Search

Introdution: Non-alcoholic fatty liver disease (NFALD) is a disease associated with metabolic syndrome and lifestyle. The purpose of the present study was to investigate the effect of 12 weeks of circuit resistance training course on interleukin-17 (IL-17) levels, 70 kDa thermal shock protein (HSP70), insulin resistance and serum levels of alanine aminotransferase (ALT), as well as aspartate aminotransferase (AST). Method: In this clinical trial study, 30 males with NFALD were selected through targeted sampling and were randomly assigned to one of two groups of practice and control intervention. The training program included 12 weeks of resistive training and 3 training sessions per week, which was performed as periodic circuit resistance training. Before eating breakfast, blood sampling was done one day before the start of training and 3 days after the last training session. For statistical analysis, paired t-test was used to compare intra-group data. Independent t-test was used for comparison between groups. Data were used via the SPSS v 22 software. The significance was defined as P≤0.05. Results: After the training course, compared to the control group a significant decrease was observed in weight (P = 0.008), BMI (P = 0.006), body fat percentage (P

Objective: Nonalcoholic fatty liver disease is the most common chronic liver disorder. The present study aimed to examine the effect of aerobic training along with Resveratrol on the cardiac expression of Mfn1 and Mfn2 in nonalcoholic fatty liver disease male rats. Methods: In this experimental study, 48 Wistar male rats were classified into two groups NAFLD (n=40) and control-normal (n=8). NAFLD was induced in rats with a high-fat diet and then subdivided into five subgroups NAFLD, SHAM, TRNAF, SUPNAF, and TRSUPNAF. Training groups have performed a running program on a motor-driven treadmill for eight weeks. Resveratrol (20 mg/kg) was injected into the SUPNAF and TRSUPNAF groups. Forty-eight hours after the last training session, the rats were anatomized; hearts were removed and immediately frozen in liquid nitrogen and stored at -80°C for measuring the Mfn1 and Mfn2. Statistical analysis was performed using a 1-way analysis of variance Tukey post hoc tests, and significance was accepted at P≤0.05. Results: The results showed that the induction of NAFLD reduced expression of Mfn1 (P=0.001) and Mfn2 (P=0.001) compared to control-normal. Also, in SUPNAF and RSUPNAF groups, Mfn1 (P=0.002 and P=0.017 respectively) and Mfn2 (P=0.000 and P=0.000 respectively) increased significantly compared to the NAFLD group. Conclusion: The combination of aerobic exercise and resveratrol may be due to changes in expression of mitochondrial fusion, modifying indexes apoptosis induced by oxidative stress in NAFLD patients.