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Introduction: Motivation is a key element in treatment and recovery of substance use disorders by influencing patients to seek, complete, and acceptance of treatment and make successful long-term changes Objective: the current study was conducted in other to evaluate treatment motivation based on cognitive self-control and self-compassion in people with substance dependency. Materials and Methods: The study carried out was a cross sectional type. The whole people with substance dependency referred to Shiraz centers of addiction treatment in the second half of 1392, comprised our statistical population of this research. One hundred and fifty people were selected by multistage random sampling method. Having conducted clinical interview, they were asked to respond to questionnaires of cognitive self-control, self-compassion and treatment motivation. Collected data were analyzed by tests of Pearson correlation and multivariate and multiple regressions. Results: The results showed that treatment motivation is negatively correlated with low self-control (r=-0.41; P<0.001), and positively with self-kindness(r=0.37; P<0.001), self-judgment(r=0.32;P<0.001), common humanity(r=0.33; P<0.001), isolation(r=0.32; P<0.001), mindfulness(r=0.40; P<0.001), and over-identification(r=0.36; P<0.001). The results of multiple regression showed that 30% variance of motivation, 30% variance of problem recognition, 28% variance of ambivalence and 24% variance taking steps are explained by self- compassion and cognitive self-control. Conclusion: The results of this study demonstrate that cognitive self-control and self- compassion play a role in predicting treatment motivation and readiness to change in drug-dependent individuals. [ABSTRACT FROM AUTHOR]