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Background & Aims: Azoospermia (lack of sperm in ejaculation) is one of the most severe types of infertility in men, due to various defects in the sperm production process or the testicular system . Azoospermia disease is caused by either obstructive mechanism (Obstructive azoospermia-OA) due to blockages in the natural sperm production system, or non-obstructive mechanism (NOA- Non obstructive azoospermia) due to defects in testicular sperm production, with over 60% of infertile men being afflicted with non-obstructive azoospermia (NOA). Treatment with busulfan may have adverse effects on various organs such as reproductive organs. Based on the understanding of hormonal control of sperm production, several drugs such as gonadotropins, androgens, estrogen receptor blockers, and aromatase inhibitors are used as experimental treatments for idiopathic male infertility. Letrozole, as an aromatase inhibitor, has been widely used in the treatment of female infertility, because the chemical structure of letrozole includes a triazole group that selectively interacts with the heme group of the enzyme P450arom, thereby reversibly inhibiting its biological activity Limited studies have evaluated the therapeutic potential of Letrozole in male infertility. In addition, excessive consumption of chemical drugs causes changes in the activity of antioxidant enzymes (TOS) and the stability of oxidative status (TAC) in the ROS pathway, leading to an imbalance between antioxidants and oxidants, resulting in oxidative stress. This phenomenon has led researchers towards the use of herbal medicines, which naturally have fewer side effects. Crocin has been identified as the main active biological component in saffron. Crocins are a type of water-soluble carotenoids that are either mono- or diglycosyl polyene esters, where D-gentiobiose and/or D-glucose appear as carbohydrate residues. A carotenoid with a 20-carbon dicarboxylic structure. Saffron contains various carotenoid chemicals that include small amounts of crocin, alpha and beta carotene, and lycopene. Six different forms of glycosylated esters from the crocin family have been found in saffron. Trans-crocins 3 and 4 are the most common analogs of crocins, which include crocins 1-4, and are essentially the glycosides of trans-crocin in saffron. Crocin can act as an antioxidant and improve the quality of sperm through increasing the expression of antioxidant genes. Therefore, phytoestrogens such as crocin bind to testicular estrogen receptors and stimulate spermatogenesis by strategies like increasing epithelial layers and the diameter of seminiferous tubules and lumen. The aim of this study was to investigate the synergistic effect of letrozole and crocin on the changes of antioxidant enzymes and testosterone hormone synthesis in the induction of spermatogenesis in azoospermia model mice with busulfan using ELISA technique. Methods: In this clinical trial, crocin and letrozole drugs were purchased from Sigma Aldrich. 30 male Wistar mice weighing 180-220 grams and aged approximately 8-10 weeks were purchased from the Pasteur Institute of Iran and transferred to the laboratory. They were kept under new conditions (at a temperature of 22-24 degrees Celsius, relative humidity of 55-60%, with a 12- hour light-dark cycle). To halt spermatogenesis and induce azoospermia, a dose of 10 mg/kg of busulfan was injected intraperitoneally for 10 days. Finally, the rats were divided into 5 groups of 6: the control group was injected with normal saline and citrate buffer inside the hemocoel; the treatment group received a single dose of 10 mg busulfan intra protanealat at a volume of 1.0 mL for 10 days; the treatment group was administered with a single dose of 10 mg busulfan intra protanealat at a volume of 1.0 mL, along with 5 mg letrozole with Black Soldier Fly (BSF) as the solvent; the treatment group received 15 mg crocin extract with normal saline, along with a single dose of 10 mg busulfan intra protanealat a volume of 1.0 mL; and the treatment group was given a single dose of 10 mg busulfan intra protanealat at a volume of 1.0 mL, along with 5 mg letrozole with BSF as the solvent, and 15 mg crocin extract with normal saline and underwent histopathological, histochemical immunological, and hormonal analyses. The data were presented as mean ± standard deviation. One-way analysis of variance (ANOVA) with Tukey's post hoc test was used to compare the means in the study groups (P <0.05), and statistically significant differences were considered. Graphs were also plotted using Graph Prism software. Results: The results demonstrated that the simultaneous treatment of letrozole and crocin increased spermatogonia, spermatocytes, and spermatids; Sertoli and Leydig cells were also enhanced. Additionally, letrozole and crocin treatment led to the preservation of the thickness of the basement membrane and the germinal epithelium of testicular tissue; the inner and outer diameters of the tubules were increased. While in the azoospermia group treated with letrozole or crocin, this level of population destruction was somewhat reduced; however, the use of letrozole or crocin in the study groups did not show a significant difference in the inner and outer diameter of the tubules. Biochemical analysis showed a significant increase in the activity of the Total Antioxidant Capacity (TAC) enzyme activity and testosterone hormone levels in the group treated with letrozole + crosine compared to the azoospermia group; however, a significant decrease was found in the letrozole or crosine treatment group compared to the control group, while the Total Oxidant Status (TOS) enzyme activity in the letrozol+crosine treatment group showed a significant decrease compared to the azoospermia group(P<0.05). Conclusion: Some of the improvements in sperm parameters can be attributed to the antioxidant properties of crocin. It seems that sperm lose a large volume of their cytoplasm due to lack of antioxidants during spermatogenesis and become more sensitive to increases in ROS. These results indicate that crocin can act as an antioxidant and enhance sperm quality by increasing the expression of antioxidant genes. Therefore, the use of a plant-derived antioxidant like crocin appears necessary without any side effects and with essential strengthening effects. Crocin can likely act as an antioxidant and potentially improve sperm quality due to its antioxidant activity. Additionally, it has been found that letrozole improves spermatogenesis without causing any observable pathological changes in testicular tissue. According to the studies of Ribeiro et al, Uzun et al, and Shoshany and colleagues, letrozole reversibly inhibits the aromatase enzyme and prevents the conversion of androgen precursors to estradiol in adipose tissue. Moreover, crocin can neutralize the negative effects of oxidative stress and increase cell ability to overcome oxidative stress conditions by preventing glutathione reduction and increasing antioxidant capacity. One of the limitations of the research can be attributed to the lack of studies and sample restrictions, as well as the death of mice during the experimental process. Further investigations and focusing on the precise dosage of crocin, along with attention to the relevant mechanisms of action, seem essential. Overall, crocin has antioxidant and defensive effects, improves the quality of some sperms, and increases morphology, viability, motility, and natural count. In fact, testosterone regulates the secretion of LH hormone from the anterior pituitary gland through a negative feedback mechanism. Busulfan induced apoptosis in germinal epithelial cells and co-administration of letrozole and crocin reduced busulfan-induced apoptosis leading to infertility; therefore, a rational relationship between apoptosis of spermatogonia in response to busulfan exposure can be obtained. It can be suggested that crocin, one of the key components of saffron, acts as a potent antioxidant that can prevent the toxic effects of busulfan and DNA damage that may occur due to oxidative stress. [ABSTRACT FROM AUTHOR]

Background & Aims Tracheostomy is often performed for people hospitalized in intensive care units (ICUs), but it can cause larynx damage and discomfort in the patient. Given that the final outcome and possible complications of tracheostomy are directly related to the quality of nursing care, this study aims to evaluate the effect of tracheostomy care training on the performance of nurses working in the ICUs of selected hospitals affiliated to Iran University of Medical Sciences. Materials & Methods This quasi-experimental study was conducted on 64 nurses working in the ICUs of Rasul Akram and Firouzgar hospitals in 2021. The data collection tools were a demographic form and the tracheostomy patient care evaluation questionnaire of Atashzadeh et al. (2015). data analysis was performed in SPSS software, version 16 using descriptive and inferential statistics (paired t-test, and analysis of variance). P<0.05 was considered statistically significant. Results The mean age of nurses was 31.49±6.02 years. Most of them were female (70.3%) with a bachelor's degree (90.6%). Their mean overall work experience was 6.74±5.13 years, and their average work experience in the ICU was 4.92±4.66 years. Most of the nurses (43.8%) had permanent employment. Most of the nurses had rotating shift (89.1%), and had not completed the course of tracheostomy care (93.8%). The results of the paired t-test showed a statistically significant difference in the mean performance score of nurses before training (45.85±8.87) and after training (93.3±42.33) (P<0.001). Conclusion Considering that the performance of nurses in caring for patients with tracheostomy in the ICUs of selected hospitals is not satisfactory, educating nurses and providing sufficient facilities based on guidelines and opinions of experts are recommended to improve the quality of services to these patients by nurses in the hospitals. [ABSTRACT FROM AUTHOR]

Background & Aims One of the concerns of nurses and physicians is the adherence to treatment in patients with heart diseases. In Iran, there are no accurate statistics on the treatment adherence of patients with coronary artery stents, and the risk of cardiovascular diseases (CVDs) in these patients has not been investigated. Therefore, this study aims to determine the relationship between treatment adherence and the risk of CVDs in patients with coronary artery stents. Materials & Methods This descriptive cross-sectional study was conducted from June to August 2021 in Shahid Madani Hospital in Tabriz, Iran. Participants were 200 patients who underwent coronary angioplasty in the past year and had coronary artery stents. They were selected by a simple random sampling method. To collect data, a demographic form, the treatment adherence questionnaire, and the Framingham risk score (FRS) were used. The collected data were analyzed in SPSS software, version 22 using descriptive statistics, Pearson correlation test, t-test, and one-way analysis of variance. Results The mean age of the patients was 61.6±10.62 years. Most of them were male (60.5%) and married (68%). The overall mean score of treatment adherence was 41.50±8.48, indicating moderate adherence. Patients had poor adherence in domains of dietary regimen and regular physical activity such that most of them used high-fat food (87%) and had the least amount of physical activity per week (92.4%), but they used prescribed medicines on time (70.3%). Based on the FRS, men were twice as likely to have CVDs as women. There was a significant association between treatment adherence and the risk of CVDs, such that the risk of CVDs in the next 10 years among patients decreased with increasing their adherence to treatment (r=-0.25, P<0.001). Conclusion Given that there is a significant relationship between treatment adherence and the risk of CVDs in patients with coronary artery stents, and considering that these patients have poor adherence to a low-fat diet and regular physical activity, it is recommended that nurses in their patient education programs emphasize adherence to having a low-fat diet and regular physical activity and identify the barriers to achieving it, so that, by increasing patients’ adherence to treatment, the risk of CVDs in the next 10 years can be reduced in these patients. [ABSTRACT FROM AUTHOR]

Background & Aims During the COVID-19 pandemic, nurses working in psychiatric departments were also involved, which affected their mental health. The present study aims to determine the effect of psychological immunization on perceived stress and anxiety caused by COVID-19 in nurses working in the psychiatry department of a hospital in Zahedan, Iran. Materials & Methods This is a quasi-experimental study that was conducted from February to June 2022. Participants were 50 nurses from the psychiatry department of Baharan Hospital in Zahedan city who were selected by a census method, and were assigned to intervention and control groups. Data collection tools included a demographic form, the perceived stress scale, and the corona disease anxiety scale. The psychological immunization was provided in two four-hour workshops. Data analysis was done in SPSS software, version 16 using mean, standard deviation and chi-square test, independent t-test, paired t-test, and Fisher’s exact test. P<0.05 was considered statistically significant. Results Most of the nurses had an infection with COVID-19 and were vaccinated. The mean and score of anxiety decreased from 11.96±10.05 to 8.12±6.92 in the intervention group (P=0.004) and decreased from 11.84±10.26 to 8.40±6.51 in the control group (P=0.07). The mean score of perceived stress changed from 27.45±5.56 to 27.20±4.20 after intervention in the intervention group (P=0.8) and from 27.48±4.71 to 28.32±4.87 in the control group (P=0.43). Conclusion The psychological immunization program has no significant effect on anxiety and stress caused by COVID-19 in nurses of psychiatric departments in Zahedan, Iran. It is recommended that psychiatric hospital managers should pay attention to the psychological problems of nurses at the beginning of the pandemic. [ABSTRACT FROM AUTHOR]

Background & Aims: At the end of December 2019 in Wuhan, Hubei Province, the corona virus disease spread rapidly throughout China. The beginning of 2020 brought a new challenge to mankind, which was the corona virus or the Covid-19 virus, and it became a global health threat. Corona virus disease is caused by severe acute respiratory disease. The acute syndrome of the corona virus is an epidemic that affects all people and Covid-19 has had a serious impact on thoughts, feelings and behaviors. Research demonstrated that mindfulness-based training can effectively relieve the negative psychological consequences of the outbreak of Covid-19 and help restore well-being, especially for the most vulnerable people. Mindfulness has made people better cope with quarantine conditions and the Covid-19 pandemic. Mindfulness training can direct attention to breathing and keep people away from negative emotions such as anxiety, depression and fear during the corona epidemic. Mindfulness is caused that individual recognize gradually their mind and thinking styles which are come regularly and habitually and also other benefits of mindfulness is to increase their patience, appreciating and awareness of their body. The purpose of the present research was to investigate the effectiveness if mindfulness therapy on dysfunctional attitudes, of Covid-19. Methods: For the present quasi-experimental study, which was performed with a pre-test-post-test design, among Covid – 19 patients with an age range of 18 to 60 years who were living in Isfahan city in the year 2020. The statistical sample of the current research consisted of 30 people who recovered from corona disease living in Isfahan city in 2020 and among them 30 people who got corona virus were selected through convenience sampling on the purpose based on the entry criteria and were randomly placed in to two experimental and control groups. In each group, there were 15 people, 9 men and 6 women in the experimental group and 5 men and 10 women in the control group. To collect the data Dysfunctional Attitude Scale (Wiseman and Beck, 1987) was used and the Mindfulness Therapy Program Intervention was applied and the treatment protocol used in the present study consisted of eight 120- minute sessions, which have been studied in various studies according to Kabat-Zinn et al.'s (1990) protocol, and the results indicated the effectiveness of mindfulness therapy on ineffective attitudes. Finally, in the current research, in addition to using descriptive indices including frequency, mean and standard deviation, inferential statistics were used to examine hypotheses from univariate covariance analysis using SPSS version 20 software at a significance level of p<0.05 for statistical analysis of data. Results: The results of ANCOVA analysis showed that there was a significant difference between the experimental and control groups in ineffective attitudes (P=0.005), in the post-test stage. Therefore, it can be concluded that the mindfulness treatment program has reduced dysfunctional attitudes in the experimental group compared to the control group. The calculated effect size or eta squared value indicates that 26% of the changes in ineffective attitudes scores were due to the effect of the independent variable (implementation of the mindfulness treatment program). Conclusion: According to the results obtained from the research findings, it can be stated that the hypothesis of the research was confirmed that eight sessions of the treatment of mindfulness has been effective in reducing dysfunctional attitudes of Covid – 19 patients. The current research, like other researches, has limitations, including the method of data collection online and virtual. The limitation of the equal number of demographic information in each group of samples and treatment follow-up can be mentioned as limitations of the research. The age range of 18 to 60 was one of the criteria for entering the research, and the findings of the results cannot be generalized to those under 18 and over 60. In the current research, only the effectiveness of mindfulness has been investigated, so other treatment approaches have not been investigated. Since the present study was conducted using a quasi-experimental study design, it may also be one of the important beginnings for other studies in the future and critical situations. The present study has practical implications for counselors, psychotherapists, educational management and policy makers. In order to confirm or not confirm the long-term effectiveness of the training given in connection with the consequences of Corona, more research should be done by other researchers. It is also suggested that the effectiveness of this treatment approach should be followed up for several months. It is suggested that the effectiveness of mindfulness on other variables such as psychological well-being, quality of life, mental health, spontaneous thoughts, and styles of coping with stress and fear of corona should be done. The results of the research are useful and practical as a non-drug treatment for people in the corona and post-corona period. Therefore, mental health professionals are advised to pay special attention to dysfunctional attitudes and coping strategies and plan to prevent and reduce the complications and risks of dysfunctional attitudes. A variety of face-to-face and online training and treatment programs are recommended by mental health experts to reduce dysfunctional attitudes for healthy people, infected with Corona, and people who have experienced bereavement caused by Corona. Since there are parts of the country without access to the Internet and mobile phones, and also elderly people may lack the necessary skills to use smartphones, therefore, it is necessary to take appropriate measures along with the observance of health protocols. [ABSTRACT FROM AUTHOR]

Background & Aims: Pain is divided into two main types, fast and slow. Pain receptors are composed of free nerve endings and use two separate pathways to transmit pain signals to the CNS. Sharp pain signals are produced by mechanical and thermal pain stimuli. These signals are transmitted to the spinal cord by peripheral nerves through Aδ fibers at a speed of 3-15 m/s. On the contrary, slow and chronic pain signals are mainly produced by chemical pain stimuli, but sometimes stable mechanical or thermal stimuli can also produce these signals. These signals are transmitted to the spinal cord by C-type fibers at a speed of 0.5 to 2 m/s (1). The mechanisms of neuropathic pain are not fully known, but the mechanisms proposed in the pathogenesis of this pain include the role of glial cells as supporting cells of the central nervous system, changes in sodium and potassium voltage-dependent channels, afferents adjacent to the neuron. It is damaged. Different neural pathways are affected differently. Therefore, identification of these pathways is important in determining the analgesic and medicinal mechanisms from physiological aspects. Although there are many studies in this field, one of the existing problems is the rate of recovery and return of nerve activity after injury. The results of researchers' research have brought relatively acceptable results, which were not without problems. In the present research, due to the high incidence of peripheral nerve injuries caused by blows and fractures in humans and animals, efforts will be made to find a drug or drug combination to accelerate the healing process of damaged nerves following experimental sciatic nerve injury in the rat animal model. Therefore, the present study will be conducted in order to investigate the analgesic effects of simvastatin and its neurophysiological interaction with the involved systems following experimental sciatic nerve ligation in rats. Methods: This research was used in 2 experimental phases on 85 adult male rats weighing 180-200 grams. These animals were transferred to the laboratory animal breeding and maintenance center of the veterinary school and were kept in standard mouse cages under standard conditions. All animals were evaluated for motor health before surgery, and then all mice were anesthetized by intraperitoneal injection of ketamine hydrochloride (60 mg/kg) and xylazine (10 mg/kg), and after scrubbing and initial leg preparation The animals were placed on their left side and an incision was made in the posterior-external skin of the thigh area of the left leg. The muscles and fascia were gently removed and after exposing the sciatic nerve, the sciatic nerve was compressed for 60 seconds using a micro hemostat. In order to trace, the injury site is marked by suturing the muscle closest to the crush site using non-absorbable silk suture (0-5) and then the muscles are placed together and the subcutaneous tissue and skin are The sequence was stitched using vicryl thread (0-4) and nylon (0-3) in a simple all round and single stitch method. Then formalin test was done and licking time was measured. The animals were divided into 4 groups: group 1: nerve damage without treatment, group 2, 3 and 4 were treated with simvastatin. Mice in group 2 (with a dose of 2 mg/kg), group 3 (with a dose of 4 mg/kg) and group 4 (with a dose of 8 mg/kg) were treated with Sivastatin. There were 5 mice in each group and they were evaluated in two time intervals of 2 and 4 weeks. Results: As seen in Figure 1, the injection of morphine (5 mg/kg) significantly reduced the pain time caused by the formalin test compared to the control group (P<0.05). The level of 4 and 8 mg/kg simvastatin significantly decreased the pain time caused by the formalin test compared to the control group (P<0.05). According to the results of the statistical analysis of repeated measurements of one factor, the summary of the analysis of variance of the changes in the duration of the animal's response to the stimulating effects of formalin affected by the effective dose (8 mg/kg) of simvastatin compared to naloxone during the acute and chronic phases is presented in Figure 2. Naloxone injection (2 mg/kg) had no effect on pain time caused by formalin test compared to the control group (P>0.05). The level of 8 mg/kg simvastatin significantly decreased the pain time caused by the formalin test compared to the control group (P<0.05). The combined injection of naloxone plus simvastatin significantly reduced the analgesic effects of simvastatin compared to the simvastatin alone group (P<0.05). According to the results of the statistical analysis of the repeated measurements of one factor, the summary of the analysis of variance of the changes in the duration of the animal's response to the stimulating effects of formalin affected by the effective dose (8 mg/kg) of simvastatin compared to speroheptadine during the acute and chronic phases is presented in Figure 3. According to the results of the statistical analysis of the repeated measurements of one factor, the summary of the analysis of variance of the changes in the duration of the animal's response to the stimulating effects of formalin affected by the effective dose (8 mg/kg) of simvastatin compared to cimetidine during the acute and chronic phases is presented in graph No. 4 . Conclusion: The aim of this study is the analgesic effects of simvastatin following experimental sciatic nerve ligation in rats. According to the obtained results, it was determined that the analgesic effects of simvastatin are dose-dependent and the findings of this test show that the effective dose (8 mg/kg) of simvastatin alone has been able to create a significant effect in reducing the painful effects of formalin in animals. It has also caused a significant decrease in the response time to formalin pain stimulus in animals. Antagonists naloxone, cyproheptadine and cimetidine were able to inhibit the analgesic effects in acute and chronic phase. Simvastatin activates the PI3K/AKt pathway and increases neurogenesis through BDNF and (Vascular endothelial growth factor) (12). Simvastatin increases the phosphorylation and expression of BDNF and VEGF gene in (Dentate gyrus) DG. As a result, cell proliferation increases and differentiation occurs in the DG area and brain recovery increases (14). Therefore, simvastatin may cause gene expression of growth factors, production of protein kinases, and subsequent induction of neurogenesis in the DG of the hippocampus, increasing dendritic branches through the activation of AKt through the signaling pathway (15). The effects of simvastatin on ischemia-reperfusion injury of the sciatic nerve in adult rats, as a result, administration of simvastatin before ischemia shows protective properties in nerve re-injury and improves blood supply again (16). [ABSTRACT FROM AUTHOR]

Background & Aims: Type 2 diabetes is the most common endocrine disease that occurs due to glucose intolerance due to imbalance between reserves and insulin demand.RBP4 is one of these adipocytes whose serum concentrations increase in different models of rats with type 2 diabetes and people with insulin resistance or type 2 diabetes. The aim of this study was the interactive effect of High Intensity Exercise Training (HIIT) and n-chromosomal royal jelly on RBP4 and AMPK gene expression in liver hepatocytes and glucose levels and insulin resistance in type 2 diabetic rats. Intense interval training is usually performed with intensities above 90% of the maximum heart rate and short rest periods and a training duration of less than 20 minutes. Royal Jelly is a yellowish white substance secreted by the submandibular glands of worker bees and by the queen bee is consumed throughout its life and the larvae during the growing period. Due to their anti-oxidant and anti-diabetic, anti-cancer, antiinflammatory effects, various drugs are obtained from Royal Jelly. Evidence from studies shows that the possibility of RBP4 and AMPK gene expression in soleus muscle plays an important role in increasing consumption glucose. Therefore, this article intends to report the interactive effect of HIIT and consumption of n-chromosomal royal jelly on glucose regulatory factors. Methods: The statistical population of the present study consisted of rats. After 20 weeks of high-fat diet, rats became diabetic by intraperitoneal injection of 25 mg STZ per kg body weight. Mice with fasting glucose between 150 and 400 mg / dL were considered to have type 2 diabetes. Mice were treated in 4 groups: 6-head diabetic control, 8-period periodic training, 7-head Royal Jelly, 8-head Periodic Exercise, and 8-head Royal Jelly training group and training protocol and gel-royal gavage. The HIIT protocol consisted of eight weeks of aerobic exercise, five sessions per week with a gradual increase in extreme frequency from 22 to 38 meters per minute and a rest period of 16 to 22 meters per minute for 15 to 34 minutes by running on a treadmill. Running time increased from 16 minutes in the first week to 34 minutes in the eighth week. At the end of the training period and 48 hours after the last training session, the experimental training groups and after 12 hours of fasting, the rats were anesthetized and sacrificed by ether anesthetic. Blood samples were collected from the heart. Glucose was measured using an auto-analyzer. Insulin measured by a special kit of Pars Azmoun Company. The insulin resistance index was calculated using the formula and gene expression was also determined by RT-PCR. To describe the data, descriptive statistics and inferential statistics of one-way analysis of variance and Bonferroni post hoc test were used to compare the differences between groups and twofactor analysis of variance and effect size index were used to compare the effect of each of the independent variables. Significance level it was considered p≤0.05. [ABSTRACT FROM AUTHOR]

Background & Aims: : Adolescence is a period in which many healthy and unhealthy habits are formed and spread to the next periods of life, and since during this period, healththreatening behaviors increase, adolescents are at risk of many health-threatening behaviors including increased food intake, decreased physical activity, and increased developmental vulnerability. Therefore, a health-promoting lifestyle in teenagers is one of the best ways that they can maintain and improve their health. Health-promoting behaviors are part of daily life activities that create a set of individual happiness, values, and well-being. A healthy lifestyle is a balanced life in which a person consciously makes healthy choices in different areas. Health promotion includes behaviors during which a person should have proper nutrition, exercise regularly, avoid harmful behaviors, protect against accidents, detect signs of illness in time in the physical dimension, control emotions, feelings, and thoughts, and cope with It deals with stress and problems in the mental dimension, independence, adaptability and modification of interpersonal relationships in the social dimension. Therefore, the type of interpersonal relationships and, as a result, the emotional system that governs the family structure and interpersonal relationships, affects the mental health of a person, because this emotional system is the ability to separate and differentiate oneself from others on a cognitive and emotional level. The purpose of the present study was to present a structural model for predicting health-promoting lifestyle in teenage girls based on self-differentiation and interpersonal sensitivity with the mediating role of social support. Methods: The research method was descriptive and correlation type using structural equations. The statistical population in this research was made up of all high school female students in Yazd who were studying in theoretical fields (humanities, experimental sciences and mathematics) in the academic year of 1402-1401. 4 schools from district one and 4 schools from district two of Yazd city (8 schools in total) and from each school three classes from among mathematics, experimental and humanitarian fields (24 classes in total) were selected and in each class the questionnaire was randomly distributed to 15 students were given to complete. Finally, due to the non-response of a number of participants and the missing questionnaires, the analyzes were performed on 340 samples. The measurement tools in this research were Walker's health-promoting lifestyle (1987), perceived social support by Zammit et al. (1988), self-differentiation by Skowron and Smith (2003), and Boyce and Parker's (1989) interpersonal sensitivity. Data analysis was done using Pearson correlation and path analysis to investigate causal relationships between variables. Results: The results of the fit of the proposed model indicated a good fit of the model with the data. The direct coefficients of the model showed that self-differentiation (P<0.001, β=0.203) and perceived social support (P<0.001, β=0.259) have a significant positive effect on healthpromoting lifestyle, and interpersonal sensitivity on style Health-promoting life has a significant negative effect (P<0.001, β=-0.309). Also, with the inclusion of perceived social support variable into the model, the indirect effect of self-differentiation and interpersonal sensitivity on health-promoting lifestyle became -0.0814 and -0.0335, respectively. Conclusion: In explaining this finding, it can be stated that interpersonal sensitivity (emotional and social) is the skill of evaluating others' abilities, states, and traits through their non-verbal signs, and people who have these characteristics are disturbed in interpersonal relationships, regardless of real criticism or not. They are sensitive to accepting and changing their behavior to follow others' expectations, and as a result, they experience dysfunctional interpersonal relationships to a greater extent. Interpersonal sensitivity can cause individual isolation and increase the feeling of social loneliness because people with high interpersonal sensitivity suffer more from pessimism, mistrust, and a hostile view of the world, and as a result, experience social isolation and reduced benefits from social support. On the other hand, they are radically changing their behavior to suit others to minimize the risk of criticism and rejection. Therefore, teenagers in stressful situations may use it as a tool to reduce their mental pressure, which leads to a decrease in their desirable lifestyle. As a result, if teenagers have characteristics that can receive the necessary social support, this support will make them reduce the number of weaknesses caused by separation anxiety and fragile self-esteem and adjust their interpersonal relationships according to their needs. These relationships further satisfy the need for approval and minimize the fear of rejection and criticism, and during a cycle, this model can strengthen the possibility of promoting a desirable lifestyle. In general, people with differentiation and interpersonal sensitivity problems have difficulty in relating to others and maintaining intimate relationships and tend to cut off communication with others, as a result, they probably receive less social support from others. On the other hand, social support can improve problems related to Psychological disorders, and problems play a moderating role. As a result, a person who has high social support is not easily involved in the process of social comparison in the process of non-differentiation, interpersonal sensitivity, or sensitivity to rejection, and it seems that social support can play a mediating role in the relationship between self-differentiation and interpersonal sensitivity with health-related lifestyle.Therefore, adolescents with differentiation and interpersonal sensitivity problems have difficulty in maintaining intimate relationships with others and tend to cut off communication with others, as a result of which they receive less social support from others and the lack of social support causes maladaptive behaviors and Health decreases in these teenagers. [ABSTRACT FROM AUTHOR]

