascorbic acid belonged to 60 mM calcium and control (distilled water), respectively. The difference between 60 and 80 mM calcium chloride treatments was not significant. [ABSTRACT FROM AUTHOR]

Objective Lettuce is considered as a model plant for biotechnology because of its compatibility with stable genetic transformation and tissue culture. GDP-mannose-3’,5’-epimerase (GME) is one of the key genes in ascorbic acid biosynthesis pathway in plants. The present study aims to transfer GME gene from Actinidia deliciosa L. into Lactuca sativa L. Materials and Methods To investigate callus induction rate using the effects of explant (cotyledon and true leaves) and 16 plant growth regulator combination including concentrations of 0.02, 0.04, 0.05, and 0.1 mg/l NAA and 0.1, 0.2, 0.4, and 0.6 mg/l BAP, and also direct regeneration rate using the effects of explant (cotyledon and true leaves) and 6 plant growth regulator combination including concentrations of 0.02 and 0.05 mg/l NAA and 0.2, 0.4, and 0.6 mg/l BAP, a factorial experiment based on completely randomized design with three replications was conducted. In order to transform GME into Lactuca sativa L. using L. sativa L. cv. Setareh and Agrobacterium tumefaciens strain (C58) on two types of explants (cotyledon and true leaves), a factorial experiment with three replications and 2 min and 8 min inoculation was done. Results The results revealed that the highest percentage of callus induction and indirect regeneration (100%) were observed on leaf and cotyledon explants and MS medium containing 0.1 mg/l BAP and 0.04 mg/l NAA. The results also confirmed the presence of pBI121+GME in transgenic plants. Conclusions The explant true leaves and 2 min inoculation (with 18 percent transformation ratio) were more suitable for transformation.

Background: There is little information on the effects of exercise in polluted air and vitamin C intake on plasma factors. The aim of this study was to investigate the effect of twelve weeks of aerobic training in polluted air and vitamin C supplementation on serum levels of endothelin-1 and nitric oxide in Wistar rats. Methods: 50 male Wistar rats were randomly divided into five groups of training, training-supplementation, training-pollution, training-pollution-supplementation, and control. Training protocol consisted of aerobic training for 40 minutes with intensity of 65%-80% of maximal speed for 12 weeks and 5 sessions per week. The amount of vitamin C consumed in each rat was 20 mg/kg/day used orally. Plasma levels of endothelin-1 and nitric oxide were measured at the end of the study. Data were analyzed using one-way analysis of variance. Findings: Endothelin-1 levels significantly increased in polluted air groups; vitamin C was able to decrease endothelin-1 levels (P < 0.05). The level of nitric oxide increased significantly in training in polluted air groups. These results were significantly different from the training-pollution-supplementation group (P < 0.05). Conclusion: According to the results of this study, vitamin C intake is effective in decreasing plasma levels of endothelin-1 during exposure to air pollution. The effect of exercise and polluted air on nitric oxide was significant, and vitamin C alone reduced nitric oxide in training in polluted air group.

ABSTRACT This study was performed to evaluate the effect of immune system stimulants (vitamins E, C and selenium) on biochemical and immunity indices of Late calcarifer. For this purpose, two treatments were selected. Treatment 1 or control group was fed with food without immune stimulant and treatment 2 with diet containing vitamins E, C and selenium at 2% of the biomass weight. Finally, growth efficiency indices were compared in two treatments. Results showed final weight of the control and treatment groups was 761.33 ± 35.8 g and 850.00 ± 5.77 g, respectively. The specific growth rate of the control and treatment groups was 1.3 ± 0.02 and 1.35 ± 0.01 but the feed conversion ratio did not show a significant difference. Hemoglobin and erythrocytes showed a significant increase compared to the control in treatments containing immune stimulants and supplementation (p < 0.05). White blood cells ranged from 41417 ± 2964.84 in the treatment to 42500 ± 683.13 in the control treatment. The number of red blood cells in the control treatment was 2810000 ± 19.1763 and the recipient treatment was 3951667 ± 14588.84. Immune system stimulants including vitamins E, C and selenium can play a role in improving the growth, blood, biochemical and safety indices of farmed Late calcarifer.

Background and Aims: Saliva is the first body fluid that is exposed to the free radicals found in cigarette smoke. Antioxidant substances in saliva, such as vitamin C, play an important role in the defense mechanism against free radicals. Therefore, the aim of this study was to examine the effect of vitamin C on the total antioxidant capacity of saliva in smokers. Materials and Methods: This randomized clinical trial was performed on 60 healthy male smokers who referred to the dental clinic in Rafsanjan in 2017. Individuals were randomly divided into three groups. The first and second groups received 500 and 1000 mg of vitamin C boiling tablets for three weeks. The third group did not receive any vitamin C supplements. The total antioxidant capacity of saliva was measured using an antioxidant kit and an ELISA reader. Data were analyzed using paired t-test, one-way ANOVA, and Duncan's multiple comparisons test. Results: The results showed that the mean total antioxidant capacity of saliva after the intervention was found statistically significant among groups (P

