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Introduction: In today's modern world where people tend to judge others by the way they speak, write, and understand words, verbal intelligence is very valuable. A literature review of 28 studies introduced the temporal cortex as the most dominant primary region for verbal intelligence. Dominant sub-regions in both the temporal and frontal cortex are critical for language processing, speech control, and speech production. Also, the temporal cortex was recognized as an important area for verbal intelligence. Since then, the neuroscience of the skills of this intelligence has been considered an important issue for psychologists and neurologists, and few studies have investigated the neuroscience of this intelligence based on its skills, and the studies have been carried out in a scattered manner. Among the research conducted on this topic, we can mention the examination of speech, writing, and reading skills. Method: This research was among case studies. The statistical population of the present study was composed of 45 male and female volunteers aged 18 years and older who were referred to the National Brain Mapping Laboratory in Tehran in 2019, and among them, two subjects were selected in a targeted manner using the developmental assessment scale of multiple intelligences. Multiple intelligences developmental assessment scales were selected. Results: The findings from data processing showed that performing the reading task was associated with the activity of the frontal and prefrontal areas as well as the temporal and fusiform gyri. Findings related to the writing task also showed that doing the task was associated with the activity of the Temporal, and Prefrontal areas, especially the inferior and middle frontal gyri. Also, the findings from data processing related to the speech task showed that the frontal and temporal regions as well as the precentral and postcentral gyrus were associated with the activity. Diagram 3 shows that the activity level of brain regions in a subject with very high intelligence is higher in all regions except for the fusiform gyrus. Discussion: This study, like other studies, was accompanied by limitations, for example, the limitation in the number of subjects due to the high cost of fMRI and the time limit of assignments. Therefore, it is suggest to conduct research in a larger sample for better generalizability. [ABSTRACT FROM AUTHOR]

Introduction: Major depressive disorder (MDD) is one of the most common mental illnesses. The results obtained from previous studies conducted in this field show that inflammatory processes increase in MDD patients. However, few studies have addressed the issue of inflammatory markers in the brains of MDD patients. The aim of this study was to investigate the expression of regulatory axis related to cytokine signaling including IL6, TNF, NRG1 and BDNF in prefrontal cortex tissue samples. Materials and Methods: In the present study, using a bioinformatics approach based on microarray data analysis, the expression of a regulatory axis related to cytokine signaling, including four genes (IL6, TNF, NRG1, and BDNF), in prefrontal cortex tissue (PFC) samples was investigated. Background correction, gene filtering and data normalization were done using different packages in R. Data quality was also evaluated using AgiMicroRna package and PCA plot.The limma package in R was used in order to identify the genes with expression changes. In addition, Pearson's correlation analysis was performed in R to check the correlation between the selected genes. Results: The obtained results showed that the expression of BDNF and NRG1 genes in the PFC tissue of MDD patients was associated with a significant decrease (P= 0.037), and on the other hand, the expression of IL6 and TNF genes was significantly increased (P< 0.001). Also, a strong negative correlation between the IL6 and BDNF (P < 0.001) genes was obtained. Conclusion: In this study, the results show that there is a complex relationship between MDD disease progression and cytokine signaling. This research provides evidence for a better understanding of the mechanisms of MDD pathogenesis. [ABSTRACT FROM AUTHOR]