Background & Aims: : In general, among the effective methods in improving academic resilience, academic resilience, and emotional self-awareness can be mentioned as educational methods that include cognition, behavior, affection, and interactions at the same time. Resilience is a kind of returning to the initial balance or reaching a higher level of balance in threatening conditions and provides the means for successful adaptation in life. In the field of people's resilience, two categories of risk factors and protective factors can be separated, the risk factor prevents the effective performance of the individual. However, the protective factor is the resources that help people avoid the effects of looking at the importance of the family in hardships and crises. Resilience is not a one-dimensional structure, but a multi-dimensional phenomenon, it is understood in its context and context, and a complex interactive model is needed to fully understand it. On the other hand, in students, academic resilience means achieving good educational results despite adverse conditions and challenges through changing existing behaviors or creating new behaviors, such as discipline, practice, or planning. The resilience process is not just a biological or psychological fact. But at the same time, it also has social dimensions and nature. In other words, students who are resilient in one situation may face problems in another situation. Students who have academic resilience, even in the presence of stressful events and conditions that can put them at risk of poor performance and eventually dropping out of school, have high motivation and good performance. In other words, resilient students maintain a high level of motivation and progress despite stressful events and conditions, which requires the acquisition of appropriate self-awareness in different cognitive, behavioral, and even emotional fields. The purpose of this research was to compare the effectiveness of teaching self-directed learning strategies and brain-based learning on the academic resilience of high school students. Methods: The research method was a semi-experimental pre-test-post-test type with an unequal control group. The statistical population of the current research is made up of all 387 female students of the first secondary school of the ninth grade of public schools in the city of Northern Swadkoh in the academic year of 2022-2023. A number of 45 people were selected based on the criteria for entering the research and were randomly replaced into two experimental groups of 15 people and a control group of 15 people. Samuels (2004) academic resilience questionnaire was used to collect data. The summary of self-directed learning strategies training sessions taken by Densero et al. (1979) in 8 60-minute sessions and the summary of brain-based learning training sessions taken by Cain et al. (2005) in 90-minute sessions were conducted on the experimental group. There was no intervention for the control group. Repeated measurement variance analysis was used with SPSS18 software to analyze the data. Results: The findings showed that teaching self-directed learning strategies and teaching brain-based learning affects the academic resilience of secondary school students. Brain-based learning training was more effective than brain-based learning training on academic resilience. The findings of this research can provide practical implications for consultants. Brain-based learning helps students learn about their brain function. This training shows them how the brain performs comprehension, memory, attention and critical thinking and how they can improve these functions. Brain-centered learning training gives students a better understanding of cognitive processes such as attention, memory, critical thinking, and problem solving compared to teaching self-directed learning strategies. This training helps students to be able to use these processes and perform better in learning and problem solving. Teaching brainbased learning helps students to strengthen their cognitive skills compared to teaching selfdirected learning strategies. In general, teaching brain-based learning to students is more effective than teaching self-directed learning strategies on academic resilience because it focuses on cognitive processes, increases motivation and willingness to learn, creates diversity in learning methods, brain-based learning education is more than education. Self-directed learning strategies can be more effective in students' academic resilience. The brain-centered method is a learning method that focuses on the principles and natural functions of the brain. This method is based on deep understanding and conscious attention to the learning process. Through direct communication with the brain, it directly helps to strengthen the mind and increase cognitive abilities. Conclusion: Brain-based learning helps students improve their cognitive skills. These skills include attention, memory, critical thinking, and problem-solving, which are effective in academic resilience and achieving better performance in various subjects. Teaching brainbased learning helps students strengthen their concentration power compared to teaching selfdirected learning strategies. This focus helps students in learning and problem-solving and increases academic resilience. The limitation of the research to the first secondary school students of the ninth grade limits the generalization of its findings to other students and other grades, therefore caution should be observed in generalization. Since the gender of the participants was female, generalization to male students is limited. The data collection tool was a questionnaire, and questionnaires, despite their usefulness, may cause the respondents to respond under the influence of social desirability. Because the research was conducted in the northern city of Swadekoh, it may be limited in generalizing its results to other places due to the specific socio-cultural context of this city. The brain-based learning teaching method is an effective method for improving academic resilience, and the findings of this research can provide practical implications in the field of improving the performance of psychological factors to academic advisors and teachers using the brain-based learning teaching method. According to the results of the article, the hypothesis that there is a difference between the effectiveness of self-directed learning strategies and brain-based learning on academic resilience in high school students was confirmed. However brain-based learning training was more effective than self-directed learning strategies on academic resilience. [ABSTRACT FROM AUTHOR]

Background & Aims: Schizophrenia is a mental disorder with frequent psychosis, whose symptoms include delusions, hallucinations, disordered speech or behavior, and impaired cognitive ability. The cause of this disease becoming a debilitating disorder for patients and their families is its early onset and chronic course, which affects one percent of the population. Antipsychotic drugs are only effective in treating half of the patients, and the pathological mechanism of schizophrenia is not fully understood. In addition, these drugs improve generally positive symptoms (such as hallucinations and thought disorders that are at the core of the disease), but negative (such as social isolation) and cognitive symptoms (such as learning and attention disorders) remain untreated. On the other hand, these drugs have severe neurological and metabolic side effects and may lead to sexual dysfunction. Schizophrenia is a multifactorial disorder that involves the interaction of several genes, environmental factors, and epigenetic processes. Over the past ten years, genetic research has yielded new findings that have given rise to hope for the biological origins of schizophrenia. The genetic role is caused by a large number of alleles, including alleles with small effects that can be identified by GWAS studies. The drug treatments that are available for schizophrenia have poor efficacy for many patients in which the mentioned genetic factors are very effective. Identifying the causes of this disease is an important step in the field of improving the treatment for this disorder, which is estimated to be half to one third of the genetic factors influencing the development of schizophrenia by common alleles reported in GWAS studies. Thus, GWAS studies are potentially an important tool for understanding the biological process of schizophrenia. GWAS Catalog is a complete collection of all published studies at the genome level, which makes it possible to investigate and identify the cause, understand the mechanism of the disease, and identify new treatment methods in this disease. In recent years, many efforts have been made to identify biomarkers in the diagnosis, prevention and treatment of schizophrenia, each of which introduces specific genes and pathways that overlap with other mental disorders. In this study, in order to investigate important genes and biological pathways in the development of schizophrenia, the genes reported in the GWAS catalog bioinformatics database were examined so that in the future, with more studies, it can help to treat and diagnose these patients more accurately. Methods: In the present study, using the GWAS catalog database and searching for the word Schizophrenia, a list of 3344 SNPs was extracted from 80 research articles. In the next step, the SNPs that cause schizophrenia and other related diseases were extracted (1165 SNPs that were the result of 19 studies). Then, among the SNPs obtained in the previous steps, those with lower and equal p-values were 5*10^-8, isolated and checked using ensemble.org in the BioMart section, in order to find the closest genes. Then, the results of BioMart were sorted and collected based on the obtained genes, and the duplicates were removed (removal of duplicate genes) and finally 336 genes were obtained. (In general, for 554 SNPs, the gene was identified, and for the other 574 SNPs, the gene name was not found, which are extragenic.) In the next step, the above list was entered in BioMart and the names of the desired genes were obtained. (Part of Ensemble genes 107; NCBI gene (formerly Entrezgene) accession) which resulted in a total of 339 genes. In the last step, the genes obtained from the previous step were checked using the Enrich R site, and through this site, the pathways that were related to the studied genes were extracted and compared with the results of different articles. Results: In this study, after entering the results in Biomart, 339 genes were obtained. Also, after entering the above list in the Enrich R site, the important pathways in which these genes are active were obtained. Pathways which Adjusted-P value was below 0.05 were considered as reliable results. Conclusion: This study was conducted on schizophrenia by analyzing the data of GWAS catalog database to identify the mechanism of the disease and the pathways involved as well as the main and important genes of drug candidates. One of the important pathways in this study was Glucuronidation, which was one of the first pathways obtained from Wiki Pathway studies, which is often involved in the metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids. and bile acids play a role. This pathway is mainly carried out in the liver, although the enzyme responsible for its catalysis. UGTs are widely expressed in the brain, but at lower levels than in the liver. Brain UGTs are inducible or inhibitable that affect drug release in the central nervous system. UGTs, cytochrome P450s, and transporters act together to influence the pharmacokinetics of drugs in the brain. After glucuronidation, many drugs have the ability to cross the blood-brain barrier. Another pathway is ascorbate metabolism. Ascorbate (vitamin C) is a vital antioxidant molecule in the brain. However, it has several other important functions, participating as a cofactor in several enzymatic reactions, including catecholamine synthesis, collagen production, and HIF-1α regulation. Ascorbate is transported to the brain and neurons through the sodium-dependent vitamin C transporter (SVCT2), which causes the accumulation of ascorbate in cells against a concentration gradient. The highest concentrations of ascorbate in the body are found in the brain and neuroendocrine tissues such as the adrenals, although the brain is the hardest organ to deplete ascorbate. Together with the regional asymmetry in the distribution of ascorbate in different regions of the brain, this shows the important role of ascorbate in the brain. The next pathway was the porphyrin metabolism pathway, which disruption in this pathway can cause neurological symptoms, neuropathy and a wide range of psychiatric symptoms in addition to specific diseases, until in 1939, Waldenstrn reported that schizophrenia in families with Acute intermittent porphyria (AIP) is very common, but no statistics were provided. Another study found that 5 of 40 AIP probands had hallucinations, suggesting a possible link between psychosis and AIP. A study in Sweden found that people with AIP were four times more likely to develop schizophrenia or bipolar disorder. In addition, first-degree relatives of these people are twice as likely to be diagnosed with schizophrenia and bipolar disorder. The other pathway was the pathway of retinoid metabolism, the first evidence linking this pathway to schizophrenia is that retinoid toxicity or deficiency frequently leads to the manifestation of symptoms that, although more severe in scope, are similar to those of schizophrenia. For example, mental disorder, mental defect, large ventricles, microcephaly and various major and minor congenital anomalies, among which cranial anomalies are prominent. Such deficits have been reported frequently among schizophrenic samples. With the increasing documentation of the prominent role of retinoids in the development of the central nervous system, the possibility of retinoid involvement in schizophrenia is strengthened. Another important pathway was drug metabolism, which drugs that are widely used today in the treatment of mental disorders, including depression, psychosis, and mood stabilizers, in many cases are associated with many side effects, and only a small number of patients respond appropriately to These drugs show Many factors, including genetic factors, are effective in the effectiveness of drugs, which are of interest today. According to the present study, it can be concluded that genetics and especially polymorphisms play a very important role in the development of schizophrenia and that these genes can be used in the diagnosis and treatment of this disease. In the future, the genes of these pathways can be studied more reliably in schizophrenia for diagnostic and therapeutic purposes. The genes obtained in this research can be suitable and new options for future studies on schizophrenia and optimization of treatment methods. [ABSTRACT FROM AUTHOR]

Background & Aims: Patent ductus arteriosus (PDA) is one of the congenital disorders in premature neonates, which is strongly associated with increased mortality in them. Currently, echocardiography is the method of choice for detecting PDA, and due to the high cost of this method and its lack of easy access, finding a suitable and low-cost alternative method, including the use of clinical parameters to quickly detect PDA in premature neonates and determine the cases in need Treatment is very important. Therefore, in this study, we decided to investigate the sensitivity and specificity of clinical criteria in the diagnosis of PDA in comparison with the echocardiography method. Preterm neonates refer to neonates who are born before 37 weeks from the first day of the last menstrual period (1) due to developmental delay and also weakness in the immune system, these neonates are about 40 times more than neonates with normal weight at risk of mortality (2). The ductus arteriosus is a vein that connects the pulmonary artery to the aorta. This duct is the fetal vascular connection between the pulmonary artery and the aorta artery, which diverts blood from the pulmonary bed to the systemic circulation during the fetal period (3). In the uterus, blood is shunted from the lungs due to the high pressure in the lungs. Therefore, the blood leaves the right ventricle, enters the ductus arteriosus, and from there enters the aorta (4). The ductus arteriosus contracts after birth and usually closes within 72 hours after birth. If this active contraction does not occur after birth, the ductus arteriosus will remain open. Usually, within 10 to 15 hours after birth, this contraction causes the functional closure of the ductus arteriosus, which starts from the side of the pulmonary artery and finally progresses to the end of the aorta (5). Therefore, keeping this duct open causes the oxygen-rich blood in the aorta to mix with the deoxygenated blood flowing in the pulmonary artery. Therefore, a lot of blood is transferred to the lungs, which increases the pressure on the heart, increases the blood pressure in the pulmonary veins, and also impairs the ventilation of the lungs (6). A large blood shunt from the ductus arteriosus increases pulmonary blood flow and also decreases systemic blood flow (7). Neonates with reduced systemic blood circulation are exposed to dangerous complications such as increased systolic and diastolic pressure, increased oxygen demand, pulmonary edema, tachycardia, active pericardium, heart failure, intracerebral hemorrhage, pulmonary hemorrhage, and necrotizing enterocolitis (8). Methods: This cross-sectional study was conducted on preterm neonates with PDA and preterm neonates without PDA who were admitted to the NICU department of Akbarabadi Hospital in Tehran during 2017 and 2018. In this study, 124 preterm neonates with a gestational age of 25 to 37 weeks were included in the study. Preterm neonates with convulsions, life-threatening infections, clinical or radiographic evidence of necrotizing enterocolitis, evidence of hemorrhage, congenital neurological disorders, metabolic and genetic syndromes, pulmonary hypoplasia syndrome, congenital heart anomalies, and other fatal abnormalities., were excluded from the study. Also, a checklist was provided in which case and demographic information related to preterm neonates was recorded. Parameters such as birth age, height and weight, gender, duration of hospitalization in NICU, duration of mechanical ventilation, history of any underlying or congenital disease (such as heart and lung disease, sepsis, other infectious diseases, diseases respiratory, history of cardiac arrest, etc.), neurological diseases, type of birth (NVD or cesarean section), gestational age, mothers' age were also recorded. After initial examinations and selection of patients based on inclusion and exclusion criteria, various clinical parameters in newborns including heart rate, peripheral pulse status, precordial pulse status, heart murmur status, cardiothoracic ratio, first minute Apgar score and Fifth, the deterioration of the respiratory condition was investigated in terms of physical and clinical examinations. A heart rate less than 160 was given a score of zero, a heart rate between 160 and 180 was given a score of 1, and a heart rate greater than 180 was given a score of 2. Cardiothoracic ratio less than 0.6, 0.6 to 0.65 and more than 0.65 were determined with zero, 1 and 2 scores, respectively. The status without murmur, systolic murmur and diastolic murmur were defined with 0, 1 and 2 scores, respectively. Normal peripheral pulse score zero, brachial banding score 1, brachial and dorsalis pedis banding score 2, precordial pulse not visible and not palpable with score 0, palpable precordial pulse with score 1 and visible precordial pulse with score 2. The scores of each of the clinical criteria were added together and a score equal to or greater than 3 was considered to be associated with the incidence of hemodynamically significant PDA. Then echocardiography was performed in the examined neonates by an experienced pediatric cardiologist. The results of this research were analyzed by SPSS software. In this study, p value equal to or less than 0.05 was considered statistically significant. To determine the sensitivity and specificity of clinical factors in determining PDA requiring treatment, the ROC diagram and the area under the ROC curve were used. The results related to the sensitivity and specificity of each of the physical and clinical examinations as a factor in the diagnosis of active PDA in need of treatment were compared with echocardiography results. Results: Based on statistical analysis and ROC curve performed in this study, the relationship between scores calculated based on Clinical criteria were demonstrated with PDA. Based on this, it can be said that by measuring clinical criteria and calculating the score can be detected PDA. Also based on the ROC curve analysis at point (score) 3, the sensitivity value is 65% and the specificity value is 95%, and at point (score) 2 the sensitivity value is 90% and the specificity value is 87%. Conclusion: AUC = 0.94 for the diagnosis of hs-PDA indicates the fact that the definition of the score parameter based on the clinical criteria presented in this research can help in the diagnosis of PDA without echo. Only the difference between the pre-ductal and post-ductal oxygen saturation and the intensity of the dorsalis pedis pulse should be taken into account. Also, since the level of sensitivity is higher in the score of two, and this means that the false negative cases are less in the score of two, therefore, the score of two can be a more appropriate score for detecting cases that need treatment. According to the ROC curve of 5 clinical criteria for the diagnosis of hemodynamically PDA, the order of effectiveness of these 5 criteria are CTR, precordial pulse, heart murmur, heart rate and peripheral pulse respectively. [ABSTRACT FROM AUTHOR]

Background & Aims: The concern about the quality of life of the elderly living in resident at home and nursing homes has been one of the controversial issues. Some studies believe that if the mental health of the elderly is provided and a suitable atmosphere is created in the nursing homes, better health care and treatment can be provided to the elderly and their life expectancy can be increased; But on the other hand, some studies believe that caring for the elderly at home and with other family members can have an effective role on their psychological health; so that the results of some studies indicate that this group of elderly people have a higher life expectancy; But on the other hand, it can threaten their physical health and make them prone to other chronic diseases and malnutrition. Admission to a nursing home evokes emotional consequences, including feelings of rejection, psychological tension, depression, instability, loss of home and the chance to contact family and friends. Research shows that the living environment of the elderly plays a very important role in their psychological health. It has been shown in various researches that the level of quality of life and mental health, happiness and social health in the elderly living in nursing homes is lower than that of the elderly living at home; Based on this, it can be concluded that there is a relationship between living in a nursing home and the psychological state of the elderly, but it cannot be said with certainty that the low mental health of the elderly indicates living in a nursing home; Because some studies have shown that the diseases and disabilities of elderly people living in nursing homes are more than other elderly people, and disabilities lead them to care centers; Maybe this factor also has an effective role in reducing their mental health. Based on this, the implementation of a comparative study in the elderly with high performance and control of physical disabilities will clarify the role of living in a nursing home in the state of mental health of the elderly, which is addressed in the present study. Also, some studies indicate that the stay of the elderly in the nursing home is associated with the feeling of exclusion and their feeling of loneliness plays an effective role. Also, the research showed that the elderly living in the nursing home experienced a feeling of insecurity and rejection and described their transition from home to the nursing home as painful; In other words, living in a nursing home can have an effective role in reducing the mental health of the elderly. Elderly people who have a high level of rejection feel that they are of no use to themselves and those around them and cannot be effective; Also, the results of this study showed that the feeling of rejection, due to its high relationship with social incompetence, has an effective role in increasing depression symptoms in these elderly people; Based on this, it can be concluded that living in a nursing home, rejection and depression are closely related. In this regard, the results of some studies show that the elderly living in nursing homes have far more symptoms of depression, anxiety and stress and report less satisfaction with life. Nowadays, due to the increase in the number of elderly people and the shrinking of families, caring for the elderly is a very important issue, and detailed and comprehensive programs for the care of this sensitive age group should be provided by conducting field research and formulating detailed care policies. Compared to younger people, older people with depression usually have multiple co-occurring medical and cognitive disorders, and depression that occurs in older patients is often underdiagnosed or undertreated. Also, previous studies have shown that inactivity and disability are factors affecting the feeling of exclusion of the elderly; which, if accompanied by family rejection, can lead to an increase in psychological distress in the elderly. Considering the importance of this topic, the present study compared the perception of rejection and depression symptoms in elderly people living in nursing homes and resident at home. Methods: The current research was descriptive and based on causal-comparative method. The statistical population of this research includes two groups of elderly people in Rasht city in 2020 who were living in nursing homes or living with their families. The sample size was calculated using G*Power software. From each group, 120 elderly people participated in a targeted manner and answered the Perceived Rejection Scale: PRS and the Geriatric Depression Scale: GDS-15. For both groups, the age gap is between 65 and 90 years, having minimum physical health to communicate and answer the questions of the questionnaire, not suffering from cognitive impairment diseases such as (Alzheimer, stroke and dementia), not being engaged in economic activity. And retirement from governmental and nongovernmental institutions and having informed consent and willingness to participate in the research were considered as entry criteria. Also, failure to answer at least 10% of the questionnaire questions, fatigue and unwillingness to complete the questionnaire were considered as exit criteria. Data analysis was performed using SPSS-24 statistical software and multivariate analysis of variance. Results: The results of multivariate analysis of variance showed that the perception of rejection (F = 14.25, P = 0.001) and depressive syndrome (F = 17.280, P = 0.001) in the elderly living in nursing homes were significantly higher than the elderly were in the control group (P <0.001). Conclusion: Overall, the results of this study showed that the perception of rejection and depression symptoms in elderly people living in nursing homes is more than that of elderly people living at home; But this difference cannot be attributed to the presence of the elderly in the nursing home. But in general, it can be concluded that elderly people living in nursing homes are more in need of appropriate interventions and educational programs to reduce the feeling of rejection and depression symptoms than the elderly people living at home. Therefore, it is suggested to provide educational and therapeutic programs to improve the psychological condition of these elderly people. [ABSTRACT FROM AUTHOR]

Background & Aims: The coronavirus 2019 first spread from Wuhan, Hubei Province, China, and became a global epidemic in just two months, according to the World Health Organization. As of March 23, 2020, the unknown virus has spread rapidly worldwide, infecting more than 187 countries and killing a significant number of people worldwide. COVID-19 is an acute respiratory infectious disease characterized by the main symptoms of fever, cough, and shortness of breath. With the outbreak of COVID-19 and subsequent changes such as the closure of high-risk jobs and the implementation of emergency public health measures and home quarantine, social and economic relations and the way people lived were severely affected. During the spread of the virus, strict measures such as social distancing and mask-wearing were taken to control the spread of the disease in different parts of the world. One of the measures taken to curb COVID-19 was establishing home quarantine, which in turn can have a variety of consequences, including increased anxiety and stress. Patients with or suspected of COVID-19 are often afraid of the aftermath of the deadly virus, such as long-term health effects or death. People in quarantine may also experience fatigue, loneliness, depression, and anger. Additionally, common symptoms of COVID-19 such as fever, body aches, loss of taste and smell, hypoxia, cough, and dry throat can increase COVID-19 anxiety in patients, which may cause psychological distress. High levels of fatigue and anxiety resulting from quarantine conditions significantly increase the need for extreme care, but due to the unknown nature of coronavirus 2019 and the lack of definitive treatment, individuals may have difficulty responding to this need. This intensifies fear, anxiety, and depression in people. Another variable that can be associated with pandemic diseases, such as COVID-19, is coping styles and types of symptoms in high-stress patients. Since the beginning of the COVID19 epidemic, there has been a wave of stress and anxiety, first among Chinese citizens and then around the world. People must use appropriate and effective coping strategies to control and reduce the stress caused by these conditions. Overall, COVID-19 anxiety, specifically health anxiety, can lead to cognitive errors, threat-related distortion, immunosuppressive behaviors, and destructive behaviors in healthy individuals who develop high levels of COVID-19 anxiety. In this regard, the present study aimed to compare psychological distress and coping styles in students with different levels of COVID-19 anxiety. Methods: The research design was descriptive and causal-comparative. The statistical population of the study included undergraduate, graduate, and Ph.D. students of the University of Tehran, Iran, in the second semester of 2020-2021. In the present study, 200 students (100 students with high levels of COVID-19 anxiety and 100 students with low levels of COVID-19 anxiety) participated in the study through an online survey conducted via WhatsApp and Instagram. Inclusion criteria included belonging to the research community, having internet access, being between 18 and 30 years of age, and reporting personal satisfaction with their current living situation. The omission of questions was also considered as a criterion for leaving the research. Due to the epidemic of COVID-19, the closure of universities and educational institutions, and to prevent the spread of COVID-19, samples of this study were collected online. Participants were assessed using the COVID-19 Anxiety Inventory, psychological distress, and coping styles and then grouped. To identify students with COVID-19 anxiety, 338 questionnaires were distributed among the participants. Individuals who obtained a standard deviation above the mean COVID-19 anxiety scale were included in the analysis as a group with high levels of COVID-19 anxiety. Finally, data analysis was performed using multivariate and univariate variance with SPSS software version 24. It should be noted that in the present study, ethical considerations based on Helsinki ethics were observed. Results: The results of the Eta squared analysis show that the difference between the two groups in the studied variables is significant, with an Eta squared value of 0.71. This means that 71% of the variance related to the difference between the two groups is due to the interaction of COVID-19 anxiety and the studied variables. The results of multivariate analysis of variance showed that stress (68.55), anxiety (79.77), depression (94.17), Emotion-oriented Coping (98.81), Problem-oriented Coping (102.74), and Avoidanceoriented coping (114/48) were all significant at the level of 0.01. These findings indicate that there is a significant difference between the two groups in these variables (P<0.01). This means that students with different levels of COVID-19 anxiety differ in their use of psychological distress and coping styles. Specifically, students with high levels of COVID-19 anxiety had higher levels of psychological distress, emotion-oriented coping, and avoidance-oriented coping than students with low COVID-19 anxiety. Conclusion: Findings from this study showed that students with high levels of COVID19 anxiety have more depression, anxiety, and stress than other students. As a result, students with high levels of COVID-19 anxiety may become more sensitive to physical signs and symptoms, which can lead to increased levels of COVID-19 anxiety. On the other hand, the results of this study indicate that people with high levels of COVID-19 anxiety are less inclined to use problem-solving coping styles and are more likely to use emotion-oriented and avoidance-oriented coping styles. However, problem-solving coping styles can further reduce the harms of experiencing COVID-19 and the stress that results from it. Although stressors play an important role in exacerbating chronic and pandemic diseases, it should be borne in mind that how people deal with stressful situations plays an important role in their health. Therefore, psychologists and counselors need to pay more attention to these areas to reduce the severity of anxiety in students. [ABSTRACT FROM AUTHOR]

Background & Aims Breast cancer (BC) is one of the important challenges of the health system due to its impact on marital relationships. This study aims to compare sexual function and sexual distress of women with and without BC. Materials & Methods In this case-control study, 75 women with BC and 75 healthy women from Zanjan, Iran participated. Data were collected using a demographic form, the female sexual distress scale-revised (FSDS-R), and the female sexual function index (FSFI). Data analysis was done in SPSS software, version 20 using the Mann-Whitney test and multivariate analysis of covariance. Results The mean age of patients was 36.49±6.53 years and the mean age of controls was 36±0.72 years. There was no statistically significant difference between the two groups in terms of some demographic variables such as age, educational level of women and their husbands, occupation of women and their husbands, place of residence, and number of children (P>0.05). The mean score of FSFI in all subscales in the patient group was lower than in the control group. This difference was statistically significant only in the dimension of desire (P=0.003). regarding the sexual distress variable, the mean FSDS-R score of healthy women was lower than that of women with breast cancer, but this difference was not statistically significant (P>0.05). Conclusion The difference between women with and without breast cancer is significant only in the desire domain of sexual function. There is no statistically significant difference between the two groups in sexual distress and in other domains of sexual function. The sexual problems of women with BC require consideration and support, and provding counseling in terms of sexual function. [ABSTRACT FROM AUTHOR]