Background: Vancomycin-induced nephrotoxicity is a common complication in patients under treatment with this drug, but no single theory has been proposed for prevention of this damage. The purpose of this study was to determine the beneficial effect of vitamin C in the preventing vancomycin-induced renal disease. Methods: In a clinical trial study, 96 patients treated with vancomycin were divided into two equal groups, in the first group 500 mg oral vitamin C was administered twice daily for ten days and in the control group, no intervention was performed. Patients in the two groups were evaluated at baseline, and 2, 4, 6, 8, and 10 days later for serum creatinine, creatinine clearance, and renal toxicity, and the results were compared. Findings: The incidence of vancomycin-induced nephrotoxicity was 3 and 6 patients in the intervention and control groups (6.25% vs. 12%), respectively, and there was no significant difference between the two groups (P = 0.320). However, the relative risk (RR) of vancomycin-induced nephrotoxicity in the control group was 4.1 times that of the vitamin C group [RR = 4.1; 95% confidence interval (CI): 1.12-15.4; P = 0.034]. Conclusion: Vitamin C intake reduces the risk of vancomycin-induced renal toxicity; it is recommended, as is useful in preventing oxidative stress poisoning.

Background and Aim Among the plants with multiple healing properties and a long and common history of use in Iranian traditional medicine, is dog-rose plant with the scientific name of “Rosa canina” that belongs to the Rosaceae family. This study aimed to review the effectiveness of Rosa canina in treatment of different body organs and tissues and emphasizes its therapeutic mechanism. Methods & Materials This is a review study. About 176 papers published from 2010 to 2018 were extracted from PubMed, Science Direct, Scopus, Google Scholar, Ovid, MagIran, and SID databases using related keywords and entered into study. Ethical Considerations Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors. Results Different studies had indicated the importance of Rosa canina as a medicinal plant protecting liver, lowering glucose and lipid levels, and having antioxidant and anti-inflammatory properties. The highest flavonoid activity in the Rosaceae family is related to Rosa canina. The use of herbal extracts in the treatment of common diseases, such as diabetes, fatty liver, urinary tract and Alzheimer's, has been recommended. Conclusion High qualitative and quantitative diversity of effective ingredients, ease of access, absence of adverse effects of consumption and endemic nature of Rosa canina plant make it necessary to use it for the control and treatment of common human diseases.

In this research, in order to optimize the extraction process of Ethanolic extract of barberry fruit, the increase and optimization of the conditions for the extraction of anthocyanin's and bioactive compounds by means of intermittent electric field pre-treatment from three levels of electric field intensity (0.5, 1.75 and 3 kV / cm) and 3 levels of number of pulses (15, 30 and 45); then with ethanol solvent was used to extract their extracts and the amount of flavonoids, total anthocyanin, DPPH, total phenolic compounds, iron regeneration capacity, vitamin C and acidity compared to control (no treatment) Was studied. The results showed that the total phenol content of the extract decreased by increasing the number of pulses and reducing the intensity of the pulsed electric field applied to the sample. The increase in the electric field strength and the number of pulses initially increased the flavonoid content, DPPH and iron ion recovery capacity, but with the increase of these variables, these three parameters decreased. Also, with increasing of these parameters, the anthocyanin level and vitamin C content increased. The acidity of the sample was reduced and then increased by increasing the electric field strength and applied pulse number. Regarding the results of the process optimization, it can be concluded that the electrical field intensity of 2.003 kV / cm and applying 29 pulses can increases the antioxidant properties of the produced product compared with the control sample. [ABSTRACT FROM AUTHOR]

Drying is one of the oldest methods of food preservation, which usually have adverse effect on the physicochemical properties and nutritional value of the final product too. Today, the demand for application of rapid drying methods such as using microwave and infrared beams has increased to prevent or reduce undesirable changes in foods. In this study, the effect of infrared drying process condition (drying temperature and time) on weight loss, vitamin C and color properties of Shahsavar Yazdi pomegranate arils were investigated and optimized by response surface method. The results showed that the amount of weight loss and L* value of pomegranate samples, increased with increasing drying time and temperature, while the amount of vitamin C decreased. Drying temperature had a greater effect on weight loss and vitamin C changes compared to drying time; however, variation of L* value under the influence of infrared drying time are more severe than the drying temperature. The amount of a* and b* value increased with increasing drying temperature while decreased with increasing infrared drying time. The best conditions for infrared drying of pomegranate arils are using drying temprature of 55 °C for 600 minutes and by applying the optimal conditions, the amount of weight loss, vitamin C and the total color difference (ΔE) of the produced pomegranate arils are equal to 69.5, 12.89 and 5.79 respectively. The results of the optimal conditions validation test showed that by applying the obtained conditions from the optimization process, the quality attributes of pomegranate such as weight loss, amount of vitamin C and the total color difference (ΔE) of the produced samples were 70, 12.45 and 7.75 respectively, which are very similar to the obtained results from the optimal conditions predicted by the response surface method. [ABSTRACT FROM AUTHOR]

