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Immunogenetic diagnostics allows identifying individuals with a high degree of risk of developing certain diseases, and associative connections with the cytokine link of immunity to expand ideas about their immunogenesis to determine prognostic markers and its course. The objective: to evaluate the associative relationships between the HLA-phenotype of patients with pathology of the genitourinary system and the cytokine link in order to determine the role in immunogenesis, improve prognosis and treatment. Materials and methods. The study was carried out within the framework of the NDP "Evaluate the effectiveness and safety of various methods of treatment of men suffering from chronic calculous prostatitis". The distribution of HLA-antigens in 464 patients with chronic cystitis (ChC), including proliferative cystitis (ChPC) and chronic prostatitis (ChP), sclerosis (SP), benign hyperplasia (HP) and prostate cancer (PC) was studied using the standard microlymphocytotoxic test (Terasaki). The reference group consisted of 350 healthy donors. Relative risk (RR≥2) and absolute (attributive) risk of the disease were determined. Levels of TNF-α, IL-18, MCP-1, IL-17, IL-4, VEGF were studied in blood serum by ELISA on the SunRise TouchScreen analyzer (Invitrogen, USA; Vector Best, Ukraine). Results. The connection of the most common diseases of the genitourinary system with certain histocompatibility antigens (RR≥2) is shown. The causal role of HLA with a reliable absolute risk of developing chronic cystitis (including proliferative) (A10, B14, B16), as well as chronic prostatitis (A24, B8, B52), prostate sclerosis (A24, A28), benign hyperplasia (A29, B38) and prostate cancer (A25, A29, B40, B44, B49) was determined. Protective antigens - A25, A26, B5, B14, B16, B17 for chronic prostatitis, as well as A10, B15, B17 for sclerosis, A9, A10, B17 for bening prostatic hyperplasia and A1, B5, B13, B15 for-prostate cancer. Associations of high production of cytokines were found for pro-inflammatory: TNF-α with HLA-A10, A11, A28, B14, B44; IL-18 - A10 and A24; MSR-1 - A28, B8, B41; IL-17 - A24, A28, B14; anti-inflammatory IL-4 - A24 and A28 (A2, B8, B14 are associated with a lower level of the production, and A10 determines the tendency); and VEGF growth factor - A9, A25 and B8. Conclusions. Associations of predictors of pathology and features of cytokines negative for its course determine additional risks for patients and act as markers for prediction and individualization of treatment. [ABSTRACT FROM AUTHOR]