Background & Aims: Considering the lack of research in finding an effective approach in the field of bipolar disorder management and the career success of people with this disorder, the present study aims to compare the effectiveness of vocational rehabilitation programs with career counseling based on the cognitive-behavioral approach on the career success of them, and the following questions were answered: Is the effect of a vocational rehabilitation program with career counseling based on the cognitive-behavioral approach different on the subjective career success of people with bipolar disorder? Is the effect of the vocational rehabilitation program different from career counseling based on the cognitive-behavioral approach to the objective job success (income) of people with bipolar disorder? Is the effect of the vocational rehabilitation program different from career counseling based on the cognitive-behavioral approach to the objective career success (promotion) of people with bipolar disorder? Methods: The design of the current research was semi-experimental, of a pre-test-post-testfallow-up type with a waiting group. All participants referred by a psychiatrist to a counseling clinic and diagnosed as having bipolar disorder were purposefully selected for the research, and among them, the volunteers were interviewed and diagnosed with a clinical interview based on the criteria of the DSM-5. To select the research sample, inclusion and exclusion criteria were considered. 24 people were selected by the available sampling method and randomly assigned to groups. 8 people in the experimental group with a vocational rehabilitation program, 8 people in the experimental group with career counseling based on the cognitive-behavioral approach, and 8 people in the waiting group. Before starting the interventions, a pre-test was taken from all 24 participants. After that, the people assigned to the two test groups received the relevant interventions in 10 sessions of 100 minutes (in the experimental intervention with the vocational rehabilitation program and the career counseling intervention based on the cognitive-behavioral approach) and the people present in the waiting group did not receive any intervention. The people participating in the interventions did not have any knowledge or contact with each other, and they tried to maintain is lack of knowledge and communication until the end of the intervention and prevent the exchange of information. For the vocational rehabilitation program and career counseling based on the cognitivebehavioral approach, a pre-developed program was used separately, the validity and reliability of which had been checked and confirmed (5). Moreover, the vocational rehabilitation program, in addition to 10 intervention sessions for the individual with bipolar disorder, included two intervention sessions for the family and two sessions for the employer or his colleague, which are carried out if the individual needs and consents to these two intervention sessions were down. At the end of the interventions, all the people in the experimental and waiting groups filled out the questionnaires again as a post-test. One month after the implementation of the post-test, the research samples filled out the research questionnaires for the third time to implement the follow-up phase. To measure the subjective dimension of career success, the job satisfaction questionnaire (29) and the objective dimension of career success were measured by measuring the amount of income and job promotion. Research data were analyzed using descriptive statistics (mean and standard deviation) and inferential (variance analysis with repeated measures) using SPSS V. 16 software (30). Based on the background of the research, pre-test variables, age, and gender were covariate. Results: In the post-test stage, the vocational rehabilitation program showed more effectiveness in subjective career success than the career counseling based on the cognitivebehavioral approach (p<0.007) and the waiting group (p<0.006), but none of the two interventions, there was no significant effect on objective career success (p<1). Also, in the follow-up phase of the vocational rehabilitation program, it was more effective on subjective career success than the career counseling based on the cognitive-behavioral approach (p<0.003) and the waiting group (p<0.0001), but between the scores of the participants in the intervention of career counseling based on the cognitive-behavioral approach and the waiting group no significant difference was observed (p<0.26). Besides, there was no significant difference between the objective career success scores (income) of the participants in the two research interventions and the waiting group (p<0.2). In comparison, between the objective career success scores (promotion) of the participants in the two research interventions, there was no significant difference with the waiting group (p<0.36). Conclusion: According to the data obtained from the results of the research, it can be said that the vocational rehabilitation program has been effective in increasing subjective career success scores, and even after one month of receiving the intervention, the effectiveness of this method has not decreased. Also, career counseling based on the cognitive-behavioral approach has not been effective in the subjective career success of people with bipolar disorder. Besides, none of the two interventions have been effective on the objective career success (income and promotion) of the people participating in the research. In general, according to the results of the research and the explanations presented, it seems that considering the clinical observations, the subjective career success of people with bipolar disorder during the interventions, especially in the vocational rehabilitation program, compared to the career counseling based on the Cognitive-behavioral approach more specifically deals with the career and its appendices, and in addition to managing people, it teaches a person how to build and deal with a real career future. Therefore, it is not far-fetched that a specialized vocational rehabilitation program that is specially designed for vocational interventions will be more effective (5). It is also important to note that increasing income is not a short-term process and requires a long time (34). In addition, this research coincided with the era of Coronavirus and the recession and closure of businesses (36), but under the influence of the interventions, at least the previous income level of the individual in these challenging conditions was maintained. Based on the clinical evidence from the reports of the people present in the research, especially the people who participated in the intervention of the vocational rehabilitation program, after participating in the intervention, these people were able to achieve a higher human credit status in the workplace than before, and the positive feedback of people around these people has confirmed that. Therefore, it seems that in addition to the objective promotion, maybe we can have a word called spiritual promotion, which based on the positive feedback these people received from the people around them at the workplace, is considered a great career success for these people. Will be In fact, it may be possible to talk about the existence of a kind of spiritual promotion in the workplace, which has not been mentioned in research so far (5). This study provides evidence of the effectiveness of the vocational rehabilitation program in increasing the career success of people with bipolar disorder. This new perspective can be used as a reliable source on the career interventions of people with bipolar disorder and can be effective as an early rehabilitation intervention in reducing the career issues of these people. [ABSTRACT FROM AUTHOR]

Background & Aims: Overweight and obesity are related to increased risk of coronary heart disease, stroke, high blood pressure, type 2 diabetes and some specific cancers. In recent years, inactivity, obesity and metabolic syndrome have been increasing in developing societies (2). Among various diseases, polycystic ovary syndrome is among the cases that are strongly related to obesity (3). Studies in recent decades have shown that PCO syndrome can be a pro-inflammatory stage, because among them cardiovascular diseases, diabetes 2, insulin resistance and metabolic syndrome are seen with a high incidence (4). In the meantime, investigating and identifying the inflammatory causes of this condition for the above reasons can help specialists in its treatment with the process of reducing its negative effects through aerobic exercise. In this regard, the above research investigated some inflammatory factors such as E-selectin and nuclear factor kappa B (NF-κB). To improve the physical condition of obese people, instead of medicine, sports activities, both anaerobic and aerobic, are used, and each of these activities affects the improvement of physical condition through different mechanisms (2). Researchers believe that regular and not heavy exercise is a healthy and natural method for patients with polycystic ovary syndrome apart from clinical treatments (18). Physical activity improves menstrual irregularity, ovulation, ovarian morphology and fertility by reducing abdominal fat, blood sugar, blood fat, reducing insulin resistance, affecting hormone secretion and reducing cardiovascular risk factors. Be (7). But the question is, what exercise? With what intensity? And for how long? Treatment with all kinds of drugs may cause male characteristics, and unfortunately, most of the side effects are irreversible, so non-drug treatment strategies are necessary and need to be examined and studied. On the other hand, by reviewing the research done inside and outside the country, no research has been done on the effect of Tabata exercise on the research variables and even aerobic exercise on the research variables in women with polycystic ovary syndrome, so the purpose of this research is to determine The effect of a session of Tabata exercise in water and metformin on E-selectin and NF-κB in obese women with PCOS. Methods: The current research was semi-experimental and applied with a pre-test-post-test research design. For this purpose, 30 women with a body mass index greater than 29.9 in Isfahan city, who were diagnosed with polycystic ovary syndrome by an endocrinologist or gynecologist and diagnostic tests and ultrasound, were considered as a statistical sample. They were selected and randomly divided into two experimental groups (metformin + exercise in water) and control. 24 Before starting the exercises, the subjects first completed the personal information questionnaire and blood was taken after 12 hours of overnight fasting to determine the level of the variables. Experimental group for 12 weeks, 3 sessions a week and each session 40 minutes of exercises in the water (including 10 minutes of walking forward, backward, sideways and soft running in the shallow part of the pool where the water level is below the neck and Then they performed stretching exercises. Then they performed Tabata exercise with a special exercise song played in the pool for 20 minutes, and then they did 10 minutes of stretching and cooling (22) and 500 mg metformin twice consumed during the day and after breakfast and dinner. 48 hours after the last training session, blood was taken again from all subjects. At the end, descriptive statistics (mean and standard deviation), Shapiro-Wilk test to check the normality of data distribution and covariance analysis to check research hypotheses using spss/21 software at a significance level of α≤0.05 were used. became. Results: The results showed that the E-selectin factor in obese women with PCOS at the end of the period in the group of Tabata exercise in water and metformin intake had a significant difference compared to the control group (P=0.001 and F=134.6). Tukey's post hoc test results It showed that there is a significant difference between the pre-test of the Tabata training group in water and the post-test of the Tabata training group in water on the one hand, and between the post-test of the Tabata training group in water and the pre-test and post-test of the control group on the other hand, but between the other groups. There is no significant difference. (Table 2). The results showed that Tabata exercise in water and metformin consumption have a significant effect on NF-Κb factor in obese women with PCOS (P=0.025 and F=354.3). The results of Tukey's post hoc test showed that there is a significant difference between the pretest of the Tabata group in water and the post-test of the Tabata group in water, but there is no significant difference between the other groups (Table 3). Conclusion: The results showed that the E-selectin factor was significantly higher in obese women with polycystic ovary syndrome at the end of the period in the aerobic exercise and metformin group than in the control group. The results of the follow-up test showed that there is a significant difference between the pre-test of the Tabata aerobic training group and the post-test of the Tabata aerobic training group on the one hand, and between the post-test of the Tabata aerobic training group and the pre-test and post-test of the control group on the other hand, but between the other There is no significant difference between the groups. Aerobic exercises decreased VCAM-1 and ICAM-1 adhesive molecules; While its effects on E-selectin and P-selectin have been inconsistent. Of course, it seems that the effect of aerobic exercise on these conditions depends on the type and duration of the exercise intervention and the disease conditions such as the presence of ischemia. As presented in this review, there is a high level of evidence that sports activity has a positive effect on key factors in the development of atherosclerosis. This can partly explain the scientifically proven anti-atherogenic effects of aerobic exercise and has significant clinical effects (23). The results showed that the NF-Κb factor in obese women with polycystic ovary syndrome was significantly lower in the aerobic exercise and metformin group at the end of the period than in the control group. The results of Tukey's post hoc test showed that there is a significant difference between the pre-test of the Tabata aerobic exercise group and the post-test of the Tabata aerobic exercise group, but there is no significant difference between the other groups. In the explanation above, it can be stated that NF-κb is stimulated and activated in response to cellular stimuli. So far, about 450 stimuli, including physical, chemical, physiological and oxidative stimuli, have been identified for NFκB. Also, mitogens, receptor ligands, bacteria, viruses, parasites, fungi and their products, pro-inflammatory cytokines and some pathological conditions are among the stimuli of this transcription factor (28). The transcription factor NFκB is responsible for supplying a large number of pro-inflammatory genes, including cytokines, chemokines, immune receptors, enzymes and other pro-inflammatory molecules (29). Inappropriate activity of NFκB is one of the mechanisms of some diseases, especially those associated with inflammation (30). [ABSTRACT FROM AUTHOR]

Background & Aims: The family is the smallest unit of society and its health and disease are directly or indirectly involved in the health and disease of the community; but despite the importance of the family as a good environment for socializing and educating future generations, today many families suffer from traumas such as divorce, marital disputes, suicide, runaway children and other issues. They have shaken and in some cases destroyed the healthy family relationship that is necessary for the survival and strengthening of the family. The phenomenon of marital boredom is a kind of burnout and physical, emotional, and psychological exhaustion that is caused by the mismatch between expectations and reality in married life. Boredom is gradual and less sudden. In fact, love and intimacy gradually fade away and decay. At worst, boredom means the total breakdown of marital relationships. The behavioral-cognitive approach is one of the most important therapeutic approaches that has attracted the attention of psychologists. Today, the application of the behavioral-cognitive approach in couple therapy has been approved. Considering that the problem of marital boredom in couples, which is caused by annoyance, frustration, despair, and a large psychological-emotional distance between couples, is one of the main reasons for emotional divorce, and if not properly addressed and treated, It provides the ground for formal divorce of couples, so it is important to pay attention to this phenomenon and treat its destructive effects on the marital and family system. On the other hand, supervised and clinical research on emotion-oriented couple therapy and cognitive-behavioral couple therapy and their effect on conflict and boredom in couples are small, so the present study to compare the effectiveness of emotion-focused couple therapy and cognitive couple therapy- Behavior on the boredom of the couple seems necessary. Since in order to increase marital satisfaction and strengthen marital relations, it is necessary to pay attention to the cause and effect of incompatibility and as mentioned, both of these theories have completely different views on this category (incompatibility), in this study, the effectiveness of couples Emotion-oriented therapy is examined in comparison with rational-emotional-behavioral couple therapy to determine which of these two approaches is more effective in reducing boredom. Methods: The present study is semi-experimental in terms of applied purpose and method of implementation. The research design of this study is a pre-test and post-test design with a control group. The statistical population of this study included all women who were referred to Azar Clinic in Kermanshah from the beginning of April 2017 to June 2017 due to marital conflicts and family conflicts to solve their problems and out of 200 patients, 30 people were randomly replaced in experimental group one (n = 10), experimental group two (n = 10) and control group (n = 10). They were selected and replaced using random sampling and random substitution. In general, the inclusion criteria in this study included those who had partial or desirable social and family commitments and mild or relative mental and physical health, and their performance in the way of adaptation and interpersonal relationships with their spouse was difficult and demanding. Eliminating marital problems and boredom, in other words, promoting mental health and increasing life satisfaction, have been intended to continue living together. Exclusion criteria were also couples with a history of severe addiction, longterm and frequent incarceration, leaving or running away from home, severe mental illness with psychiatric symptoms, extramarital sex complained of by one or more couples, or had severe physical illnesses that were medically diagnosed and were unable to maintain marital relationships, which according to the assessments that were made at the beginning of the referral were not included in the list of the statistical population of this study. In the present study, the marital boredom questionnaire was used. This scale was invented by Pines in 2003. The questionnaire has 21 items that include 3 main components of physical fatigue (eg feeling tired, lethargic, and having sleep disorders), emotional exhaustion (feeling depressed, hopeless, trapped), and mental exhaustion (such as feeling worthless, frustrated). And anger towards his wife). Also in this study, the experimental group participated in emotion-focused couple therapy sessions and cognitive-behavioral couple therapy sessions that lasted approximately two months and two sessions per week. Data were analyzed using Spss-21 statistical software. Results: The statistical results showed that emotion-oriented couple therapy and cognitive-behavioral couple therapy were effective in reducing marital boredom and also emotion-focused couple therapy and cognitive-behavioral couple therapy were equally effective in marital boredom (P <0.001). Conclusion: In general, according to the results, it can be stated that to reduce couples' boredom, emotion-based couple therapy, and cognitive-behavioral couple therapy can be used, and couples can use these approaches to deepen their life expectancy. Emotional couple therapy is used to reduce turmoil in adult romantic relationships and to reconstruct couples' interactive patterns. During treatment, small steps are taken toward safe emotional engagement, which allows couples to reassure each other and reduce conflict. Like other studies in the field of behavioral sciences, the present study also faced limitations, including the study sample, which consisted of a couple who filed for divorce due to a severe marital dispute and went to family court counseling centers. They have referred. Due to this, the generalizability of research results to other couples who have not filed for divorce despite severe marital discord should be done with caution. Also, the participants in the study were couples who simultaneously announced their readiness to participate in the study, so caution should be exercised in generalizing the findings of this study. It is better that such interventions be performed at least on couples with a history of divorce without separation. They should also be referred. It is also suggested that the effectiveness of the approaches used in this study be compared with other approaches and follow-up should be considered in the study to evaluate the continuity of therapeutic effects over time. [ABSTRACT FROM AUTHOR]

Background & Aims: Diabetic neuropathy is the most common diabetic complication. In more than 50% of patients with diabetic neuropathy, significant and irreversible nerve damage occurs before diagnosis. Diabetic neuropathy is associated with increased mortality (2). Half of patients with diabetic neuropathy suffer from neuropathic pain. These painful symptoms are usually severe and often lead to depression, anxiety and sleep disorders and reduced quality of life (2). Oxidative stress caused by hyperglycemia causes damage to mitochondria in nerve cells, but its mechanisms are not fully understood (4, 5). Sequential oxidation reactions in the mitochondria cause unpaired electron leakage in the electron transfer chain in the inner mitochondrial membrane and the production of free radicals (4). Mitochondria are primary targets for ROS-induced injury; because they are the main site of ROS formation in diabetic hyperglycemia (4). Therefore, examining the factors affecting the structural and functional components of mitochondria, such as electron transfer chain components, can provide useful information for the goals and programs of treatment and prevention of neurological damage caused by diabetic neuropathy. Cytochrome C is a small hemoprotein in the inner membrane of the mitochondria; this protein is highly soluble in water and is a key component of the electron transfer chain (6). Velayutham et al. In a study stated that cytochrome C and Fe3 play a significant role in the harmful effects of ischemia / reperfusion and diabetes due to increased production of superoxide radicals (7). On the other hand, insulin therapy has been shown to modulate neurotrophin-dependent treatment of mitochondrial membranes and the expression of genes associated with metabolite pathways and the mitochondrial electron transport chain (8). Although much research has been done on the effect of exercise on diabetic neuropathy, there is no research specifically examining the effect of exercise on cytochrome C as one of the factors affecting the mitochondrial function of the nervous system in mice with diabetic neuropathy; Therefore, the aim of the present study was to determine the effect of six weeks of aerobic exercise on the level of cytochrome C in the sensory part of the spinal cord in rats with diabetic neuropathy. Methods: In the present experimental study, 12 male Wistar rats were divided into 4 groups: healthy exercise, control exercise, control diabetes and control diabetes. In order to induce diabetes, half of the rats became intraperitoneally diabetic by injecting a single dose of streptozotocin (STZ) (55 mg / kg body weight). Forty-eight hours after STZ injection, hyperglycemic rats with serum glucose above 300 mg / dL were considered diabetic. To confirm the neuropathy of rats, the thermal hyperalgesia test was used with a tail-flick device (20). After confirmation of neuropathy, the animals were placed in the diabetic neuropathy group. The training program included 6 weeks of running training on the treadmill in 5 sessions per week. After dissection of the animals, the dorsal part of the spinal cord was analyzed as sensory neurons. Immunohistochemistry was used to measure the amount of cytochrome C protein. One-way analysis of variance and Tukey's post hoc test were used for statistical analysis. Statistical analysis was performed using SPSS software version 26 at a significant level of P ≤ 0.05. Results: The results showed that six weeks of aerobic training reduced blood glucose in the diabetic group compared to the control diabetic group (P = 0.002), but there was not observed make a significant difference in the weight of rats. The results also showed that after the training period, the level of cytochrome C protein in the healthy exercise group significantly increased compared to the healthy control group (P = 0.041) and in the diabetic group the exercise significantly decreased compared to the control diabetes group (P < 0.001). Conclusion: The results of the present study showed that induction of diabetes increased the level of cytochrome C in spinal tissue in diabetic neuropathic rats compared to healthy groups. Previous research has shown that diabetic neuropathy is associated with mitochondrial degradation due to stress due to hyperglycemia and oxidative stress due to diabetes (21, 22); in the present study, an increase in cytochrome C in diabetic neuropathy groups was positively correlated with an increase in glucose levels. In the study of the effect of exercise on cytochrome C levels, the results of the present study showed that after six weeks of aerobic exercise, a significant increase in cytochrome C protein content of spinal cord sensory tissue was observed in healthy exercise rats compared to the healthy control group. While in the diabetic exercise group, the results showed a significant decrease in cytochrome C levels compared to the diabetic control group, which showed the difference in the effect of exercise on changes in cytochrome C of sensory neurons in mice with diabetic neuropathy compared to healthy mice. Scientific research has shown that exercise is one of the effective factors in reducing hyperglycemia due to diabetes (11, 25), on the other hand, by controlling blood sugar, the level of inflammatory factors and oxidative stress in these patients is reduced (26, 27); It can be said that aerobic exercise with glycemic control reduces mitochondrial stress and thus reduces cytochrome C as one of the mechanisms of apoptosis signaling (23, 24), in the cells of the spinal cord, Which can prevent the complications of diabetic neuropathy as well as neuropathic pain. The results of the present study also showed that six weeks of aerobic exercise increased the amount of cytochrome C protein in the spinal cord of healthy rats, this was consistent with the results of Yoo et al. (28) and Bashiri and Pourrazi (29) who studied the effect of exercise on cytochrome C in the myocardial of healthy rats. It can be said that the increase in cytochrome C levels in healthy rats is one of the adaptations associated with aerobic exercise and indicates an increase in mitochondrial capacity in ATP production. It can be said that changes in cytochrome C in spinal sensory tissue are different in adapting to six weeks of training in healthy rats with neuropathy, and the increase in cytochrome C in healthy rats is associated with increased mitochondrial capacity in energy production. While the reduction of cytochrome C in rats with diabetic neuropathy is associated with a reduction in hyperglycemia and indicates the protective role of exercise on nerve tissue and reducing neuropathic damage caused by diabetes. According to the results, in addition to controlling hyperglycemia in diabetic patients, aerobic exercise can be used as one of the non-pharmacological and useful treatment methods in reducing the complications of diabetic neuropathy. [ABSTRACT FROM AUTHOR]

Background & Aims: Anterior cruciate ligament (ACL) injury is regarded as one of the most frequent knee joint injuries. ACL injury is typically non-contact and occurs during activities such as cutting, accelerating, and landing after a jump. According to the video analysis, the mechanism of non-contact ACL injuries consist of several common components such as hip adduction and internal rotation, knee valgus, tibia external rotation, and ankle eversion; Combination of these components called "dynamic knee valgus". In this situation, the role of hip abductor and external rotator muscles is to eccentrically control hip adduction and internal rotation. In closed-kinetic-chain, adequate stability in hip joint provides better knee control. Evidence for this is seen in a reported greater hip abduction correlated with less knee valgus during single leg squat. Specifically, lower eccentric hip abductor peak torque is associated with higher peak knee valgus during landing Although the literature showed the positive effects of the preventive programs, most of them include exercises that involve combination of muscles groups, so the mechanisms by which muscles group reduce dynamic knee valgus are unclear. To the best of our knowledge, no study has addressed the effectiveness of an isolated hip abductor and external rotator strengthening on dynamic knee valgus during jumplanding task. Therefore, the purpose of the current study was to determine whether an isotonic strengthening which targeting the hip abductor and external rotator would improve the dynamic knee valgus during landing. We hypothesized that dynamic knee valgus would improve post isolated hip abductor and external rotator strengthening program. Methods: Present study is a randomized controlled trial carried out by single-blinded parallel group. Thirty-two males with knee valgus angle more than 8 degree were randomized into a training (n=16) or control group (n=16). In pre-screen session, in order to determine dynamic knee valgus eligibility for participants, subjects were asked to perform single-leg jump-landing task. Subjects landed forward from the 31-cm height box with their dominant leg onto a marked place at a distance of 40% their height. The subjects landed on their dominant leg and immediately performed a countermovement jump to achieve maximal height. A digital video camera was set up on tripod at the height of the subject’s knee, 2 meter in front of the subjects landing place, and lined up vertical to the frontal plane. The frame that knee has highest medial displacement was exported into Auto CAD 2016 software (version 20.1) for calculation of knee dynamic valgus angle. In pre-test sessions, each subject warmed up for 5 minutes (walking and jogging around the laboratory at a self-selected pace), and then was instrumented with 40 retro-reflective markers. The positions of the markers were recorded at 200 Hz using a motion capture system (Qualisys AB, Gothenburg, Sweden) with eight Ocus cameras and were synchronized with a force plate (Kistler AG, made in Switzerland) collected data at 2000 Hz. Each subject completed an initial static, standing calibration trial to align local coordination system with global coordinate system, and then performed 3 attempts to singleleg jump-landing task (as described in pre-screen) with dominant leg (30 seconds rest between each attempt). Eccentric and concentric peak torques of dominant leg hip abductor (side-lying position) and external rotator (seated position with 90° flexion in the hip and knee) were quantified by a single examiner using KinCom 500H isokinetic dynamometer (Chattecx Corp. Inc. Hixson, TN). The training group carried out 8 weeks of bilateral hip abductor and external rotator strengthening 3 times per week. Each session included 3 phases: 1: warm-up, 5 minutes Walking and jogging, 2: strengthening exercises, 35 minutes hip abductor and external rotator muscles exercises, 3: cool down, 5 minutes walking. In the post-test session, participants followed the same procedure used for the pre-test session. Each participant wore the same shoes in pre and post-test sessions to prevent injury and control footwear differences effect, and all tests were completed at the same time in pre and post-test sessions. Results: During the course of the study, two subjects withdraw from the study due to personal problems (one subject in CG and one subject in TG) and one subject sustained injury due to an accident (in TG). So, data from 29 subjects were used for statistical analysis. The ANCOVA evaluating changes in hip strength from baseline to the end of the 8-week hip strengthening program revealed a significant difference between TG and CG for concentric (P<0.001) and eccentric hip abduction (P=0.002) and concentric (P=0.007) and eccentric hip external rotation (P=0.001) peak torques. Paired-sample t tests were performed to determine the training effect on the hip muscle strength. At the post-test, the TG demonstrated greater concentric (1.6±0.55 vs 2.01±0.42 Nm/Kg; P<0.001) and eccentric hip abductor (1.41±0.51 vs 1.77±0.43 Nm/Kg; P=0.004) and concentric (0.94±0.21 vs 1.07±0.19 Nm/Kg; P=0.01) and eccentric hip external rotator (0.92±0.18 vs 1.11±0.21 Nm/Kg; P<0.001) peak torques compared with pre-test. No significant differences in muscle strength were observed for the control group between pre-test and post-test. The ANCOVA evaluating changes in knee kinematic from baseline to the end of the 8-week hip strengthening program revealed a significant difference between TG and CG for peak knee valgus (P=0.02) and knee valgus range of motion (ROM) (P=0.04). After the 8-week intervention, the TG demonstrated lower peak (-5.62 ± 7.36 vs -2.74 ± 5.94; P=0.02) and range of motion (ROM) on dynamic knee valgus angle (-9.66 ± 5.56 vs -7.31 ± 3.87; P=0.04) compared with pre-test, whereas significant changes were not noted in the control group (P>0.05). Conclusion: Hip abductor and external rotator weakness is a well-documented impairment in subjects with increased dynamic knee valgus during landing and has been postulated to contribute to non-contact ACL injury. This study was conducted to investigate the effects of isolated hip abductor and external rotator exercises on lower extremity kinematic, as well as concentric and eccentric abductor and external rotator torques in male subjects who present with excessive dynamic knee valgus during landing. The most important finding of the current study was a reduction in peak and knee valgus range of motion during landing in training group. These changes might be due to an increase in concentric and eccentric hip abductor and external rotator peak torques in training group as a result of the 8-weeks resistance training. Our findings support the isolated hip abductor and external rotator strengthening as a viable preventive and rehabilitative exercises program option for subjects who shows excessive dynamic knee valgus impairment in the hope of preventing non-contact ACL injury. [ABSTRACT FROM AUTHOR]