Aiming at finding a suitable treatment for maintaining the fruit quality and increase the shelf life of strawberry, effects of ascorbic acid and essential oil of Thymbra spicata were evaluated. Fruits were dipped in 10 and 15 mM of ascorbic acid and essential oil of T. spicata (400 and 600 ppm) for two minutes, and after drying at room temperature, were packed by cellophane in the polyethylene container and transferred to 4 °C. Some of the qualitative, quantitative and biochemical parameters were measured at 7 and 14 days after storage. Results of analysis of variance showed that there were significant differences among the treatments in most of the evaluated parameters. Strawberry fruits treated with ascorbic acid and essential oil showed lower weight loss and lower fruit browning, while they had higher marketability than control plants. Ascorbic acid and essential oil treatments also led to decreases in polyphenol oxidase activity, total phenol content and electro leakage, while the vitamin C content and antioxidant capacity were significantly higher than control plants. Generally, ascorbic acid (15 mM) and essential oil (400 ppm) compounds reduced fruit's degradation during cold storage and these treatments have the potential to be used as practical postharvest treatments to retain the quality of strawberry fruits. [ABSTRACT FROM AUTHOR]

BACKGROUND: Vitamin C and Carum copticum with antioxidant activity may eliminate the negative effects of heat stress on broiler performance and immunity. OBJECTIVES: This experiment was conducted to investigate the effect of feeding heat-stressed broilers with Carum copticum seed powder (CSP) and vitamin C (VC) on their growth performance, blood metabolites, carcass characteristics, and meat quality. METHODS: Herein, we carried out A 2*3 factorial arrangement in a completely randomized design with six treatments, including three levels of CSP (0, 0.75 and 1.5 % of diet), two levels of VC (0 and 250 mg/kg of DM of diet), and four replicates, on 240 one-day-old male Ross 308 broilers. The collected data were analyzed using PROC GLM of SAS. Treatment means were compared employing the Tukey test. RESULTS: The effect of CSP on their performance was not significant whereas VC treatment improved weight gain significantly (P<0.01). Interaction of CSP and VC on weight gain and feed conversion ratio was significant as broilers fed with 250 mg VC and those fed with 1.5 % CSP had the best WG and FCR (P<0.01). The addition of VC decreased the concentration of alkaline phosphatase in the blood (P<0.05). The heterophil to lymphocyte ratio was reduced through the use of VC and 1.5 % CSP (P<0.05). CSP supplementation at the rate of 1.5 % increased the relative weight of bursa of fabricius (P<0.05). Dripping loss percentage was reduced in birds fed with 1.5 % CP and VC (P<0.01). The effect of CSP and their interaction on water holding capacity was significant and the highest amount belonged to the birds fed with 1.5 % CSP (P<0.01). Additionally, VC increased meat ash percentage compared to the control group (P<0.01). CONCLUSIONS: The results of this study indicated that addition of 250 mg VC and 1.5 % CSP could be conducive to improving growth performance, blood metabolites, and meat quality of broilers under heat stress conditions. [ABSTRACT FROM AUTHOR]

High yield, earliness and high quality of new potato cultivars have an important role in food security, reducing price fluctuations and warehousing costs, and access to fresh produce all season years. In this study, quantitative and qualitative traits of 15 potato genotypes from breeding populations were studied in a completely randomized block design (RCBD) with three replications for two years (2017 and 2018) in Ardebil region. The results showed that interaction effect of genotype in year was significant for total tuber yield, marketable tuber yield, tuber number and weight per plant, plant height and days number to tuberization significant at the 1% level, and had no significant effects on number of main stem per plant, tuber dry matter percentage, tuber specific gravity, starch percentage, vitamin C and tuber protein percentage. Genotypes 901375, 90275, Savalan, 90527, 90127, 90827, Agria and Marfona had the highest yield during two years of experiment. Among the high yielding genotypes, genotypes 901375 and Savalan had the highest percentage of tuber dry matter, tuber specific gravity, tuber starch percentage, vitamin C of tuber and protein percentage. Genotypes 901375 and Savalan were selected as high yielding genotypes with appropriate qualitative traits based on yield and yield components of tuber and measured traits. [ABSTRACT FROM AUTHOR]

