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Introduction: The most common endocrine disorder associated with altered cellular metabolism is Diabetes mellitus (DM). Lamium album, also called white dead nettle, is shown to have antiproliferative, anti-inflammatory, antioxidant, and free radical scavenging properties as well as improving fat metabolism. Objectives: The purpose of this study was to compare the effects of hydroalcoholic extract of lamium album on serum level of glucose and lipid profile in sterptozotocin induced diabetic rats with known anti diabetic effects of utricadioica. Materials and Methods: In this experimental study, thirty two male wistar rats were randomly assigned into four groups; normal control, diabetic control, diabetic receiving Urtica (100 mg/kg daily, diabetic receiving dlamium (100 mg/kg/daily) for 28 days. Serum glucose, cholesterol, triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and LDL/HDL ratio were measured. Data were analyzed by SPSS-16 and one way ANOVA followed by Tukey multiple comparison test. p < 0.05 was considered as statistically significant. Results: Hydroalchoholic extracts of Urticadioica and Lamium album caused significant decrease (p < 0.05) in serum level of glucose in streptozotocin-induced diabetic rats. Compared to diabetic control group, both plant extracts significantly decreased serum cholesterol, LDL and LDL/HDL ratio and on the opposite direction remarkably increased serum HDL (p < 0.05). However, serum TG in the diabetic rats treated with Urticadioica was lower than diabetic rats exposed to Lamium album extract (p < 0.05). Conclusion: Administration of Urticadioica and Lamium album extracts to diabetic rats by their antihyperglycemic and antilipidemic properties might be effective in the prevention or management of diabetes. [ABSTRACT FROM AUTHOR]