Background & Aims: : Coronavirus (Covid-19) is a large family of viruses that may cause respiratory infections from colds to more severe diseases such as MERS and Sars. Recently, this virus has been named Covid-19. contextual factors surrounding covid-19; including ease of transmission, lack of immunity among the global population, delayed testing, limited medical equipment, and uncertainty of the path of the pandemic; There is a level of public anxiety that shows the importance of investigating the issue. Research has reported a relationship between well-being and more effective coping strategies. Currently, psychological conceptualizations of unhealthy coping preferences often focus on individual coping strategies that are conceptualized as illness or part of the illness, for example, eating disorders, substance use disorders, self-harm, suicide, rather than biological causes. Psychological distress, antecedents of unhealthy coping strategies, and total coping strategies. Understanding the relationship between coping strategies and overwhelming distress is essential to inform diagnosis and the best targets for interventions. While healthy and unhealthy conceptualizations of coping strategies are empirically supported, to date there has been no assessment of the continuum of coping, implying that the use of coping preferences varies depending on the level of distress and relationship. According to healthy coping theory, people use unhealthy coping strategies when they feel better about a difficult situation, even if they risk other negative consequences to feel better, but this does not happen. between healthy and unhealthy coping strategies. The high individual morbidity and mortality and societal costs associated with the chronic use of unhealthy coping preferences highlight the need to understand better their relationship to overwhelming distress and healthy coping strategies. In the new theory of stress, coping skill is a major composite function that is often used due to individual differences in response to stress. Coping skills are also affected by homelessness and the special conditions of street children and adolescents for several reasons. Since the level of mental health among humans has been significantly reduced during the covid-19 epidemic and has been taken into consideration. High prevalence rates of depression, sleep disorders, and post-traumatic stress disorder (PTSD) have been reported at the peak of the disease outbreak in China; Symptoms of psychological distress are expected to be long-lasting and warrant the need for evidence-based psychological treatments aimed at immediate stress relief and prevention of psychological distress in this population. Research Background Cognitivebehavioral therapy (CBT) is effective in the treatment and prevention of several stress-related disorders in the human population. Among the treatments that can be effective for posttraumatic stress disorder and psychological events after an unexpected event is a cognitivebehavioral therapy. Cognitive-behavioral group therapy is one of the most widely used methods and one of the most important choices in the field of psychological treatment of this disorder, which has wide applications. This treatment consists of four components: exposure, prevention of response, and connection between events and thoughts. It uses maladaptive thoughts to improve cognition, emotion, and behavior by changing cognition. According to the mentioned materials, this research has addressed the question of whether cognitive behavioral therapy affects the resilience and preference of coping actions of patients who have recovered from the corona pandemic (COVID-19) at the height of the epidemic. Methods: This research was a semi-experimental type of research with a pre-test-post-test and control group. The statistical population of this research included all recovered patients of the Corona pandemic at the peak of the epidemic in Isfahan, 30 people were selected by purposeful sampling and randomly assigned to two experimental and control groups (15 people in each group). After the pre-test, the experimental group received the cognitive behavioral therapy program for 12 sessions, and then the post-test was performed. The data required for the research were collected using the scale of preference for confrontational actions by Carver, Shier, and Weintraub (1989). The resulting data were analyzed using descriptive statistics (mean and standard deviation) and inferential statistics (analysis of variance) with the help of SPSS-20 software. Results: The findings showed that cognitive behavioral therapy led to an increase in problemoriented confrontational preference and a decrease in emotion-oriented and avoidance confrontational preference in the members of the experimental group had a significant effect (P<0.01). Conclusion: Based on the findings, it can be concluded that cognitive behavioral therapy can be considered an effective treatment in reducing the problems and psychological indicators of patients who have recovered from the corona pandemic. This research finding can be explained that in cognitive behavioral therapy, tasks such as functional analysis, skill training, and dealing with impulsive desire are presented to people, which creates a feeling of mastery and empowerment in people, and is effective in improving the person's coping preference. In cognitive-behavioral therapy, people learn that they should not ignore problems and should accept problems and act to solve them. They learn to follow clear policies and try to see the bright side of things and control their emotions. In this way, they learn to take advantage of the guidance of others, but not to interfere with their problems, instead of just seeking support from others. This method teaches people to have a plan for their life (and especially their recovery). This research, like other research, has limitations such as the impossibility of holding face-to-face meetings (due to the corona situation) and the limitations related to the participation of both sexes in the interventions (the training was conducted only among female patients who have recovered from the corona pandemic). It comes with It is also suggested that in future research, the influence of other factors involved in the psychological problems of patients who have recovered from the corona pandemic should be controlled during training. Also, according to the results of this study and the effectiveness of cognitive behavioral therapy, it is suggested to conduct long-term follow-up in a larger sample in future research to evaluate the stability of the results, and also to implement educational and therapeutic courses based on cognitive therapy for patients who have recovered from the corona pandemic. [ABSTRACT FROM AUTHOR]

Background & Aims: Urinary incontinence is defined as a complaint of any involuntary leakage of urine. This new definition includes a significant range of women who have rarely experienced accidental leakage events. As a result, some studies have estimated the prevalence of urinary incontinence at 60%. Stress urinary incontinence is the most common type of urinary incontinence and is a term used to describe involuntary urination during physical activity such as coughing, sneezing, laughing, or lifting heavy objects, etc., when the pressure inside the bladder exceeds the pressure. The urethral closure arrives, it is used. Numerous factors, such as sphincter dysfunction, pelvic floor muscles, connective tissues, or nerve structures, may cause or develop urinary stress incontinence. Approximately 4% to 35% of adult women worldwide suffer from stress urinary incontinence. Limited studies have been conducted on the prevalence of urinary incontinence in Iran. In the study of Rashidi., The overall prevalence of urinary incontinence in Iranian women was 46%. In the study of Bakui., Which studied the prevalence of postpartum urinary incontinence in women referring to health centers in Babul, the frequency of postpartum urinary incontinence was reported to be 19.4%. Urinary incontinence is a distressing condition emotionally, physically, socially, and economically. It has been shown to be associated with embarrassment, anxiety and depression and has a significant negative impact on quality of life. Despite the widespread impact of urinary incontinence on quality of life, only a small number of women seek treatment and most of them live in silence, so the disease is never diagnosed or treated. Because most women do not seek treatment in the early stages of urinary incontinence (for example, mild to moderate urinary incontinence), they eventually present with advanced symptoms (severe urinary incontinence), at which time there is an opportunity to prevent or help regress the disease. It is demolished. Given this situation, the need for appropriate prevention and treatment to reduce the negative impact of stress urinary incontinence on women's lives is clear, and most research on current therapies for the management of stress urinary incontinence seeks to improve patients' quality of life. Non-surgical interventions are recommended by the International Association of Incontinence as the first line of treatment for uncomplicated urinary incontinence in women. Pelvic floor muscle training is the basis of non-surgical treatment of urinary stress incontinence. This treatment is based on the hypothesis that training to identify and strengthen the pelvic floor muscles by increasing the support of the urethra and bladder and improving the function of the urethral sphincter muscle neutralizes the weakness of the pelvic floor muscles. The easiest way for women to train their pelvic floor muscles is to insert cone-shaped weights into the vagina and then contract the pelvic floor muscles to prevent the weight from falling out. On the other hand, the timing of pelvic floor muscle contraction, which is transmitted from the brain to the muscle by the nervous system, is an important factor in controlling urination. In other words, when there is a sudden increase in intra-abdominal pressure during sneezing, coughing, etc., the pelvic floor muscles must unconsciously and reflexively activate their rapid contraction fibers to prevent involuntary leakage of urine by neutralizing the increase in pressure, but In people with stress urinary incontinence, the coordination and timing of pelvic floor muscle function is impaired during increased intra-abdominal pressure, and the reflex and subconscious function of the pelvic floor muscles is impaired in response to a sudden increase in intra-abdominal pressure, which means that Although having strong muscles in the pelvis is necessary for proper contraction, a timely contraction is also necessary to prevent involuntary leakage of urine. In other words, a strong muscle that is not activated in time during an increase in intra-abdominal pressure cannot prevent urinary incontinence. Since the negative effect of urinary incontinence on daily activities and quality of life of women is very significant and women with more severe urinary incontinence and weaker pelvic floor muscles have lower quality of life, it is necessary to take measures to increase the contractile strength of pelvic floor muscles and promote health. Think of the urinary tract. Also, according to research, the result of cone therapy is recognizing and strengthening the pelvic floor muscles and does not play a role in the simultaneous action of rapid fibers of contraction of the pelvic floor muscles when increasing intra-abdominal pressure, if, as mentioned, the timing of urethral closure Timely contraction of the pelvic floor muscles is an important factor in controlling urination and should be considered. Therefore, it seems that in addition to strengthening the pelvic floor muscles with the vaginal cone, there is a need to train movement control strategies (control motor) to change the timing of pelvic floor muscle contraction and start their activity while increasing intra-abdominal pressure to the Knack maneuver (speed and coordination). It is said to be necessary to prevent involuntary leakage of urine. Miller et al. In their study justified the effect of the Knack maneuver as an immediate method and early response to pelvic floor exercise regimens that are widely used in women with stress urinary incontinence. Therefore, this study was performed to evaluate the effectiveness of vaginal cone with the Knack maneuver on the severity of incontinence and quality of life in women with stress urinary incontinence compared to the vaginal cone. Methods: In this randomized controlled clinical trial that was performed in the pelvic floor dysfunction clinic of the Faculty of Rehabilitation Sciences, University of Iran, during the years 2021-2022, 76 patients with stress urinary incontinence were present who were randomly assigned to two groups of vaginal cones and were randomly divided into two groups: vaginal cone with the Knack maneuver and vaginal cone. Participants in both groups were finally accepted after an initial evaluation session. The initial evaluation included educating patients in plain language about the anatomy of the pelvic floor muscles, their proper contraction, and the benefits of therapeutic cones for the women participating in the study. Complete urine test (analysis and culture) to rule out participants' urinary tract infections, specific examinations of women in standard lithotomy with an empty bladder, and no vaginal bleeding. Pelvic visceral prolapse was also considered and the degree of each type was determined based on the POP-Q system, which is a standard approved by the International Continent Control Society and recorded in a special sheet. Grade 3 and 4 prolapses removed the sample from the study. Therapeutic interventions were performed for 12 weeks for both groups. The cone treatment protocol was common for both groups, and the intervention group received Knack exercises in addition to the cone treatment protocol. All patients before and after the intervention were evaluated for the severity of urinary stress incontinence due to increased intraabdominal pressure and the number of involuntary leakage of urine with Urinary Diary, pelvic floor muscle contraction with Dynamometer and quality of life with Incontinence quality of life questionnaire. Paired and Wilcoxon t-tests were used for intragroup analysis and Independent Sample t-test and Mann- Whitney tests were used to compare the differences between the two groups. Results: There was a significant difference between all values before and after the intervention in each group (P<0.05). Also, comparison between treatment groups showed significant differences in quality of life (P=0.02), pelvic floor muscle contraction strength (P=0.00), urine leakage due to increased intra-abdominal pressure (P=0.01) and the number of leaks (P=0.01). Conclusion: According to the findings of this study, the treatment of cone protocol with the Knack maneuver can be suggested as a treatment strategy for patients with stress urinary incontinence. [ABSTRACT FROM AUTHOR]

Background & Aims: Emotional resilience can lead to the improvement of the people’s mental health through increasing their mental endurance. Therefore, the present study was conducted with the purpose of investigating the efficacy of training emotional resilience on the interpersonal forgiveness and social adjustmentin assault and battery criminals in the central prison of Isfahan. Methods: It was a quasi-experimental study with pretest, posttest, control group and twomonth follow-up period. The statistical population of the present study included all assault and battery criminals in the central prison of Isfahan in 2019 in the quantitative part. 30 assault and attorney criminals were selected through purposive sampling method and they were randomly accommodated into experimental and control groups (each group of 15). The people in the experimental group underwent twelve ninety-minute sessions of training emotional resilience during three months, while the control group didn’t receive these interventions during the study. interpersonal forgiveness questionnaire (Bell, 1961) and social adjustmentquestionnaire (Ehtesham zadeh et al, 2010) were used in the current study. The data taken from the study were analyzed through repeated measurement ANOVA via SPSS23 software. Results: The results showed that training emotional resilience has had significant effect on the interpersonal forgiveness and social adjustmentin assault and battery criminals (p<0. 001) in a way that this intervention succeeded in increasing interpersonal forgiveness and social adjustment in the assault and battery criminals. Conclusion: According to the findings of the present study it can be concluded that training emotional resilience can be used as an efficient method to increase interpersonal forgiveness and social adjustment in assault and battery criminals through employing training communicational skills, having intimate communication with others, offering the components of emotional intelligence and training social sufficiency. The psychological health of prisoners and the provision of psychological services to them has attracted much attention from experts. More than 10. 1 million people worldwide and 20,000 people in Iran are in prison, whose mental health is of special importance (Gharibpour, Akbari and Abolghasemi, 1399). However, these prisoners are sometimes imprisoned for crimes such as violence, beatings, and sometimes continue their violent behavior in prison. Trauma from a forensic point of view is damage resulting from the impact of mechanical, physical, chemical and psychological factors on the human body that occur directly or indirectly. These injuries occur due to various factors such as vehicle accidents, firearms and cold steel, during conflicts, work-related injuries, accidents such as electric shocks, earthquakes and other cases (Kiani, Bazmi, Qarahdaghi and Barzegar, 2007). It seems that when people commit a behavior and consider it harmful to themselves or those around them; Feelings of guilt, shame, and guilt manifest themselves (Tangi and Deering, 2003). Self-destructive emotions are seen as a barrier to mental and physical health by reducing a person's sense of self-worth, leading to depression and anxiety, and disrupting relationships with oneself and others (Hall and Fincham, 2005; Ferguson Walter, 2013). ). Here forgiveness, as a variable that stops the process of self-destruction, plays a key role in restoring self-respect and value (Fisher & Axlin, 2010). When experiencing forgiveness, the person who has made a mistake embraces his or her mistake and allows the unpleasant feelings he or she has suppressed to be processed (Yeh, Ma and Yan, Chen, Wang et al., 2019). From a psychological point of view, forgiveness is considered a consequence of transsocial motivations; That is, the forgiving person forbids revenge and experiences positive feelings toward the wrongdoer. This experience is considered the culmination of a socially professional behavior, so that the forgiveness of the wrongdoer by the victim will have positive psychological and physical consequences. In addition, forgiving specific errors in relationships will reduce the other party's hurtful behavior in the future (Griffin, Worthington, Levy Locke, Wade & Identity, 2015). When people are unable to forgive themselves after a mistake or a mistake in a task or a relationship, they avoid similar tasks and in fact show the behavior followed and less followup in the long run to succeed in the task (Hull, Saichi and Bennett)., 2010); Here, the person, thinking that he is not able to establish healthy relationships, turns to short-term relationships, or because of guilt and self-destruction caused by not forgiving himself, constantly repeats the same damaging relationships and in the distance. Falsehood is caught up in sin and hatred (Sapmaz, Yildirim, Topkagla, Nalband, & Césir, 2016). One of the problems that results from aggression in people with injuries is a decrease in social adjustment (Liu and Graves, 2011). Adaptation is defined as the ability of an individual to adapt to the environment and has various dimensions, including social, family, emotional, health, educational, etc. (Bacham and Cassi, 2018). Every human being, consciously or unconsciously, tries to meet his diverse and sometimes conflicting needs in the living environment, and since he has to meet his needs in the form of social construction, his adaptation is inevitably social adaptation (McQuad and Brox, 2017). Social adjustment can have a direct effect on mental health (Namazi and Sohrabi, 1397). Individual health affects not only the individual and the family, but society as a whole (Stein, Coen, Donald, Adenams, Kopowitz et al., 2015). Adapting to new and diverse situations in an age of stress and rapid social change is not an easy task. Research shows that any change in a person's life, whether pleasant or unpleasant, requires some kind of readjustment (Nezu, Nezu Dozorilla, 2013). Considering that adaptation is one of the main symptoms of mental health and its importance in all aspects of life including individual, family, education, occupation and social is clear and can provide an important role in the occurrence of positive behaviors in individuals. Those who are aggressive or beaten are less adaptable and more likely to have behavioral problems (Golestan Jahromi, Shahni Bilaq, Behrozi, and Omidian, 2017). Mikaelimnia, Babaei and Hassani (2014) show that variables such as forgiveness have a positive and significant relationship with social adjustment and can predict and explain social adjustment. Individual health affects not only the individual and the family, but society as a whole (Stein, Coen, Donald, Adenams, Kopowitz et al., 2015). Adapting to new and diverse situations in an age of stress and rapid social change is not an easy task. Research shows that any change in a person's life, whether pleasant or unpleasant, requires some kind of readjustment (Nezu, Nezu Dozorilla, 2013). Considering that adaptation is one of the main symptoms of mental health and its importance in all aspects of life including individual, family, education, occupation and social is clear and can provide an important role in the occurrence of positive behaviors in individuals. Those who are aggressive or beaten are less adaptable and more likely to have behavioral problems (Golestan Jahromi, Shahni Bilaq, Behrozi, and Omidian, 2017). Mikaelimnia, Babaei and Hassani (2014) show that variables such as forgiveness have a positive and significant relationship with social adjustment and can predict and explain social adjustment. [ABSTRACT FROM AUTHOR]

Background & Aims The present study aims to compare the effects of emotion regulation training and mindfulness-based cognitive therapy (MBCT) on the resilience and self-compassion of women with irritable bowel syndrome (IBS). Materials & Methods This is a quasi-experimental study with a pre-test/post-test/follow-up design. The study population consists of 300 women with IBS who visited the clinics of internal medicine physicians in Ilam, Iran, in 2018-2019. The sample size was determined 20 for each group based on the Fleiss method. Therefore, 60 were selected by a simple cluster sampling method and based on the entry criteria. They were divided into three groups of emotion regulation (n=20), MBCT (n=20), and control (n=20). After the interventions, the post-test and follow-up assessments were conducted for the groups. The instruments were the Connor-Davidson resilience scale and the self-compassion scale of Neff (2003). For data analysis, SPSS software, version 23 and repeated measures analysis of variance were used. Results Both emotion regulation training and MBCT had a significant effect on the resilience and self-compassion of women (P=0.001), where MBCT had a greater effect compared to emotional regulation training. Conclusion The MBCT can be used as an effective method to increase resilience and self-compassion of women with IBS. [ABSTRACT FROM AUTHOR]

Background & Aims Special attention should be paid to empowering healthcare providers, including nurses. Empowerment as the clinical skill is an important goal of nursing education. The present study aims to determine the effect of a nursing manager psychological empowerment program on the management skills of nursing students. Materials & Methods This interventional study was conducted in Imam Khomeini Hospital in Tehran, Iran. Participants were 84 students in nursing management internship from Tehran University of Medical Sciences and 19 nursing managers. The nursing students were divided into two control (n=42) and intervention (n=42) groups. The intervention was a psychological empowerment program for nursing managers. After intervention, the management skills of students was assessed using a checklist completed by observation and interviewing ward supervisors. Data were analyzed in SPSS software, version 16. Results The management skills of students in the intervention group significantly increased after receiving the empowerment program by 0.274 units. Conclusion Psychological empowerment of nursing managers can improve the management skills of nursing students. The results of this study can be used to persuade nursing managers to receive psychological empowerment training, which can lead to psychological improvement of the work environment, nurses and nursing students. [ABSTRACT FROM AUTHOR]

Background & Aims: Adolescence is one of the most sensitive periods of a person's life, one of the most important tasks of psychologists and counselors is to pay attention to the problems and problems of teenagers. Part of teenagers' tensions and problems are caused by the transformation of normal growth; such as growth and hormonal change, and another part is caused by the changes that occur in connection with the change of role in the society, that if the teenager does not have the necessary skills to deal with individual and interpersonal issues, adverse consequences will occur. In fact, most teenagers are faced with low self-esteem and negative self-concept, confusion, increasing negative emotions such as anxiety and depression, and as a result, reducing adaptive and positive functions. One of the problems that teenagers face during their lifetime is the fear of negative evaluation. Some people make a negative and unique evaluation of the event, which causes a constant fear and dysfunction in them, which can be internal (like I am incapable) or external (like, no It is not a safe place. Such evaluations create powerful emotions such as anxiety, anger, regret or guilt and symptoms of arousal, and these symptoms motivate the person to control the symptoms by adopting some methods. In turn, it causes the intensification of malfunctions. One of the sources of severe and continuous fear of a person is the evaluations he makes of the event or its results, negative evaluation of the event including negative evaluation of the emotions that occurred during the event and inappropriate event and negative evaluation of the feeling. The actions and activities that occurred during the incident and the inappropriate event and the negative perception of the responses of others and the perception of sustainable change in life after the event. One of the sources of persistent and intense fear may be a type of cognitive processing style during the event, which is called psychological failure. In order to deal with the fear of negative evaluation, psychotherapists investigated and pursued different treatment methods. Among the psychotherapy methods, we can mention therapy based on acceptance and commitment, as well as reality therapy. Reality therapy is a type of therapy that can be used for all people who have problems. Not denying the reality, taking responsibility and, accordingly, planning to achieve the goals, is one of the most important human needs in the life process, which is given importance in this therapeutic approach. Reality therapy is based on the choice theory. Reality-therapy considers behavior to include four components of performance, thinking, feeling and physiology, which we have direct control over two components of performance and thinking and indirectly over feeling and physiology. This treatment method emphasizes facing reality, accepting responsibility, recognizing basic needs, making moral judgments about the rightness or wrongness of behavior, focusing on the here and now, internal control and, as a result, achieving identity. Considering that the researchers are of the opinion that for fertility and progress, the society should nurture people with high mental health and considering that so far there has been no research to investigate and compare the effectiveness of therapy based on acceptance and commitment and reality therapy on fear of evaluation. The negativity of the students has not been addressed, and considering the importance of treating the students' malfunctions, as well as with the aim of preventing damage and improving the level of mental health, the necessity of conducting this research is revealed. Therefore, the current research aims to answer this basic question: Is there a difference between the effectiveness of acceptance and commitment-based therapy and reality therapy on the fear of negative evaluation of female secondary school students? Methods: The research method was a semi-experimental pre-test-post-test design with a control group. The research community consisted of all female students of the second year of high school in Fasa city in the academic year of 2021-2022. From this, 45 people were selected among the eligible people and randomly assigned to two experimental groups and one control group (15 people in each group). For the first group, an intervention based on acceptance and commitment was applied, and for the second group, reality therapy was applied, and the control group did not receive any type of therapy. Research data with the help of the short version of Lori's fear of negative evaluation scale (1983), collection; and it was analyzed using analysis of covariance and Tukey's follow-up test. Results: The findings of the covariance analysis showed that the therapy based on acceptance and commitment and reality therapy significantly improved the fear of negative evaluation in the post-test stages (p<0.01); However, no significant difference was observed in the post-test between the two experimental groups. Conclusion: According to the findings, it can be concluded that these treatments play a significant role in improving students' fear of negative evaluation, therefore, by identifying and introducing students to treatment centers and receiving psychotherapy protocols. Their mental health can be improved. Also, in explaining the effect of reality therapy on the fear of negative evaluation by the evaluator, it can be said that people with high scores in fear of negative evaluation are easily disturbed by their emotions in stressful situations and have high levels of chronic anxiety in different periods of family life. And conversely, people with a low fear of negative evaluation, because they have a clear definition of themselves and their opinions, can choose their own direction in life and in extreme emotional situations that lead to involuntary behavior and decision making in many people. Fails don't lose control and make decisions based on reason and logic. For this reason, these people will be less in critical situations with appropriate decision-making, because they will solve problems at the right time and in a more appropriate way, and they will face fewer unsolved problems. Behaviors, qualitative world and lack of external control can help to increase management and reduce the fear of negative evaluation in relationships, especially academic relationships. As a result, it can be said that reality therapy based on the theory of choice helps to choose responsibility and self-control and freedom. It also teaches people that they have acquired a successful identity and can make better choices based on reason and logic and away from emotion in their decisions and without believing in controlling behavior. And felt by others, and in this case, they become more positive people, and with choices without mixing with others, they experience a quality life, more successful communication, and more compatibility, and have less fear of negative evaluation. [ABSTRACT FROM AUTHOR]

Background & Aims: Multiple Sclerosis or MS is one of the most common chronic diseases of the central nervous system, which causes physical changes in the body and limits the performance of patients. Multiple sclerosis or M. S. is one of the most common degenerative diseases of the central nervous system, which leads to this disease being the most common cause of disability in adolescents. This disease leads to many mental disorders in people, among which anxiety thoughts and lack of hope for life and future are more than other negative consequences of this disease. Also, among the complications of this disease, it can be mentioned that the person's performance drops, which affects the way patients play their personal and social roles in their lives. On the other hand, research results show that patients with chronic debilitating diseases such as MS also face other specific problems related to their disease. These problems increase secondary complications and limit independent life and have negative and destructive consequences on patients' lives. This disease and similar chronic debilitating diseases lead to a decrease in the quality of life of patients and create a background for their depression. Depression in these patients generally appears with aggression, irritability, anxiety, sociability, and specific reluctance. Depression is a motivating factor for the deterioration of the patients' disease, and the presence of depression in these people causes biological changes for the patients. Depression in these patients is accompanied by chronic fatigue, reduced quality of life and reduced results of drug treatments. Therefore, knowing the factors related to depression in these patients is one of the most important mental health factors and a productive factor in the disease process. On the other hand, research results show that the prevalence of MS in women is much higher than in men. Research results show that the prevalence of MS in women is 2 to 3 times higher than in men, and this rate is in the age range of 20 to 40 years. Life expectancy is one of the key indicators of human development, which is influenced by factors such as income, education, health and nutrition, and can help patients with chronic and debilitating diseases such as MS in better treatment of their disease. Therefore, the aim of this research is to investigate the effect of cognitive behavioral therapy in reducing anxiety thoughts and life expectancy of women with MS living in Tehran. Methods: The current research can be classified from different dimensions. This research is a semi-experimental type with a pre-test-post-test design and follow-up with a control group and using the selection of test and control group subjects. The method of collecting information was library (using books, theses, publications, reliable internet sites, using information) and the method of collecting information was field and questionnaire. The statistical population of the current study includes all women with MS living in Tehran who are members of the MS Association of this city. The sample of the present study was based on the purposeful sampling method and included 30 people with this disease who were randomly divided into two experimental groups including 15 respondents and 15 controls. The collected data are related to the year 2019. The experimental group underwent cognitive-behavioral therapy for 8 1.5- hour sessions, which was not done for the control group. The current research tools include the hope scale of Schneider et al. (1991), which includes the THS Trait Hope Scale (1991), the CHS Children's Hope Scale (1993), the SHS State Hope Scale (1996), and the Wells Anxiety Thinking Scale (1994). Also, Wells' Anxious Thoughts Scale (1994) is a multidimensional tool for assessing worries. The content of this questionnaire was obtained from interviews with patients with generalized anxiety disorder and panic disorder. The analysis method in this research was based on multivariate and univariate covariance analysis as well as variance analysis with repeated measurements. Results: The results of the current research, which were obtained from different age groups; So that it includes 20% of the respondents in the age group of 20 to 30 years, 46.67% in the age group of 31 to 40 years, 20% in the age group of 41 to 50 years and 13.33% in the age group of 51 to 60 years. and also, 13.33% of subjects in the control group are in the age group of 20 to 30 years, 40% in the age group of 31 to 40 years, 20% in the age group of 41 to 50 years and 26.67% of the subjects in age group are 51 to 60 years old, it shows that the effect of cognitive behavioral therapy is effective in reducing anxiety thoughts and life expectancy in women with MS, a member of the Tehran MS Association, and cognitive behavioral therapy can reduce the negative and destructive consequences of MS. improve S in these patients.. heal and provide the basis for improving their quality of life. In other words, the application of cognitive-behavioral treatment methods based on cognitive strategies in challenging thoughts and inefficient cognitive and behavioral systems through skill training can be effective in improving the life expectancy of women with MS. Cognitive behavioral therapy with the mechanisms it brings is effective in reducing anxiety thoughts and increasing people's life expectancy. In fact, the key concept in the effectiveness of cognitive behavioral therapy and its more positive effectiveness than drug therapy is improving anxious thoughts and increasing life expectancy in accepting reality and responsibility for what has happened and the change that should occur. Although these people feel better by taking the drug due to the change in the chemical process related to brain neurotransmitters, they do not consider themselves responsible for this phenomenon. Also, tasks such as functional analysis, skill training and a feeling of mastery and empowerment are created in people, which are effective in increasing the motivation of treatment or at least continuity in treatment and avoiding irrelevant thoughts such as rumination. Therefore, it can be expected that cognitive-behavioral therapy has been able to increase the life expectancy of women with MS. The assumption of the normality of the distribution of the scores of the experimental and control groups in the variables of anxious thoughts, resilience and life expectancy according to the output results of the software, indicates the verifiability of the results. This means the normality of all data in the pre-test, post-test and follow-up comparison groups. Also, the non-significance of Levin's test in most cases, which is equal to (P<0.05), shows that the assumption of homogeneity of variances has been confirmed. Conclusion: The richness of the present study is that patients with MS. They are prone to other diseases in the field of psychology, which we call multifaceted. Institutions related to the affairs of these patients should always consider the consequences of this disease. Therefore, the results of this research show that patients with MS are more likely to suffer from depression, and suffering from depression along with chronic motion sickness, including MS, can overshadow these patients even more. and this affects the quality of life of these patients. Therefore, focusing on resilience and creating sparks of hope and motivation in these patients can increase their vigor and vitality and facilitate the path of disease control. [ABSTRACT FROM AUTHOR]