Introduction1 It has been documented many times in various articles that the plasma vitamin C concentrations have been severely reduced during stress and disease in calves. Another report shows that the production of endogenous vitamin C was not apparently observed in dairy calves up to 4 months of age, and therefore the suckling calf depended on relatively low concentrations of vitamin C in consumed milk. Therefore, suckling calves are exposed to various pathogens that cause various diseases and consequently economic loss. One of the most important causes of mortality in suckling calves is their susceptibility to infections, since calves are more susceptible to intestinal and respiratory infections resulting in high mortality during this period. Therefore, use of dietary supplements and vitamins can improve the immune system and growth performance. Vitamin C is a water-soluble vitamin that has antioxidant properties and can kill free radicals produced in cells. The amount of vitamin C in the animal is reduced during stress and exposure to the disease. Therefore, providing it through starter rations can improve animal performance. There is limited research about the effects of vitamin C on the immune system and its beneficial effects in suckling calves. Hence, this study was aimed to evaluate the supplementation of vitamin C on growth performance and immune system of Holstein suckling calves. Materials and Methods For this experiment, 40 newborn Holstein calves with an average age of 1-10 days, and about 36±1 kg weight, were used in a completely randomized design with 2 treatments and 20 replications. The treatments included: 1) Control (starter and whole milk) 2) Control + daily 600 mg vitamin C. Average daily gain and feed intake were measured and feed efficiency was determined. Blood samples from each calf were taken 4 times, including 48 h immediately after birth, 7, 21, and 45 days after birth. Total protein, albumin, triglyceride, cholesterol levels were measured by commercial kits (made by Pars Test Co.). Serum concentrations of vitamin C, super oxide dismutase and glutathione peroxidase were measured by commercial kits. Results and Discussion Results showed that using 600 mg vitamin C in the diets of suckling calves had significant effect on final weight. Supplementation of vitamin C in calf starter diet increased dry mater intake in second months and total period (P < 0.05). Vitamin C supplementation had no significant effect on feed efficiency in the first, second months and the total period. Feed intake decreased with increasing vitamin C content in feeds but improved feed conversion ratio. These researchers also reported that that vitamin C use had no effect on final weight. Vitamin C supplementation in suckling calves diet had no effect on serum concentrations of glucose, cholesterol, triglyceride, albumin, and total protein at 48 hours postpartum, days 7, 21 and 45 after birth compared with the control group (P>0.05). The effects of ascorbic acid at levels of 0, 10 and 15 g in Buffalo decreased glucose concentrations, these researchers stated that as the amount of ascorbic acid increased, glucose concentration decreased. Vitamin C supplementation had no significant effect on blood concentration of superoxide dismutase except 21 days after birth and glutathione peroxidase concentration except for 45 days after birth compared to the control group. Calves received ascorbic acid had the highest amount of superoxide dismutase in the first week after birth and the lowest in the fifth week. Glutathione peroxidase also reached its lowest level 45 days after birth. Furthermore, serum vitamin C concentration in suckling calves received vitamin C containing diet increased significantly at 45 days after birth compared with the control group. This may be due to the intake of vitamin C as an agent for the control of oxidative stress. Conclusion By studying the effects of vitamin C on growth performance, blood parameters and bioavailability in suckling calves, it can be concluded that using this vitamin increased dry mater intake and average daily gain, glutathione peroxidase concentration and serum vitamin C bioavailability throughout the period. In general, supplementation of the diet of suckling calves with vitamin C had beneficial effects on the performance. It is concluded that vitamin C as supplementation of the diet (milk replacer or starter diet) may enhance immunity and resistance in Holstein suckling calves. [ABSTRACT FROM AUTHOR]

Storage of horticultural crops is associated with pre and postharvest treatments. For this purpose, an experiment was conducted in د steps. The first step, salicylic acid (0, 2 and 4 mM) and iron chelate (0, 0.1 and 1 g/1) were sprayed three times at 30, 60 and 90 days after fill bloom on plum cv. Flavor supreme pluot. The second step was carried out at storage with too temperatirres (1 and 4 °C). The experiment was performed as factorial split-plot in a completely randomized block design with three replications. Qualitative chacteristics including tissue firmness, vitamin c, titratable acid, total soluble solids and anthocyanins content were measured. The results showed that salicylic acid treatment had a significant effect on TSS, TA, vitamin c and anthocyanins at 1% level and tissue firmness at 5% level. Iron application was significant at 1% level on anthocyanins. In addition, all of the stiidied characteristics were significantly changed during storage at both temperatures, spraying plum trees with salicylic acid with 2 mM concentration retained total soluble solids, vitamin c, anthocyanin, tissue firmness and titratable acid increased more than the 4 mM. Also, treatment with iron (0.1 g/1) improved fruit quality. In general, 1 °C temperatiire was more effective than 4 °C and maintained the quality and marketability of fruits up to 60 and 40 days, respectively. [ABSTRACT FROM AUTHOR]

In order to study the application of zeolite on quantitative and qualitative characteristics of carela medicinal plant under deficit irrigation, a factorial experiment was conducted in a completely randomized design with three replications in a greenhouse at the Agricultural Institute, University of Zabol during 2018. Experimental factors included deficit irrigation in three levels, (90, 70 and 50 % F.C.), and four levels of zeolite (0, 20, 30 and 40 g/kg of soil). The results showed that application of zeolite increased fresh and dry fruit weight, fruit diameter and fruits number per plant and deficit irrigation had a decreasing effect on the mentioned fraits. Application of zeolite at all levels of deficit irrigation increased plant length, fruit length, fruit yield, chlorophyll a, b and carotenoid, vitamin c and alkaloids, so that the highest amount of these fraits was obtained from 40 gricg zeolite. In general, application of zeolite was helpfirl in reducing the adverse effects of deficit irrigation on carela's quantitative and qualitative traits. [ABSTRACT FROM AUTHOR]

Environmental pollution and occupational exposure to toxic metals, such as mercury, cadmium and lead, causes chronic and malignant diseases with significant complications in the majority of body tissues. Increased production of free radicals and reduced antioxidant activity is considered as the main factor for the incidence of lesions resulting from cadmium poisoning. The aim of this study was to evaluate the effect of clove essential oil and vitamin C on growth performance, intestinal villi morphology and immune response to Newcastle live vaccine of Japanese quails challenged with cadmium. A total of 240 one-day old quails were divided into 8 groups with 30 quails in each group (3 replicates with 10 birds). Groups 1 and 8 received basal diet; groups 2 and 7 basal diet + 500 ppm vitamin C in the diet; groups 3 and 5 received basal diet + 150 mg/kg of the diet clove essential oil; and groups 4 and 6 received basal diet + 450 mg/kg of the diet clove essential oil. Cadmium chloride (40 ppm) was added to the drinking water of groups 1, 2, 3 and 4 during the experimental period (days 7-35). On day 21, 9 blood samples were collected from each group and segments of duodenum, jejunum and ileum of 9 quails from each group were isolated and sampled on day 35. The results indicated that groups 6 and 7 had significantly (pp

