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Introduction: Since Health Information Seeking Behavior (HISB) is a psychological phenomenon like every other human behavior, it seems that personal characteristics of patients affect this behavior. On the other hand, appropriate health information seeking behavior can fasten disease healing presses or their prevention. The aim of this study was to examine the effect of personal factors HISB of diabetic patients in Isfahan. Methods: A survey method was used in this research. The statistical population consisted of 6426 diabetic patients from whom 362 patients were selected by a no percentage stratified random sampling. The Longo information seeking behavior questionnaire was used to collect data and SPSS 20 were used for analyzing collected data. Results: Independent T- test showed that there was a statistically significant difference between behavior factor in information seeking process of men and women (p< 0.001). Moreover, Spearman correlation index showed that HISB factors were directly related to educational level. This test also showed that there was a direct relationship between income and some information seeking factors. Pearson correlation index showed that there was an inverse relationship between age and most information seeking factors. Conclusion: Passive methods should be used in transferring health information to diabetic men, and more time and energy should be consumed in transferring information to old diabetic patients with low income and low educational level. Hence, by studying factors influencing health information seeking behaviors of diabetic patients, their required information can be transferred to them more efficiently leading to prevention of diabetes. [ABSTRACT FROM AUTHOR]