Background & Aims: The family is the first and most unique social institution and the health and well-being of a society is owed to the health and satisfaction of its members (1). The most prominent factor in the collapse of the family is the damage called divorce, which has devastating effects on the individual, the family and the community. Divorce may take place formally or legally or informally when the couple cohabites without intimacy and interest (2). Divorce is no longer an individual problem. Rather, it is a multi-stage process that is significant not only in terms of its effects on spouses and their children, but also because of its negative effects on society and the economy in general (7). In fact, emotional divorce is "the last step in a marriage." The rate of emotional divorces in the country is twice that of formal divorces. No action has been taken in relation to emotional divorce at home and abroad, and usually most actions are based on the emotional and emotional pressures of couples after divorce. The most important cause of divorce is the irresponsibility of the spouse (husband and wife) and the lack of adaptive skills. One of the barriers to marital problems and incompatibility, such as emotional divorce, is love addiction (10,11). Although, at present, love addiction has not yet found its place in psychiatry, there is now a greater understanding of behavioral addiction in the mental health literature (14). What is a missing link in the effects of emotional divorce can be a spouse with a high sensitivity to rejection that leads to marital bondage. Sensitivity to rejection is defined as anxious expectations of rejection, a state of defensive expectation. For quick understanding, it is a strong reaction to rejection that can be a potential barrier to conflicts in intimate marital relationships between spouses. Sensitivity to high rejection in one or both spouses can lead to personal discomfort as well as maladaptive behaviors that can damage the marital bond (15). One of the most important ways to form a cohesive family is family education, and if the teachings are appropriate to the knowledge of individuals and attractive, it can provide the necessary information transfer (17). Imago is a couple therapy approach, developed by Hendrix to improve the quality of a couple's relationship (18). Schema therapy is also a relatively new treatment method for the treatment of chronic and persistent disorders (22). Schema examines how people think, how they perceive and process, and how they remember information. Inconsistent schemas lead to bias in the interpretation of events (23). Among the factors affecting the mental health of human beings, the family has a very important role, many mental and behavioral abnormalities of human beings are rooted in the family. Emotional divorce makes the couple sick and the children of the family suffer the most. Prolonged coldness of the relationship can cause depression and isolation of couples and mental disorders in them or lead to a series of infidelities that will cause serious harm to the family and society. Recognizing the symptoms and problems that lead to emotional divorce can be the first step to change. And identifying therapeutic interventions that improve couples' interpersonal relationships is clinically and theoretically important. The main purpose of this study was to evaluate the comparison of the effectiveness of schema therapy and imago therapy approaches on sensitivity to rejection and love addiction in emotional divorce. Methods: The present study was a quasi-experimental study with a pretest, posttest and follow-up (quarterly) design with a control group. The statistical population of this study was the people who referred to Shahid Mofteh Judicial Complex in the west of Tehran in 2019. Purposeful sampling was used in this study. 137 clients who had referred to this branch to file a marriage complaint or request for divorce were selected according to the inclusion criteria and willingness to participate in the study. Then 101 people were initially evaluated according to Cochran's formula by the Emotional Divorce Questionnaire. After the number of clients reached the desired volume based on experimental theories, at least 15 people were considered for each group, and 45 people were randomly assigned to one of three groups: schema therapy, imago therapy, or control group. Interventions in two groups of schema therapy and imago therapy were held in parallel during 12 sessions of 90 minutes in groups and weekly. In order to analyze the hypotheses, multivariate analysis of covariance and Bonferroni post hoc test with repeated measures were used. In these analyzes, the effect of the control variable was removed from the dependent variable and then the groups were compared with each other. Results: The results showed that no significant difference was observed between the groups in the pretest. But in the post-test and follow-up, there was a significant difference between the mean of love addiction and rejection sensitivity in schema therapy and imago therapy with the mean of the control group at the level of p <0.01. Imago therapy approach was more effective in the love addiction variable than the rejection sensitivity variable in the schema therapy approach. Conclusion: The results showed that schema therapy and imago therapy have a significant effect on sensitivity to rejection and love addiction compared to the control group in people involved in emotional divorce. Comparison of the two treatments showed that there was no significant difference between the mean of the rejection sensitivity variable by schema therapy and the mean of the imago group. It also showed that there is a difference between the effectiveness of schema therapy and imago therapy in reducing the variable of love addiction and this difference was in favor of the imago therapy group. The results in the follow-up phase are stable. We believe that the effectiveness of schema therapy is due to structural changes in the patient's personality, which is the goal of any schema therapist, and not only because of symptom improvements as a result of structural changes, but also due to initial emotional irregularity due to maladaptive regulatory strategy. Pathologies), gives way to emotional regulation (adults). Schema therapy and the need for new therapies, which can bring complete recovery to patients, will be a powerful boost to the study of new clinical applications of this model (34). Imago therapy training promotes dialogue between spouses, increases self-understanding and understanding of spouses, understanding of one's own childhood and spouse's childhood, as well as self-confidence (46). According to research, love addiction seems to be abundant in people who have an insecure attachment style as a child and have a dependent personality and abandonment-instability schema. In fact, it is the prominent role of childhood that can have a significant impact on the creation of early maladaptive schemas as well as the creation of dependent characters and as a result addiction to love and emotional relationships in adulthood. Sensitivity to rejection often leads to distortions and misinterpretations of one's spouse's actions. Rejected children are also more likely to behave aggressively. People who experience high levels of rejection sensitivity experience greater levels of psychological anxiety if rejected. In fact, people addicted to love typically lose interest in activities outside of romantic relationships such as close friends, hobbies, and sports. And experience academic or work difficulties due to lack of focus on other areas of life (47). The present study, like other researches in the field of behavioral sciences, has faced limitations. Available sampling method Instead of nonrandom sampling, use self-reporting tool that can be considered as an internal interfering variable. schema therapy and imago therapy can be used to reduce the effect of rejection sensitivity and imago therapy can be used to reduce the variable of love addiction in people involved in emotional divorce. [ABSTRACT FROM AUTHOR]

Background & Aims: According to the report released by world health organization (WHO), the ST-segment elevation myocardial infarction- cardiogenic shock (STEMI-CS) is one of the important factors in patient mortality within hospitals (1), (2), (3), (4). CS and its related complications need a huge financial and medical burden. Some researchers stated that high mortality and complication rates of STEMI-CS patients are associated with the lack of effective early preventive treatments. Given the risk of CS and the different risk factors associated with it, accurate clinical risk prediction tools need to be developed to accurately predict the onset of CS. Recently, researchers have been used various machine learning methods to predict the risk of mortality in STEMI-CS patients. Recently, machine learning (ML) methods were developed to establish predictive models to identify the in-hospital mortality risk of STEMI-CS patients. The existing methods achieved encouraging results; however, their performance is not ideal, and more effort is needed to improve the performance. The aim of this study is to present a hybrid machine learning method for predicting the risk of mortality in STEMI-CS patients. Our proposed method combines a powerful swarm intelligence strategy, anti-coronavirus optimization algorithm (ACVO) with support vector machine (SVM) in risk prediction phase. The proposed model is compared with standard support vector machine (SVM), least absolute shrinkage and selection operator (LASSO), and adaptive neuro fuzzy inference system (ANFIS) on a real-world benchmark dataset. Methods: To predict the mortality status of STEMI-CS patients, we proposed the ACVOSVM algorithm. The proposed method is a hybrid machine learning algorithm that combines the SVM with ACVO algorithm to identify the most effective parameters on the death of patients. The incentive mechanism of using ACVO is to optimally configure the parameters of SVM to improve its prediction performance. The proposed ACO-SVM is also useful in determining the optimal subset of features and treatment strategies that have the greatest impact in predicting the status of STEMI-CS patients. The proposed approach models the problem of predicting the status of patients as an optimization problem. In order to determine the most effective features in predicting the survival or death of STEMI-CS patients, the proposed ACVO-SVM model is trained with different combinations of patient characteristics and adopted treatment strategies. Then the best combination of features that provides the highest performance is considered as the superior combination. To select the most effective features, first all the features are considered for training the SVM model, then the remaining features are ignored one by one and the model with the same structure is trained. The models were compared based on accuracy, recall rate, F1 criterion. Finally, the best model is used to predict the status of patients in test dataset. The data set used to evaluate the proposed method includes 410 records of patients hospitalized due to STEMI-CS complications in Shahid Madani Hospital of Tabriz University of Medical Sciences. The collected data is related to a 10-year period from 2009 to 2018. This data set includes five categories of main characteristics, which are demographic characteristics, type of myocardial infarction, risk factors, clinical symptoms, and type of treatment used. It should be noted that 80% of the records of the data set are considered as training data, and 20% of the records are considered as the test data set. The proposed method is implemented in MATLAB software. Results: Among M1 to M5 feature combination models, the experimental results show that the M1 model has higher performance on the training and test dataset in terms of predicting the patient's condition compared to other combination models. Model M1 includes the combination of characteristics of age, sex, type of myocardial infarction, smoking, percutaneous vascular interventions and coronary artery bypass surgery. This shows that considering the mentioned features has the greatest effect on the final condition of STEMI-CS patients. The results are in line with previous studies (2), (3) in this field, which stated that age, gender, smoking, coronary artery bypass surgery and percutaneous vascular interventions have the greatest effect on the mortality rate of patients. The M2 model ranks second in terms of efficiency in determining the status of patients, which shows that smoking also has a greater effect on the mortality of patients with STEMI-CS. Also, the M3 model indicates that the use of the balloon pump treatment strategy, along with other demographic symptoms of the patient, history of heart infarction and smoking have a great effect on the mortality rate of patients. In summary, it can be concluded that the demographic characteristics of the patient such as age and gender, smoking, history of illness and the use of coronary bypass surgery and percutaneous vascular interventions have a great impact on the mortality of STEMI-CS patients. The proposed ACVO-SVM approach is compared with several other popular approaches, which include: standard SVM model, LASSO regression, ANFIS, and XGBoost. The experimental results justify that the proposed ACVO-SVM outperformed its counterparts. Conclusion: In this study, a hybrid supervised machine learning model was presented to determine the status of patients with cardiogenic shock due to ST-segment elevation myocardial infarction. The proposed ACVO-SVM model uses an ACVO optimization algorithm to estimate the optimal parameters of the SVM model, making the SVM training process more efficient. The proposed model was evaluated using a dataset of patients with cardiogenic shock and the results were compared with the LASSO, ANFIS, XGBoost, and SVM models. The results showed that the proposed method worked well compared to other proposed classification models. We also found that age, gender, type of myocardial infarction, smoking, percutaneous vascular surgery, and coronary bypass transplantation surgery are the most effective factors for survival in STEMI-CS patients. In this research, the models were evaluated on a small dataset. Therefore, one of the necessary tasks to improve this research is to evaluate the proposed method and other counterpart models on large datasets to determine their strengths and weaknesses. Another limitation of this research is the lack of examination of all factors affecting the survival of STEMI-CS patients, such as blood sugar level and duration of ischemia. For this reason, it is necessary to investigate all factors affecting the mortality of STEMI-CS patients to improve the quality of classification and prediction of the final status of patients. [ABSTRACT FROM AUTHOR]

Background & Aims: In the last two decades, education experts have paid more attention to the categories of cognition and motivation. Cognition involves some mental abilities and actions such as knowledge, comprehension, recognition and thinking, and motivation is related to issues such as emotion, attitude and evaluation (1). In this regard, motivation for academic achievement is one of the most important issues in the field of educational psychology and in this regard is considered as one of the most important predictors of academic performance. Research has shown the effect of cognitive processes and motivational variables as appropriate predictors of academic achievement as independent variables (1,2). One of the major variables that affect academic motivation is learning strategies. And one of the components of these learning strategies is the metacognitive strategy that is used in natural learning processes as self-regulatory learning (3). Another component that seems to be related to self-regulatory learning and academic achievement is self-efficacy. Which can affect almost everything, from mental states to behaviors and motivations (7). In general, adolescence is a period of evolutionary cycle during which self-efficacy beliefs affect psychological outcomes. In this period, people face new challenges and how to cope and adapt to these challenges is partly influenced by the individual's self-efficacy beliefs (8). Considering the above and the importance of self-efficacy and motivation in academic achievement on the one hand and the importance of controlling behaviors for academic achievement on the other hand, so unfortunately with the review of research conducted inside and outside the country, research on the subject was not found. For this reason, the researcher seeks to answer the question of whether the training of self-regulatory learning guides (cognitive and metacognitive) affects the components of self-efficacy, academic motivation and students' mental health or not? Methods: The present study is experimental. To conduct this research, 46 first-year female students (second year) of Astara high schools who were studying in the 97- 96 academic year were selected by multi-stage cluster sampling method and randomly selected. The two groups (23 experimental and 23 control) were divided. Then the questionnaires of motivational beliefs and self-regulatory learning strategies (MSLQ), academic motivation (AMS) and general health (GHQ 28) to collect data in the pre-test by Subjects completed. Subjects in the experimental group were trained in self-regulated learning strategies for two sessions per week for eight 90-minute sessions and the control group did not receive any training. Finally descriptive statistics and Shapirovillek test, paired t-test and independent t-test using SPSS software were used to analyze the data. Results: The results showed that the mean scores of the experimental group in the post-test increased compared to the pre-test in the components of self-efficacy and academic motivation and decreased in the component of mental health (Table 1). On the other hand, it was found that there was a significant difference between the subjects in the experimental group who were trained in self-regulated learning strategies and the control group who did not receive any training in the variables of self-efficacy and academic motivation at the level of (p <5%). There is. But this difference is not seen in the mental health component. (Table 2). Conclusion: The results indicate the effect of teaching cognitive and metacognitive learning strategies on the variables of self-efficacy and academic motivation, but this effect was not observed in the mental health variable. It is possible to create a greater sense of autonomy and self-efficacy by changing the conditions of teaching and learning so that students can play a more active role in their learning process. Therefore, it is suggested to consider self-regulatory strategies as part of educational interventions in order to make learners more efficient. Another result of this study was increasing academic motivation in students who have benefited from the training of cognitive and metacognitive strategies. This result is also consistent with the findings of Poor Mohammad and Esmaeilpour (2015). They had high motivation and academic achievement (1). Another result of the present study was that teaching learning strategies (cognitive and metacognitive) could not increase the mental health of students in the experimental group. This result is consistent with the findings of Tavakolizadeh (2011). He rejected the effect of teaching cognitive and metacognitive learning strategies on the mental health of second year middle school male students. The results showed that teaching learning strategies in the experimental group compared to the control group did not show a significant difference in terms of mental health status (19). [ABSTRACT FROM AUTHOR]

Background & Aims: Depression is a feeling of extreme sadness and grief that can range from mild frustration to a feeling of great despair (1). Depression affects the quality of married life of individuals and impairs their performance more than anxiety disorders and as much as the most common medical diseases (2). In this regard, the development of intimacy between spouses is the first step towards creating a desirable marriage (5); Therefore, establishing and maintaining intimate relationships in marriage is a skill and an art that, in addition to early mental health and healthy experiences, requires the acquisition of skills and the performance of special tasks (6). In this regard, research shows that the root of many marital problems is the lack of intimacy and communication problems between spouses (2). Dissatisfaction with intimacy may lead to increased conflicts, decreased marital satisfaction, and emotional and psychological problems (7); In today's society, couples have severe and pervasive problems to establish and maintain an intimate relationship, and often seek treatment to re-establish levels of trust and satisfaction in their relationship, especially issues related to emotional-communication ties with important people in life (9). People who have difficulty developing intimacy often seek counseling for their marital problem, while increasing and improving intimacy is often one of the goals of couple therapy (7). Therefore, various therapeutic interventions have been performed with people with low quality marital relationships, and it has been confirmed that one of the effective therapeutic interventions to improve the quality of marital relationships and promote marital intimacy is to enrich marital life training based on Glaser theory of reality therapy. Considering the above and the importance of married life on the one hand, the negative impact of depression on life on the other hand and considering the impact of reality therapy on married life, therefore, by reviewing research conducted at home and abroad, research on the impact of reality therapy on Intimacy and marital satisfaction have not been performed in depressed married women. On the other hand, policymakers, researchers and psychotherapists in our country have not paid much attention to preventive methods and these methods need more scientific study, so the present study is necessary. Methods: For the present quasi-experimental and applied research, which was conducted with the experimental and control group and the pre-test, post-test and two-month follow-up research plan, 30 depressed women referred to two counseling and psychology centers in Mashhad in 1398 (94 people) were 30 people. They were purposefully selected and randomly divided into two groups: reality therapy and control. After completing the consent form, they completed the Walker and Thompson Marriage Intimacy Questionnaire (1983) and the Enrich Marital Satisfaction Questionnaire (1989). Then, the subjects of the experimental group underwent 8 sessions of 90 minutes under the reality therapy program of Duba et al. (2009). Immediately after the intervention and two months later, the questionnaires were completed again by the subjects Finally, descriptive statistics (mean and standard deviation) and Shapirovilk tests, analysis of variance with repeated measures and Bonferroni post hoc using SPSS software version 23 were used for statistical analysis of data. Results: The results showed that the mean marital intimacy of the experimental groups in the post-test stage increased compared to the pre-test. It was also found that group reality therapy intervention compared to the control group increased marital intimacy after the test and stability in the follow-up phase of married women. It was also found that the difference between the mean of marital intimacy between pre-test and post-test and follow-up stages was significant (P = 0.001) but the mean difference between post-test and follow-up was not significant, indicating that the results in follow-up did not return and the effect of intervention was stable. . Another finding showed that the average marital satisfaction of married women in the experimental group increased in the post-test stage compared to the pre-test. It was also found that group reality therapy intervention compared to the control group increased marital satisfaction after the test and stability in the follow-up phase in married women. The results of post hoc test showed that the mean of marital satisfaction between pre-test and post-test and follow-up stages was significant (P = 0.001) but the mean difference between post-test and follow-up was not significant, indicating that the results in follow-up stage did not return and the effect of intervention was stable. have been. Conclusion: The results showed that the mean of marital intimacy in the experimental group increased in the post-test stage compared to the pre-test. It was also found that training has been able to affect marital intimacy in the post-test and follow-up stages, and this effect has remained stable until two months after the end of training, according to the results of the Bephrone post hoc test. In the above explanation, it can be said that in reality therapy, it emphasizes on cultivating a sense of responsibility to satisfy the basic needs of oneself and one's spouse and liberation from external control; Therefore, people may not have paid enough attention to their own needs and the needs of the other party, because meeting each other's needs in the marital relationship is one of the important factors in improving marital intimacy; However, attending reality therapy training sessions has been able to draw their attention to these important issues and to consider them in practice (2). Therefore, teaching how to look at these needs and meet them has been able to help couples. (20). As a result of reality therapy training, awareness about the intensity of couples' needs and creating a sense of responsibility has increased, and as a result, satisfying their needs has been able to play an important role in creating and improving sincere relationships. Another finding showed that the mean of marital satisfaction in the experimental group increased in the post-test stage compared to the pre-test. It was also found that these trainings were able to affect marital satisfaction in the post-test and follow-up stages, and this effect remained stable until two months after the end of the training. In explaining the results in terms of the effect of reality therapy, it can be said that Glasser's emphasis on accepting responsibility for each person's behavior helps people to examine and examine their own behavior instead of addressing their spouse's behavior and putting him or her under a magnifying glass. Play their part in problems and reduce marital satisfaction And thus improve their relationships; Reality therapy counselors based on Glasser's concepts try to increase couples 'trust, intimacy and marital satisfaction in their clinical interventions by increasing responsibility in couples and teaching communication skills, and strengthen couples' sense of commitment; Another factor that Glasser considers effective in strengthening and stabilizing marital relations is the couple's attention to each other's wants and needs; They learn to satisfy their own and their spouse's needs through loving behaviors (22). [ABSTRACT FROM AUTHOR]

Background & Aims: The concept of readiness for change has been proposed in organizational studies. Due to its abstract nature, there is a willingness to change different definitions of this structure. Readiness for change is defined as individual beliefs, feelings, and intentions about the limits and capacity of the organization to successfully implement changes and that this amount of changes will be beneficial for themselves and their organization. Researchers emphasize that it is necessary to prepare for change before any planning, implementation, and change management. The first stage of Lewin's modification model shows unfreezing (opening) when the perspective of change is agreed upon. At this stage, people are involved and affected by possible changes in what is happening. Readiness for change is the basis of a person's willingness to progress in the "change process". Researchers in this field have always been asked the question of what factors affect readiness for change. Most researchers examine the factors related to readiness for change in two categories: individual and organizational factors. Individual factors for predicting individual readiness for change include self-management, personal capacity, values and beliefs, demographic characteristics, general attitudes, self-efficacy, individual resilience, variety of skills, emotional commitment, health, and Compatibility noted. The researchers in the studies conducted on the preparation for change are of the same opinion on the issue that the main and central cognitions and beliefs provide the preparations for the preparation for change. Beliefs, as relatively stable structures, are one of the most important individual characteristics that can explain a large part of a person's feelings and thoughts. It seems that an individual's readiness for change can be the result of a person's positive beliefs about himself and the world. On the other hand, social-cognitive theorists consider factors related to the individual (beliefs, motivation, and personality) as mediators between external stimuli and behavior. Therefore, it seems that examining the role of beliefs, motivation, and personality in readiness for change will help to fully and comprehensively understand this structure. Personality is one of the durable and unique characteristics that can change in response to different situations. Because among the personality traits identified by personality theorists and the five big factors of personality i.e. neuroticism, extroversion, openness, adaptability, and conscientiousness have been agreed upon by psychological experts. The theory of self-determination shows that the optimal functioning of Rome requires satisfaction and three psychological needs for autonomy (understanding the source of the internal cause), competence (feeling effective), and connection (feeling a meaningful connection with others). The researchers suggested that instead of making a list of independent variables that predict individual readiness for change, researchers should investigate the factors that mediate or moderate these relationships, in a detailed manner of the readiness profile. To clarify the change. In general, despite the existence of many theories and research in the field of readiness for change, it is necessary to explain the factors related to it. In this research, the role of self-determination as a mediating variable is investigated. It seems necessary to examine the effective factors in individual preparation for change in the student society, which can play an important role in the implementation of change programs. The researches that have been conducted so far on the structure of readiness for change are mostly in the field of organizational management and organizational change. According to the researcher's searches, no research was found that examined the relationship between readiness for change and basic beliefs and personality traits, and self-determination. Therefore, the purpose of this study is to fit the structural model, to predict readiness for change based on basic beliefs and personality traits with the mediation of self-determination in students. Methods: Descriptive-correlation research method and structural equation modeling analysis method. The research population includes all undergraduate students in the faculties located at Azad Rodhen University, who were selected as a sample using the method suggested by Schumacher and Lomax (2004) and the multi-stage cluster sampling method, and they were asked to fill in the questionnaires. They answered and after removing the distorted questionnaires, finally, 375 questionnaires were examined. To collect data from the questionnaires of Neo McGarry and Costa (1985), basic beliefs of Kathleen Webstein (1992), readiness for change, Slow (2006), and self-determination with basic psychological needs. LaGuardia et al. (2000) were used. Results: Structural equation modeling showed that all fit indices support the optimal processing of the structural model of the research with the collected data. Among the personality factors, openness and extroversion are positive, and neuroticism and conscientiousness factors negatively and significantly predict readiness for change. Conclusion: In general, it can be concluded that cognitive-social factors and personal factors (beliefs, motivation, and personality) are considered mediators between external stimuli and behavior. The current research, like most research, has limitations that it seems logical to recognize in order to conduct future research and try to reduce or eliminate these limitations. The current research was conducted on undergraduate students of Islamic Azad University, Rodhan branch, so caution should be taken in generalizing its findings to other students. The lack of familiarity of many students with research and research affairs was managed with the briefing session. Only using self-report questionnaires, especially for evaluating thoughts was one of the limitations. Therefore, it is suggested to examine the research topic in other regions of the country due to the existence of different cultural and ethnic conditions in order to examine and compare the research results with each other. [ABSTRACT FROM AUTHOR]

Background & Aims: Children with learning disabilities do not have problems with intelligence and motivation and are not lazy or deaf and dumb. In fact, most of them are as smart as others and are healthy in terms of brain, but this difference affects the way they receive and process information (4). Researches have mentioned three factors of children's characteristics, family aspects and social environment as the main and influential factors in the occurrence of children's disabilities (5). Therefore, methods that can simultaneously affect more aspects of these factors will have more and more stable therapeutic effects. Play therapy is one of these lasting and effective methods (6). Among the new methods of play therapy that are used for children with behavioral or functional problems are therapy and philial therapy. The results of various researches support the effectiveness of therapy on depression (8), anxiety (9) and behavioral problems (7) in children. In fact, this approach is a combination of interpersonal theories of human development, such as object relations theory, Balbi and Inworth's attachment theory (10). On the other hand, filial therapy, as a play therapy method, is a structured and direct theory for working with parents and children (11). Filial therapy is designed as a treatment program for children with emotional problems. In this intervention approach, children play with their caregivers and find out that they are lovable and important (12). These methods simultaneously affect the family environment, the quality of the parent-child relationship, and the psychological characteristics of children, this multifacetedness highlights the therapeutic importance of this method. One of the psychological characteristics in children that may help students with learning disorders or deepen their problems when facing stressors is coping behaviors. Coping behaviors or skills refer to cognitions that control stressful situations and become more specific along with the growth of children and adolescents (14). Therefore, the researcher is trying to answer the question of whether there is a difference between the effectiveness of play therapy in two ways, therapeutic and filial, on students' coping behaviors or not? Methods: The method of the current research was semi-experimental with a pre-testpost-test-follow-up plan with a control group. For this purpose, the statistical population of the present study includes 183 male and female students with learning disabilities in Isfahan city, 54 students (30 boys and 24 girls) with learning disabilities without mental disabilities, neurodevelopmental disorders, and obvious physical and sensory motor disorders with mothers without obvious clinical symptoms. They were selected as available for cooperation. Then they were randomly assigned to two experimental groups and one control group (18 people in each group). In the previous stages, immediately after and 2 months follow-up, they completed the Hernandez (2008) Coping Behavior Questionnaire. Also, to check and diagnose the learning disorder, the clinical interview was used based on the diagnostic criteria of DSM-5, which was conducted by a child psychiatry specialist. And the teenager took place. In the following, the Terapoly play therapy group gave its program based on the guide of Booth and Jerenberg (2019) to the first experimental group of 10 one-hour sessions (once a week for 10 weeks) and the filial therapy group gave its program based on the guide of Brighton et al. (2006). and Kalam et al. (2013) conducted 10 one-hour sessions (once a week for 10 weeks) to the second experimental group. Finally, the data were analyzed using software version 26 and using the multivariate analysis of covariance method. Results: The results showed that the mean scores of all three components of coping behaviors, including deviation from the problem, coping with the problem, and destructive coping, had a significant difference over time. Table 3 shows the results of intersubject analysis. Based on this table, the average scores for the dimension of deviation from the problem (F = 8.98 and P = 0.001), the dimension of coping with the problem (F = 6.91 and P = 0.002) and the dimension of destructive coping (42 F=83 and P=0.001) were obtained, which indicates that there was a significant difference between the experimental and control groups. The results showed that filial therapy and therapy play therapy has been effective in improving the coping behaviors of students with learning disabilities. Also, based on the results of Table 4, there was no significant difference between the average of all three components of coping behaviors in the two experimental groups in the post-test phase (P<0.001), which shows that both methods equally affect the components of deviation from the problem and coping with the problem. and destructive coping have been effective. The results of the Bonferroni test in Table 5 show that the average scores of the components of deviation from the problem, coping with the problem, and destructive coping in the post-test and follow-up stages are significantly different from the pre-test stage, but there was no significant difference between the average scores of the post-test and follow-up stages. It indicates that the average scores in the post-test and follow-up stage have changed compared to the pre-test stage and managed to maintain this change. Conclusion: The results of this research showed that therapy and filial therapy methods are effective in improving coping behaviors of students with learning disabilities. In explaining this finding, it can be said that both therapy and filial therapy methods have been able to leave a positive impact on the improvement of dimensions related to the coping behaviors of students with learning disabilities with a different structure (19). Because Teraplay is a type of short-term interactive play therapy that focuses on attachment-based games in the form of active games to create better relationships between parents and children. The therapist takes more responsibility for the progress of play sessions, as characterized by more attachment, empathic behavior, interactive play, interpersonal eye and body contact (24). Thus, in the present study, both parents and therapists helped the children in the test groups to strengthen their self-esteem and sense of competence and self-efficacy by providing playful challenges. Challenges caused frustration for children who learned how to face challenges and stress with the help of play (25). On the other hand, the emotional release capability of play is another explanation for the effect of parent-child play therapy, which helps children externalize their emotions in a completely safe and comfortable manner, and finally, these capabilities, when used in the context of parent-child play therapy are used to help not only children, but also mothers who have been placed in the role of coach and play therapist during play therapy to help their children get rid of the stresses and pressures of everyday life (16). [ABSTRACT FROM AUTHOR]