Introduction: Postmenopausal estrogen deficiency, disturbance of the antioxidant defense system, and free radical production lead to oxidative stress. This results in metabolic disturbances affecting the liver. Therefore, it is important to properly evaluate the benefits of antioxidant administration and exercise on oxidative stress in the liver. The main purpose of this study was to compare the effects of aerobic training with vitamin C and estradiol on oxidative stress in the liver among ovariectomized and normal rats. Materials & Methods: In total, sixty-four female rats were divided into two groups of normal (n=32) and ovariectomized (n=32). Each group was subdivided randomly into four subgroups consisting of sham, training, training+vitamin C, and training+estradiol. The experimental protocol was five 60-min running sessions for six weeks on a treadmill with average intensity and 55% Vo2max. Moreover, the rats were subjected to the injection of 250 mg and 0.25 mg/kg vitamin C and estradiol, respectively. Liver oxidative damage was determined by the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Findings: According to the results, ovariectomy resulted in vaginal atrophy. Moreover, it led to a significant increase in AST and ALT levels. In addition, the administration of estradiol decreased the serum level of these enzymes (P

Abstract. Fig (Ficus cariaca) is native to western and eastern mediterranean regions such as western and northwestern of Iran. Iran is one of the important fig producers in the world. In this study, biochemical, phycochemistry characteristics and genetic diversity of 38 fig genotypes from Arsbaran in East Azerbaijan province in the Horticulture Laboratory of Urmia University in 2015 were investigated. Biochemical results showed that, TSS, pH, TSS/TA, vitamin c, antioxidant capacity, total anthocyanin, total flavonoid and total phenol were significant (p ≤ 0.01). Most of the studied biochemical traits indicated high variation. The results of the molecular data showed that a total of 131 bands were scored, of which 121 bands (92%) were polymorphic. The amount of polymorphic (PIC) information for the primers used varied from 0.22 to 0.47 in ISSR7 and ISSR20 respectively. Also, marker index were between 0.15 to 2.5 in ISSR7 and ISSR20 respectively. Based on the results of cluster analysis, the studied fig genotypes were classified into two main groups, so that the most of collected genotypes from Kalibar belonged to second group. So it could be concluded that geographic location of the studied fig genotypes is the main reason for their separation by this marker. Based on obtained results, the genotypes Kh9 and H17 were suggested for breeding programs.

The effect of foliar application of zinc sulfate and seaweed on qualitative and quantitative characteristics of local Kermanshah cantaloupe (Cucumis melo L., Cantalupensis Group) cv. Kalak was investigated. After sowing seeds in the field, the plants were sprayed in three stages including the 4-6 leaf stage, flowering and after the fruit set. The experiment had a factorial design based on the randomized complete block design with 9 treatments including various concentrations of zinc sulfate (0.5 and 1 g L-1) and seaweed (0.5 and 1 g L-1) and was repeated three times. The results of analysis of variance showed that zinc sulfate at 0.5 g L-1 and seaweed at 1 g L-1 had significant effects on the weight, length and diameter of the fruit, the weight of the fresh fruit, fresh and dry weight of the plant, and fruit firmness. The highest amount of vitamin C was observed in zinc sulfate at 1 g L-1 and seaweed at 0.5 g L-1. The highest total seed weight was obtained in zinc sulfate at 0.5 g L-1 and seaweed at 1 g L-1. Foliar application of zinc sulfate and seaweed did not have a significant effect on total soluble solids (TSS). However, zinc sulfate at 0.5 g L-1 increased the amount of titratable acid (TA) in the fruit juice. The highest amount of the TSS/TA ratio of the fruits was observed in application of seaweed at 1 g L-1. Overall, the findings of the present study indicated that simultaneous application of zinc sulfate and low concentrations of seaweed extract has a significant effect on many qualitative and quantitative characteristics of “Kalak” Cantaloupe and can be recommended as a biofertilizer.

Zinc oxide nanoparticles can enter to body through breathing, skin and nourishment, and disrupt the physiology of the body. Ascorbic acid can act as a potent antioxidant to prevent the negative effects of nanoparticles. In this study, 170 individuals of rainbow trout with an average weight of 170 g were kept in 70 L tanks. Fish were exposed to concentrations of 40 and 80 mg.L-1 Nano-zinc oxide, and 400 and 800 mg.kg-1 vitamin C. After 10 days of exposure to 80 mg.L-1 Nano-zinc oxide and 800 mg.kg-1 vitamin C the liver enzyme activity was significantly lower than other treatments. Oral administration of vitamin C can improve the enzymatic parameters and reduce the harmful effects of zinc oxide nanoparticles on hepatic enzyme activity.

Oxalic acid (OA), as a natural antioxidant, delays the ripening and senescence of fruits. In this research, the effect of different concentration of OA (0, 2, 4, 6, and 8 mM) investigated on storage life and postharvest quality of loquat fruit at 5°C and 90±5% relative humidity for 28 days. Traits such as browning index, biochemical and qualitative characteristics and activity of polyphenol oxidase (PPO) and peroxidase (POD) enzymes of fruit at harvest (0), 7, 14, 21 and 28 days after storage were analyzed. With increasing storage time, the level of browning index, total soluble solids (TSS), ratio of TSS/titratable acidity (TA) and the activity of PPO and POD enzymes increased in all treatments, while firmness, ascorbic acid, total phenol and flavonoids content and antioxidant activity decreased (p˂0.05). OA application significantly reduced the level of browning index and the activity of enzymes responsible for tissue browning (PPO and POD) compared to control (p˂0.05). At the end of storage, fruits treated with different concentration of OA had a more firmness tissue and higher level of ascorbic acid, total phenol and flavonoids content and antioxidant activity in comparison to the control fruits (p˂0.05). Overall, OA application effectively reduced fruit softening and browning index with diminished the activity of PPO and POD enzymes during cold storage. [ABSTRACT FROM AUTHOR]

Pistachio is one of the most popular nuts in the world because of its taste and nutritional properties. Mostly, its consumed dry in harvest period. Major factors limiting for shelf life of pistachios are browning and water accumulation. In this study, the effects of citric acid (1, 1.5 and 2%) and ascorbic acid (15, 25 and 35 ppm) and two types of plastic packs (polyethylene and polystyrene) on storage life (days 0, 25 and 45), Ahmad aghaie pistachio was studied. According to panelists, the use of acid treatments for 25 day of storage was able to maintain the appearance and taste characteristics of pistachio and since then there was no significant difference between treatment and the control sample. Pistachios treated with 15 ppm ascorbic acid in polystyrene pack were more favorable in appearance and browning than polyethylene pack. The maximum of phenol was related to ascorbic acid treatments (15 ppm) in polyethylene pack. Anthocyanin and chlorophyll amount decreased during storage, but carotenoids first increased and then decreased. Pistachio pigments such as chlorophyll, anthocyanin and carotenoids were preserved in polyethylene packages than polystyrene. Citric acid treatment (1.5%) had the maximum percentage of fat. Overall, the polyethylene pack and ascorbic acid 15 and 25 ppm and citric acid 1.5% concentration maintained the qualitative and quantitative properties of pistachio. [ABSTRACT FROM AUTHOR]

Background: Coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass pump may cause systemic inflammatory reactions by releasing cytokines which leads to multiple organ failure. Vitamin C has anti-inflammatory and antioxidant properties. The study aimed to determine the effect of vitamin C on inflammatory markers and atrial fibrillation in patients undergoing CABG. Materials and Methods: In the present single-blind randomized controlled clinical trial, 80 patients were divided to experimental and control groups. The experimental group received vitamin C 2 g IV, and the control group received the same amount (equivalent to 4×5 cc shots) of normal saline IV 10 minutes after induction of anesthesia. Arterial blood samples were taken at specified intervals to assess IL-6 and hsCRP levels. The data were analyzed in SPSS-24. Results: The changes in IL-6 values at the specific intervals were not statistically significant (P> 0.05). Significant differences were observed in hsCRP levels only 24 hours after CABG. The incidence of atrial fibrillation was not significantly different between the two groups after the intervention. Conclusion: This study showed that ascorbic acid has no effect on reducing IL6 and hsCRP levels in patients undergoing CABG, and similarly, does not cause a reduction in post-CABG atrial fibrillation. [ABSTRACT FROM AUTHOR]

Background and aim: Defrasirox (Exjade) is an iron chelating drug used in patients with beta thalassemia major. Oxidative stress is one of the most important causes of nephrotoxicity and its progression. Defecirox due to oxidative stress and increased cell apoptosis causes dysfunction of renal tubules and renal toxicity. In this study, according to the antioxidant and anti-inflammatory properties, the effect of vitamin C on kidney damage caused by defrasirox was investigated. Material and methods: This study was performed on 30 Wistar rats in three groups, control group, Deferasirox group and Deferasirox with vitamin C group. Inorder to induce the nephrotoxicity, intra-peritoneum injection of deferasirox(75 mg/kg/day) has been used. After taking plasma from blood samples of the rats, the determination of values of [17]Cr], [Na+], [K+], [Mg+], osmolality, [BUN] in plasma and urine samples performed. The creatinine clearance, relative and absolute excretion of sodium and potassium have been calculated. After separating the two kidneys, they used for histologic study with H&E staining and, MDA and FRAP bichemical study. Results: Cotreatment with deferasirox and vitamin C, reduced renal tissue MDA and relative and absolute Na and K excretion and urine osmolarity also increased creatinine clearance and renal tissue FRAP . Conclusion: Co treatment adminstration of vitamin C has a significant protective effect on the renal toxicity induced by defacirox. The protective ability of deferasirox is because of the antioxidant properties of vitamin C in reducing oxidative stress and reducing lipid peroxidation. [ABSTRACT FROM AUTHOR]