Background & Aims: The family is the first and smallest social unit in which a person experiences collective life, and group and cooperative behavior for the first time and builds his cultural-social identity. A healthy person is the product of a healthy family, and social health is undoubtedly related to family health. The family is the most suitable system for meeting the material, mental and spiritual needs of human beings, and it has provided the best platform for providing the security and peace of mind of the members, raising the new generation, socializing the children, and meeting the emotional needs. For people, the starting point of family formation is when a man and a woman marry each other and get married to form a family. What is being paid attention to today, along with psychological issues, is the issue of cognitive flexibility. In general, the ability to change cognitive signs to adapt to changing environmental stimuli is the main element in operational definitions of cognitive flexibility. This factor requires the ability to communicate with the present and the ability to separate the person from inner thoughts and experiences. People with flexible thinking positively adjust and change their mental structure according to the environment and overcome stressful and stressful situations by accepting and tolerating them to achieve optimal mental health. Another component of research is perfectionism. Perfectionism is a motivational component that includes the individual's efforts to reach the perfect self; In other words, people have a strong drive for perfection, unrealistically high standards, compulsive effort, and all-or-nothing thinking about outcomes in the form of complete success or complete failure. These people are so scrutinizing and critical that they cannot accept their faults and mistakes or failures in different aspects of life. Of course, reaching perfection and flourishing hidden and potential talents and abilities is very valuable in itself, and in this valley, perfectionism is a positive and desirable thing, but what was mentioned is the extreme or negative aspect of perfectionism. The characteristics of perfectionism are defined in three dimensions: self-centered perfectionism, other-oriented perfectionism, and societyoriented perfectionism. It seems that people's perfectionism originates from their illogical and distorted views and thoughts; therefore, to treat these people, it is necessary to be familiar with cognitive biases and thinking errors, as well as to identify how these errors appear in perfectionism. Various methods have been used to improve psychological components in people. One of these methods is a treatment based on acceptance and commitment, whose clinical effectiveness has been shown in various research to improve the psychological components of different people. Treatment is based on acceptance and commitment, which is a combination of ways of accepting and paying attention to awareness along with commitment and changing behavior, and this approach teaches people to accept their thoughts without judgment instead of challenging them, and the goal is to People should learn to identify their life values and plan and act based on them. Action therapy is one of the treatments of the third wave of behavioral therapy, which is theoretically based on the theory of the framework of mental relations, which is how the human mind creates suffering and the useless methods of dealing with it, as well as alternative contextual approaches for It explains these areas. The treatment based on acceptance and commitment is studied by teaching this point to the sample group, i.e. overweight women, life is mixed with suffering, man cannot approach his desires by avoiding and abstaining, and by distinguishing between tolerance and Accepting and emphasizing the point that tolerance is accompanied by suffering and hides passivity in itself while accepting pain (instead of suffering) is accompanied and does not stop a person from moving; Maybe it follows the weaving. Also, accepting the fact that a valuable life is accompanied by suffering and moving in the path of values requires commitment, and words do not replace experience and can strengthen the tolerance of failure. Therefore, the purpose of this article is to answer the question, is the therapy based on acceptance and commitment effective on cognitive flexibility and perfectionism in married women? Methods: The research method is semi-experimental with two experimental and control groups, and the statistical population of the research includes all married women of 25- 50 years of age who announced their desire to participate in the research in virtual space, and their number was 120. According to the research method, 30 people were voluntarily and randomly divided into two experimental and control groups (15 people for each group) using the available sampling method. Data collection was done by Wall Wadner and Denier's cognitive flexibility and Hill et al.'s perfectionism questionnaires, and the intervention was done by acceptance and commitment protocol. Also, the statistical method of multivariate covariance analysis (MANCOVA) was used to analyze the data. Results: The results showed that the mean value and standard deviation for the cognitive flexibility variable in the experimental group were 20.65 and 6.941 in the pre-test and 73.11 and 2.915 respectively in the post-test and the control group in the pre-test. 67/13 and 3/871 and in the post-test it is 67/20 and 3/840 respectively. Also, the mean value and standard deviation for the perfectionism variable in the experimental group in the pre-test were 191.60 and 12.046 in the post-test respectively, and in the control group in the pretest 184.53 and 16.203 respectively. In the post-test, it is 183/80 and 15/001 respectively. According to the table, it can be concluded that there is a significant difference between the pre-test and post-test scores in the total cognitive flexibility and perfectionism test group. The results indicated that there was a significant difference between the total score and the subscales of the cognitive flexibility and perfectionism questionnaires in the pretest and post-test in the experimental and control groups of married women. Conclusion: Considering the effectiveness of cognitive behavioral therapy on cognitive flexibility, it can be concluded that the awareness of the intensity of needs and the psychology of internal control is a predictive factor of people at risk. Therefore, it can be suggested that these factors are identified and necessary information provided in consultations using this technique. This study, like all other studies, has some limitations, which can be mentioned as follows: Since the present study was conducted on married women, caution should be observed when generalizing it to married men. Also, the geographical area investigated in this research was Tehran, so the generalization of its results to cities and provinces should be done with caution. According to the results of this study, it is suggested to hold a therapy workshop based on patience and commitment in the direction of flexibility and perfectionism for married people. [ABSTRACT FROM AUTHOR]

Background & Aims: Ballet is not only a dramatic sport but also an activity with high physical needs. In ballet jumps and rotations, delicate movements, high flexibility and the final transition to the en pointe are performed in women (1). Every position and step in ballet requires postural control (2), and researchers consider static and dynamic balance and weight movement to be very important for motor function in ballet (3). A determining factor in maintaining balance is the size of the support surface, and ballerinas must perform some movements on very little support surface (3, 4). Doing these techniques on young ballerinas who have not had enough proper training can lead to numerous injuries (5). Balance is a key component of motor skills for maintaining posture and performing complex sports skills. It seems that maintaining balance and use training programs to improve it is a good solution that will help reduce the amount of falls during training or competitions (23). Balance is achieved through a variety of sensory input information to the CNS, including visual, vestibular, and sensorimotor (24, 25). It seems that by simultaneously stimulating the superficial and proprioceptive senses and creating sensory integration, it can increase the cortex's awareness of the organs and increase the balance this causes proper control during movement (9). Proprioceptive sense refers to the ability to integrate sensory information received from mechanical receptors and thus determine the position and movements of the body in space. Mechanical receptors for proprioceptive sensation in the muscles of the lower limb, soles of the feet, and around the ankle joint provide important information about the displacement and movement of the body mass center, as well as the characteristics of the impact surface for the CNS (7). Proprioceptive training includes activities that challenge the ability of the target joint to find and respond to input information about the position of the joint (11). Some evidence suggests that improving the proprioception of agonist muscle groups strengthens and stabilizes limb coordination, thus leading to improve movement during ballet (12, 13). Conversely, some studies show that ballerinas are more dependent on visual information to maintain balance (3, 14). Accordingly, the question of whether it is possible to increase balance by strengthening the sense of proprioception and also enhance performance in ballerinas has not been studied and needs to be investigated. Therefore, the purpose of this study was to investigate the effect of eight weeks of open or closed eyes balance training on static and dynamic balance in adolescent ballerina girls. Methods: Twenty ballerina girls aged 8-15 years with a history of 6 months to 1 year ballet training were selected and divided into two groups of ten: 1- closed-eyes balance training (proprioceptive training) in addition to routine ballet training and 2- open-eyes balance training in addition to routine ballet training. Both groups participated in balance training for 8 weeks (3 sessions per week, 30 minutes to 1 hour each session) (15). The training movements used in the balance section were 14 items and were used from simple (exercises with hand support, with two legs and without interference) to complex (exercises without support, with one foot and with interference by the trainer) (14). 48 hours after the end of the last training session in both groups, post-test was taken. Stork balance test and star excursion balance test were used to measure static and dynamic balances, respectively. Before starting the research protocol, to eliminate the learning effects, the samples were asked to perform stork and star balance tests several times during the routine ballet training period. Analysis of variance with repeated measures was used to examine the data. If time was significant, the paired t-test was used to examine the post-test changes compared to the pre-test in each group, and if the group was significant, the independent t-test was used to examine the differences between the two groups in the post-test. Significance level was set at 0.05. All calculations were performed using SPSS statistical software version 21. Results: The results of repeated measures analysis of variance showed that the group (F1, 9 = 7.50, P = 0.023) and time (F1, 9 = 593.64, P = 0.001) effects on static balance were significant. The results of paired-samples t-test showed that there were significant difference in static balance scores between pre-test and post-test in the closed-eyes (P = 0.001) and open-eyes (P = 0.001) groups. The results of independent-samples t-test showed that static balance was significantly increased in the closed-eyes group compared to the open-eyes group (P = 0.006). The results of repeated measures analysis of variance showed that the time effect on dynamic balance (dominant foot and non-dominant foot) was significant but the group effect was not significant. The results of paired-samples t-test showed that there were significant difference in dynamic balance scores between pre-test and post-test in the closed-eyes (P = 0.001) and open-eyes (P = 0.001) groups. Conclusion: The results of the present study showed that both types of balance training with open and closed eyes significantly improved static and dynamic balances in adolescent ballerinas. The result of the present study on the effect of exercise on dynamic balance is consistent with the results of Yalfani et al. (2017) (17), Ashoury et al. (2016) (18), and Sadeghi Dehcheshmeh et al (2015) (19). The results of the present study showed that closed-eyes training significantly increased static balance compared to the open-eyes training group, but in the dynamic balance there was no difference between the two groups. Gebel et al. (2018) set a minimum training duration of 12 weeks for significant balance improvement but found that 8 weeks could also be effective (15). In the present study, eight weeks of exercise improved balance in both groups, but the short duration of exercise probably had an effect on the results. Another reason could be the use of more static exercises in the present study, and therefore the significance of static balance in closed-eyes exercises compared to open-eyes exercises can be explained. The next point to consider is that open-eyes balance tests were used to assess balance in the present study, and it is possible that different results will be seen in closed-eyes balance tests. Finally, in the present study, the effect of exercise on ballet performance was not evaluated, and the stork and star tests used in the present study provide the opportunity to use more visual information to maintain balance, and as mentioned Ballerinas are more dependent on visual information to maintain balance. Therefore, if the ballet performance was evaluated according to its dynamics, it could be effective on the results. One of the limitations of the present study was the low volume of research samples, which was due to the small number of athletes active in this field according to the research criteria. Also, due to being in the growth ages, the age range of research samples was wide and it was not possible to form research groups in a more limited age range. [ABSTRACT FROM AUTHOR]

Background & Aims: Several studies have reported that obesity causes vascular disorders in all tissues such as the heart and even the central nervous system along with disorders in the function of the hypothalamus, in such a way that these disorders in the nervous system, especially in the hypothalamus as the center of homeostasis and control of satiety and hunger can cause a significant increase in weight at different ages and even in children. Recent studies have led researchers to the etiology of this global epidemic and have drawn their attention to the influence of genetics, environmental factors, social and behavioral factors. Appetite is a physiological response to eating food, and behavioral signals and energy fluctuations throughout the day regulate the appetite in the central nervous system. Among these, the monoamine neurotransmitter serotonin can cause the development and evolution of some behaviors related to appetite through the regulation of the interval between two meals and the role of this neurotransmitter in inducing satiety. On the other hand, some studies have shown that moderate and intense sports activity and even intense intermittent exercise led to an increase in serotonin levels, which can have an effect on the caloric intake of obese women. In addition, recently, the attention of sports science researchers has been drawn to the use of medicinal plants effective in fat metabolism. Among medicinal herbs, there has been a recent increase in interest in naturally sweet herbs such as stevia and garlic. The purpose of this research was to investigate the effect of endurance training with garlic and stevia supplementation on serotonin gene expression and serotonin receptor in the brain tissue of obese Wistar rats. Methods: 35 obese male Wistar rats fed with a high-fat diet (24 grams of fat, 24 grams of protein and 41 grams of carbohydrates per 100 grams) were divided into seven groups, including: 1) Sham. 2) stevia supplement, 3) garlic supplement, 4) endurance exercise, 5) stevia supplement+endurance exercise, 6) garlic supplement+endurance exercise, and 7) healthy control. The training groups performed incremental endurance training for 15-50 minutes at a speed of 15-25 meters per minute, five sessions per week for eight weeks. Garlic and stevia supplements were added to the diet of the supplemented groups at a dose of 250 mg/kg. 48 hours after the last training session and in a state of 12 hours of fasting, the rats were anesthetized with ketamine (80 mg/kg) and xylosin (15 mg/kg) in a ratio of 3 to 1. Further, after ensuring complete anesthesia and painlessness, rats were perfused with 10 cc of 9% sodium chloride to drain the brain tissue from the blood. In order to extract the brain tissue, first the rats were completely restrained and after cutting the upper part of the skull, the brain tissue was carefully separated, and after weighing and washing, they were placed in special tissue preservation cryotypes and immediately cooled to -80 were transferred. The qReal Time PCR method was used to measure the gene expression levels of the variables in the brain tissue. One-way ANOVA with Tukey’s post hoc test was used for the data analysis. All statistical methods were performed using SPSS version 26 software at a significance level of P<0.05. Results: Regarding serotonin, the results showed that there was no significant difference in serotonin gene expression level between the healthy control group and the sham group (P = 0.903). Also, there was no significant difference between the sham group with stevia (P = 0.856), garlic (P = 0.994), endurance training+stevia (P = 0.303) and endurance training+garlic (P = 0.094). However, the results showed that the serotonin gene expression level of the endurance exercise group was significantly higher than that of the sham group (P = 0.000). Another important result is that there was no significant difference between the stevia and garlic groups (P = 0.996). However, adding endurance training to stevia had a significant effect on serotonin gene expression, so that the level of serotonin gene expression in the stevia+exercise group was significantly higher than the stevia group (P = 0.022). Also, adding endurance training to garlic caused the level of serotonin gene expression in the garlic+exercise group to be significantly higher than the stevia (P = 0.005) and garlic (P = 0.021) groups. Finally, the expression level of serotonin gene in the exercise group was significantly higher than all groups (P < 0.05). Regarding the serotonin receptor, the results showed that the expression level of the serotonin receptor gene in the healthy control group is significantly higher than the sham group (P = 0.003). Also, the level of serotonin receptor gene expression in stevia (P = 0.000), exercise (P = 0.000), exercise+garlic (P = 0.002) groups was significantly higher than the sham group. From other important results, it can be stated that the level of serotonin receptor gene expression in the stevia group was significantly higher than that of the garlic group (P = 0.000). Adding endurance exercise to stevia caused the serotonin receptor gene expression level to be significantly lower than the stevia group (P = 0.000). But, adding endurance exercise to garlic caused the serotonin receptor gene expression level to be significantly higher than the garlic group (P = 0.006). Finally, the expression level of the serotonin receptor gene in the exercise group was significantly higher than all groups (P < 0.05). Conclusion: It seems that aerobic exercise with stevia supplement with AMPK activation mechanism activates hormone-sensitive lipase, improves fat and sugar metabolism and increases the expression of metabolic proteins in the hypothalamus. Therefore, it seems that consumption of stevia and aerobic exercise have synergistic effects in modulating and increasing serotonin in the brain tissue of desert rats exposed to high-fat food. Therefore, it can be concluded that endurance training with stevia supplementation synergistically affects the appetite control protein. However, more studies are needed on the changes in serotonin and serotonin receptor levels following the exercise and supplements used in this study. [ABSTRACT FROM AUTHOR]

Background & Aims: Nowadays, imaging of the blood supply of the heart muscle by single photon emission computed tomography (SPECT: Single Photon Emission Computed Tomography) due to its non-invasive nature and providing information with physiological value and low cost compared to the valuable angiography method. It is highly diagnostic. But these images undergo changes and artifacts under the influence of factors, the result of which is the reduction of the diagnostic accuracy of the images and false positive cases. During the detection process, several physical effects such as attenuation, scattering, and collimator response function affect the frequency of emitted photons; this leads to the destruction of the contrast and as a result of reducing the quantitative and qualitative accuracy of the images. Attenuation, as the most destructive factor of SPECT images, reduces the quality of SPECT images of heart blood supply and reduces the sensitivity of tests related to the diagnosis of coronary artery diseases, and for non-uniform environments, especially in nuclear imaging of chest areas. And the heart is necessary to produce a map of patient attenuation coefficients. The existence of scattered photons is also one of the main factors of error in quantization; the detection of scattered events affects the contrast of the lesions and causes the lack of image resolution and signal-to-noise ratio. Therefore, to correct the attenuation and scattering of the rays in the heart images quantitatively and qualitatively, patterns are needed in SPECT systems. Due to the importance of the topic, various research groups around the world have presented their research and results on correcting the effect of scattering of rays and also correcting the effect of weakening the rays. If there was no limitation of energy resolution, it was easily possible to identify the scattered rays and prevent them from being recorded in the image. Because we know that scattered rays lose energy. Because gamma rays are single energy and their energy amount is completely known. Therefore, each photon with less energy will represent scattered rays, but due to the limited energy resolution of the gamma camera, a range is usually considered on the sides of the main energy, which is called the energy window. It is assumed that the photons recorded in this energy range are primary photons, but in fact, many photons scattered in the body are also recorded in this window. These scattered rays do not carry correct spatial information and lead to a decrease in image resolution and contrast and quantization errors in the image. In nuclear medicine, instead of researching and examining the patient or processing the image of the patient, simulated images can be examined. Simulators can provide information about each of the image destruction factors. The purpose of this research is to propose a new method for scattering correction, in this research, a combination of Monte Carlo and modeling is used for the rapid production of scattered views, and in the proposed method, the two-matrix method is used, this method At the stage of generating mathematical views, dispersion is added and this problem leads to the removal of scattered rays. As a result, an image is reconstructed that is free from the effects of attenuation and non-ideal dispersion and leads to an increase in contrast and improvement of power. Detecting waste, increasing the signal-to-noise ratio, and increasing the accuracy of quantification. Methods: In this study, the effect of applying attenuation and dispersion correction using two energy windows (DEW) and three energy windows (TEW) methods in cardiac aspect imaging was investigated and evaluated, and to simulate cardiac aspect imaging, a special code similar to SAR Monte Carlo GATE was used as the SPECT imaging system and XCAT digital phantom with activity distribution and realistic attenuation map was used to model the human trunk. Results: Comparison of image contrast improvement in different modes of attenuation and dispersion correction shows that the highest image contrast is obtained from the (TEW1+AC) method with an average increase of 25% and MSE in different modes of attenuation correction. And the dispersion compared to the reference image was reduced from 51.5% to 54.5%. Compared to the reference image, MSE decreased from 1.4 in Un_Cor to 1.15, 1.13, 1.12, and 1.14 in AC+TEW1, AC+DEW, AC, and AC+TEW2, respectively, and the signal-to-noise ratio (SNR) increased up to 71% in all methods of applying dispersion correction along with attenuation correction compared to applying attenuation correction (AC). Conclusion: In this study, the effect of attenuation and dispersion correction in 5 non-correction modes, with attenuation correction, attenuation, and dispersion correction using two-window and three-window methods with triangular approximation and three-window with trapezoidal approximation on We evaluated XCAT phantom simulated images and heart muscle perfusion images by SPECT method and 4 different parameters were used to compare and evaluate the images, including profile, contrast, mean squared error (MSE) and signal to noise. According to the results of the quantification of reconstructed images, it is possible to apply dispersion correction along with attenuation correction. [ABSTRACT FROM AUTHOR]

Background & Aims: It is difficult to diagnose depression in children in some cases, because sometimes its symptoms are similar to some other disorders such as autism. For this reason, parents' attention and awareness of the child's behavior and timely psychological diagnosis is very important. For this reason, parents' attention and awareness of the child's behavior and timely psychological diagnosis is very important. Shyness or isolationism is another problem that has affected different people in many different ways from the past to the present. This problem has not been addressed for a variety of reasons, and the public is less likely to refer to it as a problem. Unaware that isolationism and shyness in the heart of society, the person faces many problems, including the inability to relate to others and, consequently, the inability to learn and acquire abilities of various skills (6). Therefore, the results show that the two indicators of isolation and depression can affect the mental health of the child and can affect her future life. On the other hand, research results have shown that depression can lead to isolationism, and on the other hand, isolationism stress, anxiety and depression, according to the above, seems to be one of the most important and effective treatments for mental disorders. Or communication problems among children such as depression and isolation. In this regard, the present study seeks to answer the question whether play therapy based on cognitive-behavioral approach can be effective in reducing depression and isolation of orphaned and poorly cared for girls in Tehran? Methods: For the present quasi-experimental study, which was conducted with a pre-test and post-test design with a control group, among orphaned and abused female children in Shahid Zarghami and Khayyam child care centers in Tehran in 1997-98, which had a high score of completing questionnaires on depression and isolation. A total of 24 people were randomly selected as a sample and randomly divided into experimental and control groups. Then, before the intervention, all the subjects received the Children and Adolescents Depression Inventory called CDS-A, which has 25 questions, a single-factor score based on a Likert scale of 5 points, and all elements of depression based on cognitive theory. Covers and has Cronbach's alpha validity and reliability of 0.86. And Shahim Children Behavioral Problems Questionnaire (1996) which has 28 questions and is scored based on a 5-point Likert scale and has 3 subscales of aggression, inattention and childish behaviors, isolationism and anxiety (9). Completed. In the next step, the research protocol was performed under 10 sessions of 90 minutes (two sessions per week) according to Table 1 for the experimental group. Finally, Smirnov-Kolmograph test was used to determine the normality of the data, Levin test to determine the homogeneity or equality of variances, as well as homogeneity of regression slope and covariance test were used for analysis. It should be noted that all statistical calculations were performed with SPSS software version 24. Results: Studies have shown that most people in the statistical population were between 11 and 8 years old and were studying in the first to fourth grades of elementary school.Based on the results obtained from Table 2, the weight of depression in the experimental period was 410/109 and in the control period was 169/109, and in the weight of depression in the experimental period was 74.250 and in the control period was 111.250, the weight of depression was reduced. Figure 1 In Table 3, The weight of isolation in the experimental period is 917/34 and in the control zone is 333/34, and in the weight of isolation in the experimental period is 199/9 and in the control zone is 834.34%. Isolation in the free spheres. The results showed that play therapy based on cognitive-behavioral approach is effective in reducing the isolation of orphaned and poorly cared for girls in Tehran. So that the group factor with a significant level of less than 0.05 (p = 0.0001) has an effect on the change of isolationism. While the significance level of the pre-test is more than 0.05 (p = 0.304). Another finding showed that play therapy based on cognitive-behavioral approach is effective in reducing depression in orphaned and neglected girls in Tehran. So that the group factor with a significant level of less than 0.05 (p = 0.0001) has an effect on depression. This is while the significance level of the pre-test is more than 0.05 (p = 0.341). Conclusion: The results showed that play therapy based on cognitive-behavioral approach led to a decrease in students' isolation. The results of the present study with the results of Tavakoli and Kalantari (2017) that examined the effect of play therapy with cognitive-behavioral approach on the regulation of emotion, anxiety and depression in children with type 1 diabetes and concluded that play therapy in the post-test phase has an effect on reducing aggression It did not but had an effect on other research variables such as isolationism. Also, the results in the follow-up phase showed that the mean scores of aggression, isolationism decreased significantly, which indicates the effectiveness of play therapy is consistent (11). Another finding showed that play therapy based on cognitive-behavioral approach reduces students' depression. Boyd Webb (2018) addresses play therapy for bereaved children: adapting strategies for use in the community, schools, and family environment. In this article, it is stated that play therapy is one of the most flexible treatment methods that can be changed according to the age of children, conditions, and the environment in which counseling is performed. Play therapy can be used to help children who have lost loved ones in schools, social settings, and at home. After examining the basic developmental factors that affect children's ability to understand the meaning of death, this article discusses the specific characteristics of grief in different situations. These include social counseling after Hurricane Katrina, school-based group play therapy after the teacher's death, and parent-child play therapy after a father dies in a terrorist attack. To increase the acceptability and effectiveness of play therapy, professional psychologists must consider the beliefs and practices of teachers and parents. In addition, psychologists are expected to use play-based activities to help children express their grief more easily (14). [ABSTRACT FROM AUTHOR]

Background & Aims: The COVID-19 pandemic has brought about unprecedented changes and alarmed many aspects of our existence. With the spread of the COVID-19 pandemic, most of the countries were quarantined, many people were in their homes due to social distancing and with the stress of facing an uncertain future and fear of death and loss of family members, and also economic problems caused by the disease caused psychological problems in many sections of the society (1). Wearing a mask is one of the non-pharmacological intervention measures that can be implemented effectively with minimal cost and without disrupting social activities (2). Also, one of the important strategies to prevent the spread of disease during sports activities in public environments, whether outdoors or in gyms, is to use a mask; In this regard, research results show that wearing a mask during sports can prevent the virus from spreading into the air and other people from contracting the corona virus (3, 4). The importance of wearing a mask went so far that the Centers for Disease Control and Prevention recommended that everyone wear a face mask for more than two years; especially when exercising indoors or when in public places (5). Despite the recommendation that people should use a face mask as a daily habit, wearing a mask during physical activity or sports may potentially have negative effects on the physiology. Therefore, masks should not be used during intense physical activity; because they lead to a decrease in the quality of breathing. Also, sweat can cause the mask to get wet faster, which makes breathing difficult and causes the growth of microorganisms (6, 7). Studies by Person et al. (2018) also show that wearing a mask in a 6-minute walking test has an effect on the heart rate of healthy adults (8). In this regard, the studies of Mapelley et al. (2021) showed that the increase in the feeling of shortness of breath with the use of a protective mask during exercise is more intense (9). The COVID-19 outbreak is having a profound impact on almost every aspect of life. Universal mask coverage is recommended as a means of controlling this disease. Regular exercise in a safe environment is an important strategy for healthy living in this crisis (1). Since gyms and public spaces may be sources of virus transmission, masking may become an integral part of physical activity (7). On the other hand, one of the main problems of using a mask is that it can prevent breathing. Also, the mask is gradually moistened and its resistance to incoming air increases (18). According to the mentioned materials, the purpose of this research is to compare the effect of eight weeks of combined training (aerobic and resistance) with a double-layered medical and fabric mask on maximal oxygen consumption (VO2max) of young non-athletes. Methods: In this semi-experimental research with a pre-test-post-test design, among untrained young men with an age range of 35-25 years (average age 29.40 years, average height 175.30 cm, average weight 73.37 kg and body mass index 23.56 kg/m2 ) Tehran city, 40 participants were selected purposefully and randomly in four groups of 1- combined exercises with medical mask, 2-combined exercises with cloth mask, 3- combined exercises and 4- control. In this research, the shuttle run test was used to measure VO2max of the subjects; then, using the relevant formula, the estimation of the VO2max level of the subjects was calculated. The intervention phase was conducted in eight weeks and 3 sessions every week and every other day, the exercise groups performed a combined exercise program (aerobic-resistance training) using a medical mask, a cloth mask and without a mask. During this time, the control group was doing their daily activities. The obtained data were analyzed using paired sample t-test, analysis of covariance and post hoc Benferoni test. Statistical analysis was done with SPSS software version 24 at a significant level of P<0.05. Results: The results of the present study showed that combined exercise training significantly increases the VO2max of young men (P<0.01), but other results showed that the use of a medical mask and cloth mask decreases the VO2max compared to the training group without mask (P<0.01). Also, other results showed that there is no significant difference between cloth and medical masks in cardio-respiratory indices of young men (P<0.05). Conclusion: The results of the present study showed that combined exercises both with the use of masks (medical and cloth mask) and alone (without the use of masks) significantly increased the VO2max of young men. In line with the current research, Jimeno-Almazán et al. (2023) showed that combined exercises increase the maximum oxygen consumption in patients who have recovered from Corona (24). Also, PrietoGonzalez et al. (2022) showed that combined training increases the VO2max in recreational endurance athletes (25). In addition, Khalifi et al. (2022) in a review study showed that combined exercises, compared to aerobic exercises and separate resistance exercises, cause more improvement in heart and sweat factors in middle-aged men (26). In examining the effect of mask on VO2max, the findings of our research showed that combined training with either fabric or medical mask reduces VO2max in young men compared to combined training without mask. In line with the findings of the present study, Driver et al. (2022), reported a decrease in VO2max during sports activity with a cloth mask (5). Umutlu et al. (2021) also reported a decrease in VO2max during exercise with a surgical mask (35). Although in these two studies, the acute effect of sports activity on VO2max was investigated, but probably the cumulative effects of training sessions are also related to the acute effect of training sessions, and the adaptations resulting from long-term training are also consistent with the training response on VO2max. Overall, the results of this research showed that the use of combined exercises with and without the use of a mask increased VO2max in non-athletic men. Also, the results of our research showed that using a mask during sports training reduces VO2max improvement compared to training without a sports mask. [ABSTRACT FROM AUTHOR]