This study was conducted to evaluate the interactive effects of different levels of dietary ascorbic acid and density on growth parameters of rainbow trout. The eighty- one rainbow trout broodstock (812 ± 1.5 g) distributed into six groups as experimental treatments and were fed different levels of ascorbic acid including 0, 100 and 1000 mg/kg L-ascorbyl-2-polyphosphate. The feeding trial was carried out in two different densities (3 and 6 fish/m3) for a 16- week period in triplicates. Each diet was fed to triplicate groups of fish to apparent satiation two times a day. Changes of body weight increase were observed from fourth week to 12th week. The highest amounts of weight gain and specific growth rate were observed in high density (6 fish/m3), but no significant difference was observed between 100 and 1000 mg/kg ascorbic acid in high density. At the end of the experiment, fish fed -C diet had a lowest final mean weight (885.2 ± 2.09 g) than those fed +C diet. These results indicated that dietary ascorbic acid significantly influenced growth performance of rainbow trout broodstock, especially in high density and the level of 100 mg ascorbic acid per kilogram diet can lead to desirable growth of female rainbow trout breeders. [ABSTRACT FROM AUTHOR]

BACKGROUND AND OBJECTIVE: Cadmium is one of the pollutants in ecosystems. This heavy metal as a toxin affects the reproductive system and causes the destruction of the spermatogenesis process. The aim of this study was to compare the effect of Origanum vulgar aqueous extract and vitamin C on cadmium chloride damage in testicular tissue. METHODS: This experimental study was performed on 30 wistar male rat in four groups of six rats. The control received Cadmium 2 mg/kg of single dose intraperitoneal, T1 group received cadmium with vitamin C 250 mg/kg. T2, T3 and T4 groups received cadmium and aqueous extract of Marjoram at 125, 250 and 500 mg/kg, respectively for 10 days intraperitoneal. At the end of the period, the animals were weighed. Serum antioxidant level and malondialdehyde in testis tissue were measured. In addition, after staining were counted calls in testicular tissue. FINDINGS: The highest concentration of MDA was observed in the control group at 1.4±0.018 and the lowest in the T4 at 93.03±0.30 μmol/ml. The lowest antioxidant capacity in control was 796.41±40.76 and the highest in T4 group was 1198.91±51.45 μmol/ml. There was no statistically significant difference in the concentration of MDA and TCA between T1 and T3 groups (p=0.076). However, the mean of testicular tissue cells (sertoli, spermatogonia, spermatocytes and laydic) in T3 was the highest and lowest mean in control group and the difference was significant (P=0.048). CONCLUSION: According to results of this study, Marjoram aqueous extract in controlling oxidative stress damage in the same dose 250 mg/kg has a better performance than vitamin C.

Background: In recent years, the potential effects of nanoscale materials on the central nervous system have become even more noticeable. The cerebellum is one of the areas of the brain with high absorption of zinc. The aim of this study was to investigate the effects of zinc oxide nanoparticles (NPs) on oxidative stress indices in rat cerebellum in the presence and absence of vitamin C. Materials and Methods: In this experimental study, male Wistar rats (250-200g) were divided into the following groups (n=7): a normal saline group (control), three groups that received different doses of zinc oxide NPs (1.25, 2.5 and 5 mg/kg), three groups that received different doses of vitamin ¬C (30, 60 and 120 mg/kg) and three groups that received 1.25, 2.5 and 5 mg/kg of zinc oxide NPs combined with 30 mg/kg of vitamin¬ C. Half an hour after receiving the medication, the rats were anesthetized and then their cerebellum was removed and the malondialdehyde (MDA) and thiol groups of the cerebellum region were measured. Results: The MDA level decreased significantly in the groups received 5mg/kg of zinc oxide NPs, in the groups received different doses of vitamin¬ C, and in the groups received different doses of zinc oxide NPs combined with 30 mg/kg vitamin¬ C compared with the saline group. Total thiol concentration did not change significantly in the different study groups compared to the control group. Conclusion: Zinc oxide NPs alone or in combination with vitamin C has a reduced effect on oxidative stress in the rat cerebellum.

In this study, the quantitative and qualitative characteristics of eight native apple varieties selected from the Azerbaijan area were evaluated. The studied varieties included 8 varieties consisting of Romina, Manochehri, Meshki, Torsh Alma, Sari Alma, Khan Almasi, Kozehee and local autumn that the varieties of Torsh Alma, Sari Alma and Khan Almasi were selected as the summer cultivars, and the varieties of local autumn, Romina, Manochehri, Meshki and Kozehee were selected as autumn cultivars. This experiment was carried out in Kahriz Horticultural Research station, Urmia in the form of completely randomized blocks design with three replications. The results of data variance analysis indicated the difference between varieties in terms of quantitative and qualitative studied traits, and revealed that the impact of variety on fruit total soluble solids (TSS), fruit pH, fruit ascorbic acid content (vitamin C), and fruit tissue firmness, fruit sugar and fruit juice is significant at 1% level. In the study, the varieties of Manochehri, Khan Almasi, Kozehee and Meshki had the highest content of total soluble solids (TSS), fruit sugar, ascorbic acid content, pH and fruit juice, and were in the superior statistical group. Also, the two cultivars of Khan Almasi and Torsh Alma had the highest tissue compared to other varieties. varieties.