Background & Aims: Neurodevelopmental disorders are disorders that begin during the developmental period, often before the child enters school, and are characterized by developmental deficits that impair personal, social, academic, or occupational functioning. Neurodevelopmental disorder is a term used to describe neurological and mental disorders starting in childhood. Neurodevelopmental disorder includes specific learning and language disorders, motor coordination disorders, intellectual disability, autism spectrum disorder, attention deficit hyperactivity disorder, tic disorders and defiant-obstinacy disorder. Among the neuro-developmental disorders, autism spectrum disorder is considered a complex neuro-developmental disorder that usually has problems in communication and social interaction, limited interests and repetitive behaviors. Most of these children are also impaired in theory of mind, symbolic play, and imitation skills. According to the Center for Disease Control and Prevention, its prevalence has quadrupled in the last decade. Autism spectrum disorder is a lifelong condition that is generally stable and includes persistent impairments in language, deficits in social skills, and inability to perform daily activities. Social, behavioral, communication and language problems. Therefore, it is challenging for children with autism spectrum disorder to communicate socially with their parents and manage their behavior. Methods: The present research method was a semi-experimental research with a pretest and post-test design and a control group. The independent variable in this research was parenting education based on executive functions and the dependent variable was parenting stress and its subscales. The statistical population of the study included all parents (mothers) of children with neurodevelopmental disorders in Tehran, who were present in the medical clinics of Tehran and received specialized services. The sample of this research includes mothers of 15 children with autism spectrum disorder as the experimental group and mothers of 15 children with autism spectrum disorder as the control group were selected through purposive sampling and were randomly assigned to two experimental and control groups. The criteria for entering the study are: the presence of neuro-developmental disorders in children such as autism spectrum disorder, the age of children between 7 and 11 years, the absence of physical and mental illness of mothers, full consent of mothers to participate in the research and participation in all sessions by the researcher in considered The exclusion criteria were non-cooperation and non-participation of parents in more than two sessions. Results: For another assumption of univariate covariance analysis, Levine's test of homogeneity of variances was used to check the assumption of homogeneity of variances. In this research, the use of this test showed that the assumption of homogeneity of variances has been fulfilled for all variables because the variables of childhood and parent's territory have F-statistics equal to 3.48 and 2.43, respectively, with degrees of freedom of 28 and 1 at the significance level. Equal to 0.07 and 0.13, they have homogeneity of variances in groups. Whenever the value obtained for this test is greater than 0.05, the assumption based on the homogeneity of Levin's variances is confirmed. After confirming the presuppositions of univariate covariance analysis, the research hypotheses were checked. The data were analyzed by independent t-test. Data analysis showed that the experimental group compared to the control group, after participating in the training course, there was a statistically significant difference in test results. The results showed that parenting training based on executive functions had a positive effect on reducing the realm of childhood and the realm of parents with children with autism spectrum disorder Conclusion: The purpose of this research was to evaluate the effect of parenting education based on executive functions on reducing parental stress of parents with children with autism spectrum disorder. The results of the research indicated that parenting training based on executive functions was effective in reducing parental stress. In this research, the effect of parenting training based on executive functions on two subscales of parental stress, such as the domain of childhood and parents, has been investigated. Research on the effect of parenting training based on executive functions on other psychological variables of parents with children with special needs and normal has not been done. For researchers interested in parenting training based on executive functions in students with autism spectrum disorder, it is suggested to implement this training on fathers of students with autism spectrum disorder and compare it with the results of this research on mothers. Also, implement the effect of parenting training based on executive functions on other groups of neurodevelopmental disorders. Also, the results of this research should be followed up in the long term. In addition to these suggestions, the effect of parenting training based on executive functions on the anxiety and stress of mothers with children with neurodevelopmental disorders should be investigated in future researches. Also, as practical suggestions, it can be acknowledged that brochures in the field of parenting skills based on executive functions are prepared and made available to parents, especially mothers, so that in the long term, the positive effect of this training on the psychological problems of parents, especially mothers, can be seen. [ABSTRACT FROM AUTHOR]

Background & Aims Error is considered as a part of reality and an integral part of human life. Error reporting is defined as a strategic indicator for error prevention. Nursing managers use management measures and strategies to create an climate in the workplace that nurses increase the rate of reporting errors. The purpose of this study was to determine of the components of nursing errors reporting in selected hospitals of Tehran University of Medical Sciences in 2020. Materials & Methods This research is a descriptive study. The research population includes nurses working in selected hospitals of Tehran University of Medical Sciences. The number of samples was determined using the cochran formula, 336 were determined. Samples were selected by relative stratified random sampling method in July 2020.The tools used in the present study include Made Questionnaire the components of nursing errors reporting. Content validity of both questionnaires was confirmed by content validity method based on the view of 10 faculty members in the field of nursing care and nursing management. Cronbach's alpha coefficient for the components of nursing errors reporting questionnaire (0.78) were measured. Data were analyzed using descriptive analysis and inferential tests such as Kolmogorov-Smirnov, Cramer's v and Mann-Whitney U using SPSS software, version 16. Results According to the results,the mean scores of nursing errors were 80.3% and 32.64% of nurses revealed errors after observing them. Despite the positive nurses’ attitudes toward nursing errors reporting,"fear" and "Managerial barriers" is the most prominent barrier contributing to underreporting. There were significant relationships between nursing errors reporting and hospital ward type, education, nursing error experience, errors reporting method and job experience(P˂0.001). Conclusion Based on the results of the study, creating an anonymous, effective and efficient system for reporting and recording nursing errors, in order to prevent errors, is a necessity in nursing management. Managers have a systematic perspective to identify the factors affecting the occurrence of errors along with their positive reaction and supportive behaviors to the reported errors of nurses can create a culture of fearless learning at the department and organization level and overcome Barriers to reporting nursing errors. [ABSTRACT FROM AUTHOR]

Background & Aims Coronavirus disease 2019 (COVID-19) caused many psychological and social problems in people around the world, especially nurses. The present study aims to investigate and compare post-traumatic stress disorder (PTSD), burnout, and psychological disorders in nurses with and without COVID-19. Materials & Methods This is a causal-comparative study. The study population includes all male and female nurses of non-government hospitals in Tehran from July to September 2021. Of these, 220 nurses (110 without COVID-19 infection and 110 with COVID-19) voluntarily participated in the study. The questionnaires were the Mississippi Scale for Combat-Related Post-Traumatic Stress Disorder, the Maslach Burnout Inventory, and the Depression, Anxiety, Stress Scale. Finally, data analysis was performed using multivariate and univariate analysis of variance in SPSS software, version 16. Results There was a significant difference between the two groups in terms of PTSD, burnout, and psychological disorders (P<0.05). Nurses with COVID-19 had higher scores in PTSD (F=96.38, P<0.001), emotional exhaustion (P<0.001, F=12.45), depersonalization (F=15.49, P<0.001), depression (F=92.97, P<0.001), anxiety (F=37.94, P<0.001) and stress (F=47.6, P<0.001). The nurses with no COVID-19 had higher score in personal accomplishment. Conclusion Nurses who were infected with COVID-19 had lower psychological health compared to noninfected nurses. For this purpose, it is necessary to take measures to identify and provide psychological treatments to improve the mental health of vulnerable nurses. [ABSTRACT FROM AUTHOR]

Background & Aims: Following a serious injury, microtrauma and as a result of microscopic damage in joint surfaces, pain disorders in the skeletal and muscular system develop over time. Pain in the musculoskeletal system, in addition to injury, causes secretion and fatigue in the pastoral structure, which leads to disruption of the neuromuscular system. Although the foot is the last part of the lower limb chain and resists the incoming forces, it is expected to cause movement pathology, pathokinesiology and increased stress and thus injury due to improper distribution of forces. It reaches the tissues and muscles of the leg, and as a result, the risk of joint pain increases. In futsal, which is one of the vulnerable sports, most of the injuries of the lower limbs are assigned to the wrist and knee, According to the report of the National Association of American Sports Science Colleges, ankle injuries compared to other body joints in disciplines such as; It has basketball, volleyball, futsal, etc. Ankle pain can be caused by aspirin, instability, arthritis, gout, tendonitis, fracture, nerve compression and infection in this joint. In this popular field, due to the fact that players have to withdraw from this sport due to pain and injury in their basic ages, and as a result, talents are not lost, attention was paid to movement sciences and rehabilitation. Familiarity with biomechanical principles in injury or disease is a very important part of air and treatment activity. If we can provide a targeted ability in ankle pain and evaluate and perform the tasks they do in static and dynamic conditions, it will allow athletes and even non-athletes to return to sports faster and more confidently. And they do everyday, was a witness The first step in this field is to know the rehabilitation method that optimally minimizes the frequency of pain and re-injury. As a result, biomechanical principles and evaluations become reliable in treatment and help to increase better performance. Research shows that mechanical proprioception movements with ultrasound supplements improve and increase neuromuscular function and balance of the plantar pressure center, as well as a significant reduction in pain, in the same direction, from existing changes and the degree of impact on foot posture or position. in which the patient is located, by using biomechanical evaluations in the initial or final stages of the rehabilitation period, it helps the treatment to increase the effectiveness of the methods used with higher validity and to use better methods with higher effectiveness. take. Take, Therapeutic strategies to prevent and increase the return to daily and sports activities include: external supporters, manual therapy, and deep sensory exercises, which generally divide rehabilitation into two types, mechanical and physical. Studies have shown that deep sensory exercises and orthoses and tapings reduce the amount of damage by 50%. In addition, the postural changes or the condition in which the patient or the injured person is located, recovery during the rehabilitation phase helps the specialists to take appropriate actions to have a better effect. In the meantime, examining the amount of electrical muscle activity and the pressures on the person in the biomechanical analysis of the person will give valuable information about treatment and rehabilitation strategies. According to the available documents, foot and ankle problems even cause pain in the upper limb areas such as the back due to its effects on the posture and the way the forces interact in walking over time. Considering the increasing trend of basic ages in futsal, in order to avoid re-injury or to prevent it, it is necessary to take preventive measures. In this approach, the use of proprioception exercises and the use of ultrasound waves on the injured area of the ankle have a significant effect on the walking process, the sense of the position of the ankle joint, and the function of the muscles around the joint. Failure to use proprioception exercises reduces performance and ankle sprains, which is the result of instability followed by chronic ankle pain. is looking for To get a better result, the use of ultrasound therapy modality by applying a length of heat in the ankle along with deep sensory exercises will be useful in controlling and improving the function of the device and foot posture. In rehabilitation planning, understanding the mechanism of applied forces will help professionals to provide the appropriate protocol to increase the function of the device and joints. Because a period of rehabilitation before and after the changes in the posture or the condition in which the patient or athlete is located, can have a great help in the therapeutic methods of care and treatment of its effectiveness in the treatment protocol. it shows. In most cases, in the field of rehabilitation, the therapist is unwilling and according to the conditions of the teams and the pressure of the coaches and sports managers upon the player's return, he trains and competes with the speed of action of the fields. But this athlete's return is mostly temporary and causes joint injuries and choices in the future. Therefore, in the evaluations and screenings at the beginning and end of the season, as in the field of football, in this field as well, the amount of injuries can be minimized by taking into account clinical evaluation tests. In this study, our aim was to investigate the effects of deep sensory training with ultrasound therapy on the chronic ankle pain of young players along with the evaluation of the center of pressure and the changes in the activities of the 2 specialized muscles, tibialis anterior and peroneus longus during walking, in response to changes in their activity can help people with ankle injuries. Methods: The statistical sample of this study included 24 people (12 people in the experimental group and 12 people in the control group). Pain intensity in both groups was assessed through the standard Visual analogue scale form, which is characterized by a pain scale of 1 to 10, and the selection criterion was a score of 7 (high pain intensity). Also, for analysis and evaluation of electrical muscle function by electromyography system of anterior tibialis and peroneus longus muscles, subjects of both groups were recorded using UK Biometrics system in stance phase in 14-meter path of both groups (pre-test). The experimental group then received a deep sensory training protocol with 3 MHz ultrasound for three weeks. The control group performed its normal activities during this period. After the treatment period, both groups re-tested and checked the pain and recorded the electrical activity of the muscles as a pre-test (post-test). For statistical analysis, correlated T-test was used for intra-group comparison and independent for inter-group comparison (p<0.05). Results: The results showed a significant difference only in the activity of Peroneus longus muscle in comparison with pre- and post-test of the experimental group. Also, a significant difference in the amount of pain in the experimental group before and after rehabilitation interventions was observed in the comparison within the group. Conclusion: Based on the results of this study, it can be mentioned that the use of deep sensory exercises with ultrasound waves as an effective method in the rehabilitation of the musculoskeletal system in chronic pain can be used by physiotherapists and other sports rehabilitation specialists. Because its effectiveness was effective in reducing the amount of pain and normal function of selected muscles in static and dynamic positions (walking). [ABSTRACT FROM AUTHOR]

Background & Aims: The aging of the population has caused an increase in the number of elderly people who receive treatment for cardiovascular disease. The prevalence of coronary artery disease is higher in the elderly, and on the other hand, complications after cardiac events are worse in the elderly. The most common cause of death in the elderly is cardiovascular disease. Rapid restoration of blood flow can lead to myocardial survival, preservation of cardiac function, and prolongation of the patient's life, and many clinical trial studies have been conducted to investigate the effect of Thrombolytics, and their results showed that Thrombolytics preserve ventricular function. Primary coronary angioplasty was defined as the primary revascularization strategy for acute myocardial infarction without or with prior thrombolytic therapy. In the last two decades, it has been shown that the complications of coronary artery syndrome have decreased with the development of therapeutic strategies such as revascularization, medical treatment, and risk factors in follow-up after discharge. Data from many cardiovascular centers have shown that angioplasty not only leads to a significant reduction in mortality but also in coronary ischemic events. Elderly people who have concurrent diseases such as lung diseases, kidney diseases, and cerebrovascular accidents and suffer from coronary accidents accept angioplasty with caution. This is even though in symptomatic patients with chronic coronary disease, revascularization leads to the resolution of symptoms and improvement of the patient's life expectancy. Despite the effects of coronary artery disease on the quality of life, morbidity, and mortality of the elderly, in the majority of cardiovascular studies, the elderly 75 years and older were significantly less expressed and directly due to advanced age, and complex co-morbidities, and significant physical and cognitive disabilities., fatigue, living in a nursing home, and decline in daily functioning were excluded from the study. Therefore, recent guidelines cannot provide evidence-based recommendations for the diagnosis and treatment of coronary diseases in the elderly. Choosing the correct treatment strategy for the elderly with acute coronary artery disease is due to the importance of the burden of care from the economic, social, and family points of view. Also, few studies are comparing the effect of medical treatment with revascularization in the elderly 75 years and older. The aim of the study is to determine whether elderly people benefit from primary angioplasty compared to medical treatment alone and the side effects of each of these treatments in the elderly. Methods: The present study is a prospective cohort type, which was approved by the ethical code IR.TUMS.MEDICINE.REC.1397.934 in the ethical code commission of the Faculty of Medicine of Tehran University of Medical Sciences and 97 samples were taken in 9 months from June 2018 to the end of March. were collected and then for 24 hours and 30 days after the treatment (medical/angioplasty), the elderly (mostly 60 years old) with acute coronary artery disease were followed up in terms of the effectiveness and side effects of the treatments. All elderly people diagnosed with acute coronary syndrome hospitalized in two teaching hospitals of Tehran University of Medical Sciences were included in the study and evaluated in two groups. The first group of the interventional treatment group: was patients who were diagnosed with acute coronary syndrome and were treated with angioplasty from the beginning, and the second group, the optimal medical treatment group: patients who were treated with standard medical treatment from the beginning (including Thrombolytics, oral beta blockers, intravenous nitrates, antiplatelet Duals such as aspirin and Clopidogrel, intravenous anticoagulants such as heparin or enoxaparin, statin and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers 2) were included according to the latest guidelines. In this prospective cohort study, all patients aged 60 years and older with the acute coronary syndrome were collected by face-to-face interview and case evaluation from two teaching hospitals, Tehran University of Medical Sciences from 2018, and they were divided into two primary and medical angioplasty groups in terms of complications., mortality and efficacy of 24 hours and 30 days were compared. Results: Out of 120 patients with an average age of 71.2±8.2 years, 52 and 68 patients received primary angioplasty and medical treatment, respectively. The majority of patients in the primary angioplasty group were male (57.7%) and female (57.4%) in the medical group (p=0.07). In the first 24 hours, comparing the two groups with the logistic regression method, atrial fibrillation was significantly 11 times higher in the medical group (p=0.016) and improvement of angina in the primary angioplasty group was 3.8 times higher (p=0.04). The 30-day mortality rate was significantly higher in the medical group (p=0.006). Conclusion: These results indicate that we overestimate the risks associated with revascularization in the elderly and deprive people of useful treatments. With increasing age, despite the significant reduction of hospital and short-term mortality by about 5 times, increasing the rate of angina recovery and fewer complications in angioplasty, this treatment method is less often chosen in elderly patients, and elderly people are less likely to choose this method due to their age. They are denied treatment. There are sufficient reasons for the elderly and very elderly with good tolerance to angioplasty. The success rate of immediate angioplasty and the survival rate without complications are similar to young patients, so old age is not a contraindication for angioplasty. Also, old age is not an independent risk factor for poor prognosis. In addition, complete revascularization in very elderly patients may improve prognosis and reduce the incidence of cardiac events. This study included limitations. Collecting samples from two different hospitals, one of these hospitals was not able to perform angioplasty in patients with angioplasty indication due to the lack of an angiography department, and the patients were forced to undergo medical treatment, which also led to a decrease in the number of The samples included in the angioplasty group and the bias in the selection of patients with real indications for medical treatment. On the other hand, it also leads to an increase in complications. The low sample size and the age of the patients included in the study were among the limitations of this study. [ABSTRACT FROM AUTHOR]

Background & Aims: Adopted children usually have a range of experiences of abuse, such as physical abuse and neglect by biological parents before adoption, which negatively affects their adjustment. Most adopted children have the experience of living in an institution that is associated with a variety of alternative problems. In this regard, tips for informing families and society about this phenomenon and creating appropriate conditions to help decision-making families who are willing to do so are important and effective issues in improving the situation of adopted children and families. It is child-friendly and another important issue is to help reduce the problems and challenges after adoption and adoption. Because each family has a unique emotional state and atmosphere and their management method and type of operations are different from each other. Therefore, family performance is one of the most important factors that play an effective role in successful adoption. Family performance is one of the important indicators and guarantees the quality of life and mental health of the family and its members, and their negative relationships are considered one of the most important factors in creating and maintaining mental and emotional disorders. Therefore, finding a way to improve family functioning can be fruitful, and in the meantime, parental empowerment is one of the factors that can lead to good family functioning. When parents have the necessary abilities to adopt and raise a child, they can help improve their family functioning and ultimately communicate effectively with the adopted child. Empowerment is essential to create the right connection and this lasting and needed trust and to prevent wasting time and manpower. Empowerment leads to changes in parents' attitudes, behaviors, and behaviors, and these changes are a good platform for improving the situation of families. Because the parents' view of the situation and conditions and behavior of their children is different and he finds more and better awareness of them, and he also changes their attitude and behavior towards this awareness, and in contrast, children who behave calmly and firmly in At the same time, they observe the parents decisively and seriously and take action to change themselves, because if they do not change their behavior, they will see that the consequence will only be felt by themselves. Therefore, if immediate action is not taken today to empower parents and children (especially adolescents), irreparable damage will be done to the family body, then the importance of this empowerment process will become clear. In this regard, the researcher seeks to answer the question of whether the empowerment program for parents of adopted families has an impact on family performance components. Methods: The present study is an applied and quasi-experimental study that was conducted with a pretest-posttest design with a control group. For this purpose and to conduct this research, among all families with adopted children in Tehran Welfare in 1399, 30 parents with adopted children who were eligible to enter the study were selected as a sample by the available sampling method and randomly divided into two control groups. With an average age of 46.87 90 5.90 and experiments with a mean age of 44.60 6 6.23. Then, all subjects completed the Family Performance Questionnaire by Nathan B. Epstein et al. (1983). Then, the subjects in the experimental group received 8 sessions of parental empowerment training. Finally, the findings were analyzed using descriptive statistics (tables and graphs) and inferential statistics including Shapirovilk and multivariate covariance (MANCOVA) tests using SPSSV19 software. Results: Before the analysis of covariance, the assumptions of this test were examined and the results showed that all the assumptions of this test were observed. The results of the multivariate analysis of covariance showed a significant difference in family performance scores of the two groups (P = 0.018, F =3.53, Pilay effect = 0.626). The results indicate that there is a significant difference between the experimental and control groups in the family performance variable. In order to determine this difference, univariate analysis of covariance was used and the results showed that a significant difference was observed between the groups in all components of family functioning. Also, by observing the averages of family performance components, it can be acknowledged that the parental empowerment program of families with adopted children was effective in family performance. Conclusion: The purpose of this study was to the effectiveness of parental empowerment programs for adopted families on family performance components. The results of this study showed that the parental empowerment program has made a significant difference between all groups on all components of family functioning. Therefore, the parental empowerment program of families with adopted children was effective on family performance, in other words, the experimental group received higher scores on family performance after receiving parental empowerment intervention. In justifying the results of this study, it can be said that family performance is one of the important indicators and guarantees the quality of life and mental health of the family and its members, and their negative relationships as one of the most important factors causing and maintaining mental disorders and People's emotions are raised. Family functioning is an important aspect of the family environment that affects the physical, social, and emotional health of children. What happens within the family and how it works can be a key factor in creating flexibility and reducing current and future risks associated with unfortunate events and unfavorable conditions. Enabling and nurturing environments enable children to learn and develop. Conversely, poor family environments can be very detrimental to many aspects of children's development and their positive transition to adulthood. Therefore, empowering parents to improve family performance is one of the methods used today. When parents take action to empower themselves, they are instilled with the fact that they are a helpful and effective factor in improving family functioning, more interested in participation, and more supportive. Therefore, by empowering parents with adopted children, it is possible to help these families improve their performance so that they can show better performance with their adopted children. Having said that, and considering parental empowerment and recognizing it as one of the most important and influential factors that individuals can experience and also as an effective and interfering factor in the quality of family functions, parents can Acquire knowledge in the field of empowerment and transmitting it to their children, while having a positive effect on their growth and personality, improve the performance of family and children. [ABSTRACT FROM AUTHOR]

Background & Aims: One of the important goals of development programs in any country is to reduce social harms, and achieving this goal requires recognizing the effective factors that cause it in society. Nowadays, researchers consider social capital as one of the underlying and effective factors in social health and reducing risk in society .Students in a society constitute a large segment of the active population of a country, which various factors such as internal stimuli and external stressors, can endanger their social and mental health and are exposed to various social harms. And put at risk . Many efforts have been made in countries around the world to identify environmental and individual factors that predispose to risk. Among these efforts, attention to the social dimension is possible. Social capital is the result of the "social capital" of health, which is the study of phenomena such as mutual trust, social interaction, social groups, a sense of collective identity, a sense of a shared vision of the future and teamwork with effective interpersonal and group interactions. It can provide risk prevention and many social harms such as violence, drug use, alcohol and high-risk sexual behaviors. Studies have shown that youth and adolescents' access to social capital can reduce social and behavioral problems, so by providing the basis for social interaction, social skills and teamwork can reduce the rate of social harm and risk. They provided opportunities for academic advancement and health promotion. The purpose of this study was to present a model of social capital communication model and high-risk behaviors of social identity in students of Kermanshah University of Medical Sciences. Methods: The present study is descriptive-correlational in terms of applied purpose and in terms of data collection method. n terms of applied purpose, the present study is descriptive-correlational in terms of data collection method because no manipulation has been done on variables and factors and based on the research approach, it is small. The statistical population of the present study will be selected from all students studying medicine in Kermanshah (2000 people in total) in the academic year 1399-1398 using Morgan table and available sampling method of 322 people to compensate for the possibility of falling sample size. 350 people were considered who will eventually be removed after completing the questionnaires by the volunteers of the distorted questionnaire and the relevant data of 322 people were analyzed. To measure high-risk behaviors, the High-Risk Behaviors Scale (YRBSS) was used. The adaptation of the High Disease Behavior Questionnaire of the US Centers for Disease Control and Prevention (CDC) was designed and developed in 2010 (15). The reliability of the high-risk behaviors questionnaire by Brenner et al. (2002, quoted by Mohammadi, Refahi and Samani, 2013) was evaluated through a test-retest and the results of the items ranged from 14.5 to 91.1 kappa. (1998) has three structural, communication and cognitive dimensions that examine the seven subscales of networks, trust, cooperation, mutual understanding, relationships, values, and commitment, and are arranged in 28 items based on a five-scale scale. Likert (I strongly agree = 5, I agree = 4, I have no opinion = 3, I disagree = 2 and I strongly disagree = 1). The reliability coefficient of this questionnaire in Sardari, Silavio Silavi (2016) research was 0.89 (16) and the Ethical Identity Questionnaire is a self-report scale that was developed and validated by Ako Bino and Reid (2002) and has two subscales of internalization from questions 1 to 5. (The degree to which moral identity is centralized in the individual's self-concept) and symbolism from questions 6 to 10 (the degree to which each subject shows moral identity in their appearance) (17). The answer to this questionnaire is in the range of 1 (strongly agree) to 5 (strongly agree) in each of the questions. The scoring of two items 4 and 7 is done in reverse. First, the person is asked to pay attention to the moral traits written at the top of the questionnaire, and then 10 questions about these traits are asked of the subjects to determine the extent to which these traits are important to the person. Cronbach reported these two dimensions as 0.77 and 0.76, respectively. Results: In order to analyze the data, descriptive statistics indicators (frequency, mean, standard deviation, graphs) and inferential statistics were used. In order to determine the validity and reliability of the research instrument, Cronbach's alpha statistical methods and confirmatory factor analysis were used to evaluate the normality of data distribution, skewness and elongation indices, and path analysis was used to examine the relationships between variables. SPSS and Smart PLS software were used to perform these tests. The results of the present study showed that moral identity and social capital have a significant effect on high-risk behaviors of students of Kermanshah University of Medical Sciences. Conclusion: Laying the groundwork for improving and increasing the social capital of young people both at the family level and at the community level by increasing the sense of social trust, social solidarity, social awareness, providing the necessary social support and youth participation in social and cultural affairs. It seems that according to the theories and backgrounds and the results of the present study, the existence of a significant amount of social capital facilitates social actions and paves the way for achieving certain goals and Subsequently, it can act as a shield against social problems and harms, such as the occurrence of risky behaviors of young people. Universities and institutions of higher education should design and implement special training courses or classes in the form of extracurricular activities in order to educate and familiarize students with the field of social identity and social capital and high-risk behaviors with its constituent components. [ABSTRACT FROM AUTHOR]

Background & Aims: The novel coronavirus disease 2019 or Covid-19 is an acute respiratory disease that is closely related to the Sars virus. Although all medical personnel is exposed to corona disease, emergency medical personnel are more exposed to this type of disease due to the special nature of their job. The uncertainty and low predictability of this disease not only threaten the physical health of people but also affects the mental health of emergency medical personnel in terms of emotions and cognition. Long-term negative emotions reduce people's immune function and destroy the balance of their normal defense mechanisms. So people may overreact to any illness, which can lead to destructive behaviors, worry, anger, and fear. According to the review of the sources, it can be stated that the occurrence of a sudden and life-threatening illness can create extraordinary pressure on the medical staff. Medical staff is particularly vulnerable to psychological and mental health problems such as aggression, anxiety, and depression, and their quality of life is affected. Depression, as one of the mental disorders, includes a wide range of emotional and mental states, from sadness and low self-esteem to emotional and physical disability. Anxiety is an unpleasant emotion that is usually described with words such as worry, anxiety, tension, and fear; Emotions that everyone experiences with different intensity. New studies have also shown that anxiety can increase or decrease the level of people's functions. Aggression is often a response to a person's expectations not being met or a response to behaviors that are considered unacceptable to the person. From a psychological point of view, aggression is defined as behavior aimed at hurting, annoying, or harming another person. The increase in psychological and physical problems observed in the life of medical workers leads to the configuration of a large volume of studies on how to increase the health level of this group of people. Measures should be taken to prevent and treat these cases. Among the treatments that can be used in this regard are the treatment focused on compassion and the treatment of acceptance and commitment. In acceptance and commitment therapy, the main goal is to create psychological flexibility. Acceptance and commitment therapy focuses less on reducing symptoms and more on increasing quality of life. On the other hand, some experts believe that the core of helping people is based on a sense of compassion. In compassion-based therapy, people learn not to avoid or suppress their painful feelings, so they can first recognize their experience and feel compassion for it. This plays a significant role in calming the mind and reducing stress and negative spontaneous thoughts. Additionally, self-compassion requires active and patient acceptance of difficult feelings. Due to being on the first line of dealing with this disease, emergency medical workers are more likely than others to be exposed to psychological disorders and extreme fluctuations in physical indicators. A cross-sectional study conducted on medical personnel in China during the outbreak of Covid- 19 has shown that among 512 personnel, about 164 had direct contact with an infected patient. Among them, the prevalence of anxiety was about 12.5%, of which 10.35% experienced mild anxiety, 1.36% experienced moderate anxiety, and about 0.78% experienced severe anxiety. The importance of conducting this research is because the more the number of psychological treatments including compassion-focused therapy and acceptance and commitment therapy increases, the more likely psychological indicators will decrease, including anxiety, stress, aggression, and the level of quality of life-related to their health. It is created and people can do their treatment tasks with more confidence. Methods: The current research was of a semi-experimental type with a pre-test, post-test, and follow-up plan with a control group, which was conducted on 60 medical emergency workers infected with Corona in Mashhad in the year 1400 and the form of three groups (two experimental groups and one control group) was done. The treatment groups were compassion-focused therapy and acceptance and commitment therapy. The list of symptoms of mental disorders and the quality of life questionnaire were used to collect information. The interventions of the two groups were implemented as a group in the Skyroom software, and no intervention was done for the control group. Both experimental groups were exposed to treatment for 8 sessions of 90 minutes, but the control group was placed on the waiting list. After the end of the treatment, the post-test was performed for all three groups, and after three months after the last group meeting, the follow-up was done. After scoring, the obtained data were analyzed using SPSS-26 statistical software. Results: Based on the results of this study, there was a significant difference between the three stages of pre-test, post-test, and follow-up related to psychological indicators and quality of life in the experimental groups of treatment focused on compassion, treatment of acceptance and commitment, and the control group (P<0.05 ). Conclusion: The results of the present study indicated that the treatment focused on compassion and the treatment of acceptance and commitment improve psychological indicators and quality of life. It is suggested that in future comparative studies, the effectiveness of two treatment approaches focused on compassion and acceptance and commitment therapy on physiological characteristics (heart rate and blood pressure) and other psychological outcomes of patients with corona should be studied. The findings of this research were about emergency medical workers in Mashhad, so the generalization of the findings with other samples and statistical societies should be done with caution. The self-reporting of the tools used and the purposeful sampling method are other limitations of this research that must be taken into account. [ABSTRACT FROM AUTHOR]

Background & Aims: One of the areas that has undergone change in Iran is childbearing. Statistical data show a decrease in the fertility rate in the last few decades; To the extent that in recent years the number of children of a mother is less than the required index in replacing generations (1/2 children) (1). This downward change in fertility rate indicates a change in the fertility of Iranian families and their desire for one child. On the other hand, having one child is the result of any factor or factors, creating a fundamental change not only in the demographic structure and socialization of the family, but also in various aspects of school performance and all aspects of the individual's personality in the future. There are many treatments for psychological disorders today. Each of these therapies may be stronger and more specialized than the other. Third wave therapies focus more on families and proper communication, because human beings are social beings and the type of communication style they have with others has a great impact on their mental health and that of their families (3). Among the important therapies for the component of marital satisfaction in families, especially mothers, is the Boeing therapy and the new ACT therapy, which largely complements cognitive-behavioral therapy. These treatments can increase family cohesion and raise children properly. Among these therapeutic interventions is Bowen's treatment, whose approach is family therapy. Bowen's family therapy approach deals with the family as an emotional unit and a network of intertwined relationships that must be analyzed from a different context or historical perspective to better understand it. Bowen believes that the whole family system is an emotional unit that cannot be separated from each other or successfully (5). In other words, the foundation of this theory is based on the concept of separation. Bowen family therapists believe that all the problems in family functioning, including marital dissatisfaction in the couple, which has a negative effect on the children and causes emotional divorce, arise from inappropriate family systems. Accordingly, the main goal of Bowen's therapies is to reduce chronic anxiety by being aware of the family's emotional system, focusing on changing oneself rather than trying to change others (6). On the other hand, ACT therapy is rooted in a philosophical theory called functional contextualism and is based on a research program on language and cognition called the theory of the framework of mental relationships (7). Despite the many studies on the effectiveness of ACT therapy on anxiety, depression, heart disease, marital conflict, marital satisfaction and many more; However, no research has been conducted on the effectiveness of ACT therapy on cognitive emotion regulation; Research has also been conducted on other variables in the field of Boeing family therapy; But so far little research has been done on marital satisfaction. Therefore, considering the significant effects of cognitive emotion regulation on many aspects of a person's development and interpersonal relationships, the need for such research and the application of its results is clearly understood. In order to compare the effectiveness of Boeing family therapy and ACT treatment on differentiation, the following hypotheses are proposed. Methods: This research was conducted by quasi-experimental method and using a pretest-post-test design with two experimental groups and a control group. The independent variables of the study were Boeing family therapy and ACT treatment method and the dependent variable was marital satisfaction. The dependent variable scale was collected in two stages: pre-test and post-test. The statistical population of this study was all single mothers of preschool children in Kermanshah in the spring of 1399. The sampling method was simple by using random sampling and assignment. Forty-five mothers of preschool children were randomly selected and due to the prevalence of coronary heart disease in online sessions, intervention sessions were held for them through online sessions. The subjects' marital satisfaction scale was measured using the Enrich Marital Satisfaction Questionnaire for every 45 people (pre-test). Then, by simple random sampling, individuals were assigned to three groups of 15 people (two experimental groups and one control group). The experimental group members separately participated in eight 1.5-hour weekly sessions of the Boeing Family Therapy and ACT, conducted by a trained therapist, and the control group was placed on a waiting list. Meetings were held at Setareh Preschool Center on a weekly basis for two months. Participants in the sessions expressed their willingness to cooperate to receive intervention and participate in the research. Analysis of covariance and Bonferroni post hoc test were used to analyze the data. Results: The Benferoni post hoc test is performed to compare between the control group, ACT and Bowen. As can be seen in Table 5, there is no significant difference in marital satisfaction scores between the ACT and Bowen groups, and therefore Bowen-based therapy and ACT-based therapy have the same effect on marital satisfaction. Conclusion: The aim of this study was to compare the effect of Boeing family therapy and ACT treatment on cognitive emotion regulation of single mothers in preschool centers in Kermanshah. Stable and meaningful. Also, Bonferroni post hoc test showed that due to the differences in the comparison of these two interventional methods, the effectiveness of Buenie family therapy and ACT treatment on marital satisfaction is the same. The findings of the present study on the effectiveness of Boeing family therapy interventions on marital satisfaction are not unexpected and are consistent with the results of a large number of previous studies. The results showed that there was no significant difference between pre-test and post-test scores in the Boeing family therapy method and the ACT method on marital satisfaction. Couples in Buenos Aires believe that the phenomenon of marriage requires a high degree of adaptability. None of the couples feel safe and caring if there is no normal and acceptable level of adaptation in the marriage. In addition, marital intimacy requires a strong sense of self-awareness and self-differentiation. Couples with low levels of differentiation and high fusion are not able to understand their desires in the relationship, therefore, this process has a negative effect on their life satisfaction, when these couples with factors the change of role that reduces satisfaction, they face, they feel failure. Couples who are able to accredit themselves instead of seeking approval have a better working spirit in marriage. [ABSTRACT FROM AUTHOR]

Background & Aims: Intimacy is one of the most basic elements in a couple's relationship. Intimacy is a dynamic concept in human relationships, especially in marital relationships, which means openness and non-inhibition in relationships and the closeness of two or more people in various emotional, logical and functional dimensions. Couples who experience a higher degree of intimacy, apart from socioeconomic status, report significantly fewer adjustment problems in their marital relationship (1). Given the importance of intimacy, identifying effective intervention and educational approaches to increase couple intimacy to improve couple relationships will be very useful. One of these approaches is motivational interviewing, which is a combination of principles and techniques derived from a very wide range of models of psychotherapy and behavior change (4). In addition, given that many marital problems have emotional roots, the recent approach to meta-diagnostic treatment to resolve couples' problems has come into focus; Because this treatment emphasizes emotions and maladaptive emotion regulation strategies, emotional experience and response to emotion is the main basis in the meta-diagnostic approach (12). But it is not clear which intervention is more effective. On the other hand, it is not clear whether these interventions affect intimacy or not, and which intervention is more effective is also in a state of ambiguity. Methods: In order to conduct applied and quasi-experimental research with pre-test and posttest design, from couples referring to counseling centers in Shahrekord in 1399-1400 (1250 couples), by purposive sampling method and provided entry conditions For the study (with at least a third grade of middle school, age range 25 to 45 years, no disabling physical or mental illness) 60 couples were selected and randomly divided into three groups of motivational interview, meta-diagnostic treatment and witness. Before, immediately after and 45-day follow-up, the subjects completed the Wonden Brook and Bertman (1995) intimacy questionnaire, and the experimental groups each received 8 sessions of 90-minute intervention. Finally, from descriptive statistics (mean and standard deviation) and Kalmogorov-Smirnov tests, analysis of variance with repeated measures and Bonferroni post hoc using SPSS software version 25 at a significance level of 0.05 for statistical analysis of data used. Results: The results showed that the meta-diagnostic therapy group and motivational interviewing could lead to a change in the mean scores of the couple's intimacy (intimacy, agreement, honesty, love and commitment) in the post-test and follow-up stages. In order to be effective, the meta-diagnostic therapy and motivational interview therapy group was able to increase the mean scores of the couple's intimacy (intimacy, agreement, honesty, interest and love and commitment) in the post-test and follow-up stages. On the other hand, it was found that there were no significant changes between the pre-test scores. The results showed that the mean scores of the couple's intimacy variable, regardless of the effect of grouping, changed significantly during the post-test and follow-up stages, which is a significant difference compared to the pre-test (p = 0.001). On the other hand, it was found that the variable of grouping (post-diagnostic treatment group therapy) regardless of stages (pre-test, post-test and follow-up) had a significant effect on the intimacy variable of couples. This means that meta-diagnostic treatment was a significant effect compared to the control group (p = 0.001). Finally, the results indicate that meta-diagnostic treatment with the interaction of stages also had a significant effect on the test stages (pre-test, post-test and follow-up) of the couple intimacy variable (p = 0.001). The results of post hoc test (Table 3) show that the difference between the mean scores of pretest and post-test is significant by following the variable of couple intimacy. However, there is no significant difference between the mean of the post-test and the follow-up of this variable. This means that the mean scores of couples intimacy in the follow-up phase did not change significantly compared to the post-test, but due to the lack of follow-up scores compared to the post-test and a significant change in follow-up scores compared to the pre-test shows that the effectiveness of meta-diagnostic treatment on intimacy over time Preserved. On the other hand, it was found that the difference between the mean scores of intimate couples in the experimental group of meta-diagnostic therapy and the experimental group of motivational interviews was not significant and this finding means that the effectiveness of meta-diagnostic treatment and motivational interviews on the intimacy of couples was not significant. However, the difference between the experimental groups (meta-diagnostic therapy and motivational interview) with the control group was significant. In a summary, it can be stated as follows: Transdiagnostic treatment intervention and motivational interview have a significant effect on the level of intimacy of couples; However, the effectiveness of meta-diagnostic treatment and motivational interviewing on the level of intimacy of couples are not significantly different (Table 4). Conclusion: In explaining the effectiveness of motivational interview on couples intimacy, it should be noted that the therapist's goal in motivational interview is to create a safe environment to express problems and then, strengthen the desire to change to improve relationships in the client, which leads to increased intrinsic motivation. . Since intimacy is a feature that is not a fixed feature and changes when the couple is faced with stressful situations. Therefore, motivational interviewing, by increasing the couple's inner motivation to maintain intimacy in difficult life situations, causes the couple to communicate with each other emotionally (increase interest), then plan with interest to improve their relationship (reduce boredom) and from this Satisfy and enjoy your action (increase intimacy) (9). In explaining this finding, it may be pointed out that couples are more likely to not be able to use positive emotions effectively in times of conflict, and on the contrary, they have a lot of negative emotions, which causes other problems such as negative perception. Concerns about their relationship with their spouse and improper marital functioning become a reason for their intimacy to be disrupted. However, emotional awareness training in meta-diagnostic therapy makes them aware of the existence of negative emotions and their negative impact on themselves, or try to recover emotions in different situations to keep the emotion healthy, and thus, the rate of marital problems is reduced and in The result is marital intimacy (14). [ABSTRACT FROM AUTHOR]

Background & Aims: Autism is one of the neurological diseases that lead to changes in hormone levels. Therefore, the aim of this study was to the effect of a swimming exercise course on glucose and insulin in mice with autism. Scientific research has shown that people with autism have behavioral disorders including anxiety and depression. These patients are mostly isolated from social activities. The causes of this disease are not fully known, however, research by scientists in the last two decades has shown that accidents or the use of certain chemical drugs during fetal and early life can increase the risk of developing this disease in children. Clinical and animal evidence has shown the relationship between increased inflammation in the brain and autism. However, which brain area is involved in this disease is not completely clear. Although extensive research has been conducted on pharmacological and behavioral treatments, the response to these treatments has been largely unsuccessful. One method that has attracted researchers' attention in recent years is the use of sports protocols from adolescence to adulthood to reduce neurobehavioral disorders in adulthood. In addition, exercise has been confirmed as a factor in lowering inflammatory levels in the body and brain. Also, recent studies have shown that sports activities can reduce behavioral disorders including anxiety and depression, and increase social behaviors. Therefore, in this study, we decided to investigate the therapeutic effects of swimming in an animal model of autism on behavioral disorders, including anxiety, depression, and social behaviors, as well as the level of inflammation in the hippocampus and prefrontal brain regions, which are involved in these neurological disorders. Methods: The present study was approved by the code of ethics IR.PNU.REC.1400.269 in the Code of Ethics Commission of Payam Noor University. C57BL6 female and male mice with an approximate age of 80-90 days and a weight of 20-22 grams were maintained under light conditions of 12 hours of light and 12 hours of darkness and a temperature of 23 ± 1 degrees Celsius, with sufficient water and food at their disposal. was placed After two weeks of adaptation to the environment, each male and female animal was placed in a cage for mating, then the next morning the vaginal plaque was checked as an indicator of pregnancy. In order to cause autism disease in mice, the animals were divided into control and autism groups on the 12th day of pregnancy (each group of pregnant mice included 10 heads). In the autism group, pregnant rats received a dose of 600 mg/kg intraperitoneally with sodium valproate. After that, children were allowed to be born. At the age of 21 days, the children were separated from the mother by gender and kept in groups of 5 in each separate cage. On the 28th day after birth (one week after separation from the mother), the juvenile animals were divided into 4 groups of 10 as follows: the control group that does not exercise, the control group that exercises, the autism group that They don't exercise, the autism group who exercise. The animals were subjected to swimming exercise for 8 weeks (56 days) from the age of 28 days to the age of 56 days. The training was done 5 days a week, and in this protocol, the animals rested 2 days a week. The results were subjected to a one-way analysis of variance using SPSS-26 software, and the significance level was considered less than 0.05. Results: The results of the one-way analysis of variance test showed that there is no significant difference in the weight of mice of different research groups. Also, the results of the one-way analysis of variance showed that there is a statistically significant difference in the level of glucose in the mice of the research groups. The results of Tukey's post hoc test showed that the glucose level in the autism group with exercise has a significant decrease compared to the control group without exercise and also compared to the autism group without exercise (P value is equal to P ≥ 0.000 and P ≥ 0.016 respectively), also the glucose level in the autism group without exercise was significantly lower than in the control group without exercise (P ≥ 0.001). Also, the results of the oneway analysis of variance test showed that there is a statistically significant difference in insulin levels in the mice of the research groups (P<0.001). The results of Tukey's post hoc test showed that the insulin level in the autism group with exercise has a significant increase compared to the control group without exercise and also compared to the autism group without exercise (P value is equal to P ≥ 0.001 and P ≥ 0.000 respectively). Conclusion: Exercise decreased glucose and insulin in autistic mice, so it is suggested to use the swimming training protocol to improve the physical and hormonal condition of autistic patients. Scientific research has shown that people with autism have behavioral disorders including anxiety and depression. These patients are mostly isolated from social activities. The causes of this disease are not fully known, however, research by scientists in the last two decades has shown that accidents or the use of certain chemical drugs during fetal and early life can increase the risk of developing this disease in children Clinical and animal evidence has shown the relationship between increased inflammation in the brain and autism. However, which brain area is involved in this disease is not completely clear. Although extensive research has been conducted on pharmacological and behavioral treatments, the response to these treatments has been largely unsuccessful. One method that has attracted researchers' attention in recent years is the use of sports protocols from adolescence to adulthood to reduce neurobehavioral disorders in adulthood. In addition, exercise has been confirmed as a factor in lowering inflammatory levels in the body and brain. Also, recent studies have shown that sports activities can reduce behavioral disorders including anxiety and depression, and increase social behaviors. Therefore, in this study, we decided to investigate the therapeutic effects of swimming in an animal model of autism on behavioral disorders, including anxiety, depression, and social behaviors, as well as the level of inflammation in the hippocampus and prefrontal brain regions, which are involved in these neurological disorders. [ABSTRACT FROM AUTHOR]

Background & Aims: Ionic liquids are organic salts composed of organic cations and organic and / or inorganic anions that have many remarkable properties and properties, such as wide liquid state range, low vapor pressure, easy recovery process, high ionic conductivity, wide electrochemical window and design capability. Structural engineering with appropriate modification to represent cations or anions .Recently, many researchers have focused on the development of a new branch of ionic fluids called dichotomous ionic fluids (DILs); These fluids usually consist of two cationic groups that are connected to each other by a rigid or flexible spacer and are connected to two counter anions. Compared to mono-cationic ionic liquids, multi-cations have higher melting point, viscosity, surface tension and thermal stability, have a wider liquid range and more stable physical and chemical properties. Therefore, these liquids have a wide range of applications; Including solar cells, fuel cells, batteries, lubricants, reaction media, separation technology, material preparation, catalytic reactions and most recently, improving the normal isomerization rate of pentane and electrolytes for photo-harvesting. Structures containing xanthine are known for their wide range of biological and pharmacological activities, such as antibacterial, antiinflammatory, and anti-viral activities. In addition, xanthine ions are present as structural units in a large number of natural products. Methods: In this paper, for the first time, the catalyzed synthesis of xanthenedione and 4,3- dihydropyrimidine-2 (1H) - they are under Solvent-free conditions have been reported by the Brunsted ionic acid liquid .Ionic liquids are organic salts composed of organic cations and organic and / or inorganic anions that have many remarkable properties and properties, such as wide liquid state range, low vapor pressure, easy recovery process, high ionic conductivity, wide electrochemical window and design capability. Structural engineering with appropriate modification to represent cations or anions All reagents and solvents were commercially available and used without further purification. 1H NMR and 13C NMR in DMSO-d6 were recorded on a Bruker Avance Ultrashield spectrometer at 500 and 125 MHz, respectively. Chemical shifts were reported in parts per millions (δ), relative to the internal standard of tetramethylsilane (TMS). Thermal analysis (TG–DTA) of the DIL was recorded on a STA-1500 Rheometric Scientific TGA. Mass spectrometry (MS) studies were performed using 5957C VL MSD with a triple-axis detector, Agilent Technologies (ion source: electron impact (IE) 70 eV, ion source temperature: 230 °C, analyzer: Quadrupole). FTIR spectrum was taken on a FTIR PerkinElmer Spectrum Version 10.51 with KBr plates. Melting points were recorded on a Mettler Toledo Type FP62 in open capillary. Generally To a mixture of aromatic aldehyde (1 mmol) and 5, 5-dimethyl-1, 3 cyclohexanedione (2 mmol), 25 mol% of {[SO3H–Pyrazine–SO3H]Cl2} (0.25 mmol) was added and the reaction mixture was heated at 100 °C with stirring. After completion of the reaction monitored by thin-layer chromatography (TLC), the reaction mixture was allowed to cool at room temperature. Water (10 mL) was added and filtered to separate the catalyst. Then, the obtained solid product was filtered and then recrystallized from ethanol to afford the pure product. The products were identified by IR, 1H NMR and physical data (M.P.) with those reported in the literature. Also To a mixture of aromatic aldehyde (1 mmol), ethyl acetoacetate (1 mmol) and urea (2 mmol), 25 mol% of {[SO3H–Pyrazine–SO3H]Cl2} (0.25 mmol) was added and the reaction mixture was heated at 120 °C with stirring. After completion of the reaction evident from thin-layer chromatography (TLC), the reaction mixture was allowed to cool at room temperature. Water (10 mL) was added and the obtained solid product was filtered and then recrystallized from ethanol. The products were identified by IR, 1H NMR and physical data (M.P.) with those reported in the literature. The spectra data for some selected compounds are presented in the following. Results: To achieve the appropriate reaction conditions, the reaction of 4-chlorobenzaldehyde and 5,5 dimethyl-1,3-cyclohexanedione catalyzed by {[SO3H–Pyrazine–SO3H]Cl2} was chosen as model reaction, and the reaction was carried out under different sets of conditions with respect to solvents, amounts of catalyst and temperatures. Initially, the model reaction was investigated in different solvents. The solvents did not improve the yield of the reaction in the presence of the catalyst. Therefore, we carried out the model reaction under solvent-free conditions. The result indicates that the yield of the reaction under solvent-free conditions was higher and the reaction time was shorter in comparison with solvent conditions. To optimize the reaction temperature, the model reaction was heated at 90 and 110 °C .The results showed that the 100 °C led to highest yield; therefore, it was selected as the reaction temperature for all further reactions. Finally, the model reaction was optimized by varying the amounts of catalysts (20 and 30 mol%) at 100 °C under solvent-free conditions. The results show that 25 mol% of the catalyst is sufficient for the best results. To determine the role of the catalyst, the model reaction was performed in the absence of the catalyst at the same condition, which results in very low yield of the product, which indicates the high catalytic activity of {[SO3H–Pyrazine–SO3H]Cl2} in the synthesis. To evaluate the scope and the limitations of this method, we extended our studies to various aldehydes under the optimized conditions. From the results, we could see that all reactions proceeded smoothly to afford the corresponding xanthenediones in high to excellent yields in the short reaction times. Various functional groups present in the aryl aldehydes such as halogen, methoxy, hydroxy and nitro groups were tolerated. Extension of this methodology to heterocyclic aldehyde was also successful. In view of green chemistry, reusability of the catalyst is important. Therefore, some experiments were run under the same optimal conditions mentioned above over the {[SO3H–Pyrazine–SO3H]Cl2}. The results showed that the catalyst could accelerate the reaction three runs without a significant loss in its catalytic activity. The mechanism of the reaction starts with facilitating Knoevenagel condensation due to activating carbonyl group of aldehyde by acidic property of catalyst. In the following, the catalyst again plays a significant role in accelerating the Michael addition and dehydration. Conclusion: A comparative study on the catalytic activity of the introduced catalyst in this paper with some reported catalysts was carried out using 3a as a model compound. From this study, {[SO3H– Pyrazine–SO3H]Cl2} can be regarded as a more powerful catalyst for the synthesis of xanthenediones in terms of the yield and the reaction time. Multicomponent reactions (MCRs) are defined as one-pot processes that combine at least three reactants to selectively form single complex compounds as well as small heterocycles containing essentially all the atoms of the reactants. Among MCRs, the Biginelli reaction allows for the straight access of multifunctionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) through one-pot cyclocondensation of an aldehyde, a β-keto ester and urea in the presence of catalytic amount of acid Molecules containing DHPM core and its derivatives are of immense biological importance due to a wide range of pharmaceutical and therapeutic properties such as antiviral, antitumor, antibacterial,anti-inflammatory, anti-HIV agents mitotic kinesin inhibition, calcium channel modulation, α1aadrenergic antagonists and A2B adenosine receptor antagonists. In the classical Biginelli conditions, low yields and difficult isolation of the products are the main drawbacks due to strongly acidic conditions. Hence, many catalytic methods including Brönsted and Lewis acid, ionic liquids polymer-supported catalyst and nanoparticles have been introduced to enhance the efficiency of the synthesis of these important heterocycles. After obtaining acceptable results from xanthenediones synthesis catalyzed by {[SO3H–Pyrazine–SO3H]Cl2}, we decided to study its efficiency in the synthesis of DHPMs. In order to obtain the optimized conditions, the model reaction involving cyclocondensation of 4 chlorobenzaldehyde, ethyl acetoacetate and urea was examined. The best result was obtained when the reaction was carried out at 120 °C in the presence of 25 mol% of {[SO3H–Pyrazine–SO3H] Cl 2} under solvent-free conditions. After getting the satisfactory reaction condition in hand, the scope and efficiency of this approach were examined with respect to aldehydes. Fortunately, a variety of functional groups, such as halo, methoxy, hydroxy and nitro, were all well tolerated. In addition, heterocyclic aromatic aldehyde afforded the corresponding product with high yield. A plausible one-pot reaction pathway for the synthesis of DHPMs catalyzed by {[SO3H–Pyrazine–SO3H]Cl2}. Initially, acyl imine intermediate (I) is produced via condensation of aryl aldehyde and urea in the presence of the catalyst as a Brönsted acidic catalyst. Next, ethyl acetoacetate attacks the (I), followed by intramolecular cyclization and dehydration reaction under acidic condition to yield the Biginelli product. Next, the reusability of {[SO3H–Pyrazine–SO3H]Cl2} was examined in the reaction of 4-chlorobenzaldehyde, ethyl acetoacetate and urea under optimized conditions. The catalyst could be reused three times without a significant loss in its catalytic activity. In order to show the efficacy of {[SO3H–Pyrazine–SO 3H]Cl2}, a comparison of the present method and some reported methods is shown in results. As revealed from this table, the catalyst can be considered as a more powerful catalyst for the synthesis of DHPMs in terms of the yield and reaction time. [ABSTRACT FROM AUTHOR]