In order to study the effects of putrescine (Put) and humic acid (HA) on growth, yield and pod quality of okra (Abelmoschus esculentus L. 'Kano') under deficit irrigation stress, the field experiment was conducted in split plot based on randomized complete block design with three replications. Three different irrigation regimes (33, 66 and 100% ETc) and foliar application of Put (0, 0.5, 1 and 2 mM) and HA (0, 150 and 300 mg.l-1) were conducted. The results showed that deficit irrigation significantly decreased growth, yield and vitamin C content. Significant (P>0.05) increase in growth and yield was observed with the application of both HA and Put. The highest plant growth was obtained whit application of HA 300 mg.l-1 and Put 1mM under irrigation 100% ETc. Also, the maximum yield was observed whit foliar application of HA 300 mg.l-1 and Put 1mM under irrigation 100% ETc. Application of Put and HA at irrigation 100% ETc and HA 150 and 300 mg.l-1 and Put 1mM under deficit irrigation 66% ETC had highest effects on vitamin C content. According to the results, application of HA 300 mg.l-1 and Put 1mM can be proposed to improve growth and yield of okra.

Introduction: Plums (Prunus spp.) as one of the most popular stone fruits, have low calories and high nutritional value. Over the past decades global production of European and Japanese plums reached from 6,110,870 tons in 1990 to 11,528,337 tons in 2013. In the same period plum production in Iran reached from 118,936 tons to 305,262 tons. Great variety of plum fruits caused differences in chemical composition as well. Plum fruits are rich in bioactive compounds or biochemicals such as vitamins (A, C and E), anthocyanins and other phenolic compounds which have high antioxidant activity. Materials and Methods: This research was done in a randomized complete block design with three replications in Horticultural Research Station at College of Agriculture and Natural Resources of Tehran University in 2013-2015. Fruit quality characteristics such as vitamin C content, color traits of the fruit skin and flesh, the content of carotenoids, anthocyanins, total phenolics and antioxidant capacity of 16 plum and prune cultivars and genotypes were evaluated. Results and Discussion: Analysis of variance showed significant differences in terms of all measured factors. The highest L* index (brightness) of fruit skin was observed in 'Tanasgol" and "Compooti" and then in "Golden Drop" and "Shams" cultivars and the lowest level of that was measured in "Sugar" and "Gogeh Sabz" cultivars. "Black Star" and "Gogeh Germez" Showed the highest brightness of fruit flesh among examined cultivars and the lowest brightness of fruit flesh was investigated in "Sugar". A* color index of skin and flesh of fruit also showed significant differences among investigated cultivars and the highest level of that in "Ozarak" cultivar was observed. "Gogeh Sabz" and "Golden Drop" also had the lowest level of this index. "Gogeh Germez" had the highest of a*color index of fruit flesh and "Japanese" cultivar was in second place. The lowest level of this index was measured in "Ozarak" and "Shams" cultivars. "Tanasgol" and "Compooti" had the highest fruit skin b*color index among cultivars and "Santarsa", "Sugar," "Stanley" and "Bukhara" showed the lowest of that. "Black Star" and after that "Tanasgol" and "Dargazi" had the highest b*color index of fruit flesh. "Japanese" had also the lowest b* color index of fruit flesh. The intensity or color purity varied among cultivars and the highest of that was observed in "Tanasgol" and "Compooti" and then in "Ozarak". "Black Star" had the highest chroma of fruit skin and the highest fruit flesh color intensity. The lowest of this index in the fruit flesh was observed in "Santarosa", "Sugar" and "Japanese" cultivars. Vitamin C (ascorbic acid) content varied in investigate cultivars. "Gogeh Germez" and "Japanese" had the highest vitamin C content and "Stanley" was showed the lowest amount of vitamin C. "Golden Drop ","Santarosa" and "Compooti" showed the highest total carotenoid among examined cultivars and "Gogeh Germez" had the lowest total carotenoid. "Gogeh Germez" and "Compooti" had the highest and lowest amount of anthocyanin index respectively. The highest total phenol and antioxidant activity was measured in "Ozarak". The lowest total antioxidant capacity was in"Gogeh Sabz". The results showed that There was high correlation (r= 0.93) between antioxidant capacity and a* fruit skin color index. High correlation (r= 0.83) between phenol content and antioxidant capacity of fruits was also observed. Between a* color index of fruit skin and phenolic content was observed high correlation (r= 0.89). As well as between anthocyanin and phenolic content and between anthocyanin and a* fruit skin color index, respectively (r= 0.86) and (r= 0.59) high correlation was detected. Conclusions: "Ozarak" in terms of antioxidant activity and total phenol component was superior. The highest amount of anthocyanin related to the "Gogeh Germez". "Golden Drop"," Santarosa" and "Compooti " had the highest total carotenoid and "Gogeh Germez" and "Japanese" had the highest vitamin C content among investigated cultivars. By identification of superior cultivars In terms of phytochemical compounds, these cultivars can be used in breeding programs to improve these nutritional quality of fruits. The results showed that the major phenolic compounds were gathered on the skin of plum fruits. Hence the "Ozarak" cultivar having the highest a*color index of fruit skin had the highest total phenol and antioxidant capacity among the investigated cultivars but "Gogeh Germez" by having the highest a*color index of fruit flesh and anthocyanins content higher than "Ozarak" cultivar, had low phenolic content and antioxidant capacity compared to the "Ozarak".